SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence - Ludwig Cancer Research
... modified nuclear cyclin D1 and inhibits retinoblastoma protein (Rb) phosphorylation. The lysine residue, K33, of cyclin D1 is a ... we show that nuclear cyclin D1 is far more potent than wild-type (WT) cyclin D1 in bypassing Ras-induced senescence. Thus, this ... study identifies SUMO modification as a positive regulator of nuclear cyclin D1, and reveals a new way by which cell cycle ... modified nuclear cyclin D1 and inhibits retinoblastoma protein (Rb) phosphorylation. The lysine residue, K33, of cyclin D1 is a ...
SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence - Oxford Stem Cell Institute
... modified nuclear cyclin D1 and inhibits retinoblastoma protein (Rb) phosphorylation. The lysine residue, K33, of cyclin D1 is a ... we show that nuclear cyclin D1 is far more potent than wild-type (WT) cyclin D1 in bypassing Ras-induced senescence. Thus, this ... study identifies SUMO modification as a positive regulator of nuclear cyclin D1, and reveals a new way by which cell cycle ... modified nuclear cyclin D1 and inhibits retinoblastoma protein (Rb) phosphorylation. The lysine residue, K33, of cyclin D1 is a ...
Mantle Cell Lymphoma: Practice Essentials, Overview, Pathophysiology
... as well as an overexpression of cyclin D1. [11] Chen et al noted that the association with cyclin D1 overexpression in hairy ... Cyclin D1 plays a key role in cell cycle regulation and progression of cells from G1 phase to S phase by activation of cyclin- ... Cyclin D1 is overexpressed. Immunophenotyping helps differentiate MCL from other small B-cell lymphomas (see the Table, below). ... 11] Chen et al assessed expression of sox11 and evaluated its association with t(11;14) and overexpression of cyclin D1 in 211 ...
Expression of d1- and d3-cyclin genes in pea (Pisum sativum L.) root meristem under clinorotation
... Artemenko O.A. ... Artemenko O.A. Expression of d1- and d3-cyclin genes in pea (Pisum sativum L.) root meristem under clinorotation, Tsitol Genet ... Using in situ hybridization the d1- and d3-cyclin gene expression has been shown in pea (Pisum sativum L.) root meristem cells ... The delay of degradation of cyclin subunits is the cause of G1-phase prolongation under clinorotation leading to delay of pea ...
Mantle Cell Lymphoma: Practice Essentials, Overview, Pathophysiology
... as well as an overexpression of cyclin D1. [11] Chen et al noted that the association with cyclin D1 overexpression in hairy ... Cyclin D1 plays a key role in cell cycle regulation and progression of cells from G1 phase to S phase by activation of cyclin- ... Cyclin D1 is overexpressed. Immunophenotyping helps differentiate MCL from other small B-cell lymphomas (see the Table, below). ... 11] Chen et al assessed expression of sox11 and evaluated its association with t(11;14) and overexpression of cyclin D1 in 211 ...
Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with...
... another is mutation of T286 in cyclin D1 (CCND1) causing the loss of phosphorylation of T286 is involved in nuclear ... "Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1," Oncogene, vol. 25, no. 47, pp ... accumulation of cyclin D1 in esophageal cancer [14].. However, some of these previous studies concluded the relationship ...
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats
... evidenced by proliferative cell nuclear antigen and cyclin D1 immunohistochemical staining, and induced apoptosis in these ...
Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100) | Oncotarget
... direct binds to cyclin d1 mRNA 3′-UTR and inhibits Cyclin D1 protein translation, putative miR-302d binding site in cyclin d1 3 ... Human Cyclin D1 is a protein encoded by the CCND1 gene and is an important regulator of cell cycle progression [14]. Cyclin D1 ... Cyclin D1 is encoded by the CCND1 gene in human and is overexpressed in many cancers [13]. Cyclin D1 overexpression has been ... Followed this, the Cyclin D1 protein degradation rate was compared. As shown in Figure 3H, the Cyclin D1 protein degradation ...
Cyclin D1 G870A polymorphism and breast cancer risk: A meta-analysis involving 23,998 subjects<...
Cyclin D1 G870A polymorphism and breast cancer risk: A meta-analysis involving 23,998 subjects. Oncology Research. 2012;19(12): ... Cyclin D1 G870A polymorphism and breast cancer risk: A meta-analysis involving 23,998 subjects. / Yang, June; Liu, Hong; Lu, Su ... Cyclin D1 G870A polymorphism and breast cancer risk : A meta-analysis involving 23,998 subjects. In: Oncology Research. 2012 ; ... Yang, J., Liu, H., Lu, S., Gao, M., Du, Q., & Tang, S. C. (2012). Cyclin D1 G870A polymorphism and breast cancer risk: A meta- ...
Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of...
