Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug-induced...
... consisting of the adaptor protein Fas-associated death domain protein (FADD [MORT-1]) and procaspase-8 (FADD-like IL-1β- ... associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14:5579-5588, pmid:8521815.. ... DISC formation is mediated by two homophilic protein interaction domains: FADD contains a COOH-terminal death domain (DD), ... 1998) Apoptosis signaling by death receptors. Eur J Biochem 254:439-459, pmid:9688254.. ...http://jem.rupress.org/content/188/5/979
TRAIL‐ and TNF‐induced signaling complexes-so similar yet so different | The EMBO Journal
... "death domain" (DD) and make use of basically the same set of signaling proteins to induce apoptotic or necroptotic cell death, ... TNF receptor‐1 (TNFR1) and TRAIL death receptors preferentially induce pro‐inflammatory or cytotoxic signaling, respectively, ... This "complex I" contains the DD adapter protein TRADD and the serine/threonine kinase RIP, which recruit complexes of TRAF2 ... cytotoxic activities are most prominent in TRAIL death receptor signaling. These relative preferences appeared to be due to ...http://d2ni3bh4dzb2ig.cloudfront.net/content/early/2017/04/11/embj.201796997
Apoptosis - wikidoc
... and Fas-associated death domain protein (FADD). Binding of this receptor can also indirectly lead to the activation of ... or directly transducing the signal via adapter proteins to the apoptotic mechanisms. The whole preparation process requires ... Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Adaptor protein ... the pathway that leads to caspase activation via the intermediate membrane proteins TNF receptor-associated death domain (TRADD ...http://www.wikidoc.org/index.php/Apoptosis
Phospho-SXXE/D Motif Mediated TNF Receptor 1-TRADD Death Domain Complex Formation for T Cell Activation and Migration | The...
... members and their adaptor proteins may serve to function as a specific interaction module for the α-helical death domain signal ... TNFR1 and TRADD death domains play a critical role in the death domain-death domain protein interaction and death domain signal ... TNFR-associated death domain protein (TRADD), Fas-associated death domain protein, and receptor-interacting protein kinase ... For SH2 domain-bearing proteins, such as growth factor receptor adaptor proteins or transcription factors like STATs, ...http://www.jimmunol.org/content/187/3/1289.long
John J Laterra - Research Output - Johns Hopkins University
Death Domain Receptor Signaling Adaptor Proteins Proto-Oncogene Proteins c-met 2009 ... Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. Li, Y., ... c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Li, Y., Li, A., Glas, M., ... EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase. Wang, S. D ...https://jhu.pure.elsevier.com/en/persons/john-j-laterra/publications/
Role of Raf-1 in Fas-mediated apoptosis: a working mode | Open-i
Cytoskeletal Proteins/metabolism. *Death Domain Receptor Signaling Adaptor Proteins. *Dose-Response Relationship, Drug ... Thus, Rok-α downstream signaling has an impact on both the strength and duration of the apoptotic signal, and restraining Rok-α ... Thus, Rok-α downstream signaling has an impact on both the strength and duration of the apoptotic signal, and restraining Rok-α ... In this study, we show that the kinase-independent modulation of Rok-alpha signaling is also the basis of the antiapoptotic ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2171328_200504137f8&req=4
Find Research Projects - Penn State
Death Domain Receptor Signaling Adaptor Proteins Autophagy Membranes Neoplasms Tools for integrative genomics and disease ... Mitochondrial uncoupling protein 2 (UCP2) prevents neuronal death in stressed hippocampal neurons. Barnstable, C. ... Development of Cryo-EM/TEM Technologies for Small Protein and RNA Systems. Lindner, S. E. & Hafenstein, S. ... Genome-wide structural organization of proteins within human gene regulatory complexes. Pugh, B. F. & Mahony, S. A. ...https://pennstate.pure.elsevier.com/en/projects/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=
Peter, M. E.<...
