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*  A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines | The EMBO Journal
Bohman C and Eriksson S (1988) Deoxycytidine kinase from human leukemic spleen: preparation and characteristics of homogeneous ... while the deoxycytidine kinase (dCK, EC 2.7.1.74) phosphorylates dAdo, dGuo and dCyd (Arnér and Eriksson, 1995; Hatziz et al., ... but also deoxycytidine (dCyd). Deoxyguanosine kinase (dGK, EC 2.7.1.113) phosphorylates deoxyadenosine (dAdo) and ... The intracellular localization of deoxycytidine kinase. J Biol Chem, 273, 30239-30243. ...
http://emboj.embopress.org/content/21/7/1873
*  Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase | Adenosine Kinase...
AID deaminates deoxycytidine (dC) bases in targeted Ig gene areas, transforming the targeted bases to deoxyuridine (dU), and ... thus directly causes BMS-754807 transition mutations of dC/dG (deoxycytidine/deoxyguanosine) foundation pairs BMS-754807 to dA/ ...
http://cutelevision.org/affinity-maturation-and-class-switching-of-antibodies-requires-activation-induced-cytidine-deaminase/
*  Structure-function studies of mammalian deoxycytidine kinases - Epsilon Open Archive
Deoxycytidine kinase is a cytosolic enzyme and one of four deoxynucleoside kinases in mammalian cells. Human deoxycytidine ... An NMR conformational study of the complexes of ¹³C/²H double-labelled 2'- deoxynucleosides and deoxycytidine kinase (dCK). J. ... A pre-steady-state kinetic analysis of substrate binding to human recombinant deoxycytidine kinase: a model for nucleoside ... The effect of high salt concentrations on the regulation of the substrate specificity of human recombinant deoxycytidine kinase ...
https://pub.epsilon.slu.se/221/
*  DCK Gene - GeneCards | DCK Protein | DCK Antibody
Deoxycytidine Kinase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... NTP + deoxycytidine = NDP + dCMP. *DCK_HUMAN,P27707. UniProtKB/Swiss-Prot Function: Required for the phosphorylation of the ... deoxycytidine kinase,pyrimidine salvage pathway *DCK. UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM ... Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers. (PMID: 16799820) ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=DCK&keywords=GH04H070969&prefilter=genomic_location
*  Deoxycytidine - Wikipedia
Deoxycytidine can be phosphorylated by deoxycytidine kinase (DCK).. ... Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine, but ...
https://en.wikipedia.org/wiki/Deoxycytidine
*  Deoxycytidine kinase - Wikipedia
dCK predominantly phosphorylates deoxycytidine (dC) and converts dC into deoxycytidine monophosphate. dCK catalyzes one of the ... Grégoire V, Rosier JF, De Bast M, Bruniaux M, De Coster B, Octave-Prignot M, Scalliet P (June 2002). "Role of deoxycytidine ... Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. ... Conversely, increased deoxycytidine kinase activity is associated with increased activation of these agents to cytotoxic ...
https://en.wikipedia.org/wiki/Deoxycytidine_kinase
*  Deoxycytidine diphosphate - Wikipedia
"Possible Metabolic Functions of Deoxycytidine Diphosphate Choline and Deoxycytidine Diphosphate Ethanolamine". Journal of ... Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, ... Reichard, Peter (1962). "Enzymatic Synthesis of Deoxyribonucleotides: I. FORMATION OF DEOXYCYTIDINE DIPHOSPHATE FROM CYTIDINE ... deoxycytidine diphosphate is abbreviated as dCDP. DNA Cofactor Cytosine MeSH term, accessed Dec. 31, 2012 Kennedy, Eugene P.; ...
https://en.wikipedia.org/wiki/Deoxycytidine_diphosphate
*  Deoxycytidine deaminase - Wikipedia
In enzymology, a deoxycytidine deaminase (EC 3.5.4.5) is an enzyme that catalyzes the chemical reaction deoxycytidine + H2O ... As every deoxycytidine deaminase is also a cytidine deaminase, they share the same EC number. The recommended name assigned by ... The systematic name of this enzyme class is cytidine/2'-deoxycytidine aminohydrolase. This enzyme participates in pyrimidine ... displaystyle \rightleftharpoons } deoxyuridine + NH3 Thus, the two substrates of this enzyme are deoxycytidine and H2O, whereas ...
https://en.wikipedia.org/wiki/Deoxycytidine_deaminase
*  Deoxycytidine triphosphate - Wikipedia
Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that contains the pyrimidine base cytosine. The triphosphate ... DNA polymerase enzymes use this energy to incorporate deoxycytidine into a newly synthesized strand of DNA. A chemical equation ...
https://en.wikipedia.org/wiki/Deoxycytidine_triphosphate
*  Deoxycytidine monophosphate - Wikipedia
Deoxycytidine monophosphate (dCMP), also known as deoxycytidylic acid or deoxycytidylate in its conjugate acid and conjugate ...
https://en.wikipedia.org/wiki/Deoxycytidine_monophosphate
*  2'-deoxycytidine (CHEBI:15698)
... has role Escherichia coli metabolite (CHEBI:76971) 2'-deoxycytidine (CHEBI:15698) has role ... 2'-deoxycytidine (CHEBI:15698) has role human metabolite (CHEBI:77746) 2'-deoxycytidine (CHEBI:15698) has role mouse metabolite ... 2'-deoxycytidine UniProt 4-. amino-. 1-. [(2R,4S,5R)-. 4-. hydroxy-. 5-. (hydroxymethyl)tetrahydrofuran-. 2-. yl]pyrimidin-. 2( ... CHEBI:15698 - 2'-deoxycytidine. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:19240
*  Deoxycytidine kinase (DCK)
Homo sapiens deoxycytidine kinase mRNA, complete cds. P. BC103764.1. Homo sapiens deoxycytidine kinase, mRNA (cDNA clone MGC: ... PREDICTED: deoxycytidine kinase. P. troglodytes. 98.8. 259. XP_003898841.1 * Conserved domains (CDD) * * Gene summary * * ... Homo sapiens deoxycytidine kinase (DCK), mRNA. PA. CR536527.1. Homo sapiens full open reading frame cDNA clone RZPDo834F0322D ... Homo sapiens cDNA, FLJ94081, Homo sapiens deoxycytidine kinase (DCK), mRNA. P. AK303292.1. Homo sapiens cDNA FLJ51425 complete ...
https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=709
*  2'-Deoxycytidine - DrugBank
Deoxycytidine. PDB Entries. 1j90 / 1p60 / 1p61 / 1rmy / 1vq5 / 1vqp / 2a2z / 2a30 / 2no1 / 2vp5 … ... deoxycytidines, and a process for making oligonucleotides with N-modified 2'-deoxycytidines.' U.S. Patent US5633364, issued ... UDeoxycytidine kinase. Not Available. Humans. Absorption. Not Available. Volume of distribution. Not Available. Protein binding ... 2'-Deoxycytidine. Accession Number. DB02594 (EXPT01140) Type. Small Molecule. Groups. Experimental, Investigational. ...
https://www.drugbank.ca/drugs/DB02594
*  2'-Deoxycytidine 5'-triphosphate - DrugBank
UDeoxycytidine triphosphate deaminase. Not Available. Escherichia coli (strain K12). Absorption. Not Available. Volume of ... Details4. Deoxycytidine triphosphate deaminase. Kind. Protein. Organism. Escherichia coli (strain K12). Pharmacological action ... 2'-deoxycytidine phosphate, pyrimidine 2'-deoxyribonucleoside 5'-triphosphate (CHEBI:16311) / Deoxyribonucleotides (C00458) ... 2'-Deoxycytidine 5'-triphosphate. Accession Number. DB03258 (EXPT01137) Type. Small Molecule. Groups. Experimental. Description ...
https://www.drugbank.ca/drugs/DB03258
*  Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine | PNAS
Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine Message Subject (Your Name) has sent you a message from ... Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine. Minmin Liu, Hitoshi Ohtani, Wanding Zhou, Andreas Due ... 1998) Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 58(1 ... In vitro, when vitamin C is added at physiological levels to low doses of the DNMTi 5-aza-2′-deoxycytidine (5-aza-CdR), there ...
https://www.pnas.org/content/113/37/10238
*  Deoxycytidine molecule - Stock Image F012/5920 - Science Photo Library
Deoxycytidine triphosphate (dCTP) nucleotide molecule. DNA building block. Stylized skeletal formula (chemical structure). ... Caption: Deoxycytidine triphosphate (dCTP) nucleotide molecule. DNA building block. Stylized skeletal formula (chemical ... deoxycytidine, deoxycytidylate, deoxycytidylic, deoxycytidylyl, deoxyribonucleic, deoxyribose, dna, drawing, flat, formula, ...
http://www.sciencephoto.com/media/694562/view
*  RCSB PDB - 1NJE: THYMIDYLATE SYNTHASE WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) Methods Report Page
1NJE: Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1NJE
*  Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs |...
