Germline Bottlenecks and the Evolutionary Maintenance of Mitochondrial Genomes | Genetics
1994b Mutation load under vegetative reproduction and cytoplasmic inheritance. Genetics 137: 311-318. ... We suggest that uniparental inheritance has a similar effect. The bottleneck process in our model is closely related to a ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... 1988 Natural selection with nuclear and cytoplasmic transmission. III. Joint analysis of segregation and mtDNA in Drosophila ...
Genetics of Mother-Dependent Sex Ratio in Blue Mussels (Mytilus spp.) and Implications for Doubly Uniparental Inheritance of...
This pattern of strong bimodal bias of sex ratio is not known in any system of sex-ratio bias mediated by a cytoplasmic factor ... It is clear that beyond the obvious need to investigate at depth the nature of the link between sex inheritance and inheritance ... 1994b A new type of mitochondrial DNA inheritance in the blue mussel Mytilus. Proc. Natl. Acad. Sci. USA 91: 7463-7467. ... 1995 Uniparental inheritance of mitochondrial and chloroplast genes: mechanisms and evolution. Proc. Natl. Acad. Sci. USA 92: ...
Molecular Genetic Dissection of Mouse Unconventional Myosin-VA: Tail Region Mutations | Genetics
MYO4 is one of five cytoplasmic genes identified in a genetic screen that are required for mother-specific HO expression (J ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... 1996 Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic ... Hiu et al. (1996) demonstrated a requirement for MYO2 in vacuolar inheritance in yeast. ...
The Mitochondrial Genome of the Sea Anemone Metridium senile (Cnidaria): Introns, a Paucity of tRNA Genes, and a Near-Standard...
1995b Mitochondrial import of a cytoplasmic lysine-tRNA in yeast is mediated by cooperation of cytoplasmic and mitochondrial ... In most other Metazoa examined, mtDNA inheritance is strictly maternal (Buzzoet al. 1978; Fauron and Wolstenholme 1980). If ... It seems likely that in plants and T. brucei at least, some specific nuclear DNA-encoded tRNAs are used in both cytoplasmic and ... 1992 Mitochondrially-imported cytoplasmic tRNALys (CUU) of Saccharomyces cerevisiae: in vivo and in vitro targetting systems. ...
A Regulatory Module Controlling Pharyngeal Development and Function in Caenorhabditis elegans | Genetics
In contrast to the embryo, expression in the adult pharynx is both nuclear and cytoplasmic. For images C and D, anterior is ... Inheritance of sup-37(+) from either progenitor would then be sufficient for rescue. ... Given that PHA-1 is constitutively cytoplasmic, whereas SUP-35 translocates from the cytoplasm to the nucleus at the time of ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ...
The 2000 T. H. Morgan Medal Essay: H. J. Muller and the Nature of the Gene | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... whereby it converts some of the surrounding cytoplasmic material into an end product identical with itself. This reaction "is ... and quantitative inheritance. The neo-Darwinian "new synthesis" had united genetics and Darwinian evolution, which had long ...
High Frequency Intragenic Recombination During Macronuclear Development in Tetrahymena thermophila Restores the Wild-type SerH1...
1987 Nucleo-cytoplasmic interaction during macronuclear differentiation in ciliate protists: Genetic basis for cytoplasmic ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... processing of micronuclear regions into two or more macronuclear chromosomes and the peculiar epigenetic inheritance of altered ...
Chloroplast DNA variation in a wild plant, tolmiea menziesii. | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... diploid and tetraploid Tolmiea do not experience cytoplasmic gene flow. Last, three cytoplasmically distinct groups of diploid ...
Suppression of an Atypically Spliced Rice CACTA Transposon Transcript in Transgenic Plants | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... 2000 A delta opioid receptor lacking the third cytoplasmic loop is generated by atypical mRNA processing in human malignomas. ...
Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans |...
2014 The DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans. Curr. Biol. 24: 832-838. ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ...
Extragenic Suppressors of Loss-of-Function Mutations in the Aspergillus FlbA Regulator of G-Protein Signaling Domain Protein |...
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... 1994 The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and ...
A Screen to Identify Drosophila Genes Required for Integrin-Mediated Adhesion | Genetics
1986 Cytoplasmic myosin from Drosophila melanogaster. J. Cell. Biol. 103: 1517-1525. ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... Thus several of these loci are good candidates for genes encoding cytoplasmic proteins required for integrin function. ... This screen should have succesfully identified genes that encode cytoplasmic proteins that are essential and fairly specific ...
Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast | Genetics
Planta, R. J., and W. H. Mager, 1998 The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14: 471-477. ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... Over 50% of the structural components of the cytoplasmic ribosome are haploinsufficient. Because ∼75% of the ribosomal genes ...
The Ketel Gene Encodes a Drosophila Homologue of Importin-β | Genetics
The protein is cytoplasmic with pronounced accumulation in the NEs (Figure 7, A and C). Nurse cells dump their Ketel protein ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... The Ketel protein is cytoplasmic and is not present in every cell type: As other members of the importin-β family, the Ketel ... When importin-β is added and no energy is supplied the substrate docks on the cytoplasmic surface of the NE (B). When, however ...
Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae | Genetics
We found that both gpn2-2 and gpn3-1 mutants show defects in Rpb1-GFP localization, as there is a strong cytoplasmic ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... 2010 HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol. Cell 39 ... In yeast, reduction of function of NPA3/GPN1 leads to chromatid cohesion defects, cell-cycle defects, and cytoplasmic ...