Death Domain Receptor Signaling Adaptor Proteins Medicine & Life Sciences Caspase 8 Medicine & Life Sciences ... Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Galluzzi, L., Vitale, I ... Training Program in Signal Transduction and Cancer. Leikin, R. G., Peter, M. E. & Platanias, L. C. ... Marcus E. Peter studies various forms of cell death including apoptosis, which is a fundamental process to regulate homeostasis ...https://www.scholars.northwestern.edu/en/persons/marcus-ernst-peter
Caspase 8 - Caspase-8 Summary Report | CureHunter
... can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. ... A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS ... can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. ... A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS ...http://www.curehunter.com/public/keywordSummaryD053181.do
Interfering with Rok-α and ezrin restores normal sensi | Open-i
Cytoskeletal Proteins/metabolism. *Death Domain Receptor Signaling Adaptor Proteins. *Dose-Response Relationship, Drug ... In contrast, in KO fibroblasts, hyperphosphorylation of ezrin prevents internalization and prolongs the death signal, thereby ... In contrast, in KO fibroblasts, hyperphosphorylation of ezrin prevents internalization and prolongs the death signal, thereby ... In this study, we show that the kinase-independent modulation of Rok-alpha signaling is also the basis of the antiapoptotic ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2171328_200504137f5&req=4
Initiator Caspases Summary Report | CureHunter
... protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; ... DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other ... A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions ... protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; ...http://www.curehunter.com/public/keywordSummaryD053471.do
An Innovative Cis-Diammineplatinum (II) Benzene-Polycarboxylic-Acids Complex Inhibits Growth of Burkitt`s Cell Lymphoma In...
The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in ... The signal transduction of this receptor is mediated by various death domain containing adaptor proteins.. ... The TNFRSF-1B protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a ... 1996) A death-domain-containing receptor that mediates apoptosis. Nature 384: 372-375. ...https://www.omicsonline.org/open-access/an-innovative-cisdiammineplatinum-ii-benzenepolycarboxylicacidscomplex-inhibits-growth-of-burkitts-cell-lymphoma-in-vitro-and-in-v-2329-8790-1000234.php?aid=70066
The signal transduction of this receptor is mediated by various death domains containing adaptor proteins. Recently, it has ... 1 EU/mg of protein. , 10 EU/mg of protein. , 100 EU/mg of protein. ... CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 ... DR3, also known as TNFRSF25, lymphocyte-associated receptor of death (LARD), WSL-1, TRAMP, TR3 and APO3, is a 55 kD ...https://www.biolegend.com/fr-lu/immunobiology
TNFRSF25 monoclonal antibody (M02), clone 3A16 - (MAB5668-M02) - Products - Abnova
TNFRSF25 (AAI17190.1, 24 a.a. ~ 199 a.a) partial recombinant protein with mouse IgG2a-Fc tag. (MAB5668-M02) - Products - Abnova ... The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in ... apoptosis-mediating receptor,death domain receptor 3 soluble form,death receptor beta,lymphocyte associated receptor of death, ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the ...http://www.abnova.com/products/products_detail.asp?catalog_id=MAB5668-M02
EDARADD - Ectodysplasin-A receptor-associated adapter protein - Homo sapiens (Human) - EDARADD gene & protein
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ... Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ... Protein. Similar proteins. Species. Score. Length. Source. Q8WWZ3. Ectodysplasin-A receptor-associated adapter protein ( ... Protein. Similar proteins. Species. Score. Length. Source. Q8WWZ3. Ectodysplasin-A receptor-associated adapter protein ( ...https://www.uniprot.org/uniprot/Q8WWZ3
anti-DR3 antibody | GeneTex
... tumor necrosis factor receptor superfamily, member 25) for IHC-P, WB. Anti-DR3 pAb (GTX105713) is tested in Human samples. 100 ... The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in ... lymphocyte-associated receptor of death antibody, apoptosis-inducing receptor AIR antibody, death domain receptor 3 soluble ... death receptor beta antibody, protein WSL-1 antibody, apoptosis inducing receptor antibody, tumor necrosis factor receptor ...http://www.genetex.com/DR3-antibody-GTX105713.html
A New TRADDition in Intracellular Antiviral Signaling | Science Signaling
