Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT <sub>1A</sub> ...
Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT 1A receptor via phosphorylation In: Biochemical and ... Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT 1A receptor via phosphorylation Biochemical and ... Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT 1A receptor via phosphorylation . / Takahashi, Miyuki; ... We studied here phosphorylation of 5-HT 1A R by cyclin-dependent kinase 5 (Cdk5), a neuron-specific membrane-bound Ser/Thr ...
Development of Selective, Allosteric Inhibitors of Cyclin-Dependent Kinase 2 for theTherapeutic Treatment of Cancer
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Depletion of BubR1 promotes premature centrosomal localization of cyclin B<sub>1</sub> and accelerates mitotic...
As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ... As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ... As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ... As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ...
Mantle Cell Lymphoma: Practice Essentials, Overview, Pathophysiology
Cyclin D1 plays a key role in cell cycle regulation and progression of cells from G1 phase to S phase by activation of cyclin- ... as well as an overexpression of cyclin D1. [11] Chen et al noted that the association with cyclin D1 overexpression in hairy ... Cyclin D1 is overexpressed. Immunophenotyping helps differentiate MCL from other small B-cell lymphomas (see the Table, below). ... 11] Chen et al assessed expression of sox11 and evaluated its association with t(11;14) and overexpression of cyclin D1 in 211 ...
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Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats
Plasmodium falciparum cyclin-dependent-like kinase CLK3 | Kinases (<i>Plasmodium</i> spp.) | IUPHAR/MMV Guide to MALARIA...
Plasmodium falciparum cyclin-dependent-like kinase CLK3 - Kinases (Plasmodium spp.). Detailed annotation on the ... P. falciparum cyclin-dependent-like kinase CLK3 (PfCLK3) has been validated as an antimalarial target acting at multiple ... Kinases (Plasmodium spp.): Plasmodium falciparum cyclin-dependent-like kinase CLK3. Last modified on 18/08/2022. Accessed on 10 ... parasite life stages [1]. PfCLK3 is one of four members of the cyclin-dependent like protein kinase family (PfCLK1-4) with a ...
Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis. - Oxford Neuroscience
Untimely cyclin A2-associated kinase activity in meiosis I leads to precocious sister separation, whereas inhibition of cyclin ... we found that cyclin B1, but not cyclin A2, inhibits separase in meiosis I. These findings indicate that separase-dependent ... Accordingly, endogenous cyclin A is localized to kinetochores throughout meiosis II, but not in anaphase I. Additionally, ... Using mouse oocytes, our study reveals that cyclin A2 promotes entry into meiosis, as well as an additional unexpected role; ...
Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100) | Oncotarget
As shown in Figure 2A and 2B, knockdown of p100/p52 expression profoundly led to activation of Cyclin A, Cyclin D1 and Cyclin E ... The antibodies against Cyclin D1, Cyclin E, Cyclin A, E2F1 and β-Actin were purchased from Santa Cruz Biotechnology (Santa Cruz ... Human Cyclin D1 is a protein encoded by the CCND1 gene and is an important regulator of cell cycle progression [14]. Cyclin D1 ... Cyclin D1 is encoded by the CCND1 gene in human and is overexpressed in many cancers [13]. Cyclin D1 overexpression has been ...
Cell cycle regulators in Arabidopsis thaliana (Brassicaceae) transgenic plants under clinorotation. Cyclin-depending kinases /...
Cyclin-depending kinases. Cite:. Artemenko, O. A. (2014). Cell cycle regulators in Arabidopsis thaliana (Brassicaceae) ... Cyclin-depending kinases. Ukrainian Botanical Journal , 71 (5), 620-625. http://jnas.nbuv.gov.ua/article/UJRN-0000326906 [In ...
The study of relationship between cyclin D1 overexpression and clinicopathological prognotic factors... - کتابخانه دیجیتال...
The study of relationship between cyclin D1 overexpression and clinicopathological prognotic factors... , کتابخانه دیجیتال ... The study of relationship between cyclin D1 overexpression and clinicopathological prognotic factors in breast invasive ductal ... Cyclin D1 staining was performed on paraffin- embedded tumor tissue samples and the relationship between cyclin DI status and ... Cyclin DI status showed statistically significant relationship with tumor grade, ER, and PR status. Higher scores of cyclin DI ...
Cyclin F: a component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer<...
Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex, SCFcyclin ... Galper, J., Rayner, S. L., Hogan, A. L., Fifita, J. A., Lee, A., Chung, R. S., Blair, I. P., & Yang, S. (2017). Cyclin F: a ... Galper, J, Rayner, SL, Hogan, AL, Fifita, JA, Lee, A, Chung, RS, Blair, IP & Yang, S 2017, Cyclin F: a component of an E3 ... Cyclin F: a component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer. International Journal of ...
Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics | Oncotarget
... cyclin E (HE12), cyclin E (HE111), cyclin E (M-20), cyclin B1, cyclin A (H432), Cdk2 (M2) (Santa Cruz Biotechnology, Santa Cruz ... but not cyclin A. Cyclin E knockdown had no effect on the levels of Cdk2, cyclin A, cyclin B1, and pro-survival Bcl-2 proteins ... H. Expression levels of Mcl-1 and cyclin E in cyclin E-/- MEFs after expression of Mcl-1 and Cyclin E constructs, alone or ... There was no change in Cdk2 and cyclin A, while cyclin B1 levels were decreased (Figure 1A). To investigate how cyclin E ...
Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase...
Cyclin-dependent kinase (CDK) inhibitors regulate the CDK-cyclin complex activities in endoreduplicating cells of developing ... Two maize Kip-related proteins differentially interact with, inhibit and are phosphorylated by cyclin D-cyclin-dependent kinase ... Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin- ... Degradation of the cyclin-dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases.. Ren H, Santner A ...
