Cyclin D1 specifically regulates the G1/S phase, and cyclin D1 overexpression accelerates progression from G0/G1 to S. Cyclin ... On the other hand, based on flow cytometric analysis, the G2/M arrest of MCF-7 cells may be related to cyclin B1 and CDK1 ... However, it is surprising that although VALD-3 downregulated cyclin B1 and CDK1 in MDA-MB-231 cells, the induction of G2/M ... The S phase arrest induced by VALD-3 in MCF-7 and MDA-MB-231 cells may be linked to downregulation of cyclin D1. ...
It detects human Cyclin E1 and is antigen affinity purified. It is great for use in WB. ... Our Cyclin E1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. ... CCNE, CCNE1, cyclin E variant ex5del, G1/S specific cyclin E UniProt Details. UniProt (Human): P24864. UniProt (Immunogen ... Our Cyclin E1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Cyclin E1 and is ...
Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. Mol. Med. Rep. ... Trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol. Cancer, 2006, 5(1), 8.. [ ...
During early G1 phase, mitogenic signals trigger activation of the CDK4/6-cyclin D complex, which partially deactivates Rb by ... Ibrance (palbociclib) is an inhibitor of cyclin-dependent kinase (CDK) 4 and 6. Cyclin D1 and CDK4/6 are downstream of ... Rb blocks cell cycle progression in G1 by binding E2F transcription factors. In order to enter S phase, cells must sequentially ... Activation of the CDK2-cyclin E complex results in hyperphosphorylation of Rb and fully releases E2F. The expression of further ...
Taken together, the results we report here suggest that Kem1p might have a previously unrecognized role at the G1 to S ... by degrading the mRNA of the mitotic cyclin CLB2. Here, we describe the identification of a KEM1 truncation, KEM1(1-975), that ... accelerated the G1 to S transition and initiation of DNA replication when over-expressed. Interestingly, although this ...
Cyclin-G1 - Also known as CCNG1_HUMAN, CCNG1, CCNG, CYCG1. May play a role in growth regulation. Is associated with G2/M phase ... cyclin family DESCRIPTION Also known as CCNG1_HUMAN, CCNG1, CCNG, CYCG1. May play a role in growth regulation. Is associated ...
... that are homologous to human oncoproteins including a cyclin that inhibits the retinoblastoma protein that controls the G1-to-S ... Cyclin encoded by KS herpesvirus. Nature. 1996;382(6590):410.. 52. Cheng EH, Nicholas J, Bellows DS, et al. A Bcl-2 homolog ...
Purpose: Cell cycle progression is regulated by interactions of specific cyclins and cyclin dependent kinases (CDKs) at the G1- ... There was correlation between the expression of cyclin B1 and expression of p34cdc2 (p=0.002), between the expression of cyclin ... Furthermore, overexpression of cyclin B1 may play an important role in lymph node metastatic potential of gastric cancer. Thus ... Results: Out of 23 cases studied, cyclin B1 was diffusely expressed in 20 cases (87.0%), p34cdc2 in 14 cases (60.9%) and p53 in ...
Sherr C, Roberts J. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995;9:1149-1163. Crossref, Medline, Google ... For epithelial cells to proliferate, they must move from the G1 to S phase of the cell cycle and this step requires ... inhibits cell cycle progression during early S and G1 phases (45-47). Hyperphosphorylation leads to progression into the S ...
Cyclin D2 35% * G1 Phase Cell Cycle Checkpoints 31% * Ectopic Gene Expression 26% ... Dive into the research topics of Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest ... Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation. ...
... loss of Cdh1 induced unscheduled accumulation of mitotic cyclins in G1, resulting in abrogation of G1, arrest caused by ... loss of Cdh1 induced unscheduled accumulation of mitotic cyclins in G1, resulting in abrogation of G1, arrest caused by ... loss of Cdh1 induced unscheduled accumulation of mitotic cyclins in G1, resulting in abrogation of G1, arrest caused by ... In yeast and Drosophila, Cdh1-dependent APC (Cdh1-APC) activity targets mitotic cyclins from the end of mitosis to the G1 phase ...
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Author(s): Toyoshima H, Hunter T ... p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Author(s): ... Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest. ... NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Author(s): Guttridge DC, ...
Alkylaminophenol induces G1/S phase cell cycle arrest in glioblastoma cells through p53 and cyclin-dependent kinase signaling ...
... cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this ... The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or - ... Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At ... through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. ...
Mitotic G1 phase and G1/S transition (Homo sapiens) * G0 and Early G1 (Homo sapiens) * Transcription of E2F targets under ... Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens) * Cyclin B:CDK1 [nucleoplasm] (Homo sapiens) * CDK1 [ ... Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens) * Cyclin B:CDK1 [nucleoplasm] ( ... G1/S Transition (Homo sapiens) * E2F mediated regulation of DNA replication (Homo sapiens) * E2F-enabled inhibition of pre- ...
