MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma
Cyclin dependent kinase inhibitor 1A. crRCC:. Chromophobe renal cell carcinomas. ccRCC:. Clear cell renal cell carcinomas. ... mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase- (PI3K-) AKT, signal transducer and activator of ... kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation," The Journal of Biological Chemistry, vol. 273, ... S. Benvenuti and P. M. Comoglio, "The MET receptor tyrosine kinase in invasion and metastasis," Journal of Cellular Physiology ...
Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network...
... cyclin-dependent kinase inhibitor 1A (CDKN1A/P21), interleukin 6 (IL6), MYC protooncogene (MYC), interleukin 1 beta (IL1B), C-C ... T. Lan, S. Jiang, J. Zhang et al., "Breviscapine alleviates nonalcoholic steatohepatitis by inhibiting TGF-β-activated kinase 1 ... A. Selma Dagtas and K. M. Gilbert, "p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy ... "DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity," Cell, vol. 173, no. 4 ...
A Systems' Biology Approach to Study MicroRNA-Mediated Gene Regulatory Networks
p21, also known as cyclin-dependent kinase inhibitor 1 (CDKN1A), is a transcriptional target of p53. It is required for proper ... The reporter activity can be analyzed at different time points such as 24 hr, 48 hr and 72 hr to determine the time dependent ... and protease inhibitors. The proteins from each sample are quantitated using Bradford or BCA reagents and compared with bovine ...
The Compatibility of Alisma and Atractylodes Affects the Biological Behaviours of VSMCs by Inhibiting the miR-128-5p/p21 Gene
The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and ... i,Result.,/i, AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, ... miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome ... VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of ...
Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes
Using an adenoviral vector that encodes cyclin-dependent kinase inhibitor p27 with target sequences for EC-specific miR-126-3p ... PI3 is phosphoinositide 3-kinase; Akt is serine/threonine kinase; p53 is p53 protein. ... Moreover in this population the use of miravirsen has showed prolonged dose-dependent reductions in HCV RNA levels without ... In fact insulin-dependent T2DM patients have a worse functional recovery and a worse prognosis after CRT [18, 19, 21-24]. These ...
Adjudication of the Alleged Role of Vitamin D in the Antimicrobial Pathway
... cyclin-dependent kinase inhibitor 1), and C/EBP (CCAAT-enhancer-binding proteins). The relative importance of the latter two ... The strong link between mir21 and the two vitamin-D-dependent antimicrobial peptides was confirmed using mir -infected ... 25(OH)2D3, which resulted in a dose-dependent increase in expression of activated cathelicidin as well as a direct ... P. T. Liu, M. Wheelwright, R. Teles et al., "MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy," ...
N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis
Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) (. , ), and PMA-Induced Protein 1 (NOXA) (. , ), which were also validated by Q- ... CDKN1A (p21), a cell cycle-dependent kinase inhibitor, has been identified as a target gene downstream of p53 and can promote ... P. Li, D. Nijhawan, I. Budihardjo et al., "Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an ... C. Zhang, V. Richon, X. Ni, R. Talpur, and M. Duvic, "Selective induction of apoptosis by histone deacetylase inhibitor SAHA in ...
The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of...
Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by ... cyclin-dependent kinase inhibitor-1A) and P27 (cyclin-dependent kinase inhibitor-1B), were determined in TCEE treated Hep3B and ... S. Shin, B.-J. Sung, Y.-S. Cho et al., "An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7," ... In the presented study, one-way ANOVA was used for analyzing the dose-dependent effect of TCEE on Hep3B and HepJ5 cells, and ...
The Signaling of Cellular Senescence in Diabetic Nephropathy
... and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16INK4A, ARF proteins, and p21 [13-16]. Furthermore, ... In turn, p21CIP1/WAF1 inhibits cyclin-dependent kinase 2- (CDK2-) mediated phosphorylation of the retinoblastoma protein (Rb). ... Mitophagy depends on the signaling cascade of kinases. The most important kinase is the PTEN-induced putative kinase 1 (PINK1 ... in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2," Biogerontology, vol. 17, no. 2, pp. 305-315, ...
Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
... indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. Moreover, intratumoral administration of terpinen-4-ol ... Our results indicated that terpinen-4-ol elicited a dose-dependent cytotoxic effect, as determined by MTT assay. Increased sub- ... the cyclin-dependent kinases (Cdks), and the expression of their cyclin partners, whereas inhibitors of Cdks, including p21 and ... Y. Xiong, G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach, "p21 is a universal inhibitor of cyclin kinases," ...
Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
"Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21Sdi1/ ... probably due to the release of p21 suppression of cyclin-dependent kinase activity via G0/G1-S transition [32]. Accelerated ... Then, the transforming growth factor-β-activated kinase 1 (TAK1) activates the IκB kinase IKK that phosphorylates the IκBα, ... PCSK9 Inhibitors. Recent studies are addressing the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors ...
Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of...
Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. Mitochondrial regulation of apoptosis further ... resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. Furthermore, Tan IIA- ... Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, ... Cyclin-dependent kinase 2 (CDK2), a member of a highly conserved family of protein kinases that regulates the eukaryotic cell ...
Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum
In mammalian, the core cell-cycle mechanism comprising cyclin and cyclin-dependent kinase complex is the main cause of cell ... FAK-I (FAK-inhibitor) and CYTD (cytochalasin D) can inhibit the invasion and metastasis effect of cancer cells, while ... H. Wang, B. N. Nicolay, J. M. Chick et al., "The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival," Nature, ... Resveratrol displayed a dose-dependent and time-dependent cytotoxicity on lung cancer cells A549 through inhibiting the mRNA ...
Rett Syndrome: Coming to Terms with Treatment
... expressing cyclin-dependent kinase-like 5, is located on X-chromosome at Xp22. It has an as yet unknown function but does ... Proton-pump inhibitors have been the most effective medication for GERD, although H2-blockers may provide temporary benefit. ... In a related study of serotonin function in male Mecp2 mutant mice, use of the serotonin reuptake inhibitor, citalopram, ... W. Li, G. Calfa, J. Larimore, and L. Pozzo-Miller, "Activity-dependent BDNF release and TRPC signaling is impaired in ...
Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and...
... cyclin D1, glutathione, cytosolic phospholipase A2, inhibitor of NF-κB kinase-1-2, P38MAPK, p-Tau (p-τ), and TNFα. ... "Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling ... Curcumin inhibits the inhibitor of κB kinase and IκBα phosphorylation [112-115]. ... S-phase kinase-associated protein 2. SOCS1 and SOCS3:. Genes that encode members of the STAT-induced STAT inhibitor family (SSI ...
Earthworms Dilong: Ancient, Inexpensive, Noncontroversial Models May Help Clarify Approaches to Integrated Medicine Emphasizing...
... mediated phosphatidylinositol 3-kinase/serine-threonine kinase (PI3K/Akt) pathway. It also activated protein expression of cell ... Dilong also stimulated ERK1/2, but p38 phosphorylation was reduced by pretreatment with chemical inhibitors (U0126 and SB203580 ... These encouraging and confirmatory experiments have been considered successful by interpreting a dose-dependent delivery of ... leading to upregulation of the PI3K/Akt pathway and activation of the cell cycle regulatory proteins cyclin D1, E, and A, ...
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Coadministration of Ki16425, an LPA1/3 antagonist, with sunitinib, a tyrosine kinase inhibitor, prolonged the responsiveness of ... and PI3K-dependent mechanism that required Src kinase for optimal MAPK phosphorylation, enhancing OC invasion [106]. ... cyclin D1, c-Myc, and HIF-1α were lower compared to ApcMin/+ mice, while β-catenin was primarily cytoplasmic in Lpar2−/− ApcMin ... ATX-LPA axis has been studied in airway inflammation where protein kinase C δ (PKCδ) mediates LPA-induced NFκB transcription ...
High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
HMGB1 binds to cyclin-dependent kinases like CDK2 that control transcriptional regulation of genes related to cell cycle ... κB signalling via stimulation of inhibitor NF-κB kinase, IKK [173]. The stimulation of AR signalling leads to activation of SRC ... probably by mitogen-activated protein kinase kinase (MEK) and protein-serine/threonine kinases (ERK1/2) signalling [88]. ... H. C. Dan, M. J. Cooper, P. C. Cogswell, J. A. Duncan, J. P.-Y. Ting, and A. S. Baldwin, "Akt-dependent regulation of NF-κB is ...
Temporal Identification of Dysregulated Genes and Pathways in Clear Cell Renal Cell Carcinoma Based on Systematic Tracking of...
... cyclins and cyclin-dependent kinases, etc.), which led to failure of cell cycle arrest, may thus serve as markers of a more ... B. H. ONeil, L. W. Goff, J. S. W. Kauh et al., "Phase II study of the mitogen-activated protein kinase 1/2 inhibitor ... was expressed in dividing somatic cells and regulated cell cycle progression by interacting with cyclin-dependent kinase (CDK) ... S. H. Woo, S.-K. Seo, S. An et al., "Implications of caspase-dependent proteolytic cleavage of cyclin A1 in DNA damage-induced ...
Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast...
... an inhibition of cyclin E1, cyclin-dependent kinase 2, cyclin-dependent kinase 4, cMYC, and RB, CSK/EGFR signaling, and the ... K. Zins, T. Lucas, P. Reichl, D. Abraham, and S. Aharinejad, "A rac1/cdc42 GTPase-specific small molecule inhibitor suppresses ... The aurora kinase family includes Aurora kinase B (AURKB), a mitotic serine/threonine protein kinase, and aurora kinase A ( ... which included NAD-dependent deacetylase sirtuin 2 (SIRT2), cyclin D1 (CCND1), serine/threonine-protein kinase Aurora-B (AURKB ...
A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription...
... is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an ... The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated ... phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. ... we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. Several ...
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
D. Becker, J. Richter, M. A. Tocilescu, S. Przedborski, and W. Voos, "Pink1 kinase and its membrane potential (Δψ)-dependent ... C. Lee, H.-K. Park, H. Jeong et al., "Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of ... The first described is the phosphorylation by Cdk1/cyclin B which enhances mitochondrial fragmentation during mitosis [160]. ... mTOR kinase, and RB1-inducibile Coiled-Coil 1 (RB1CC1). Inhibition of the mTOR kinase leads to the generation of the Beclin1- ...
Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt...
... a PI3K inhibitor. mRNA of ghrelin receptors(GHS-R1a and GHS-R1b), as well as, protein levels of GHS-R1a, were expressed ... L. Wang, Q. Chen, G. Li, and D. Ke, "Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways ... C. P. Carden, A. Stewart, P. Thavasu et al., "The association of PI3 kinase signaling and chemoresistance in advanced ovarian ... a PI3K inhibitor. mRNA of ghrelin receptors(GHS-R1a and GHS-R1b), as well as, protein levels of GHS-R1a, were expressed ...
Integration of Gene Expression Profile Data to Verify Hub Genes of Patients with Stanford A Aortic Dissection
D. Spira, G. Grözinger, N. Domschke et al., "Cell cycle regulation of smooth muscle cells--searching for inhibitors of ... and receptor tyrosine kinase binding and the up-DEGs are mainly enriched in ATP binding, poly(A) RNA binding, DNA clamp loader ... and Cyclin B. It has been also identified that Cdc20 exerts its function through destruction of critical cell cycle regulators ... activity, single-stranded DNA-dependent ATPase activity, and purine nucleobase binding.. Table 2 ...
The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion
c) Real-time PCR analysis showed that 16-day TGF-β1 incubation reduced cyclin D and PCNA transcription, while 7-day EGF ... Seven-day EGF incubation allows for time-dependent reversal of the TGF-β1-induced myofibroblast phenotype in hepatic oval cells ... with proteinase inhibitor cocktail (Sigma-Aldrich). Protein concentrations were determined by a Micro BCA™ protein assay ... in E-cadherin expression in hepatic oval cells but had no effect on the progenitor marker M2-isozyme of pyruvate kinase. In the ...
Integrating Multiple Microarray Data for Cancer Pathway Analysis Using Bootstrapping K-S Test
H. Hsu, J. Huang, H.-B. Shu, V. Baichwal, and D. V. Goeddel, "TNF-dependent recruitment of the protein kinase RIP to the TNF ... which can inhibit the action of cyclin-CDK complex. The cyclin-CDK complex can phosphorylate RB and make RB dissociate from the ... Inhibitor of apoptosis (IAP) suppresses the activities of caspases and inhibits different apoptotic pathways [40]. IAP and ... H. Xiong, Y. Zhang, and X.-W. Chen, "Data-dependent kernel machines for microarray data classification," IEEE/ACM Transactions ...
MicroRNA-323a-3p Negatively Regulates NEK6 in Colon Adenocarcinoma Cells
"Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6," Scientific Reports, vol. 8, no. 1 ... "Never in mitosis gene A-related kinase 6 promotes cell proliferation of hepatocellular carcinoma via cyclin B modulation," ... miR-191 promotes cellular viability of estrogen-dependent breast cancer cells by directly suppressing the expression of DAB2 ... E. Gerçeker, S. O. Boyacioglu, E. Kasap et al., "Never in mitosis gene A-related kinase 6 and aurora kinase A: new gene ...