Cyclin B1 - Wikipedia
"Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction". EMBO J. 19 (6): 1378-88. doi: ... G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein ... Cyclin B1 can reside in the nucleus or the cytoplasm which can have an effect on the malignant potential of cyclin B1 when ... Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis. Another mechanism by which cyclin B1-Cdk1 ...
Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in...
We then studied the effect of Dox on the p34cdc2/cyclin B1 complex because it plays a key role in regulating G2/M phase ... In contrast, Dox treatment was found to induced cyclin B1 accumulation as a result of stimulating its synthesis and inhibiting ... Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in ... Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in ...
Ccnb1ip1 Mouse Gene Details | cyclin B1 interacting protein 1 | International Mouse Phenotyping Consortium
Cyclin B1 Antibody (100-401-152) | Rockland
Get Rocklands Anti-Cyclin B1 (RABBIT) Antibody - 100-401-152 for IHC, WB. Reacts with Human. Order online now! ... Related products to: Cyclin B1 Antibody. Cyclin B1 phospho S126 Antibody 600-401-464 ... No reaction was observed against other related cyclins. Cross reactivity with Cyclin B1 from other species may also occur. ... Anti-Cyclin B1 antibody was produced by repeated immunizations of full length fusion protein corresponding to the human gene. ...
Cyclin B1 Antibody V92.1 | V2024 NSJ Bioreagents
This published Cyclin B1 monoclonal antibody, clone V92.1, is suitable for use in FACS, IF and IP and is guaranteed to work as ... Immunoprecipitation : 1-2ug/500ug protein (precipitates active CDK1/cyclin B1 complexes). Limitations. This Cyclin B1 antibody ... This antibody recognizes a protein of 55-62kDa, identified as Cyclin B1. In mammals, Cyclin B1 associates with inactive p34cdc2 ... Cyclin B1 antibody. SDS-PAGE analysis of purified, BSA-free Cyclin B1 antibody (clone V92.1) as confirmation of integrity and ...
Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in...
Human glioma tissue microarrays indicated the positive expression rates of CDC2/CyclinB1 with a positive correlation with ... results have demonstrated overexpression of CDC2/Cyclin B1 in various tumors however there is still no report of CDC2/Cyclin B1 ... Expression of CDC2 and CyclinB1 in different grade brain tumors. In CDC2/CyclinB1 immunostaining, CDC2/CyclinB1 was expressed ... Park M, Chae HD, Yun J, Jung M, Kim YS, Kim SH, Han MH, Shin DY: Constitutive Activation of Cyclin B1-associated cdc2 Kinase ...
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
... which disrupted Cyclin B1-CRM1 interactions, led to a marked nuclear accumulation of Cyclin B1. In mitosis, Cyclin B1 undergoes ... Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. Cyclin B1 localization ... Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.. Publication , Journal Article ... "Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1." Genes & Development 12, no. 14 ...
![CycB Cyclin B [Drosophila melanogaster (fruit fly)] - Gene - NCBI](data:image/png;base64,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)
CycB Cyclin B [Drosophila melanogaster (fruit fly)] - Gene - NCBI
2g; 3510; CG3510; chr2R:18312808..18312907; cyc B; Cyc B; cyc-B; CYC-B; cycb; cycB; Cycb; CYCB; cyclin B; CYCLIN B; Cyclin B1; ... Cyclin_N; Cyclin, N-terminal domain. pfam02984. Location:387 → 513. Cyclin_C; Cyclin, C-terminal domain. ... Cyclin_N; Cyclin, N-terminal domain. pfam02984. Location:389 → 515. Cyclin_C; Cyclin, C-terminal domain. ... Cyclin_N; Cyclin, N-terminal domain. pfam02984. Location:383 → 509. Cyclin_C; Cyclin, C-terminal domain. ...
Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2 | Nature
Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable. J. Biol. Chem ... Boos, D., Kuffer, C., Lenobel, R., Korner, R. & Stemmann, O. Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like ... Holland, A. J. & Taylor, S. S. Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction. ... Structural basis of human separase regulation by securin and CDK1-cyclin B1 *Jun Yu ...
Determinants of Human Cyclin B1 Association with Mitotic Chromosomes • MatTek Life Sciences
Cyclin B1 scaffolds MAD1 at the kinetochore | Max Planck Institute of Molecular Physiology
... mammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability. Cyclin B1 localises to an ... Therefore, Cyclin B1 is the long-sought-after scaffold that links MAD1 to the corona, and this specific pool of MAD1 is needed ... Cyclin B1 Scaffolds MAD1 at the Kinetochore Corona to Activate the Mitotic Checkpoint. Allan LA, Camacho Reis M, Ciossani G, ... Robustness arises because Cyclin B1:MAD1 localisation loses dependence on MPS1 kinase after the corona has been established, ...
Cdc2/cyclin B1 interacts with and modulates inositol 1, 4, 5-trisphosphate receptor (type 1) functions
Depletion of BubR1 promotes premature centrosomal localization of cyclin B<sub>1</sub> and accelerates mitotic...
