CXCL10, IP-10, interferon gamma-induced protein 10) using human serum, tissue homogenates, plasma and ... CXCL10 ELISA kit can detect C-X-C motif chemokine 10 ( ... CXCL10, sometimes referred to as IP-10, is a negative chemokine ... CXCL9, CXCL10 and CXCL11 are biomarkers for the development of heart failure and left ventricular dysfunction. This indicates ... CXCL10 ELISA kit is a method designed for determining in vitro quantitative concentrations of CXCL10 (C-X-C motif chemokine 10 ...

The mRNA levels of IFN-γ, as well as its inducible chemokines, CXCL9 and CXCL10, were not changed significantly. However, the ... S4 A and B). The comparable transcript levels of CXCL10, CCL2, and BCL2, as well as viral loads were observed between control ... chemokine expression, and junction proteins in the brain (Fig. 5d, S3 and S5). It is reported that neutrophil migration from ... qPCR data showed that ZIKV-infected mouse primary microglia increased the expression of several inflammatory cytokine/chemokine ...

... chemokine β8), MIG/CXCL9 (monokine induced by IFN-γ) and IP-10/CXCL10 (IFN-γ-inducible protein 10) ... chemokine β8), MIG/CXCL9 (monokine induced by IFN-γ) and IP-10/CXCL10 (IFN-γ-inducible protein 10) ... MIG/CXCL9 and IP-10/CXCL10. Of these, it seems that in infectious processes such as granulomas, the osteoclast chemotactic and ... Silva TA, Garlet GP, Fukada SY, Silva JS, Cunha FQ (2007) Chemokines in oral inflammatory diseases: apical periodontitis and ...

... performed with a chemokine panel showed enrichment in responses from individuals with high expression of CXCL9 and CXCL10 ... STAT-1 mediated signaling and additional pathways produce the chemokines CCL5 and CXCL9 (2). This recruits additional T cells ... a Complex interplay of chemokines and cytokines classify the inflammatory state of the tumor microenvironment. Interferon-g ( ... expression profiling has the potential to accurately determine the inflammatory status of a tumor by quantifying chemokines, ...

... increased transcripts for chemokine CXCL9, CXCL10 and CXCL11) and functionality (i.e., increased transcripts for IFN-γ, IL- ...

... possibly by downregulating the chemokines CXCL9 and CXCL10. ...

51. Tsutsumi E, Stricklin J, Peterson EA, Schroeder JA, Kim S. Cxcl10 Chemokine Induces Migration of ING4-Deficient Breast ... and T and NK cells can be induced to be enriched in tumors by CXCL9/10/11 [49]. Previous evidence has confirmed the vital roles ... 48. Marcuzzi E, Angioni R, Molon B, Calì B. Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization. Int J Mol ... GO enrichment revealed these DEGs were related with "chemokine-mediated signaling pathway" and "response to chemokine". ...

The ligands for CXCR3 are Mig (CXCL9), IP-10 (CXCL10), and ITAC (CXCL11). IFN-c induces these ligands. Especially, macrophages ... Chemokine receptor CXCR3 is a chemokine receptor primarily expresses on activated CD4+ and CD8+ T cells with a Th1 phenotype. ... All in all, AMG 487 is a chemokine receptor 3 CXCR3 antagonist with antimetastatic effect. Blockade of CXCR3 may play a ... in in vitro functional assays demonstrates that AMG 487 inhibits CXCR3-mediated cell migration by the three CXCR3 chemokines ( ...

CXCR3 is activated by the three IFN-γ-inducible chemokines of the CXC family: CXCL9, CXCL10, and CXCL11 (Lu et al., 1999). The ... CXCR3 is activated by the three IFN-γ-inducible chemokines of the CXC family: CXCL9, CXCL10, and CXCL11 (Lu et al., 1999). The ... extract suppressed the expression of chemokine (C-C motif) receptor 1 (CCR1), interleukin 2 receptor beta (IL2Rβ), ... extract suppressed the expression of chemokine (C-C motif) receptor 1 (CCR1), interleukin 2 receptor beta (IL2Rβ), ...

The expression of cutaneous leukocyte antigen (CLA) and CC-chemokine receptor 4 (CCR4; associated with skin-homing) as well as ... suggest that homing of T cells to the subarachnoid space could be governed by a CNS-specific adhesion molecule or chemokine ... based on their expression of adhesion molecules and chemokine receptors. We reasoned that a bias (either enrichment or ... Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. J ...

... to some extent by simply inducting expression involving chemokines CXCL9 along with CXCL10 from an individual -inflammatory ... This kind of resulted in the actual hiring regarding chemokine receptor CXCR3-expressing BRM tissue for you to attacked regions ...

