The nature of significant progress! Gene editing and ascend to a new level! The development of an efficient mitochondrial DNA…
recently a study published inNatureon the breakthrough research on A bacterial cytidine deaminase toxin contains CRISPR-free ... 2】A bacterial cytidine deaminase toxin contains CRISPR-free mitochondrial base editing ... these deaminase only on single-stranded DNA play a role. CRISPR Duo includes a RNA chain, which help to unravel the double ... this technique is the use of a similar enzyme Catalyst-A is called a deaminase enzyme with CRISPR technology of the two ...
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Otsuka and Astex announce that the European Commission has approved INAQOVI® (oral decitabine and cedazuridine) for the...
... an inhibitor of cytidine deaminase4-6. By inhibiting cytidine deaminase in the gut and liver, the fixed-dose combination is ... and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. ... composed of low-dose oral decitabine combined with a novel Cytidine Deaminase Inhibitor (CDAi) E7727. Poster presented at the ...
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Precision Medicine for Gastric Cancer: Applicability from the Perspective of Helicobacter pylori Infection
David Van Mater | Assistant Professor of Pediatrics | Duke Cancer Institute
Identification of the yeast cytidine deaminase CDD1 as an orphan CU RNA editase. April 15, 2001. Nucleic Acids Res ...
Sugano K., Tack J., Kuipers E.J., Graham D.Y., El-Omar E.M., Miura S., Haruma K., Asaka M., Uemura N., Malfertheiner P. Kyoto...
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat ... aberrant activation-induced cytidine deaminase expression, which induces nucleotide alterations involved in DNA mutations, [120 ...
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Hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding activation-induced CYTIDINE DEAMINASE. ...
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nab-paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. ... For GnP, nab-paclitaxel decreases the levels of the primary gemcitabine-metabolizing enzyme, cytidine deaminase, thus ... For GnP, nab-paclitaxel increases gemcitabine levels by inhibiting the gemcitabine-metabolizing enzyme cytidine deaminase. FT, ...
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In the course of both innate and adaptive immunity, cytidine deaminases within the activation induced cytidine deaminase (AID)/ ... AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates. ... AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates. ... Thus, cytidine deamination is probably an ancient innate immune mechanism that predates the protostome/deuterostome divergence ...
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Affinity enhancement of antibodies: how low-affinity antibodies produced early in immune responses are followed by high...
GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder | SMJ
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Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase. Chemical Science 2018, 9, 3248-3253. ... Wang, Y.; Wang, S.; Chen, W.; Song, L.; Zhang, Y.; Shen, Z.; Yu, F.; Li, M.; Ji, Q.*, CRISPR-Cas9 and CRISPR-Assisted Cytidine ... CRISPR/Cas9-based Genome Editing in Pseudomonas aeruginosa and Cytidine Deaminase-Mediated Base Editing in Pseudomonas Species ... Deaminase Enable Precise and Efficient Genome Editing in Klebsiella pneumoniae. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2018, 84 ...
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Deaminases and Why Mice Sometimes Lie in Immuno-Oncology Pre-Clinical Trials? | Annals of Clinical Oncology | Science...
These developments lead us to reappraise the likely impact of AID/APOBEC and ADAR deaminases in human cancer progression with ... There is now much evidence for the involvement of deaminase-mediated somatic mutagenesis during cancer progression. ... and is a blocker with no demonstrable deaminase activity); A, adenosine; AID, activation induced cytidine deaminase, an APOBEC ... As well as the related APOBEC-like gene for activation induced cytidine deaminase (AID), there is a single APOBEC3 gene in ...
Pomalidomide enhanced gemcitabine and nab-paclitaxel on pancreatic cancer both in vitro and in vivo | Oncotarget
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Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and...
... innate cellular cytidine deaminase family, particularly APOBEC3F and APOBEC3G, can cause extensive and lethal G-to-A mutations ... and possibly other deaminases) occurred 16% more often than average G-to-A mutations. These results were supported by analyses ... whereas mutagenesis caused by APOBEC3F and/or other deaminases may result in sublethal mutations that might facilitate viral ... patients by determining whether G-to-A mutations occurred in motifs that were favored or disfavored by these deaminases. G-to-A ...
Th17-inducing dendritic cell vaccines stimulate effective CD4 T cell-dependent antitumor immunity in ovarian cancer that...
The Bugs that Eat Cancer Drugs | Microbiology Community
S-EPMC4631049 - Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells. - OmicsDI
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2019 ASH - Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross over Phase 3 Study ...
A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID...
Activation-induced cytidine deaminase (AID) mRNA expression, Iγ-Cμ and Iα-Cμ circular transcripts (CTs; markers of ongoing ... Activation-induced cytidine deaminase (AID) mRNA expression, Iγ-Cμ and Iα-Cμ circular transcripts (CTs; markers of ongoing ... Aged, Arthritis, Rheumatoid, B-Cell Activating Factor, B-Lymphocytes, Coculture Techniques, Cytidine Deaminase, Female, ...