Many effects of NO are mediated through its canonical receptor, the soluble guanylyl cyclase, and the second messenger cyclic ... The classical targets of cGMP are cGMP-dependent protein kinases (cGKs), cyclic nucleotide hydrolysing phosphodiesterases, and ... Cyclic GMP / pharmacology * Cyclic GMP / physiology* * Humans * Neuronal Plasticity / drug effects * Neuronal Plasticity / ... Publication types * Research Support, Non-U.S. Govt * Review MeSH terms * Animals ...
Cyclic GMP-Dependent Protein Kinases 20% * Behov, bistånd, budget. Elmersjö, M., Hultqvist, S. & Johansson, S., 2023, Socialt ... Epidemiology and Pathogenesis of Type 1 Diabetes. Stene, L. C. & Lernmark, A., 2023, Transplantation of the Pancreas. Gruessner ... A Potential Neuroprotective Role for Pyruvate Kinase 2 in Retinal Degeneration. Zhou, J., Rasmussen, M. & Ekström, P., 2023, ... Combined with Crosslinking Mass Spectrometry for Identification and Structural Modeling of Host-Pathogen Protein-Protein ...
DSBs are widely repaired by nonhomologous end joining (NHEJ), a process that requires DNA-dependent protein kinase (DNA-PK) ... which can be sensed by cyclic GMP-AMP synthase (cGAS) to produce cGAMP. Then, cGAMP activates stimulator of interferon genes ( ... Different types of DCs function differently. Conventional type I dendritic cells (CD103+cDC1) cross-presented antigens on MHC ... receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase domain-like (MLKL) pathway can also activate cGAS-STING ...
Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ... Cyclic-GMP Phosphodiesterase. 3,5-Cyclic-GMP Phosphodiesterases. 3,5-Cyclic-Nucleotide Phosphodiesterase. 3,5-Cyclic-AMP ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Unpublished Works [Publication Type]. Unpublished Works. V03 - Study Characteristics. Case Reports [Publication Type]. Case ...
Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ... Cyclic-GMP Phosphodiesterase. 3,5-Cyclic-GMP Phosphodiesterases. 3,5-Cyclic-Nucleotide Phosphodiesterase. 3,5-Cyclic-AMP ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Unpublished Works [Publication Type]. Unpublished Works. V03 - Study Characteristics. Case Reports [Publication Type]. Case ...
Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ... Cyclic-GMP Phosphodiesterase. 3,5-Cyclic-GMP Phosphodiesterases. 3,5-Cyclic-Nucleotide Phosphodiesterase. 3,5-Cyclic-AMP ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Unpublished Works [Publication Type]. Unpublished Works. V03 - Study Characteristics. Case Reports [Publication Type]. Case ...
Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ... Cyclic-GMP Phosphodiesterase. 3,5-Cyclic-GMP Phosphodiesterases. 3,5-Cyclic-Nucleotide Phosphodiesterase. 3,5-Cyclic-AMP ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Unpublished Works [Publication Type]. Unpublished Works. V03 - Study Characteristics. Case Reports [Publication Type]. Case ...
... is known to be enhanced by cyclic nucleotides and by an increase in cytosolic Ca(2+). We examined the role of cGMP-dependent ... through a guanylyl cyclase-dependent stimulation of the pacemaker current I(f), without affecting basal I(Ca-L). The activity ... Animals, Calcium, Carbazoles, Cyclic AMP-Dependent Protein Kinases, Cyclic GMP, Cyclic GMP-Dependent Protein Kinases, Dose- ... "Now they help, now they dont!" - A mysterious story about how L-type calcium channels help dopamine be released…but only ...
... reduced STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses. NLRC3 ... is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here ... Interferon Type I. Membrane Proteins. Mice. Mice, Knockout. Protein Binding. Protein Transport. Protein-Serine-Threonine ... The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine ...
Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult ... Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family). Cell Signal. 7, 445-455, 1995.. Marques LJ, ... injury with a possible role for cGMP-dependent protein kinase-1 (Das et al., 2006). Sildenafil has also shown production of a ... Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits. Am J Physiol Heart Circ Physiol. ...
1997) Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: ... subunit of the type 1 cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase. J Biol ... 1981) Effect of phosphorylation on the regulatory subunit of the type 1 cAMP-dependent protein kinase. J Biol Chem 256:4536- ... 1992) cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates Δ-CREB, and a synthetic Δ-CREB ...