C) A549 or H460 cells were transfected with Annexin A2 shRNA or control shRNA, expression of p21, p27, Cyclin B1, CDK1 and CDK2 ... Results showed that Annexin A2 knockdown significantly decreased the cell number in G1 phase and increased the cell number in ... NSCLCs: non-small cell lung cancers; EMT: epithelial-to-mesenchymal transition; CKI: cyclin-dependent kinase inhibitor; CDK: ... CDK2 and Cyclin B1 (Figure 3C-D). Together, these results suggest that knockdown of Annexin A2 inhibits cell proliferation by ...
Association of human cyclin E with a periodic G1-S phase protein kinase ... Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with ... Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes ... Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport ...
At G1 phase (figure 2) , Cyclin D1 and c-myc are induced and inactivation of E2F1 when bind to Rb. The transition of G1 to S ... The miR-15a and miR-16 target cell cycle regulators such as cyclin D1, cyclin D3, cyclin E1 and CDK6, this causes the cell ... Furthermore, let-7 represses number of cell cycle regulator gene: cyclin D1, cyclin A, cyclin D3, CDK4 and CCNA2, CDK6, CDC25A ... cyclin D1, cyclin E1, cyclin D3 and CDK6). (9) As miRNAs proposed to control the expression up to one third of all genes and ...
G1/S-specific cyclin-E 7232. scaffold_163:132280-135713 NCBI_GNO_60824 GPI ethanolamine phosphate transferase 1,Phosphati... ...
G1/S-specific cyclin-D1. CCND1. P24385. 3 Reference(s). T42EAZ. Vascular endothelial growth factor A. VEGFA. P15692. 4 ... Cyclin-dependent kinase 1. CDK1. P06493. 3 Reference(s). T64W2K. Cyclin-dependent kinase inhibitor 1. CDKN1A. P38936. 7 ... Cyclin-dependent kinase inhibitor 2A. CDKN2A. P42771. 2 Reference(s). T55EFK. Transcription factor E2F1. E2F1. Q01094. 1 ... Cyclin-dependent-like kinase 5. CDK5. Q00535. 1 Reference(s). T00RT4. Inosine-5-monophosphate dehydrogenase 1. IMPDH1. P20839 ...
cyclin D3 [Source:HGNC Symbol.... CCNG1. 900. CCNG1. cyclin G1 [Source:HGNC Symbol.... ...
G1/S-specific cyclin-D1. View. P25025. C-X-C chemokine receptor type 2. View. ...
Cyclin-Dependent Kinase 4 - Preferred Concept UI. M0208277. Scope note. Cyclin-dependent kinase 4 is a key regulator of G1 ... Cyclin D Dependent Kinase CDK4 Cyclin D-Dependent Kinase CDK4 Cyclin Dependent Kinase 4 Cyclin-Dependent Kinase, Cdk4 PSK J3 ... Cyclin D Dependent Kinase CDK4. Cyclin D-Dependent Kinase CDK4. Cyclin Dependent Kinase 4. Cyclin-Dependent Kinase, Cdk4. PSK ... Cyclin-Dependent Kinase 4 Entry term(s). Cdk4 Cyclin Dependent Kinase Cdk4 Cyclin-Dependent Kinase Cdk4 Protein Cdk4 Protein ...
Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System. Cell Reports 2017, 21(5), 1386-1398. ... Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6- ...
Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the ...
During the G1 phase of the cell cycle, the helicase is loaded in an inactive form onto DNA. In S phase, MCM2-7 is activated by ... the cyclin-dependent and Dbf4-dependent kinases to become a processive replicative helicase. This activation requires the ... During the G1 phase of the cell cycle, the ORC functions with the proteins Cdc6 and Cdt1 to load the MCM2-7 helicase onto DNA, ...
6, FN1 (fibronectin 1), CCND1 (Cyclin D1), CDH2 (cadherin 2), MET (MET proto-oncogene, receptor tyrosine kinase), were ... whose activity is required for cell cycle G1/S transition. It was proven as a DEG and used as a diagnostic and predictive ... Cyclin D1 (CCND1) functions as regulators of CDK kinases, and forms a complex with and functions as a regulatory subunit of ... which genes are involved in the regulation of cyclin gene or cadherin gene, and could participate in the development of PTC. ...
The mTOR protein is involved in the regulation of cyclins D1/A, cyclin-dependent kinases, cyclin-dependent kinase inhibitors ( ... Brown EJ, Albers MW, Shin TB, Ocjlawa K, Keith CT, Lane WS, Schreiber SL: A mammalian protein targeted by G1-arresting ... This can, in part, be explained by the fact that some cell cycle regulators, e.g. cyclin D1, c-MYC and growth factors such as ... Inhibition of mTOR leads to G1 arrest of many malignant cell lines, and currently analogs of rapamycin are being investigated ...