CDKN1B gene: MedlinePlus Genetics
Weis2014 - Data driven Mammalian Cell Cycle Model | BioModels
The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1 ... The approach provided expression profiles of cyclin A2, cyclin B1, and phospho-S10-histone H3. The model was built by ... models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 ... enhanced transcription of mitotic cyclins during late S/early G2 phase, and the sustained synthesis of cyclin B during mitosis ...
Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A...
Cyclin B. Cyclin G1. Cyclins. Cyclin-Dependent Kinases. CDC2 Protein. Biochemistry. Cell Biology. Molecular Biology Show all ... Cyclin B. Cyclin G1. Cyclins. Cyclin-Dependent Kinases. CDC2 Protein Kinase. Cell Cycle. Cell Cycle Proteins. Saccharomyces ... Several cell cycle events require specific forms of the cyclin-CDK complexes. It has been known for some time that cyclins not ... Multiple rounds of centrosome reproduction were blocked by selective inactivation of cyclin-dependent kinase 2-cyclin E (Cdk2-E ...
Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis.<...
Hur, K, Kim, JR, Yoon, BI, Lee, JK, Choi, JH, Oh, GT & Kim, DY 2000, Overexpression of cyclin D1 and cyclin E in 1,2- ... Cyclin D1 expression was detected in 56.3% of the adenomas and in 61.5% of the adenocarcinomas examined, whereas cyclin E ... Overall, cyclin D1, cyclin E and PCNA expression was significantly increased at both the mRNA and protein levels in normal ... Cyclin D1 expression was detected in 56.3% of the adenomas and in 61.5% of the adenocarcinomas examined, whereas cyclin E ...
Cyclin D1 G870A polymorphism and breast cancer risk: A meta-analysis involving 23,998 subjects - Fingerprint - Augusta...
BMP2/6 synergizes with p73 to increase the cyclin dependent kinase inhibitor p57 expression, 7/August/2013, 7.43 am
Expression of cyclin (PCNA) and the phosphoprotein dividin are late obligatory events in the mitogenic response - ePrints -...
Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and sertoli cells of the testis<...
... cyclin D1, and cyclin E in the testis. The abundance of Cdk5 and cyclin E in the Leydig cell line, TM3, was significantly ... cyclin D1, and cyclin E in the testis. The abundance of Cdk5 and cyclin E in the Leydig cell line, TM3, was significantly ... cyclin D1, and cyclin E in the testis. The abundance of Cdk5 and cyclin E in the Leydig cell line, TM3, was significantly ... cyclin D1, and cyclin E in the testis. The abundance of Cdk5 and cyclin E in the Leydig cell line, TM3, was significantly ...
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin...
N2 - Aims: Cyclins and other cell-cycle regulators have been used in several studies to regenerate cardiomyocytes in ischaemic ... AB - Aims: Cyclins and other cell-cycle regulators have been used in several studies to regenerate cardiomyocytes in ischaemic ... Aims: Cyclins and other cell-cycle regulators have been used in several studies to regenerate cardiomyocytes in ischaemic heart ... abstract = "Aims: Cyclins and other cell-cycle regulators have been used in several studies to regenerate cardiomyocytes in ...
Therapeutic efficacy of cyclin-dependent kinase inhibition in combination with ionizing radiation for lung cancer. | Int J...
To evaluate the therapeutic efficacy of cyclin-dependent kinase (CDK) inhibition in combination with ionizing radiation for ... Therapeutic efficacy of cyclin-dependent kinase inhibition in combination with ionizing radiation for lung cancer. ... Therapeutic efficacy of cyclin-dependent kinase inhibition in combination with ionizing ra ... Mechanistic studies showed reduced expression of cyclin A with combined treatment, indicating cell cycle shifting effects. An ...
p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas...
Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of...
... resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. Furthermore, Tan IIA- ... C. Müller-Tidow, W. Wang, G. E. Idos et al., "Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at ... The expression and activity of the second cyclin binding partner of Cdk2, cyclin A, as well as the expression and degradation ... cyclin A1 [28, 29], cyclin E1 [30], and p21 [29]. Recent research demonstrated that Cdk2 has an unanticipated role in ...
Differential regulation of cyclin A, cyclin B and p21 concentrations in a growth-restricted human fibroblast cell line | NTU...
Polbase - Reference: Immunocytochemical identification of proliferative hepatocytes using monoclonal antibody to proliferating...
PCNA/cyclin). Comparison with immunocytochemical staining for DNA polymerase-alpha. ... Hepatocytes that were positive for PCNA/cyclin were observed in both types of substrate specimens. In acute hepatitis and ... In hepatocellular carcinoma, many PCNA/cyclin-positive tumor cells were seen throughout the neoplasms. Hepatocytes that were ... PCNA/cyclin). Comparison with immunocytochemical staining for DNA polymerase-alpha. Kawakita N, Seki S, Yanai A, Sakaguchi H, ...
Alterations in the p16<sup>INK4a</sup>/cyclin D1/RB pathway in gastrointestinal tract endocrine...
Li, A. F. Y., Li, A. C. H., Tsay, S. H., Li, W. Y., Liang, W. Y., & Chen, J. Y. (2008). Alterations in the p16INK4a/cyclin D1/ ... Li, AFY, Li, ACH, Tsay, SH, Li, WY, Liang, WY & Chen, JY 2008, Alterations in the p16INK4a/cyclin D1/RB pathway in ... Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors. / Li, Anna Fen Yau; Li, Alice Chia ... Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors. In: American Journal of Clinical ...
Metformin Inhibits Growth of Breast Cancer Cell T47D through Decreasing Expression of Protein P53, BCL2 and Cyclin D1
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