CXCL9, CXCL10, CXCL11, CXCL4 and its variant CXCL4L1 are members of the CXC chemokine family, which bind to the CXCR3 receptor ... The CXC chemokines, CXCL4, -9, -10, -11, CXCL4L1, and the CC chemokine CCL21, activate CXC chemokine receptor 3 (CXCR3), a cell ... BACKGROUND: Platelet-derived chemokines are implicated in several aspects of vascular biology. However, for the chemokine ... CXC chemokines are involved in chemotaxis, regulation of cell growth, induction of apoptosis and modulation of angiostatic ...

Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity-a tale of conflict and conundrum ... chemokine (C-C motif) ligand 5 (CCL5), chemokine (C-X-C motif) ligand 10 (CXCL10), and toll like receptor 3 (TLR3). In ... Chemokines. The chemokines observed to be upregulated by WNV infection of RPE cells have roles in the recruitment of leukocyte ... Navratilova Z. Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases. Biomed Pap ...

Recent pioneering observations revealed how silenced expression of Th1/Tc1-inducing chemokines (e.g., CXCL9 and CXCL10) among ... Recent pioneering observations revealed how silenced expression of Th1/Tc1-inducing chemokines (e.g., CXCL9 and CXCL10) among ... Reciprocally, neutralizing CXCR3, the receptor for Th1/Tc1-inducing chemokines CXCL9, CXCL10, and CXCL11, before or soon after ... Reciprocally, neutralizing CXCR3, the receptor for Th1/Tc1-inducing chemokines CXCL9, CXCL10, and CXCL11, before or soon after ...

... the expression levels of the chemokine receptor CXCR3 and the migration of cells in response to CXCL9 and CXCL10 increased ... the expression levels of the chemokine receptor CXCR3 and the migration of cells in response to CXCL9 and CXCL10 increased ... the expression levels of the chemokine receptor CXCR3 and the migration of cells in response to CXCL9 and CXCL10 increased ... the expression levels of the chemokine receptor CXCR3 and the migration of cells in response to CXCL9 and CXCL10 increased ...

Résumé , Liens , BibTeX , Étiquettes: Animals, arthritis, Biological, Chemokine CXCL10, Chemokine CXCL11, Chemokine CXCL9, ... keywords = {Animals, arthritis, Biological, Chemokine CXCL10, Chemokine CXCL11, Chemokine CXCL9, CXCR3, Dumortier, Humans, I2CT ... receptor that binds and is activated by the three IFN-gamma-inducible chemokines of the CXC family named CXCL9, CXCL10, and ... receptor that binds and is activated by the three IFN-gamma-inducible chemokines of the CXC family named CXCL9, CXCL10, and ...

CXCL9 and CXCL10. The detection of cytokine/chemokine levels in peritoneal fluids was measured by cytometric bead array ... CXCL-9 and CXCL-10. In the group of women with EOC, 10 (38.5 %) had stage I/II and 16 (61.5 %) were stage III/IV . Concerning ... CXCL-9 e CXCL-10. No grupo das pacientes com CEO, 10 (38,5%) apresentavam estágios I/II e 16 (61,5%) estágios III/IV. Com ... CXCL9 e CXCL10. A detecção dos níveis de citoquinas/quimioquinas nos fluidos peritoneais foi realizada através do método ...

The need for the C-X-C theme chemokine ligands CXCL-9 and CXCL-10 in mediating adaptive anti-tumour immunity is reinforced by ... chemokines or co-stimulatory molecules into viral virulence genes, therefore fulfilling a second strategy aside from optimising ... chemokines or co-stimulatory substances into viral virulence genes, hence fulfilling another strategy from optimising tumour ... chemokines or co-stimulatory substances into viral virulence genes, therefore fulfilling another strategy apart from optimising ...

Moreover, the researchers observed a reduction in the secretion of chemokines CCL2, CCL5, and C-X-C motif chemokine 10 (CXCL10 ... CXCL9, CXCL10 in clinical triple-negative breast cancer (TNBC) specimens [87]. A supporting study demonstrated that using LSD1 ... Key chemokines direct migration of immune cells in solid tumors. Cancer Gene Ther. 2022;29(1):10-21. ... LSD1 inhibition results in CD8 T cell attracting chemokines secretion. However, an increased amount of TGFβ secretion may ...

We determined the steady-state catalytic parameters for a relevant selection of chemokines (CCL3b, CCL5, CCL11, CCL22, CXCL9, ... CXCL10, CXCL11, and CXCL12) previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV- ... Chemokines coordinate many aspects of leukocyte migration. As chemoattractants they play an important role in the innate and ... The data not only provide insight into the selectivity of the enzyme for specific chemokines, but they also contribute to the ...

