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*  Cyclin-Dependent Kinase Inhibitor p27 Summary Report | CureHunter
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL ... It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it ... binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2. ... CDK Inhibitor, p27; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor p27; Kip1 Protein, p27; p27, CDK ...
http://www.curehunter.com/public/keywordSummaryD050760-Cyclin-Dependent-Kinase-Inhibitor-p27.do
*  Asymmetric inheritance of Cyclin D2 maintains proliferative neural stem/progenitor cells: A critical event in brain development...
Many reports have indicated that cell cycle regulators such as cyclins and cyclin-dependent kinases and their inhibitors have ... Cyclin D1 and D3 (Matsushime et al. 1991). Cyclin D2 protein forms a complex with cyclin-dependent kinases (Cdk) 4 or 6 and ... Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain ... An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature ...
http://onlinelibrary.wiley.com/doi/10.1111/dgd.12135/full
*  Cell Cycle Gene
Cyclin-Dependent Kinase Gene. Cyclin-Dependent Kinase Inhibitor Gene. Cyclin Gene. DOC-1R Gene. GAS8 Gene. GMNN Gene. KIF11 ... including cyclin-dependent kinases, mitogen-activated kinases, cyclins, and phosphoprotein phosphatases, as well as their ...
http://www.cancerterms.net/define-Cell+Cycle+Gene/
*  Cyclin Dependent Kinase (CDK) Inhibitors | SpringerLink
... the discovery of cyclin-dependent ki- nases (Cdks) ushered in a new era in the understanding of cell proliferation and its ... found to be dependent on these protein kinases, but the reg- ulatory assumption intrinsic to cyclin-dependent kinases, a stable ... Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development ... Small-Molecule Inhibitors of Cyclin-Dependent Kinases: Molecular Tools and Potential Therapeutics ...
https://link.springer.com/book/10.1007/978-3-642-71941-7
*  JCI - Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
We have previously demonstrated that loss of one candidate gene at this locus, cyclin-dependent kinase inhibitor 2B (Cdkn2b), ... Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. Yoko Kojima, … , Tom Quertermous, Nicholas J ...
https://www.jci.org/articles/view/70391/figure/4
*  Cyclin-dependent kinase inhibitors: The latest anti-inflammatory
... By University of Edinburgh Sep 4, 2006, 16:41. ... Now they have shown that CDK inhibitors, like Roscovitine which is already being tested in human cancer are capable of inducing ... The researchers have found that certain non-biological drugs, known as CDK inhibitors, can knock out the inflammatory cells ...
http://www.rxpgnews.com/printer_4922.shtml
*  cyclin-dependent kinase inhibitor 1Ca ELISA Kits | Biocompare.com
Compare cyclin-dependent kinase inhibitor 1Ca ELISA Kits from leading suppliers on Biocompare. View specifications, prices, ... cyclin-dependent kinase inhibitor 1Ca ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody- ... Your search returned 11 cyclin-dependent kinase inhibitor 1Ca ELISA ELISA Kit across 1 supplier. ...
https://www.biocompare.com/pfu/110627/soids/2-1946484/Assay_Kit/ELISA_cyclin-dependent_kinase_inhibitor_1Ca
*  CDKN1A | CAP20 | Cyclin-Dependent Kinase Inhibitor 1
... also known as Cyclin-Dependent Inhibitor 1, for cancer and cell biology research areas. Order CAP20 antibodies for your ... Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase ... This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin- ... Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, ...
http://www.abgent.com/products/AP13468b-CDKN1A-Antibody-C-term
*  Cyclin-Dependent Kinase Inhibitor 1C - CAGS
Cyclin-Dependent Kinase Inhibitor 1C (CDKN1C) is a tumor suppressor; a protein involved in the regulation of cell division. ... Because it is a strong, tight inhibitor of several G1 cyclin/CDK complexes, this protein is a negative regulator of cell ...
