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*  FDA approves Korlym for patients with endogenous Cushing's syndrome - Healthcanal.com : Healthcanal.com
This drug was approved for use in patients with endogenous Cushing's syndrome who have type 2 diabetes or glucose intolerance and are not candidates for surgery or who have not responded to prior surgery. Korlym should never be used (contraindicated) by pregnant women.. Prior to FDA's approval of Korlym, there were no approved medical therapies for the treatment of endogenous Cushing's syndrome.. Endogenous Cushing's syndrome is a serious, debilitating and rare multisystem disorder. It is caused by the overproduction of cortisol (a steroid hormone that increases blood sugar levels) by the adrenal glands. This syndrome most commonly affects adults between the ages of 25 and 40. About 5,000 patients will be eligible for Korlym treatment, which received an orphan drug designation by the FDA in 2007.. Korlym blocks the binding of cortisol to its receptor. It does not decrease cortisol production ...
https://www.healthcanal.com/disorders-conditions/26784-fda-approves-korlym-for-patients-with-endogenous-cushings-syndrome.html
*  FDA Approves Korlym for Patients With Endogenous Cushing's Syndrome
SILVER SPRING, Md., Feb. 17, 2012 /PRNewswire-USNewswire/ -- FDA Approves Korlym for Patients With Endogenous Cushing's Syndrome.
https://www.prnewswire.com/news-releases/fda-approves-korlym-for-patients-with-endogenous-cushings-syndrome-139542353.html
*  Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects
Objective: Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidemia, central obesity, osteoporosis and vertebral fractures. We aimed to investigate the accuracy of different SH diagnostic criteria in predicting the concomitant presence of these complications.. Patiets: In this retrospective study we evaluated data of 231 patients (120 females and 111 males) affected with adrenal incidentalomas (AI).. Methods: We studied the accuracy of different SH diagnostic criteria (cortisol after 1 mg overnight dexamethasone suppression test 1 mg-DST at different cut-off such as 50, 83, 138 nmol/l, elevated urinary free cortisol, reduced ACTH levels alone or various combination of these parameters) in predicting the concomitant presence of the following three complications: hypertension, type 2 diabetes and vertebral fractures.. Results: The criterion characterized by the presence of two out of 1 mg-DST ,83 nmol/l, elevated UFC, ...
http://www.endocrine-abstracts.org/ea/0022/ea0022p21.htm
*  Adrenal suppression and Cushing's syndrome secondary to ritonavir and budesonide. - Free Online Library
Free Online Library: Adrenal suppression and Cushing's syndrome secondary to ritonavir and budesonide.(Scientific Letters, Letter to the editor) by 'South African Medical Journal'; Health, general Budesonide Complications and side effects Dosage and administration Cushing syndrome Development and progression Risk factors HIV infection Drug therapy Prognosis HIV infections Ritonavir
https://www.thefreelibrary.com/Adrenal+suppression+and+Cushing%27s+syndrome+secondary+to+ritonavir+and+...-a0226567959
*  FDA Okays Corcept's Korlym For Cushing's Syndrome; Stock Up 57%
Shares of Corcept Therapeutics Inc. soared 57 percent in extended trade Friday, after the U.S. Food and Drug Administration approved Korlym as the first therapy to treat high blood sugar in adults suffering from a hormonal disorder called endogenous Cushing's syndrome.
http://www.rttnews.com/1823373/fda-okays-corcept-s-korlym-for-cushing-s-syndrome-stock-up-57.aspx?simrec=2&pageNum=2
*  New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome - Full Text View - ClinicalTrials.gov
Cushing Syndrome is an endocrine disorder causing an over production of the hormone cortisol. Cortisol is produced in the adrenal gland as a response to the production of ACTH in the pituitary gland.. Between 10% and 20% of patients with hypercortisolism (Cushing Syndrome) have ectopic production of the hormone ACTH. Meaning, the hormone is not being released from the normal site, the pituitary gland. In many cases the ectopic ACTH is being produced by a tumor of the lung, thymus, or pancreas. However, in approximately 50% of these patients the source of the ACTH cannot be found even with the use of extensive imaging studies such as CT scans, MRIs, and nuclear scans (111-indium pentetreotide). The ability of these tests to locate the source of the hormone production is dependent on the changes of anatomy and / or the dose and adequate uptake of the radioactive agent. The inability to detect the source of ectopic ACTH production often results ...
