Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases...
Recombinant expression, purification, and functional analysis of two novel cystatins from sugarcane (Saccharum officinarum)
beta 2-Strand of salivary S cystatins: A 'chemeleon sequence'
beta 2-Strand of salivary S cystatins: A "chemeleon sequence". Vitali, A;Carelli Alinovi, Cristiana;De Rosa, Mc;Petruzzelli, R. ... Secondary structure prediction of salivary cystatins S, SA, and SN carried out by several methods label the 39-58 sequence (β2- ... The results obtained indicate that the β2-strand of salivary S cystatins has high helical propensity when isolated from native ... Secondary structure prediction of salivary cystatins S, SA, and SN carried out by several methods label the 39-58 sequence (β2- ...
Cystatin - Wikipedia
Type 1 cystatins are also known as Stefins (after the Stefan Institute where they were first discovered ) The Type 2 cystatins ... Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly ... The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of ... Cystatins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the ...
Tear lipocalin and the eye's front line of defence
Cystatins / physiology * Cysteine Proteinase Inhibitors / physiology* * Evolution, Molecular * Eye Infections / prevention & ...
Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer | Nature Communications
Publication : USDA ARS
These enzymes can be inactivated by specific proteins found in plants called cystatins. Because cystatins interact specifically ... compared to plants without the cystatins. Some plants with cystatins had increased resistance to spring blackstem and leaf spot ... The genes fo two cystatins from rice seeds and the gene for a marker enzyme were fused to a promoting DNA sequence so that the ... Production of cystatins in roots reduced the populations of the root-lesion nematode 71-79% ...
Subject: Kidneys--Diseases | Search Results | Academic Commons
Frontiers | Neuroprotective Effect of Bexarotene in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Browsing Research Articles (Plant Science) by Issue Date
Saliva, Chewing Gum, and Oral Health - Dentistry Today
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi...
Proteoform Atlas - Consortium for Top Down Proteomics
Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage.
BACKGROUND: Cerebral amyloid angiopathy (CAA) with intracerebral hemorrhage (ICH) occurs both sporadically and as a result of mutations in either cystatin C or the amyloid precursor protein. ICH due to cystatin C mutations typically occurs in young people of Icelandic origin. CASE DESCRIPTION: We report a case of sporadic CAA with ICH in an elderly Croatian man with a mutation in cystatin C identical to that found in Icelandic hereditary cerebral hemorrhage with amyloidosis. CONCLUSIONS: This is the first case report of sporadic CAA associated with the same mutation causing hereditary cerebral hemorrhage with amyloidosis of the Icelandic type. Sporadic CAA may thus be associated with genetic mutations in some patients. The frequency of these mutations is yet to be determined.. ...
Two-step mechanism of inhibition of cathepsin B by cystatin C, due to the inhibitor displacing the occluding loop of the enzyme...
... rendering cathepsin B much less susceptible than other cysteine proteinases to inhibition by cystatins. (Less). Links. * ... rendering cathepsin B much less susceptible than other cysteine proteinases to inhibition by cystatins.}}, author = {{Nycander ...
TIMPs of parasitic helminths - a large-scale analysis of high-throughput sequence datasets | Parasites & Vectors | Full Text
Klotz C, Ziegler T, Danilowicz-Luebert E, Hartmann S: Cystatins of parasitic organisms. Adv Exp Med Biol. 2011, 712: 208-221. ... Hartmann S, Lucius R: Modulation of host immune responses by nematode cystatins. Int J Parasitol. 2003, 33: 1291-1302. ... cystatins) [19], as well as in the inhibition of host molecules responsible for the initiation of blood coagulation (serpins) [ ... cystatins and serpins, respectively; MEROPS family I25 and I04, respectively) are known to participate in the cascades of ...
Local pH-dependent conformational changes leading to proteolytic susceptibility of cystatin C - McMaster Experts
DeCS 2016 - June 12, 2016 version
Björk, J.<...
I have a keen interest in methodological issues in epidemiological research and how the Swedish register infrastructure can be used to improve validity. How can we trust results from observational studies, which often get substantial publicity in media? How can we improve risk predictions and our understanding of causes and effects by smarter study designs and novel analytic approaches? One such novel analytic approach is machine learning, i.e. methods where computer programs learn to complete a task, perform classifications or to foresee outcomes based on extensive input data. In an on-going interdisciplinary project called AIR Lund (see www.lupop.lu.se/airlund), partly financed by VINNOVA, we investigate how machine learning methods applied on the Swedish register infrastructure can contribute to improved prevention, diagnosis and prognosis of cardiometabolic diseases. We will critically assess the added value of these methods compared to more simplistic risk scoring schemes and statistical ...
DeCS 2019 - June 12, 2019 version
DeCS 2018 - July 31, 2018 version
DeCS 2017 - July 04, 2017 version
DeCS 2020 - June 23, 2020 version
Graduate Institute of Biomedical Informatics - Research output - Taipei Medical University
Lu, Y., Van Zandt, M., Liu, Y., Li, J., Wang, X., Chen, Y., Chen, Z., Cho, J., Dorajoo, S. R., Feng, M., Hsu, M. H., Hsu, J. C., Iqbal, U., Jonnagaddala, J., Li, Y. C., Liaw, S. T., Lim, H. S., Ngiam, K. Y., Nguyen, P. A., Park, R. W., & 11 othersPratt, N., Reich, C., Rhee, S. Y., Sathappan, S. M. K., Shin, S. J., Tan, H. X., You, S. C., Zhang, X., Krumholz, H. M., Suchard, M. A. & Xu, H., Mar 24 2022, In: JAMA network open. 5, 3, p. E223877. Research output: Contribution to journal › Article › peer-review ...
轉譯醫學博士學位學程 - 研究成果 - 臺
Shi, J., Shiraishi, K., Choi, J., Matsuo, K., Chen, T. Y., Dai, J., Hung, R. J., Chen, K., Shu, X. O., Kim, Y. T., Landi, M. T., Lin, D., Zheng, W., Yin, Z., Zhou, B., Song, B., Wang, J., Seow, W. J., Song, L., Chang, I. S., 及其他202Hu, W., Chien, L. H., Cai, Q., Hong, Y. C., Kim, H. N., Wu, Y. L., Wong, M. P., Richardson, B. D., Funderburk, K. M., Li, S., Zhang, T., Breeze, C., Wang, Z., Blechter, B., Bassig, B. A., Kim, J. H., Albanes, D., Wong, J. Y. Y., Shin, M. H., Chung, L. P., Yang, Y., An, S. J., Zheng, H., Yatabe, Y., Zhang, X. C., Kim, Y. C., Caporaso, N. E., Chang, J., Ho, J. C. M., Kubo, M., Daigo, Y., Song, M., Momozawa, Y., Kamatani, Y., Kobayashi, M., Okubo, K., Honda, T., Hosgood, D. H., Kunitoh, H., Patel, H., Watanabe, S. I., Miyagi, Y., Nakayama, H., Matsumoto, S., Horinouchi, H., Tsuboi, M., Hamamoto, R., Goto, K., Ohe, Y., Takahashi, A., Goto, A., Minamiya, Y., Hara, M., Nishida, Y., Takeuchi, K., Wakai, K., Matsuda, K., Murakami, Y., Shimizu, K., Suzuki, H., Saito, M., ...
Plasma Levels of Middle Molecules to Estimate Residual Kidney Function in Haemodialysis without Urine Collection - Fingerprint ...
A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva | Parasites &...
Two types of cystatins have been reported in ticks: type 1 cystatins, which are intracellular and involved in the intracellular ... Chmelař J, Kotál J, Langhansová H, Kotsyfakis M. Protease inhibitors in tick saliva: the role of serpins and cystatins in tick- ... digestion of haemoglobin and developmental processes, and type 2 cystatins, which are typically secreted to saliva, where they ... protease inhibitors were serine protease inhibitors and the remaining three were cysteine protease inhibitors or cystatins. ...
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