Unusual and Typical Features of a Novel Restorer-of-Fertility Gene of Sugar Beet (Beta vulgaris L.) | Genetics
2006 Cytoplasmic male sterility, pp. 147-180 in Flowering and Its Manipulation, edited by Ainsworth C.. Blackwell Publishing, ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... 2007 Cytoplasmic male sterility: a window to the world of plant mitochondrial-nuclear interactions. Trends Genet. 23: 81-90. ... 2006 Cytoplasmic male sterility of rice with boro II cytoplasm is caused by a cytotoxic peptide and is restored by two related ...
The Paternal Gene of the DDK Syndrome Maps to the Schlafen Gene Cluster on Mouse Chromosome 11 | Genetics
Because the DDK syndrome embryonic lethality requires inheritance of a paternal C57BL/6 allele, there should be an excess of ... Nuclear and cytoplasmic transfer studies have demonstrated that the embryos die as a result of an incompatible interaction ... As shown in Figure 2 there is a highly significant transmission ratio distortion against the inheritance of the recombinant ... This conclusion was confirmed by analyzing the inheritance of paternal alleles in the surviving offspring of the two males, ...
Chromosome Rearrangements Induce Both Variegated and Reduced, Uniform Expression of Heterochromatic Genes in a Development...
Imaginal discs from lt+/lt+ larvae (A) exhibited a more intense cytoplasmic staining pattern than did those from lt+/Df larvae ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... Uniform, cytoplasmic staining for cta mRNA was observed in leg discs (C-E) and eye-antennal discs (F-H), from a single ... Consequently, the cytoplasmic RNA concentration would be inversely proportional to the precociousness of replication of the ...
Dynamic Changes in the Distribution of a Satellite Homologous to Intergenic 26-18S rDNA Spacer in the Evolution of Nicotiana |...
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... nuclear cytoplasmic interaction (NCI) hypothesis (Jiang and Gill 1994)]. The A1/A2 satellite might have been eliminated as a ... 1984 Ribosomal DNA spacer-length polymorphisms in barley: Mendelian inheritance, chromosomal location, and population dynamics ... lost and they suggested that there is some instability in the male-derived genome of an allopolyploid in the cytoplasmic ...
Female Genotypes Affect Sperm Displacement in Drosophila | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... mediated by seminal proteins and cytoplasmic provisioning, and of the environment that the female provides for sperm storage. ...
A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in...
Gallardo, F., C. Olivier, A. T. Dandjinou, R. J. Wellinger and P. Chartrand, 2008 TLC1 RNA nucleo-cytoplasmic trafficking links ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ...
Genotype-by-Environment Interactions Influencing the Emergence of rpoS Mutations in Escherichia coli Populations | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... which control the cell envelope and cytoplasmic heat-shock responses, respectively (Yura et al. 2000). ...
Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis...
D) Nuclear:cytoplasmic DAF-16 fluorescence signal ratios in intestinal cells of day 2 of wild-type, daf-9, fem-2, and fem-2;daf ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... B) Nuclear:cytoplasmic DAF-16 fluorescence signal ratios in intestinal cells of wild-type and fem-2 worms. Mean ± SEM were ... D) Nuclear:cytoplasmic DAF-16 fluorescence signal ratios in intestines. Constitutive DA feeding significantly increases nuclear ...
Isolation and Characterization of HRT1 Using a Genetic Screen for Mutants Unable to Degrade Gic2p in Saccharomyces cerevisiae |...
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... Hrt1p-GFP was predominantly nuclear with a diffuse cytoplasmic staining (Figure 7C), but was excluded from large round ... this model we have recently found that ectopic expression of Cdc4p in the cytoplasm is sufficient to destabilize a cytoplasmic ...
Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers | Genetics
Centrosomal and/or cytoplasmic γ-tubulin may play a role in regulating cellular architecture via the nucleation of microtubules ... Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... These include Delta/Serrate/Lag-2 type ligands, cytoplasmic/nuclear proteins such as Su(H) and mastermind, and Notch-regulated ... mAb22C10, which recognizes futsch, a cytoplasmic protein primarily expressed in neuronal cells, was the kind gift of Seymour ...
New Positive Regulators of lin-12 Activity in Caenorhabditis elegans Include the BRE-5/Brainiac Glycosphingolipid Biosynthesis...
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... which encodes a cytoplasmic serine/threonine kinase that may influence LIN-12 trafficking (Fares and Greenwald 1999) and of sel ...
Specific α- and β-Tubulin Isotypes Optimize the Functions of Sensory Cilia in Caenorhabditis elegans | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... Prominent among these is the sensory cilium, a tubulin-based cytoplasmic extension that interrogates the extracellular ...
Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication in Neurospora crassa | Genetics
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... a cytoplasmic protein, or anti-V5 antibodies, which detect HAM-11-V5 protein. (D) Δham-11 (Pccg1-soft-gfp) germlings co- ... resulting in cell fusion and cytoplasmic mixing (Roca et al. 2005; Fleissner et al. 2009). Over 70 genes involved in mediating ... HAM-11-V5 in the gradient showed minimal overlap with the fractions containing the ER/Golgi protein ERV-25 or the cytoplasmic ...
Introgression Through Rare Hybridization: A Genetic Study of a Hybrid Zone Between Red and Sika Deer (Genus Cervus) in Argyll,...
Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. ... or has concentrated on associations with cytoplasmic markers (Asmussen and Arnold 1991). Moreover, analyses are often based on ...