Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA. A related activation-induced (cytidine) ... Taysi S, Polat MF, Sari RA, Bakan E (May 2002). "Serum adenosine deaminase and cytidine deaminase activities in patients with ... Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene encodes an enzyme involved in pyrimidine ... "Entrez Gene: CDA cytidine deaminase". Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016). "Programmable editing of a ...
The APOBEC3 cytidine deaminases are potent antiviral factors that restrict the. The APOBEC3 cytidine deaminases are potent ... is definitely another member of the APOBEC3 cytidine deaminase family that is indicated in lymphoid cells and offers poor anti- ...
Cedazuridine is in a class of medications called cytidine deaminase inhibitors. It helps to increase the amount of decitabine ...
View and buy high purity products active at Deaminases from Tocris Bioscience. ... and cytidine deaminase (E.C. 3.5.4.5).. Adenosine deaminases (ADA) irreversibly convert adenosine into inosine by the removal ... two well known members of this group are adenosine deaminase and cytidine deaminase. ... Cytidine deaminases convert cytosine and deoxycytosine to uridine and deoxyuridine respectively, and are involved in ...
Fold c.97: Cytidine deaminase-like [53926] (2 superfamilies). core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta- ... Superfamily c.97.1: Cytidine deaminase-like [53927] (4 families) contains extra C-terminal strand 5, order 21345. ... PDB Description: The crystal structure of yeast cytosine deaminase. PDB Compounds: (B:) Cytosine deaminase. SCOP Domain ... Protein Cytosine deaminase [89801] (1 species). *. Species Bakers yeast (Saccharomyces cerevisiae) [TaxId:4932] [89802] (6 PDB ...
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45:970-76 [Google Scholar] ... An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45:970-76 [Google Scholar] ... DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. eLife 2: ... DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. eLife 2: ...
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin ...
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). ...
The contribution of novel cytidine deaminase regulatory systems to bacterial evolution. 000. 4. NIH. 12/26/2023. $510,469. ...
Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion. Zong Y, Wang Y, Li C, Zhang R, Chen K, Ran ...
Recent discovery of Activation Induced cytidine Deaminase (AID) has revealed that class switch recombination and somatic ...
Restriction of foamy viruses by APOBEC cytidine deaminases. J Virol. 2006;80:605-14. DOIPubMedGoogle Scholar ...
Apolipoprotein B mRNA-editing catalytic polypeptide-like enzymes (APOBEC) are a family of cellular cytidine deaminases that ... Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo. Proc Natl Acad Sci ... as well as by host-encoded cytidine/adenine deaminases. Our current knowledge of viral mutation rates indicates that viral ... Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture ...
Cytidine deaminase (in most tissues, including tumors) subsequently converts 5-DFCR to 5-DFUR ...
2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is ... 2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is ... 2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is ... 2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is ...
Using catalytically inactive dCas9 to recruit variants of cytidine deaminase (AID) with MS2-modified sgRNAs, we can ...
... family of cytidine deaminases implied in kataegis, a focal hypermutation phenotype, which was observed in 4/8 (50%) cases. We ... family of cytidine deaminases implied in kataegis, a focal hypermutation phenotype, which was observed in 4/8 (50%) cases. We ...
Cytidine Deaminase. 1. 2020. 13. 0.780. Why? Mice. 28. 2020. 6413. 0.770 ...
The APOBEC3s are a family of cytidine deaminases that restrict viruses by introducing mutations in their genomes. Viruses ... The APOBEC3s are a family of cytidine deaminases that restrict viruses by introducing mutations in their genomes. Viruses ... The APOBEC3s are a family of cytidine deaminases that restrict viruses by introducing mutations in their genomes. Viruses ... The APOBEC3s are a family of cytidine deaminases that restrict viruses by introducing mutations in their genomes. Viruses ...
Cytidine deaminase1. *1. Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high ... levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies. (nih.gov) ... Tetrahydrouridine is a synthetic pyrimidine analogue that inhibits deoxycytidine monophosphate (dCMP) deaminase, which in turn ...
CRISPR-dCas9 mediated cytosine deaminase base editing in bacillus subtilis. Yu, S., Price, M. A., Wang, Y., Liu, Y., Guo, Y., ... Activation-Induced Cytidine Deaminase 50% * Transversion 50% * DNA chisel, a versatile sequence optimizer. Zulkower, V. & ...
activation-induced cytidine deaminase. Localization. Reference sequences. * DNA: AB040430 (EMBL) * cDNA: AB040431 (EMBL) ...
... "cytidine deaminase [Ensembl]. zinc-binding domain, Cytidine and deoxycytidylate deaminase domain [InterProScan].","protein_ ... "cytidine deaminase [Ensembl]. Cytidine and deoxycytidylate deaminase zinc-binding region [Interproscan].","protein_coding" " ... "cytidine/deoxycytidine deaminase [Ensembl]. Cytidine and deoxycytidylate deaminase zinc-binding region [Interproscan]."," ... "cytidine/deoxycytidine deaminase [Ensembl]. Cytidine and deoxycytidylate deaminase zinc-binding region [Interproscan]."," ...
AICDA, activation-induced cytidine deaminase; AR, autosomal recessive; BLNK, B-cell linker protein; BLOC-3, biogenesis of ...
Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models. ... Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. ... Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential ...
Functions of the Activation Induced Cytidine Deaminase (AID) and Toll-like Receptors (TLR) on Regulation of the Central B cell ... Çakan, E., Functions of the Activation Induced Cytidine Deaminase (AID) and Toll-Like Receptors (TLR) on Regulation of the ...
... which is set up from the B cellCspecific element activation-induced cytidine deaminase (Help; Muramatsu et al., 2000), can be a ...
Hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding activation-induced CYTIDINE DEAMINASE. ...
However, a role for the APOBEC family of cytidine deaminases is proposed. ...