... deoxycytidine (DAC) in a rat model for acute myeloid leukemia is mediated by mutations in the deoxycytidine kinase (DCK) gene. ... deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response. Clin Cancer Res ... deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene. Biochem Biophys Res Commun 293(5): ... Qin T, Jelinek J, Si J, Shu J, Issa JP (2009) Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. ...
https://link.springer.com/article/10.1007%2Fs10549-011-1477-3
*  5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story | Cancer Research
5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story. Z. Sheng Guo, Nicholas P. Restifo and David S. Schrump ... De novo induction of a cancer/testis antigen by 5-aza-2′-deoxycytidine augments adoptive immunotherapy in a murine tumor model ... Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with ... 5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story ...
http://cancerres.aacrjournals.org/content/67/6/2901
*  dck Protein, deoxycytidine kinase - Creative BioMart
... increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside ... Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. ... Recombinant Human Deoxycytidine Kinase, His-tagged. E. coli. Human. His. +Inquiry. DCK-796H. Recombinant Human DCK, His-tagged ... Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. ...
https://www.creativebiomart.net/symbolsearch_dck.htm
*  Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity | Cancer Research
Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity. Shinjiro Nagai, Kazumasa ... Deoxycytidine kinase siRNA. We used the Silencer Select Validated siRNA for dCK, ID s186, and the Silencer Select Negative ... Cloning and mutagenesis of human deoxycytidine kinase. The open reading frame of human dCK was obtained by using a pair of ... Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants. J Pharmacol Exp Ther ...
http://cancerres.aacrjournals.org/content/71/5/1781
*  Electrogenerated chemiluminescence of triazole-modified deoxycytidine analogues in N,N-dimethylformamide - Physical Chemistry...
... of these deoxycytidine (dC) analogues, 1-4, were investigated as the monomers. Cyclic voltammetry and diffe ... Triazole-modified deoxycytidines have been prepared for incorporation into single-stranded deoxyribonucleic acid (ssDNA). ... deoxycytidine. analogues in N,N-dimethylformamide Kalen N. Swanick,a David W. Dodd,a Jacquelyn T. Price,a Allison L. Brazeau,a ... deoxycytidine. analogues in N,N-dimethylformamide K. N. Swanick, D. W. Dodd, J. T. Price, A. L. Brazeau, N. D. Jones, R. H. E. ...
http://pubs.rsc.org/en/Content/ArticleLanding/2011/CP/c1cp22116g
*  Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents | SpringerLink
Momparler RL (2005) Pharmacology of 5-aza-2′-deoxycytidine (decitabine). Semin Hematol 42(3 Suppl 2):S9-S16CrossRefPubMedGoogle ... Demethylating agent 5-Aza-2′-deoxycytidine Breast carcinoma Anticancer agents Chemosensitivity Sameer Mirza and Gayatri Sharma ... Kanda T, Tada M, Imazeki F, Yokosuka O, Nagao K, Saisho H (2005) 5-Aza-2′-deoxycytidine sensitizes hepatoma and pancreatic ... Gomyo Y, Sasaki J, Branch C, Roth JA, Mukhopadhyay T (2004) 5-Aza-2′-deoxycytidine upregulates caspase-9 expression cooperating ...
https://link.springer.com/article/10.1007%2Fs11010-010-0473-y
*  5-Aza-2′-deoxycytidine - LKT Labs
Decitabine is a deoxycytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT1/3A/3B) activity. ...
https://www.lktlabs.com/product/5-aza-2%E2%80%B2-deoxycytidine/
*  Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2′-deoxycytidine...
... deoxycytidine (5-aza 2′dC) is clinically effective in acute myeloid leukemia; however, it has shown limited results in ... Breast cancer Epigenetic therapy EGCG 5-Aza-2′-deoxycytidine This is a preview of subscription content, log in to check access. ... Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, Jacob ST (2005) 5-Aza-deoxycytidine induces selective degradation ... Valdez BC, Li Y, Murray D, Corn P, Champlin RE, Andersson BS (2010) 5-Aza-2′-deoxycytidine sensitizes busulfan-resistant ...
https://link.springer.com/article/10.1007%2Fs10549-015-3295-5