DAI-DNA-dependent activator of IRFs; IFNs-type-I interferons; STING (also known as MITA, MPYS, or ERIS); cGAMP-cyclic GMP-AMP; ... Notably, MEMO1, an oncogenic protein, was identified as an intracellular Cu-dependent protein, which is required for in vitro ... TBK1-TANK-binding kinase 1; cGAMP-cyclic guanosine monophosphate-adenosine monophosphate; DAI-DNA-dependent activator of IRFs; ... c-di-GMP-cyclic di-GMP; c-di-AMP-cyclic di-AMP; STING-stimulator of interferon genes; IRF3-interferon (IFN) regulatory factor 3 ...
Within cluster che I are genes encoding two Par-like proteins: ParC and ParP. Both Par-like proteins are needed for wild type ... a phosphodiesterase which degrades cyclic-di-GMP and is important for biofilm dispersion and chemotaxis. Deletion of dipA ... Cluster formation of the chemotaxis histidine kinase CheA was reduced by 50% in the absence of either Par-like protein, thus ... CheA cluster formation is dependent on ParC. Due to the direct interactions and interdependence of cluster formation of ParP ...
... inhibitors improve the formation of hippocampus-dependent memories in several rodent models of cognition. However, studie ... Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD (1994) Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term ... Prickaerts J, Steinbusch HW, Smits JF, de Vente J (1997) Possible role of nitric oxide-cyclic GMP pathway in object recognition ... Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E (1998) Rolipram, a type IV-specific phosphodiesterase inhibitor, ...
These responses were significantly attenuated by RCE treatment and were associated with the activation of AMP-activated kinase ... and extracellular signal-regulated kinase 1/2 signaling pathways. In summary, we showed that RCE protected endothelial cells ... Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism. Hypertension ... Reihill, J.A.; Ewart, M.A.; Hardie, D.G.; Salt, I.P. AMP-activated protein kinase mediates VEGF-stimulated endothelial NO ...
Pagnussat, G. C., Fiol, D. F. and Salerno, G. L. (2002). A CDPK type protein kinase is involved in rice SPS light modulation. ... Pagnussat, G. C., Lanteri, M. L. and Lamattina, L. (2003). Nitric oxide and cyclic GMP are messengers in the indole acetic acid ... Lanteri, M. L., Pagnussat, G. C. and Lamattina, L. (2006). Calcium and calcium-dependent protein kinases are involved in nitric ... Nitric oxide mediates the indole acetic acid induction activation of a mitogen-activated protein kinase cascade involved in ...
Cyclic GMP is the intracellular trigger for penile erection. Cyclic GMP activates cGMP-dependent protein kinase (PKG), which in ... Some types of PDE are specific for either cyclic adenosine monophosphate (cAMP) or cGMP, and some degrade both. PDE11, for ... cGMP binds to regulatory binding sites for protein kinase G thereby activating the catalytic units that enable protein kinase G ... Categories ED, PDE-5 inhibitorTags mechanism of penile erection, PDE5 inhibitors, protein kinase, sildenafilLeave a comment on ...
Cyclic GMP-Dependent Protein Kinases 100% * Plasmodium falciparum 79% * Cyclic AMP-Dependent Protein Kinases 78% ... Phosphodiesterase type 5 inhibitors: Discovery and therapeutic utility. Rotella, D. P., 5 May 2001, In: Drugs of the Future. 26 ... Plasmodium falciparum cGMP-Dependent Protein Kinase - A Novel Chemotherapeutic Target. Rotella, D., Siekierka, J. & Bhanot, P. ... Recent results in protein kinase inhibition for tropical diseases. Rotella, D. P., 15 Nov 2012, In: Bioorganic and Medicinal ...
Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway. Mol Cell Biol 1998;18:6983-94. ... There are 2 clinical types of TD: type 1 (TD1, MIM 187600) and type 2 (TD2, MIM 187601). The characteristic bowed femurs in TD1 ... including mitogen-activated protein kinase (MAPK) cascades (Fig. 1) [10,11]. Gain-of-function variants in the FGFR3 gene lead ... TD type 1. 187600. AD. Gain-of-function. Dwarfism, lethal. Marked shortening and bowing of the long bones. ...
