"Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human ... VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. Vasodilator-stimulated phosphoprotein has been shown ... "The vasodilator-stimulated phosphoprotein is regulated by cyclic GMP-dependent protein kinase during neutrophil spreading". J. ... 2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins ...

Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]. *Cyclic GMP-Dependent Protein Kinases [D08.811. ... "Cyclic GMP-Dependent Protein Kinases" by people in Harvard Catalyst Profiles by year, and whether "Cyclic GMP-Dependent Protein ... "Cyclic GMP-Dependent Protein Kinases" by people in Profiles.. * Mechanisms That Activate 26S Proteasomes and Enhance Protein ... "Cyclic GMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ...

Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]. *Cyclic AMP-Dependent Protein Kinases [D08.811. ... Cyclic AMP-Dependent Protein Kinases [D12.644.360.200.125]. *Cyclic AMP-Dependent Protein Kinase Type II [D12.644.360.200. ... Cyclic AMP-Dependent Protein Kinases [D12.776.476.200.125]. *Cyclic AMP-Dependent Protein Kinase Type II [D12.776.476.200. ... Cyclic AMP-Dependent Protein Kinase Type II*Cyclic AMP-Dependent Protein Kinase Type II ...

Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]. *Cyclic AMP-Dependent Protein Kinases [D08.811. ... "Cyclic AMP-Dependent Protein Kinases" by people in this website by year, and whether "Cyclic AMP-Dependent Protein Kinases" was ... "Cyclic AMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit ...

Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]. *Cyclic AMP-Dependent Protein Kinases [D08.811. ... Cyclic AMP-Dependent Protein Kinases [D12.644.360.200.125]. *Cyclic AMP-Dependent Protein Kinase Type II [D12.644.360.200. ... Cyclic AMP-Dependent Protein Kinases [D12.776.476.200.125]. *Cyclic AMP-Dependent Protein Kinase Type II [D12.776.476.200. ... Cyclic AMP-Dependent Protein Kinase Type II*Cyclic AMP-Dependent Protein Kinase Type II ...

... cAMP-dependent protein kinase; GEF, guanine nucleotide exchange factor; PDE, phosphodiesterase; DNA-PK, DNA-dependent protein ... Cyclic AMP, Exchange protein directly activated by cyclic AMP, Interleukin-6, Extracellular signalling-regulated kinase, ... Keywords: Cyclic AMP; exchange protein directly activated by cyclic AMP; interleukin-6; extracellular signalling-regulated ... CCAAT/enhancer binding protein; JAK, Janus kinase; MEK, mitogen-activated protein/ERK kinase; SHP-2, SH2 domain-containing ...

... the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES ... A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, ...

... leading to the conversion of guanosine triphosphate nucleotide into cyclic guanosine monophosphate (cGMP). The increase in ... intracellular cGMP leads to a decrease in calcium influx and relaxation of smooth muscle cells by stimulating protein kinase G. ... 9, 10] cGMP is down-regulated by phosphodiesterase 5 activity. Phosphodiesterase 5, which is abundantly expressed in lung ... Previous investigators have demonstrated that inhibition of the activity of Rho A/Rho kinases using the Rho kinase inhibitor ...

... leading to the conversion of guanosine triphosphate nucleotide into cyclic guanosine monophosphate (cGMP). The increase in ... intracellular cGMP leads to a decrease in calcium influx and relaxation of smooth muscle cells by stimulating protein kinase G. ... 9, 10] cGMP is down-regulated by phosphodiesterase 5 activity. Phosphodiesterase 5, which is abundantly expressed in lung ... Previous investigators have demonstrated that inhibition of the activity of Rho A/Rho kinases using the Rho kinase inhibitor ...

... major role in intracellular signaling systems is to regulate protein serine-threonine kinases that phosphorylate other proteins ... Although second messengers such as cyclic nucleotides and Ca2+ may directly gate ion channels, their ... Protein phosphatases, also categorized into serine-threonine or tyrosine subfamilies, reverse the actions of protein kinases ... NEUROTROPHIC FACTOR-REGULATED PROTEIN PHOSPHORYLATION CASCADES * SIGNALING TO THE CELL NUCLEUS: THE DYNAMIC REGULATION OF GENE ...

... and the entered free Ca2+ binds to the sets of Ca2+-regulated proteins such as calmodulin and calcium dependent protein kinases ... cyclic nucleotide-gated cation channel, and ionotropic glutamate receptor; (2) the roles of Ca2+ at the key steps during ... Calcium-dependent protein kinases (CDPKs) are a family of plant specific proteins that link calcium-signal perception and ... Chapter 38 Function of plant calcium-dependent protein kinases in the activation of abiotic and pathogen-related stress ...

... binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins ... Not all protein kinases respond to cAMP. Several classes of protein kinases, including protein kinase C, are not cAMP-dependent ... In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ... Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the ...

Non-Canonical Allostery in Cyclic Nucleotide Dependent Kinases Journal Articles * Protein kinase A-catalyzed phosphorylation of ... heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane Journal Articles ... roles for protein kinase A and pyruvate dehydrogenase kinase Journal Articles * Cyclic 3,5-Adenosine Monophosphate Mediates ... dependent protein kinase by capillary electrophoresis: Impact of cAMP dissociation on protein stability Journal Articles ...

Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major ... Estimating the rate of cAMP-regulated and cGMP-regulated protein phosphorylation in intact cells. Eur. J. Biochem ... Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major ... Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP- ...

Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150] Cyclic Nucleotide-Regulated Protein Kinases ... MAP Kinase Kinase Kinases Entry term(s). Kinase, MAP3 Kinases, MAP Kinase Kinase Kinases, MAP3 MAP Kinase Kinase Kinase MAP3 ... MAP Kinase Kinase Kinase. MAP3 Kinase. MAP3 Kinases. MAPK ERK Kinase Kinase. MAPK ERK Kinase Kinases. MAPK-ERK Kinase Kinase. ... Kinase Kinases, MAPK-ERK Kinase, MAPK-ERK Kinase Kinase, MEK Kinases, MAPK-ERK Kinase Kinases, MEK MAPK ERK Kinase Kinase MAPK ...

Two structurally related families of channels regulated by cyclic nucleotides have been identified, the cyclic nucleotide-gated ... Histidine protein kinases and serine, threonine, or tyrosine protein kinases play essential roles in signal transduction in ... Cyclic nucleotide-regulated cation channels are ion channels whose activation is regulated by the direct binding of cAMP or ... A third type of protein kinase, an arginine protein kinase, has been identified. McsB of Bacillus subtilis hosphorylates the ...

Cold Shock Proteins and Peptides. *Cyclic Nucleotide-Regulated Protein Kinases. *Cyclin-Dependent Kinase Inhibitor Proteins ... Mitogen-Activated Protein Kinase Phosphatases*Mitogen-Activated Protein Kinase Phosphatases. *Mitogen Activated Protein Kinase ... "Mitogen-Activated Protein Kinase Phosphatases" by people in this website by year, and whether "Mitogen-Activated Protein Kinase ... "Mitogen-Activated Protein Kinase Phosphatases" is a descriptor in the National Library of Medicines controlled vocabulary ...

... the cyclic AMP-regulated enhancer (CRE), participates in the diverse r... ... Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res 98:993-1001 ... 2004) Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci 24:3786-94 ... The current proposal takes a fresh look at trying to understand how a single DNA element, the cyclic AMP-regulated enhancer ( ...

Subsequent activation of protein kinase A (PKA) and the cAMP-regulated guanine nucleotide exchange factor II (cAMP-GEFII) leads ... Binding of GLP-1 to its G protein coupled receptor causes adenylate cyclase activation resulting in the formation of cyclic ... Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB ( ... Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB ( ...

It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors ... and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5-AMP. The PDE ... information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. The objective of ... we also wanted to determine the nucleotide and amino acid sequences by experimental evidence. Using RT-PCR, 5- and 3-RACE ...

VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]. ... Valosin Containing Protein ELISA Kits * V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) ELISA ... In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. ... Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena- ...

Extracellular signal-regulated protein kinase 1/2. ESC:. Embryonic stem cell. HCN4:. Hyper-polarization activated cyclic ... nucleotide gated potassium channel 4. HGF:. Hepatocyte growth factor. HIF-1:. Hypoxia-inducible factor-1 ... of miR-126 in obese ADSCs inhibited the extracellular signal-regulated protein kinase 1/2/mitogen-activated protein kinase ( ... ADSC-derived exosomes inhibit mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH-kinase (PI3K) pathways, ...

... channels are modulated by changes in tyrosine phosphorylation catalyzed by protein tyrosine kinases (PTKs) and phosphatases (P ... Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods ... Abbreviations used in this paper: CNG, cyclic nucleotide-gated; PTK, protein tyrosine kinase; PTP, protein tyrosine phosphatase ... Abbreviations used in this paper: CNG, cyclic nucleotide-gated; PTK, protein tyrosine kinase; PTP, protein tyrosine phosphatase ...

1989) Enhancement of kainate-gated currents in retinal horizontal cells by cyclic AMP-dependent protein kinase. Brain Res 481: ... 2011) Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells. J ... The effects of cAMP are thought to be regulated through both CREB-dependent signaling and mitogen-activated protein kinase ( ... 1991) Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science 253:1135-1138, doi ...

... stimulation of β-adrenergic receptors increases cyclic AMP levels and activates protein kinase A (PKA)5, which stimulates ... which are often spatially compartmentalized by anchoring proteins to increase signalling specificity1. These scaffold proteins ... measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein ... Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, ...

The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used ... Drosophila contains ∼30 AGC kinases, including members of the cyclic nucleotide-dependent kinases, protein kinase C (PKC), AKT ... Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and ... SNF1/AMP-dependent kinase, EMK, CHK2, myosin light chain kinase (MLCK), phosphorylase kinase, death-associated protein kinase, ...

Mitogen-Activated Protein Kinase *Mitogen-Activated Protein Kinase Kinase *Mitogen-Activated Protein Kinase-Activated Protein ... important determinant from the response may be the activity amounts and localization of 1 or even more cyclic nucleotide ... These outcomes suggest that the pool(s) of cAMP regulating androgen production are controlled by PDE8s working in conjunction ... Launch The cAMP-dependent proteins kinase (PKA) signaling pathway can be an important regulator of several different ...

... cyclic nucleotide cGMP (cyclic guanosine monophosphate) is elevated, leading to the activation of PKA (protein kinase A), and ... Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. ... zinc protein; PDE, phosphodiesterase; cGMP, cyclic guanosine-monophosphate; GMP, guanosine-monophosphate; PKA, protein kinase A ... through the expression of the A20 protein. A20 is a zinc-finger protein that negatively regulates tumor necrosis factor ...

... and this response was regulated at the transcriptional level rather than an increased IL-1Ra mRNA stability. Studies with PDE4- ... Cyclic AMP Response Element-Binding Protein, Cyclic AMP-Dependent Protein Kinases, Cyclic Nucleotide Phosphodiesterases, Type 4 ... Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. ... Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. ...