https://clinicaltrials.gov/ct2/show/NCT00001849?term=Cushing
*  New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome - Full Text View - ClinicalTrials.gov
Cushing Syndrome is an endocrine disorder causing an over production of the hormone cortisol. Cortisol is produced in the adrenal gland as a response to the production of ACTH in the pituitary gland.. Between 10% and 20% of patients with hypercortisolism (Cushing Syndrome) have ectopic production of the hormone ACTH. Meaning, the hormone is not being released from the normal site, the pituitary gland. In many cases the ectopic ACTH is being produced by a tumor of the lung, thymus, or pancreas. However, in approximately 50% of these patients the source of the ACTH cannot be found even with the use of extensive imaging studies such as CT scans, MRIs, and nuclear scans (111-indium pentetreotide). The ability of these tests to locate the source of the hormone production is dependent on the changes of anatomy and / or the dose and adequate uptake of the radioactive agent. The inability to detect the source of ectopic ACTH production often results ...
https://clinicaltrials.gov/ct2/show/NCT00001849?term=nichd+Cushing
*  New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome - Full Text View - ClinicalTrials.gov
Cushing Syndrome is an endocrine disorder causing an over production of the hormone cortisol. Cortisol is produced in the adrenal gland as a response to the production of ACTH in the pituitary gland.. Between 10% and 20% of patients with hypercortisolism (Cushing Syndrome) have ectopic production of the hormone ACTH. Meaning, the hormone is not being released from the normal site, the pituitary gland. In many cases the ectopic ACTH is being produced by a tumor of the lung, thymus, or pancreas. However, in approximately 50% of these patients the source of the ACTH cannot be found even with the use of extensive imaging studies such as CT scans, MRIs, and nuclear scans (111-indium pentetreotide). The ability of these tests to locate the source of the hormone production is dependent on the changes of anatomy and / or the dose and adequate uptake of the radioactive agent. The inability to detect the source of ectopic ACTH production often results ...
https://clinicaltrials.gov/ct2/show/NCT00001849?term=nuclear+heart+scan+OR+nuclear+stress+test&recr=Open&fund=01&rank=9
*  Benign Lesions of the Adrenal Glands - Symptoms & Evaluation | Weill Cornell Medicine: Department of Urology - New York
Incidental Tumor:Most adrenal tumors do not produce hormones (non-functional) and are found incidentally on CT or MR imaging and therefore do not cause symptoms. An adrenal incidentaloma is found in up to 5% of all people who are undergoing imaging studies for another medical condition. Your physician will perform a history and physical examination for symptoms and signs of excessive hormonal production, and order blood and urine tests to rule out overproduction of hormones by the incidentaloma.Adrenal Cushing's Syndrome:In adrenal Cushing's syndrome, excess cortisol is produced by adrenal gland tumors or hyperplastic adrenal glands.Symptoms of Adrenal Cushing's Syndrome:Weight gain and fat distribution mostly in the abdominal regionEasy bruising/thinning of the skinPoor wound healingRound faceWeak bones, which can lead to fracturesFatigueHigh blood pressureHigh blood sugarIrritability, anxiety, mood swings, ...
http://urology.weillcornell.org/clinical-conditions/kidney-health-%E2%80%93-non-cancerous/benign-lesions-adrenal-gland/symptoms-evaluation
*  Cushing's Syndrome | eMedMD.com
Measurement of the cortisol:creatinine ratio in the first urine specimen passed on waking obviates the need for a timed collection, and has been used by some as a sensitive screening test, particularly if cyclical Cushing's syndrome is suspected. Urine aliquots are stable at room temperature for up to 7 days, and can then be sent by post to the local endocrine laboratory.. Late night plasma/salivary cortisol. In normal subjects, plasma cortisol concentrations are at their highest first thing in the morning and reach a nadir at around midnight (up to100 nmol/litre in the morning and ,50 nmol/litre at midnight effectively excluding Cushing's syndrome). This circadian rhythm is lost in patients with Cushing's syndrome, such that in most patients the 09.00 level of plasma cortisol is normal, but nocturnal levels are raised. Random morning levels of plasma cortisol are therefore of little value in making the ...
http://emedmd.com/content/cushings-syndrome
*  Cushing's & Cancer: High prevalence of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas: a...
