Cyclin-dependent kinase 2 - Wikipedia
The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein ... cyclins and cyclin dependent kinases". Oncogene. 15 (2): 143-57. doi:10.1038/sj.onc.1201252. PMID 9244350. Shintani S, Ohyama H ... the process is controlled by different levels of cyclin-dependent kinases (Cdks) and their partner cyclins. Cells utilize ... "Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4". Molecular and ...
RCSB PDB - 1FIN: CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
CYCLIN-DEPENDENT KINASE 2. A, C. 298. Homo sapiens. Mutation(s): 0 Gene Names: CDK2, CDKN2. EC: 2.7.1 (PDB Primary Data), 2.7. ... CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX. *PDB DOI: https://doi.org/10.2210/pdb1FIN/pdb ... The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution ... These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the ...
Cells | Free Full-Text | Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin...
Amongst the candidates was the so far hardly characterized cyclin-dependent kinase 18 (CDK18). Our further analysis revealed a ... We carried out an siRNA screen targeting 719 kinase-related genes, representing the majority of the kinases of the human genome ... STUB1 functions as an A-kinase anchoring protein (AKAP) tethering PKA to the protein complex and bridging AQP2 and CDK18. The ... The cAMP activates protein kinase A (PKA), which initiates signaling that causes an accumulation of AQP2 in the plasma membrane ...
Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity - PubMed
... for crystallization using the CDK-activating kinase 1 (CAK1) from Saccharomyces cerevisiae and have grown crystals using ... We have prepared phosphorylated cyclin-dependent protein kinase 2 (CDK2) ... Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Poon RY, ... Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity N R Brown 1 , M E Noble, A M ...
Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2...
... rs7756992 in cyclin-dependent kinase 5 (CDK5) regulatory subunit associated protein 1-like 1 (CDKA … ... Novel risk loci for type 2 diabetes, single nucleotide polymorphism (SNP) ... is a common disorder in women that shares many genetic features with type 2 diabetes mellitus. ... Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 ...
Cyclin-dependent kinases regulate the antiproliferative function of Smads
Here we show that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Except for … ... Cyclin-dependent kinases regulate the antiproliferative function of Smads Nature. 2004 Jul 8;430(6996):226-31. doi: 10.1038/ ... Here we show that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Except for the ... Cyclin-Dependent Kinase Inhibitor p15 * Cyclin-Dependent Kinases / genetics * Cyclin-Dependent Kinases / metabolism* ...
Prognostic implications of cyclins (D1, E, A), cyclin-dependent kinases (CDK2, CDK4) and tumor-suppressor genes (pRB, p16INK4A)...
... for their expression of cyclins (D1, E, A), cyclin-dependent kinases (cdk2, cdk4) and tumor-suppressor genes (pRb, p16INK4A), ... Prognostic implications of cyclins (D1, E, A), cyclin-dependent kinases (CDK2, CDK4) and tumor-suppressor genes (pRB, p16INK4A ... for their expression of cyclins (D1, E, A), cyclin-dependent kinases (cdk2, cdk4) and tumor-suppressor genes (pRb, p16INK4A), ... There was also a significant correlation between expression of cyclin D1 and frequency of recurrence. For cyclin E and cyclin A ...
NIH 3D - HUMAN CYCLIN-DEPENDENT KINASE 2Cyclin-dependent kinase 2 (CDK2) continues to be reported to become needed - Apoptosis in amphibian organs
Cyclin-dependent kinase 2 (CDK2) continues to be reported to become needed. August 10, 2018. phytid0 comments ... Cyclin-dependent kinase 2 (CDK2) continues to be reported to become needed. Home / Uncategorized / Cyclin-dependent kinase 2 ( ... Cyclin-dependent kinase 2 (CDK2) continues to be reported to become needed for cell proliferation in a number of individual ... Crucial regulators from the changeover along cell routine phases will be the cyclin-dependent kinases (CDKs), a family group of ...
The cell cycle - Part 2: Cyclins, cyclin dependent kinases (CDKs), CDK inhibitors - onkoview.com
Cyclins, cyclin dependent kinases (CDKs), CDK inhibitors. 7. October 2021 ... Cyclin dependent kinases (CDKs) phosphorylate several substrates such as transcription factors and cytoskeletal proteins, which ... Importantly, CDKs are inhibited by specific cyclin dependent kinase inhibitors. In many types of cancer, proteins that regulate ... CDKs are activated by cyclins, which are expressed in distinct phases during the cell cycle. ...
Carcinogenic potential of benzene and toluene when evaluated using cyclin-dependent kinase activation and p53-DNA binding. |...
Benzene and toluene were found to activate cyclin-dependent kinase 2 in rat liver epithelial (RLE) and HL6... ... Carcinogenic potential of benzene and toluene when evaluated using cyclin-dependent kinase activation and p53-DNA binding.. *C ... Benzene and toluene were found to activate cyclin-dependent kinase 2 in rat liver epithelial (RLE) and HL60 cells. pRb105 was ... Kinase activation and subsequent hyperphosphorylation of pRb105 and p53 by benzene or toluene may be responsible for their ...
MicroRNAs in Systemic Rheumatic Diseases
CDK2, cyclin-dependent kinase 2; DNMT1, DNA methyltransferase 1; IRAK1, IL-1 receptor-associated kinase 1; LPS, ... LPS-induced Brutons tyrosine kinase expression; turn-off IL-18 expression in response to LPS. [60]. ... Angela Ceribelli1, Bing Yao1, Paul R Dominguez-Gutierrez1, Md A Nahid1, Minoru Satoh2 and Edward KL Chan1* 1Department of Oral ... 2Division of Rheumatology and Clinical Immunology, Department of Medicine, and Department of Pathology, Immunology, and ...
RCSB PDB - LZE Ligand Summary Page
Cyclin-dependent kinase 2. MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR.... unknown. Cyclin-dependent kinase 1. ... AT7519 is a selective inhibitor of certain Cyclin Dependent Kinases (CDKs) leading to tumour regression. It is developed by ... 4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide. Find entries where: LZE. is present as a ... InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)( ...
CATH Superfamily 1.10.510.10
Dipole moment for 1di8: THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETH
Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water...
To facilitate the evaluation of CDK2 (cyclin-dependent kinase 2) as a cancer target, the in vitro and in vivo properties of ... Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water ... NU6102 (O-6-cyclohexylmethyl-2-(4-sulphamoylanilino) purine) and a water soluble prodrug (NU6301) were investigated. NU6102 ...
AbMiner - Antibody Detail | Genomics and Pharmacology Facility
SCOPe 2.08: Structural Classification of Proteins - extended
Publication Detail
Cyclin-Dependent Kinases/genetics; Cyclin-Dependent Kinases/metabolism*; Cyclin-Dependent Kinases/pharmacology; Humans; Mice; ... Title: Cyclin-dependent kinase 11p110 and casein kinase 2 (CK2) inhibit the interaction between tyrosine hydroxylase and 14-3-3 ... Casein Kinase II; Cell Line; Cyclin-Dependent Kinase 2; ... From this, mouse-derived cyclin-dependent kinase 11 (CDK11)p110 ... Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism*; Protein-Serine-Threonine Kinases/ ...
Multiple hyperlinks to UniProt
Your request to link to UniProt for Cyclin-A1/Cyclin-dependent kinase 2 ... Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D,K98T] ... Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2 ... Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P ...
Biomarkers Search
3. The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.. Brewster CD; Birkenheuer CH; ... CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent ... 1. Retroviral cyclin controls cyclin-dependent kinase 8-mediated transcription elongation and reinitiation.. Birkenheuer CH; ... Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional ...
SMART: CYCLIN domain annotation
The structural basis of CDK2 activation by cyclin E. 1xo2. Crystal structure of a human cyclin-dependent kinase 6 complex with ... CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2. ... Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for ... Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB ...
cell cycle | Journal of Neuroscience
Cyclin-Dependent Kinases and P53 Pathways Are Activated Independently and Mediate Bax Activation in Neurons after DNA Damage ... Cyclin-Dependent Kinase Activity Is Required for Apoptotic Death But Not Inclusion Formation in Cortical Neurons after ... Cyclin-Dependent Kinase-2 Controls Oligodendrocyte Progenitor Cell Cycle Progression and Is Downregulated in Adult ... Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed ...