Science Signaling. 29 Jul 2008. : pe36 The tumor necrosis factor (TNF) receptor-associated death domain (TRADD) adaptor protein ... Science Signaling. 29 Jul 2008. : pe36 The tumor necrosis factor (TNF) receptor-associated death domain (TRADD) adaptor protein ... A study now describes a role for the tumor necrosis factor receptor (TNFR)-associated death domain (TRADD) in the antiviral ... Your Name) has forwarded a page to you from Science Signaling Message Body. (Your Name) thought you would like to see this page ...https://stke.sciencemag.org/content/1/30/pe36
Infection-derived lipids elicit an immune deficiency circuit in arthropods | Nature Communications
Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is ... The insect IMD signalling pathway detects invading pathogens. ... the death domain protein FADD and the adaptor molecule IMD. The ... Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas- ... PGRP-LC interacts with the protein IMD3, which recruits the molecule Fas-Associated protein with Death Domain (FADD)4. FADD ...https://www.nature.com/articles/ncomms14401?error=cookies_not_supported&code=e12a933e-6bd6-4205-b5cd-d254fcfd1d9a
Table of Contents - July 29, 2008, 1 (30) | Science Signaling
The tumor necrosis factor (TNF) receptor-associated death domain (TRADD) adaptor protein plays a role in the antiviral response ... Arginine methylation of estrogen receptor alpha promotes its interaction with cytoplasmic signaling proteins. ... Science Signaling. 29 Jul 2008. : ec275 Full AccessRestricted Access. When a plant membrane receptor is activated by a steroid ... Science Signaling. 29 Jul 2008. : ec274 Full AccessRestricted Access. Two tyrosine residues in the actin-binding protein HS1 ...https://stke.sciencemag.org/content/1/30
Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation. -...
Catalytic Domain, DNA-Binding Proteins, Death Domain Receptor Signaling Adaptor Proteins, Enzyme Activation, Glutamine, Guanine ... Protein Conformation, Signal Transduction, Transfection, rab GTP-Binding Proteins, rab1 GTP-Binding Proteins, rab5 GTP-Binding ... Rab GTPase, membrane traffic, nucleotide exchange factor, Adenosine Triphosphate, Aspartic Acid, Bacterial Proteins, ...https://www.neuroscience.ox.ac.uk/publications/449205
TNF-α Mediates Macrophage-Induced Bystander Effects through Netrin-1 | Cancer Research
Tnfrsf1a receptors possess a cytoplasmic death domain that rapidly engages apoptotic signaling, whereas Tnfrsf1b receptors ... receptors that, when bound, recruit intracellular adaptor proteins to activate multiple signal transduction pathways including ... Tnfrsf1b receptor signaling resulted in the activation of antiapoptotic survival proteins. The proproliferative consequences of ... Through Tnfrsf1b receptor signaling initiated by E. faecalis-infected macrophages, TNF-α leads to increased epithelial cell ...http://cancerres.aacrjournals.org/content/72/20/5219.full
Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients...
... the death effector domain-containing DNA-binding protein and apoptosis-associated speck-like protein containing a CARD) occurs ... and related observed differences to their lymphocyte apoptosis gene profiles.Lymphocytes were assessed for cell death by ... Death Domain Receptor Signaling Adaptor Proteins, CARD Signaling Adaptor Proteins ... the death effector domain-containing DNA-binding protein and apoptosis-associated speck-like protein containing a CARD) occurs ...https://www.ndorms.ox.ac.uk/publications/108455
CD99 Signals Caspase-Independent T Cell Death | The Journal of Immunology
... recruitment of distinct adapter molecules such as Fas-associated death domain protein for Fas, DR4, and DR5 (33, 34) and both ... The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. J. Exp. ... Fas-associated death domain protein and TNFR-associated death domain protein for TNFRI/p55 (35) to the death domain of the ... FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505. ...http://www.jimmunol.org/content/166/8/4931.long
This complex consists of trimerized receptors, the death domain-containing adaptor protein Fas-associated death domain, and ... two death receptors that can trigger the death signal by TRAIL (7, 8), and DcR1 (TRAIL-R3), DcR2 (TRAIL-R4), and ... An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997;277:815-8. ... TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction ...http://mct.aacrjournals.org/content/5/12/2970
Discover the death domain-containing adapter protein (FADD), which is the key conduit for the flow of death signals from death ... iii) Demonstrate that death receptors signal by a novel mechanism of recruiting and activating a death protease (caspase-8). ( ... Show that the death-domain containing molecule MyD88 was a key adaptor in innate immune signaling. (vi) Discover two ancient ... which is a process of fundamental importance to the regulation of death and cytokine receptor signaling. (viii) Discover the ...http://www.nasonline.org/member-directory/members/20028663.html