... cytotoxic T cell trafficking towards tumor sites with increased chemokine expression including CCL5, CXCL9, and CXCL10, which ... in the promoter regions of these chemokine genes, leading to more CD8+ T cell recruitment and disease remission [38]. Another ... NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the ...

C-X-C motif chemokine ligand 9 (CXCL9) and CXCL10 and is correlated to lower metastasis risk and better outcome for patients[1- ... Moreover, expression of CXCL9 and CXCL10, consecutive to the IRFs activation, improved the efficiency of anti-PD-L1 protocols ... Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8(+) T- ... and DNMT1 which repressed the production and secretion of CXCL9 and CXCL10 by Th1 therefore inhibited the recruitment of CD8+ T ...

... chemokine (C-X-C motif) ligand 9 (CXCL9), CXCL10, CXCL11, C-C chemokine receptor type 7 (CCR7) and human leukocyte antigen, MHC ... Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M: The chemokine system in diverse forms of macrophage activation ... inflammatory chemokines and matrix metalloproteases in macrophages [7]. IL-10 has been implicated to play a critical ...

Innate PRR signaling also induces a spectrum of chemokine and cytokine expression (e.g., CXCL3, CXCL5, CXCL8, CXCL9, CXCL10, IL ... The increased type-1 and type-2 chemokine levels in children with acute RSV infection alter the development of adaptive immune ... The hRSV G protein also contributes to immune evasion by modifying host cytokine and chemokine responses whose expression is ... and chemokine release mediated by whole viral particles or the F protein has been shown to initiate neutrophil, CD4+ T cell and ...

CXCL10) IFN-inducible T-cell α-chemoattractant (CXCL11) monocyte induced by IFN-γ (CXCL9) epithelial-derived neutrophil- ... CXCL8 and CXCL6 bind to the chemokine receptors CXCR1 and CXCR2 whereas CXCL1 and other CXC-chemokines that have a Glu-Leu-Arg ... Table 1 CXC- C- CX3C- and CC-chemokine and receptor families As the CXC-chemokines CXCL1 and GW788388 CXCL8 have been ... enhanced tumorigenic capacity and metastasis whereas expression of ELR-negative CXC-chemokines C-chemokines and CC-chemokines ...

... and its downstream CXC chemokine ligand 9 (CXCL9) and CXCL10 mRNA expression levels were detected by real-time fluorescence ... In the 92.1, OMM2.3 and MEL290 cell lines, qPCR showed increases in STAT1, CXCL9 and CXCL10 mRNA expression after transient ... The increases of CXCL9 and CXCL10 mRNA in OMM2.3 and MEL290 cell lines were suppressed by STAT1 inhibitors. Conclusion ·RBX1 ... and the mRNA expression levels of CXCL9 and CXCL10 were detected by qPCR. Results ·TCGA database analysis showed that RBX1 was ...

In particular, the T cell chemokines CXCL9 (MIG), CXCL10 (IP-10) and CCL19 (MIP3B) were coordinately increased in the mediator- ... The levels of CXCL9/10 did not relate to the size or number of skin lesions but elevated levels of serum CXCL9/CXCL10 were ... Consistent with the role of CXCL9/CXCL10 in attracting immune cells to the site of infection, CXCR3+ CD4 T cells are reduced in ... Chemokines and cytokines are key signaling molecules that orchestrate the trafficking of immune cells, direct them to sites of ...

We determined that the up-regulated genes encoding chemokines included the CXC subfamily (Cxcl9, Cxcl10, Cxcl11 and Cxcl13) and ... C-X-C motif chemokine, interleukin, C-C motif chemokine, tumor necrosis factor (TNF) and interferon gamma (IFNγ), which are ... Cxcl3 and Cxcl10), leukocyte activation factors (Csf1 and Csf2), surface receptors (Fas), inflammatory cytokines (Il1b, Il6, ... Requirement of interleukin 17 receptor signaling for lung Cxc Chemokine and granulocyte Colony-stimulating factor expression, ...

CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions o... ... Ogawa N, Ping L, Zhenjun L, Takada Y, Sugai S. Involvement of the interferon-gamma-induced T cell-attracting chemokines, ... chemokines, and adhesion molecules. As T and B lymphocytes migrate into the gland, they themselves become activated by ...

It is necessary to mention that IL-17 can increase CXCL9, CXCL10, and CCL20 levels on tumor cells, which generally elicit their ... Most tumor cells can produce CC chemokines (β-chemokines) and CXC chemokines (α-chemokines). Glatzel et al. [54] showed using ... To date, specific chemokines in the environment and chemokine receptors on the surface of γδ T cells have not been clearly ... CXCL9 [monokine induced by gamma interferon (MIG)], CXCL10 [interferon gamma-induced protein 10 (IP-10)], CXCL11 [interferon- ...