As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ... As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ... As expected, BubR1 depletion leads to degradation of cyclin B1 in the G2 phase. Intriguingly, cyclin B1 is prematurely targeted ... This is in contrast to control cells where cyclin B1 appears at the centrosomes in early prophase based on cell cycle-specific ...
Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability
Cyclin B * Cyclin B1 * Ubiquitin-Protein Ligase Complexes * Anaphase-Promoting Complex-Cyclosome ... PSMA-expressing cells prematurely degrade cyclin B and exit mitosis due to increased APC activity and incomplete inactivation ...
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. - CAMS...
Cyclin H Antibody (1B8) (H00000902-M01): Novus Biologicals
View Mouse Monoclonal anti-Cyclin H Antibody (1B8) (H00000902-M01). Validated Applications: WB, ELISA, ICC/IF, IHC. Validated ... Reviews for Cyclin H Antibody (H00000902-M01) (0) There are no reviews for Cyclin H Antibody (H00000902-M01). By submitting a ... Blogs on Cyclin H. There are no specific blogs for Cyclin H, but you can read our latest blog posts. ... Diseases for Cyclin H Antibody (H00000902-M01). Discover more about diseases related to Cyclin H Antibody (H00000902-M01). ...
Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis | Cell Death & Disease
9F). Knocking down of ATP6V1A resulted in Cyclin B1 and pH3 accumulation (Fig. 9G). These data demonstrated that Plk1 is ... The result demonstrated that reduced ATP6V1A expression caused Cyclin B1 and pH3 accumulation indicating cell cycle arrest (Fig ... 8A, B). Both CyclinB1 and pH3 protein accumulates (Fig. 8C). CyclinB1 could not be degraded without Plk1 [27]. BI6727 showed ... anti-cyclin B1 (Cell Signaling Technology, 4138T, USA), anti-Plk1 (Abcam, ab17057, UK), anti-LC3 (Novus Biological, NB100-2220 ...
2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b...
Staff Profile | Faculty of Medical Sciences | Newcastle University
RPL10 ribosomal protein L10 [Homo sapiens (human)] - Gene - NCBI
Toxins | Free Full-Text | The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1...
... the activity of Cyclin B1-CDK1 will gradually increase [55], and then the activated Cyclin B1-CDK1 will be transferred into the ... Cyclins could activate different cyclin dependent kinases (CDKs) to accelerate the cycle progression, while cyclin dependent ... Gong, D.; Ferrell, J.E. The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol. Biol. Cell. 2010, 21, 3149- ... Jackman, M.; Lindon, C.; Nigg, E.A.; Pines, J. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. ...
![CCNB1IP1 Mouse Monoclonal Antibody [Clone ID: OTI4H3] - TA502700 | OriGene](data:image/png;base64,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)
CCNB1IP1 Mouse Monoclonal Antibody [Clone ID: OTI4H3] - TA502700 | OriGene
SCOPe 2.08: Structural Classification of Proteins - extended
Compound: g2/mitotic-specific cyclin-b1. Species: Homo sapiens [TaxId:9606]. Gene: CCNB1, CCNB. Database cross-references and ... Compound: Cyclin-dependent kinase 1. Species: Homo sapiens [TaxId:9606]. Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2. Database ... Compound: Cyclin-dependent kinases regulatory subunit 2. Species: Homo sapiens [TaxId:9606]. Gene: CKS2. Database cross- ... Keywords: cdk1, cyclinb1, cks2, inhibitor, cell cycle. Deposited on 2018-06-19, released 2018-12-05. The last revision prior to ...
Weis2014 - Data driven Mammalian Cell Cycle Model | BioModels
The approach provided expression profiles of cyclin A2, cyclin B1, and phospho-S10-histone H3. The model was built by ... The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1 ... models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 ... enhanced transcription of mitotic cyclins during late S/early G2 phase, and the sustained synthesis of cyclin B during mitosis ...
Alumni - Biochemistry & Molecular Biology - Doctor of Philosophy(Ph.D.) - Graduate Education - Education - University of...
Browsing by Subject "Biological Transport"
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. ... Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. Cyclin B1 localization ... Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. Yang, J; Bardes, ES; Moore, JD ... Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes are localized to the nucleus when active. Although ... ...
Ghent University Academic Bibliography
B1‐type cyclins control microtubule organization during cell division in Arabidopsis Mariana Romeiro Motta, XinAi Zhao, ...
Pitt researchers find promising candidate protein for cancer prevention vaccines - ScienceBlog.com
"Cyclin B1 is known to be produced in excess amounts in several kinds of cancer," she said. "While we were studying it, we noted ... "Cyclin B1 and MUC1 are part of a big family of self-proteins that become over-produced during cancer development, so they have ... "Because cyclin B1 is a self protein, there have been concerns that boosting the immune response against it would produce ... She is working with collaborators to open, by the end of the year, a clinical trial of a cyclin B1 treatment vaccine in lung ...
Oral Florid Papillomatosis: Background, Pathophysiology, Etiology
Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with ... 16] An exploration of nuclear expression of cyclin B1 suggested overexpression is salient in early carcinogenesis, cell ... Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma was found to correlate with lack of histological ... Angadi PV, Krishnapillai R. Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with ...