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, ... cyclin D1 and cyclin E was altered by di-GA treatment (10 μ M). Western blot analyses showed that cyclin D1 expression ... Di-GA downregulated cyclin D1 and thus presumably inhibited Cdk4 and/or Cdk6. Cyclin D1 was identified as the Prad 1 oncogene, ... sc-8007; anti-cyclin D1 (M-20) Cat. No. sc-718; anti-cyclin E (M20) Cat. No. sc-481 and anti-p21Cip/Waf (C-19) Cat. No. sc-397 ...
The study of relationship between cyclin D1 overexpression and clinicopathological prognotic factors... - کتابخانه دیجیتال...
The study of relationship between cyclin D1 overexpression and clinicopathological prognotic factors... , کتابخانه دیجیتال ... The study of relationship between cyclin D1 overexpression and clinicopathological prognotic factors in breast invasive ductal ... Cyclin D1 staining was performed on paraffin- embedded tumor tissue samples and the relationship between cyclin DI status and ... There was no relationship between cyclin D1 status on one hand and age, tumor stage, and HER2- Neu status on the other. Cyclin ...
Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis.<...
Hur, K, Kim, JR, Yoon, BI, Lee, JK, Choi, JH, Oh, GT & Kim, DY 2000, Overexpression of cyclin D1 and cyclin E in 1,2- ... Cyclin D1 expression was detected in 56.3% of the adenomas and in 61.5% of the adenocarcinomas examined, whereas cyclin E ... Overall, cyclin D1, cyclin E and PCNA expression was significantly increased at both the mRNA and protein levels in normal ... Cyclin D1 expression was detected in 56.3% of the adenomas and in 61.5% of the adenocarcinomas examined, whereas cyclin E ...
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin...
However, proliferation of cardiomyocytes induced by nuclear-targeted cyclin D1 (D1NLS) stops after one or two rounds of cell ... However, proliferation of cardiomyocytes induced by nuclear-targeted cyclin D1 (D1NLS) stops after one or two rounds of cell ... However, proliferation of cardiomyocytes induced by nuclear-targeted cyclin D1 (D1NLS) stops after one or two rounds of cell ... However, proliferation of cardiomyocytes induced by nuclear-targeted cyclin D1 (D1NLS) stops after one or two rounds of cell ...
Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest. | J Biol...
The down-regulation of cyclin D1 protein was suppressed by a proteasome inhibitor, MG132. The cyclin D1 down-regulation by MPP ... Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest.. Bai, Jie; ... suppressed the cyclin D1 down-regulation caused by MPP(+). Our results demonstrate that MPP(+) induces cell cycle arrest ... induced hypophosphorylation of retinoblastoma protein and rapidly down-regulated the protein but not mRNA levels of cyclin D1 ...
p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas...
Alterations in the p16<sup>INK4a</sup>/cyclin D1/RB pathway in gastrointestinal tract endocrine...
Li, A. F. Y., Li, A. C. H., Tsay, S. H., Li, W. Y., Liang, W. Y., & Chen, J. Y. (2008). Alterations in the p16INK4a/cyclin D1/ ... Li, AFY, Li, ACH, Tsay, SH, Li, WY, Liang, WY & Chen, JY 2008, Alterations in the p16INK4a/cyclin D1/RB pathway in ... Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors. / Li, Anna Fen Yau; Li, Alice Chia ... Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors. In: American Journal of Clinical ...
Metformin Inhibits Growth of Breast Cancer Cell T47D through Decreasing Expression of Protein P53, BCL2 and Cyclin D1 |...
Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive...
... studied the chemopreventive effects of resveratrol on cyclin D1 expression and the signaling pathways that regulate cyclin D1 ... Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive ... Also, resveratrol treatment downregulated cyclin D1 as well as p38 MAP kinase, Akt and Pak1 expression and activity in HepG2 ... It is known that cyclin D1 is overexpressed in liver cancers. Accordingly we have ...
The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene...
We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. ... Repression of cyclin A transcription by ATF3 required the CRE in the cyclin A promoter. In parallel, ATF3 overexpression ... that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A ... cyclin D1 and cyclin A wild type promoters significantly, whereas the mutant cyclin A construct showed no response to ATF3 ...
he cascade reaction of p-pak-1/P--Catenins-675/c-myc/Cyclin-D1 to promote the malignant proliferation of colon cancer cells ...
Catenins-675/c-myc/Cyclin-D1 to promote the malignant proliferation of colon cancer cells (Chen et al., 2017; Yang et al., 2017 ... he cascade reaction of p-pak-1/P--Catenins-675/c-myc/Cyclin-D1 to promote the malignant proliferation of colon cancer cells ( ... he cascade reaction of p-pak-1/P-Catenins-675/c-myc/Cyclin-D1 to promote the malignant proliferation of colon cancer cells ( ... Uncategorized , he cascade reaction of p-pak-1/P--Catenins-675/c-myc/Cyclin-D1 to promote the malignant proliferation of colon ...