http://cags.org.ae/ctga/details.aspx?id=2212&se=Latest
*  Efficient Activation of Reconstructed Rat Embryos by Cyclin-Dependent Kinase Inhibitors
... combined with a variety of cyclin-dependent kinase inhibitors is an effective way to activate rat embryos. This is in contrast ...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009799
*  RCSB PDB - Protein Feature View - Cyclin-dependent kinase inhibitor 1B - P46527 (CDN1B HUMAN)
Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in ... Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed: ... Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or ... Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction is required for cyclin D and CDK4 complex assembly, ...
http://www.rcsb.org/pdb/protein/Q5U0H2
*  RCSB PDB - Protein Feature View - Cyclin-dependent kinase inhibitor 2A - P42771 (CDN2A HUMAN)
Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase ... This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. UniProt ...
http://www.rcsb.org/pdb/protein/P42771
*  Cyclin-Dependent Kinase 9 (CDK9) Inhibitor -Pipeline Insight, 2018
Figures 1: Total Products for Cyclin-Dependent Kinase 9 (CDK9) Inhibitor. Figure 2: Cyclin-Dependent Kinase 9 (CDK9) Inhibitor ... Total Pipeline Products for Cyclin-Dependent Kinase 9 (CDK9) Inhibitor. Table 2: Cyclin-Dependent Kinase 9 (CDK9) Inhibitor ... 2. Cyclin-Dependent Kinase 9 (CDK9) Inhibitor - Overview. 3. Pipeline Therapeutics*An Overview of Pipeline Products for Cyclin- ... Dependent Kinase 9 (CDK9) Inhibitor 4. Comparative Analysis. 5. Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Pipeline Products in ...
https://www.researchandmarkets.com/reports/4382863/cyclin-dependent-kinase-9-cdk9-inhibitor
*  Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics | Molecular Pharmacology
1996) Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382:325-331 ... Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics. Mary E. Law, Patrick E. Corsino, Satya Narayan and Brian K. Law ... Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics Message Subject (Your Name) has forwarded a page to you from ... 2013) Cyclin-dependent kinase inhibitors closer to market launch? Expert Opin Ther Pat 23:945-963. ...
http://molpharm.aspetjournals.org/content/88/5/846
*  Cyclin-Dependent Kinase (CDK) Inhibitors Therapeutics Pipeline Analysis 2017
CDK inhibitors are the proteins that networks with a cyclin-CDK complex to inhibit the kinase activity of the complex, usually ... Cyclin-Dependent Kinase (CDK) Inhibitors Therapeutics Pipeline Analysis 2017. Cyclin-Dependent Kinase (CDK) Inhibitors ... CDK inhibitors are the proteins that networks with a cyclin-CDK complex to inhibit the kinase activity of the complex, usually ... CDK with cyclin combines to form a cyclin-CDK complex for the regulation of cell cycle. Cyclin-CDK complex gets activated after ...
https://www.psmarketresearch.com/market-analysis/cdk-inhibitors-therapeutics-pipeline-analysis/
*  Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor | Molecular Cancer Therapeutics
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 1996;68:67-108. ... Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor. David Parry, Timothy Guzi, Frances Shanahan, ... Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor. David Parry, Timothy Guzi, Frances Shanahan, ... Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor. David Parry, Timothy Guzi, Frances Shanahan, ...
http://mct.aacrjournals.org/content/9/8/2344
*  Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect : Figure...