Cushing's (572) pituitary (403) adrenal (212) surgery (195) cortisol (169) tumor (160) ACTH (126) adenoma (108) growth hormone (91) MaryO (79) kidney cancer (79) cancer (75) weight (73) transsphenoidal (70) NIH (58) diabetes (51) adrenal insufficiency (50) acromegaly (48) Addison's (47) hypercortisolism (47) obesity (47) thyroid (43) UFC (40) hypopituitarism (39) MRI (38) gland (38) renal cell carcinoma (37) radiation (36) hormone (35) endocrine (34) adrenalectomy (33) clinical trial (33) endocrinologist (33) kidney (33) pasireotide (33) fatigue (32) Cushing's Awareness Challenge (30) steroids (30) message boards (29) podcast (29) salivary (28) Cushing's Help (27) dexamethasone suppression (27) Corlux (26) interview (26) prolactinoma (26) surgeon (25) 40 Days (24) PCOS (24) Thankfulness (24) blog (23) endoscopic (23) ketoconazole (23) Adrenal Crisis (22) hirsuitism (22) Cushie (21) Korlym (21) stretch marks (21) tumour (21) CT scan (20) Johns Hopkins (20) ...
http://cushingshelp.blogspot.com/2011/03/high-prevalence-of-subclinical.html
*  Cushing's Syndrome Treatments | CushieBlog
Medications, Surgery, and Other Treatments for Cushing's Syndrome Written by Julie M. Gentile | Reviewed by Daniel J. Toft MD, PhD Treatment for Cushing's syndrome depends on what symptoms you're experiencing as well as the cause of Cushing's syndrome. Cushing's syndrome is caused by an over-exposure to the hormone cortisol. This excessive hormone exposure can…
https://cushieblog.com/2017/01/01/cushings-syndrome-treatments/
*  Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome - Full Text...
Between 10% and 15% of patients with endogenous hypercortisolism (Cushing syndrome) have ectopic (non-pituitary) production of adrenocorticotropin hormone (ACTH) that causes cortisol excess. In approximately 50% of these patients, the tumoral source of ACTH cannot be found initially despite very detailed and extensive imaging, including studies such as computed tomography, magnetic resonance imaging, and octreotide scan (Octreoscan) using the standard dose of indium-111 pentetreotide ([(111)In-DTPA-D-Phe]-pentetreotide). The sensitivity and specificity of structurally based imaging studies depends on anatomic alterations and the size of the tumor. In contrast, positron emission tomography (PET) and somatostatin ligand (like octreotide) imaging detect pathologic tissue based on physiologic and biochemical processes within the abnormal tissue. This protocol tests the ability of [(18)F]-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) PET, Octreoscan and another somatostatin imaging ...
https://clinicaltrials.gov/ct2/show/NCT02019706?recr=Open&cond=%22Adrenal+Gland+Diseases%22&rank=7
*  Long Term Post Operative Follow-Up of Cushing Syndrome - Full Text View - ClinicalTrials.gov
INCLUSION CRITERIA:. Patients with Cushing syndrome documented at the NIH will be recruited into this protocol prior to surgery intended to cure Cushing syndrome selectively. Thus, patients undergoing transsphenoidal exploration for resection of an adenoma, or unilateral adrenalectomy for an adenoma, or resection of a tumor producing ACTH ectopically will be candidates for this study. We will also recruit as many of the 500 patients treated since 1983 as possible, so as to have a group of 'late follow-up' patients. These individuals will participate primarily by questionnaire.. Hematocrit about 30%. A CBC will be obtained prior to entering the study. Patients with hematocrit above 30% will be accepted into the study; iron replacement will be given to those patients with low TIBC.. Ages 18 - 85. Children less than 18 are being studied under other protocols and the questionnaire has not been validated for younger individuals.. For the ...
https://clinicaltrials.gov/ct2/show/NCT00029952?cond=%22Cushing+disease%22+OR+%22Hypercortisolism%22+OR+%22Cushing+Syndrome%22&rank=4
*  Genetics of Cushing's Syndrome - Yaneva M.
en] Cushing's syndrome (CS) is characterized by pathologically elevated free glucocorticoid levels. Endogenous hypercortisolism is usually due to ACTH-secreting pituitary corticotropic adenomas and less often due to ectopic ACTH-secreting neuroendocrine neoplasms or ACTH-independent adrenal cortisol hypersecretion. CS is a serious chronic disease leading to a several-fold increase in cardiovascular morbidity and mortality. Multiple genetic alterations have been described in the setting of sporadic corticotropinoma formation. Changes in the expression profiles have been demonstrated in growth factors and their receptors, cell-cycle regulators and in various genes related to hormonal gene transcription, synthesis and secretion. Sporadic adrenal adenomas and carcinomas may demonstrate dysfunction in genes such as TP53 among others. Cushing's disease can be an inherited condition also. Multiple endocrine neoplasia type 1 (MEN1) and familial isolated pituitary ...
http://orbi.ulg.ac.be/handle/2268/73832
*  Korlym New FDA Drug Approval | CenterWatch
Korlym (mifepristone): For the control of hyperglycemia in adults with endogenous Cushing's syndrome. New approved drug details including side effects, uses and general information.