Publications - Sushil G. Rane, Ph.D. - NIDDK
Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and ... Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis.. Reddy HK, Mettus RV, Rane SG, Graña X ... Janus kinases: components of multiple signaling pathways.. Rane SG, Reddy EP.. Oncogene (2000 Nov 20) 19:5662-79. Abstract/Full ... JAKs, STATs and Src kinases in hematopoiesis.. Rane SG, Reddy EP.. Oncogene (2002 May 13) 21:3334-58. Abstract/Full Text. Germ ...
Perspectives of circular RNAs in diabetic complications from biological markers to potential therapeutic targets (Review)
... cyclin-dependent protein kinase 2; cZNF609, circular RNA zinc finger protein 609; DR, diabetic retinopathy; ESM1, endothelial- ... circRNA FTO α-ketoglutarate dependent dioxygenase; circHIPK3, circRNA homeodomain interacting protein kinase 3; circLRP6, ... circRNA homeodomain interacting protein kinase 3; circMET, circRNA MET proto-oncogene, receptor tyrosine kinase; circPWWP2A, ... Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ and Kjems J: miRNA-dependent gene silencing involving ...
Marinus Pharmaceuticals Receives Positive CHMP Opinion for ZTALMY® (ganaxolone) for the Adjunctive Treatment of Seizures...
... oral suspension for the adjunctive treatment of epileptic seizures associated with cyclin-dependent kinase-like 5 (CDKL5) ... oral suspension for the adjunctive treatment of epileptic seizures associated with cyclin-dependent kinase-like 5 (CDKL5) ... 2 Olson H et al. 2019 Pediatric Neurology 3 Jakimiec M et al. 2020 Brain Sci. ... 2 It is caused by a mutation of the cyclin-dependent kinase-like 5 (CDKL5) gene, located on the X chromosome. The CDKL5 gene ...
Juxtacortical Tumors: Background, Periosteal Chondroma, Periosteal Chondrosarcoma
... and cyclin-dependent kinase 4 (CDK4). They found that 57% of the tumors in their series were positive for MDM2 and 100% for ... 31] 3-6% of all osteosarcomas, and 2% of primary osseous neoplasms. [15] These lesions are almost exclusively seen around the ... Mutations in isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) have been described in periosteal chondromas, as well as ... 38] used immunohistochemistry to assess for the protein products of the oncogenes murine double-minute type 2 (MDM2) ...
The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine
... derepressing the gene encoding for cyclin-dependent kinase inhibitor 2A. This prevents cyclin-dependent kinases (1, 2, 4, and 6 ... most converging on the activation of cyclin-dependent kinase inhibitors (p15, p16, p21, p27, and/or p53). The mediators of cell ... polymorphism analyses in humans and in atherosclerotic murine models revealed that lower levels of cyclin-dependent kinase ... The human K+ channel ether-à-go-go gene (hERG) might also be interested by age-dependent mutations causing rhythm instabilities ...
Publications -
NYU Abu Dhabi
UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Mol Biol Cell. 2012 Jan; ... MAP kinases regulate unfertilized egg apoptosis and fertilization suppresses death via Ca2+ signaling. Mol Reprod Dev. 2004 Mar ... 2011 Aug;54(2):452-62. PubMed PMID: 21488074; NIHMSID: NIHMS286931; PubMed Central PMCID: PMC3140628.. ... 2011 Aug;54(2):495-508. PubMed PMID: 21538441; NIHMSID: NIHMS291611; PubMed Central PMCID: PMC3145024.. ...
2017 | MD Anderson Cancer Center
Next-generation cyclin dependent kinase 2/9 (CDK2/9) inhibitors offer a novel way to treat lung cancer with minimal toxic side ... Discovery of a dual role played by the enzyme phosphoglycerate kinase 1 (PGK1) may indicate a new therapeutic target for ... Phase 2 CAR-T study reports significant remission rates at 15-month follow up ...