Cyclin D1 is a protein which associates with cyclin-dependent kinase-4 and -6 (CDK-4 and -6) to form heterodimers that progress...
Cyclin D1 is a protein which associates with cyclin-dependent kinase-4 and -6 (CDK-4 and -6) to form heterodimers that progress ... Cyclin D1 is a protein which associates with cyclin-dependent kinase-4 and -6 (CDK-4 and -6) to form heterodimers that progress ... Cyclin D1 is a protein which associates with cyclin-dependent kinase-4 and -6 (CDK-4 and -6) to form heterodimers that progress ... Cyclin D1 is a protein which associates with cyclin-dependent kinase-4 and -6 (CDK-4 and -6) to form heterodimers that progress ...
"Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct" by Kimberly Nath, Cara Fisher et al.
HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing...
HIV-1-infected podocytes showed markedly elevated cyclin D1 mRNA and cyclin D1 protein, the latter of which did not down- ... hallmarks of cyclin D1-mediated G1 → S phase progression. We assessed cyclin D1 and phospho-pRb (Ser780) expression in two well ... abrogated cyclin D1 expression, underlying the requirement for HIV-1 encoded products to induce cyclin D1. Indeed, HIV-1 virus ... a target of active cyclin D1/cyclin-dependent kinase-4/6 known to promote G1 → S phase progression. ...
Role of complex cyclin D1/Cdk4 in somatostatin subtype 2 receptor-mediated inhibition of cell proliferation of a medullary...
... which triggers phosphorylation-dependent cyclin D1 degradation. Indeed, we observed a reduction in cyclin D1 protein half-life ... which triggers phosphorylation-dependent cyclin D1 degradation. Indeed, we observed a reduction in cyclin D1 protein half-life ... Moreover, treatment with both SRIH and BIM-23120 decreases cyclin D1 levels, with a parallel increase in phosphocyclin D1 ... Moreover, treatment with both SRIH and BIM-23120 decreases cyclin D1 levels, with a parallel increase in phosphocyclin D1 ...
Overexpression of cyclin D1 and c-Myc gene products in human primary epithelial ovarian cancer | International Journal of...
Cyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant ... Although our preliminary results need to be validated in a larger number of tumors, the abnormal expression of cyclin D1 and c- ... No abnormal expression of cyclin D1 or c-Myc was demonstrated in any of the 12 normal ovarian specimens. However, compared to ... Overexpression of cyclin D1 and c-Myc gene products in human primary epithelial ovarian cancer ...
The Association of FLT3-ITD Gene Mutation with Bone Marrow Blast Cell Count, CD34, Cyclin D1, Bcl-xL and hENT1 Expression in...
Methods: We investigated FLT3-ITD mutations, bone marrow blast cell count, CD34, cyclin D1, Bcl-xL and hENT1 expression in bone ... CD34 and cyclin D1 expressions were higher (MFI 328.80 vs 25.78, p =0.003 and MFI 74.51 vs 57.15 p =0.005) than the patients ... cyclin D1 and hENT1 expressions, however no association was obtained with Bcl-xL expression. These findings support the role of ... cyclin D1 and Bcl-xL expressions as indexes of cell proliferation and anti-apoptosis and human equilibrative nucleoside ...
CDK4, CDK6, Cyclin D1 and Notch1 immunocytochemical expression of oral brush liquid-based cytology for the diagnosis of oral...
View of A Study of Cyclin D1, E-cadherin, EGFR, HER- 2, Ki67, and p53 Tumor Marker Expressions in Neoplastic and Non ...
The values of Transgelin, Stathmin, BCOR and Cyclin-D1 expression in differentiation between Uterine Leiomyosarcoma (ULMS) and...
We aimed to assess the diagnostic utility of Transgelin, Stathmin, BCOR and Cyclin-D1 separately and in-combinations in ... The combination of BCOR and Cyclin-D1 expression has high sensitivity and specificity for diagnosis of ESS and differentiating ... The diagnostic performances of Transgelin, Stathmin, BCOR and Cyclin-D1 were assessed in samples from all patients using ... The combination of Stathmin and Transgelin, BCOR and CyclinD1 expression has high sensitivity and specificity for diagnosis of ...
Cyclin D1 + large B-cell lymphoma with altered CCND1 and BCL-6 rearrangements: a diagnostic challenge | Biomarker Research |...
We report a case of diffuse large B-cell lymphoma with cyclin D1 expression. The underlying mechanism for cyclin D1 expression ... Duplication of CCND1 gene was attributed to some of the cases with cyclin D1 expression. The mechanism of overexpression of ... The phenotype and genetic abnormalities of DLBCL with cyclin D1 overexpression can be complex and may be difficult to ... A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle ...