Cytidine deaminase - Wikipedia
Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA. A related activation-induced (cytidine) ... Taysi S, Polat MF, Sari RA, Bakan E (May 2002). "Serum adenosine deaminase and cytidine deaminase activities in patients with ... Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene encodes an enzyme involved in pyrimidine ... "Entrez Gene: CDA cytidine deaminase". Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016). "Programmable editing of a ...
6K63: The crystal structure of cytidine deaminase from Klebsiella pneumoniae
RCSB PDB - 3DMO: 1.6 A crystal structure of cytidine deaminase from Burkholderia pseudomallei
1.6 A crystal structure of cytidine deaminase from Burkholderia pseudomallei ... 1.6 A crystal structure of cytidine deaminase from Burkholderia pseudomallei. Seattle Structural Genomics Center for Infectious ... 1.6 A crystal structure of cytidine deaminase from Burkholderia pseudomallei. *PDB DOI: https://doi.org/10.2210/pdb3DMO/pdb ...
Aicda MGI Mouse Gene Detail - MGI:1342279 - activation-induced cytidine deaminase
SCOPe 2.07: Fold c.97: Cytidine deaminase-like
Cytidine deaminase-like. Timeline for Fold c.97: Cytidine deaminase-like: *Fold c.97: Cytidine deaminase-like first appeared ( ... Cytidine deaminase. *Fold c.97: Cytidine deaminase-like appears in SCOPe 2.06. *Fold c.97: Cytidine deaminase-like appears in ... Fold c.97: Cytidine deaminase-like [53926] (2 superfamilies). core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta- ... c.97.1: Cytidine deaminase-like [53927] (7 families) contains extra C-terminal strand 5, order 21345. ...
Activation induced cytidine deaminase expression in lymphocyte predominant Hodgkin lymphoma | Journal of Clinical Pathology
Smit LA, Bende RJ, Aten J, et al. Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkins ... We analysed whether activation induced cytidine deaminase (AID) is expressed in lymphocytic and histiocytic (L&H) cells as an ... Somatic hypermutation requires activation induced cytidine deaminase (AID).6 Recent studies of AID protein expression using ... which is strictly dependent on the enzyme activation induced cytidine deaminase (AID), is restricted to the early phase of ...
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s
The human cytidine deaminase family of APOBEC3s (A3s) plays critical roles in both innate immunity and the development of ... Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s. J Biol Chem. 2021 Aug;297(2):100909. doi ...
Mutation Signatures Linked to Polymerase Epsilon Defects and APOBEC Cytidine Deaminase Activity Occur Early in a Range of...
Mutation Signatures Linked to Polymerase Epsilon Defects and APOBEC Cytidine Deaminase Activity Occur Early in a Range of ... Mutation Signatures Linked to Polymerase Epsilon Defects and APOBEC Cytidine Deaminase Activity Occur Early in a Range of ...
Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression
Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression. ... A method of treating a disorder associated with the overexpression of cytidine deaminase or deoxycytidine deaminase comprises ...
Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases -...
Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases. ... Thus, although HTLV-1 DNA can indeed be edited by at least four APOBEC3 cytidine deaminases in vitro, they are conspicuously ... In the absence of the human immunodeficiency virus type 1 (HIV-1) Vif protein, the host-cell cytidine deaminases APOBEC3F and - ... Nonetheless, a small percentage of genomes (0.1,f,5 %) were edited extensively: up to 97 % of cytidine targets were deaminated ...
PDF) SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes
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A0KJH4 | SWISS-MODEL Repository
Plantae | The pentatricopeptide repeat PPR-E proteins mediate RNA C-to-U editing by recruiting a cytidine deaminase | Plantae
The pentatricopeptide repeat PPR-E proteins mediate RNA C-to-U editing by recruiting a cytidine deaminase March 17, 2023. /in ... The DYW domain in PPR-DYW proteins provides the cytidine deaminase activity for RNA C-to-U editing and PPR-E+ proteins recruit ... protein function in RNA editing in which the PPR-E protein recognizes the target site and recruits the trans cytidine deaminase ... Maize PPR-E proteins mediate RNA C-to-U editing in mitochondria by recruiting the trans deaminase PCW1. Plant Cell. https://doi ...
Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced...
Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced ... Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced ... title = "Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated ... Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced ...
A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding...
T1 - A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA- ... A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding ... A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding ... A cytidine deaminase expressed in the post-infective L3 stage of the filarial nematode, Brugia pahangi, has a novel RNA-binding ...
Prospective study on the role of cytidine deaminase activity in lung cancer patients treated with gemcitabine-platinum-based...
Home / Presentations / Prospective study on the role of cytidine deaminase activity in lung cancer patients treated with ... Carmelo Tibaldi: Prospective study on the role of cytidine deaminase activity in lung cancer patients treated with gemcitabine- ... Prospective study on the role of cytidine deaminase activity in lung cancer patients treated with gemcitabine-platinum-based ...
Controllable genome editing with split-engineered base editors | Nature Chemical Biology
... all BEs so far use a constitutively active DNA deaminase. The absence of regulatory control over promiscuous deaminase activity ... In base editors (BEs), the combination of DNA deaminase mutator activity with CRISPR-Cas localization confers the powerful ... We show that the seBE strategy facilitates robust regulated editing with BE scaffolds containing diverse deaminases, offering a ... Here, we reveal sites that permit splitting of DNA cytosine deaminases into two inactive fragments, whose reapproximation ...
Capecitabine for locally advanced and metastatic colorectal cancer: A review
Decitabine and Cedazuridine: MedlinePlus Drug Information
Antibody - Wikipedia
PDB 1ux1
Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase ... Cytidine deaminase. P19079. CDD_BACSU. Bacillus subtilis subsp. subtilis str. 168. Cytidine deaminase. ... Cytidine deaminase. P19079. CDD_BACSU. Bacillus subtilis subsp. subtilis str. 168. Cytidine deaminase. ...
Orphanet: Hyper IgM syndrome type 2
DailyMed - ONUREG- azacitidine tablet, film coated
Azacitidine undergoes spontaneous hydrolysis and deamination mediated by cytidine deaminase.. Excretion Following the ... Azacitidine is a pyrimidine nucleoside analog of cytidine that inhibits DNA/RNA methyltransferases. Azacitidine is incorporated ...
APOBEC-mediated viral restriction: not simply editing? - Fingerprint - King's College London
Clinical translation of epigenetics in cancer: eN-CORe-a report on the second workshop | Molecular Cancer Therapeutics |...
Cytidine deaminase ↓, synergistic activity Ned Newman 5-Fluoro-2′-deoxycytidine Tetrahydrouridine (cytidine deaminase inhibitor ... Cytidine deaminase ↓, synergistic activity Ned Newman 5-Fluoro-2′-deoxycytidine Tetrahydrouridine (cytidine deaminase inhibitor ... 4), currently in phase I trials (Newman).5 Zebularine can also inhibit cytidine deaminase and has shown synergy in vitro and in ... 3).5 Inhibition of deamination by the cytidine deaminase inhibitor tetrahydrouridine may enhance specific antineoplastic ...
Systems Analysis of Highly Multiplexed CRISPR-Base Editing in Streptomycetes<...
CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically simplified ... abstract = "CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically ... N2 - CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically ... AB - CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically ...
Frontiers | Abundance and Expression of Shiga Toxin Genes in Escherichia coli at the Recto-Anal Junction Relates to Host Immune...
SARS-COV-2 Vaccines and Neurodegenerative Disease | The Epoch Times
X-linked Immunodeficiency With Hyper IgM Treatment & Management: Medical Care, Surgical Care, Consultations