Figure 5: Western blot analysis of apoptotic related proteins in HeLa cells treated with alsterpaullone. HeLa cells were cultured with 20 μM alsterpaullone. Cells were then lysed and protein extracted. The proteins (50 μg) were then subjected to SDS-PAGE immunoblot analysis with the use of antibodies specific for α-tubulin, survivin, Mcl-1, PARP, pRB, Bcl-2, and Caspase-3. Cells were also exposed to 0.3% DMSO and showed stable basal levels of the various proteins at the different time points ...
https://www.hindawi.com/journals/jamc/2013/602091/fig5/
*  Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma
... cyclin-dependent kinase inhibitor 2C (CDKN2C), and the CIP/KIP family member, cyclin-dependent kinase inhibitor 1A (CDKN1A). ... Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma. JNCI Journal of the National ... Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma. ... Resistance to BRAFV600E inhibitors is associated with reactivation of mitogen-activated protein kinase (MAPK) signaling at ...
https://dash.harvard.edu/handle/1/10581966
*  Cyclin-dependent kinase inhibitor protein - Wikipedia
A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor ... "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325 ... Cyclin-Dependent Kinase Inhibitor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are ...
https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_inhibitor_protein
*  Cyclin-dependent kinase inhibitor 1C - Wikipedia
Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator ... Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is protein which in humans is encoded by the CDKN1C ... Lee MH, Reynisdóttir I, Massagué J (Mar 1995). "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain ... Fink JR, LeBien TW (Apr 2001). "Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors". ...
https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_inhibitor_1C
*  Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1.
Cyclin-Dependent Kinase Inhibitor p27 / genetics, metabolism*. Mice. Mice, Knockout. Taste Buds / cytology, metabolism*. ... The cyclin-dependent kinase inhibitor p27Kip1 has been shown to influence cell number in several developing tissues, by ... Hirota M,Ito T,Okudela K,Kawabe R,Hayashi H,Yazawa T,Fujita K,Kitamura H,Expression of cyclin-dependent kinase inhibitors in ... Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1 ...
http://www.biomedsearch.com/nih/Accelerated-turnover-taste-bud-cells/21507264.html
*  A Study Of Oral PD-0332991, A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer
PD-0332991 is in a new class of drugs called cyclin-dependent kinase (CDK inhi ... A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer.. Trial Phase:. Phase 1. Minimum Age:. 18 Years. Maximum ... A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer. ...
http://www.knowcancer.com/cancer-trials/NCT00141297/
*  Molecules | Free Full-Text | Synergism of Cyclin-Dependent Kinase Inhibitors with Camptothecin Derivatives in Small Cell Lung...
... by cyclin-dependent kinase 4 inhibitors is extended here to a panel of camptothecin analogs comprising 10-hydroxy-CPT (HOCPT), ... Whereas the CDK4/6 inhibitor PD0332991 proved less effective to chemosensitize SCLC cells to CPT analogs, the CDK inhibitors ... Synergism of Cyclin-Dependent Kinase Inhibitors with Camptothecin Derivatives in Small Cell Lung Cancer Cell Lines. Gerhard ... "Synergism of Cyclin-Dependent Kinase Inhibitors with Camptothecin Derivatives in Small Cell Lung Cancer Cell Lines." Molecules ...
http://www.mdpi.com/1420-3049/19/2/2077/xml
*  Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology...
Cyclin-Dependent Kinase Inhibitor p21. *Cyclin-Dependent Kinase Inhibitor p27. *Cyclin-Dependent Kinases/antagonists & ... Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology ... Following IL-6 treatment of LNCaP, Western blot analysis showed that the protein levels of cyclin-dependent kinase-2 (CDK2), ... In vitro kinase assays revealed that the CDK-associated histone H1 and CDK4- and CDK6-associated pRb kinase activities were ...
https://www.ncbi.nlm.nih.gov/pubmed/10198259?dopt=Abstract
*  Voltage-Activated K+ Channels and Membrane Depolarization Regulate Accumulation of the Cyclin-Dependent Kinase Inhibitors...
... cyclins and cyclin-dependent kinase inhibitors (cdkis) known to regulate cell cycle progression through this phase are affected ... 1997) Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation. EMBO J ... Blockage of K+ channels and membrane depolarization also caused accumulation of the cyclin-dependent kinase inhibitors p27Kip1 ... 1997) Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. ...
http://www.jneurosci.org/content/19/13/5380