http://www.centerwatch.com/drug-information/fda-approved-drugs/drug/1188/
*  Welcome! / Cushings-Help.com Support for Cushing's Syndrome and Cushing's Disease
Welcome to Cushings Help. This site provides information, support, RSS feeds, news, and education for people with Cushing's or other endocrine problems, their friends and families. Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of cortisol. This website also deals with Thyroid Disorders, Addison's Disease, Adrenal Disorders, Cushing's Syndrome, Pituitary Disorders, Pituitary disease, Growth Hormone, Pheochromacytomas, Fibromyalgia, Chronic Fatigue Syndrome, Hormone and Gland Disorders, Conn's Disease, Hyperaldosteronism, High Blood Pressure, Hypertension, Diabetes, Sheehan's Syndrome, Men1, Acromegaly, Nelson's Syndrome, PCOS, Arthritis, Bipolar Disorder, Headaches, Autoimmune Diseases, PTU, Cortisol, ACTH, and Thyroid Antibodies
http://www.cushings-support.com
*  Cushing's Syndrome Made Easy on Meducation
This video explains Cushing's syndrome and how to differentiate between different types of Cushing's syndrome and also how to treat Cushing's syndrome ...
https://meducation.net/resources/33400-Cushing-s-Syndrome-Made-Easy
*  Cushing's Syndrome or hypercortisolism: pain relief, Cushing's syndrome diet, medicines for, insurance coverage, common...
Cushing's Syndrome also called hypercortisolism: symptoms, cause, treatment, long-term outlook, complications, prevention, risks
http://mamashealth.com/syndrome/cushing.asp
*  Negative magnetic resonance imaging in Cushing's disease
Introduction: Cushing s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.. Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free cortisol level was elevated. Differential diagnostic testing was showed ACTH-dependent lesion (ACTH=17.4/95.6 ng/l), of the pituitary origin: suppression of cortisol level to 83% of baseline in 2 days 8 mg dexamethasone suppression test and a rise in the cortisol value of 23% above basal level along with a rise in ACTH value of 85% above basal level in CRH stimulation test. Pituitary abnormalities were not observed during repeated MRI scanning. Inferior petrosal sinus (PS) sampling was performed: i) baseline ratio ACTH ...
http://www.endocrine-abstracts.org/ea/0022/ea0022p555.htm
*  cushing's syndrome Archives - NurseStudy.Net
Cushing's Syndrome Endrocrineinfo.com Cushing syndrome occurs when your body is exposed to elevated degrees of the hormone cortisol for quite a long time. The most usual cause of Cushing syndrome, occasionally called hypercortisolism, is the use of oral corticosteroid medication. The status may also happen when your body makes an excessive amount of cortisol. Too much cortisol can produce a […]. » Read more ...
http://nursestudy.net/tag/cushings-syndrome/
*  PPT - Diagnosis of Cushing's Syndrome PowerPoint Presentation - ID:804971
Diagnosis of Cushing's Syndrome. William Harper, MD, FRCPC Endocrinology & Metabolism Assistant Professor of Medicine McMaster University. Nomenclature. Cushing's Syndrome Hypercortisolism of any cause Cushing's Disease Corticotropin (ACTH) secreting pituitary adenoma....
https://www.slideserve.com/fareeda/diagnosis-of-cushing-s-syndrome
*  Cushing - Symptoms, Treatments and Resources for Cushing
Cushing - MedHelp's Cushing Center for Information, Symptoms, Resources, Treatments and Tools for Cushing. Find Cushing information, treatments for Cushing and Cushing symptoms.
http://www.medhelp.org/tags/show/34609/Cushing
*  Study of Cushing's Syndrome Not Related to ACTH Production - Full Text View - ClinicalTrials.gov
This study is designed to provide information about the cause of two unusual types of Cushing's syndrome and to evaluate quality of life before and after cure of the disease. In Cushing's syndrome, the adrenal glands produce too much of the hormone cortisol. This often causes weight gain, skin changes (bruising and stretch marks), and mood changes such as irritability, easy crying and depression. Adrenocorticotrophic hormone (ACTH) normally regulates cortisol production; when cortisol is low, ACTH rises, stimulating the adrenals to produce more cortisol, and when cortisol is high, ACTH levels fall. In two forms of Cushing's syndrome, however, the adrenal glands produce cortisol even when ACTH is low.. Patients 18 years of age and older with Cushing's syndrome not related to ACTH production may participate in this study. Candidates will be have a history and physical ...
https://clinicaltrials.gov/ct2/show/NCT00006278?term=nichd+Cushing