... and neurological deficits via STING-dependent IRE1α/ASK1/JNK signaling pathway after TBI. Thus, Cl-amidine treatment may ... to produce a second messenger called cyclic GMP-AMP (2′3′-cGAMP), which activates the adaptor protein stimulating Interferon ... and triggers the tank-binding kinase 1 (TBK1)/ I interferon regulatory factor 3 (IRF3)/ type I interferons (IFNs) signaling ... Cyclic guanosine 5′-monophosphate (GMP)-adenosine 5′-monophosphate (AMP) synthase (cGAS) is a crucial cytoplasmic DNA receptor ...
... stimulation of the sciatic nerve of the anesthetized rat in vivo led to a time-dependent translocation of protein kinase C and ... Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells. Ohsako, S., Deguchi, T. J. ... The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid ... Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle ...
phosphodiesterase 5A - Phosphodiesterases, 3,5-cyclic nucleotide (PDEs). Detailed annotation on the structure, function, ... 2000) Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric ... 1999) Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol ... 1996) Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J ...
Cyclic GMP-Dependent Protein Kinases 100% * PC12 Cells 86% * Endotoxins 75% * Nitric Oxide Synthase 73% ... Association of colony variation in Serratia marcescens with the differential expression of protease and type 1 fimbriae. ... cGMP-dependent protein kinase, and Ca2+ channels. Simard, J. M., Tewari, K., Kaul, A., Nowicki, B., Chin, L. S., Singh, S. K. ... Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae. Kaul, A. K., Kumar, ...
... which encodes cyclic GMP-dependent protein kinase 1 and is involved with understanding, memory, and circadian rhythm regulation ... cGMP-dependent, type I Mitogen-activated protein kinase 9 Fragile histidine triadSolute carrier household 25 (mitochondrial ... voltage-dependent, R type, alpha 1E subunit dCTP pyrophosphatase 1 Basigin (Ok blood group) Discs, huge (Drosophila) homolog- ... Zinc finger CCCH-type containing 3 Flap structure-specific endonuclease 1 Serine/threonine kinase 32A CTD (carboxy-terminal ...
Plasmodium falciparum calcium-dependent protein kinase 1 also target cyclic GMP-dependent protein kinase and heat shock protein ... Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes. Authors (17)* ... Suppression of NYVAC infection in HeLa cells requires RNase L but is independent of Protein Kinase R activity. Authors (7)* ... Activation of ULK kinase and autophagy by GABARAP trafficking from the centrosome is regulated by WAC and GM130. Authors (8)* ...
cGMP-dependent protein kinase activity of Cyclic GMP-dependent protein kinases (PKGs) [cytosol] ... NO-induced activation of cGMP-dependent protein kinase (PKG) increases the open probability of large conductance Ca2+-activated ... Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens) Activity cGMP-dependent protein kinase activity (GO: ...
... cyclic GMP-AMP synthase). Upon binding of dsDNA, cGAS produces a cyclic di-nucleotide molecule, cGAMP. STING (Stimulator of ... Signalling downstream of TLRs is mediated by 2 main adaptor proteins; the MyD88- and/or TRIF-dependent pathways. The ... TRAF3 also mediates the expression of type I IFNs following activation of the IFN regulatory factors (IRFs). From Balka KR, De ... We have previously identified that the proximal TLR kinase, IRAK4 has a critical scaffold function in Myddosome formation and ...
Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major ... Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Rev. Physiol. Biochem. Pharmacol ... Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major ... Abbreviations used in this paper: cGKI, cGMP-dependent protein kinases type I; EHNA, erythro-9-(2-hydroxy-3-nonyl)-adenine; ...
A specific inhibitor of cyclic GMP dependent protein kinase, Rp-8pCPT-cGMPS, partially inhibited the effect of dinitrosyl-iron- ... A model complex, dinitrosyl-iron-thiosulfate (at 1-10 μM) produced a concentration-dependent enhancement of electrical field ... DNIC can provide at least two types of nitrosative modification of proteins, forming either protein-S-nitrosothiols or protein- ... Cyclic GMP-dependent protein kinase does not play a role. The membrane permeable and metabolically stable competitive inhibitor ...
... of caveolin-enriched lipid rafts from mouse lung and western blotting showed that GC-A and cGMP-dependent protein kinase I ... the caveolae scaffold protein. In contrast, the vasodilating effect was preserved. Concomitantly, the acute hypovolaemic action ... Hence, ANP, via its guanylyl cyclase-A (GC-A) receptor and intracellular cyclic GMP as second messenger, stimulates endothelial ... Hence, ANP, via its guanylyl cyclase-A (GC-A) receptor and intracellular cyclic GMP as second messenger, stimulates endothelial ...