Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes. Lewno, M. T., Cui, T. & Wang, X., Jun 28 2021, In: ... CRISPR-Associated Protein 9 95% * Genes 77% * Clustered Regularly Interspaced Short Palindromic Repeats 70% ...
Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity. Ohsawa, K., Imai, Y., ... Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila development. ... Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis. Broihier, H. T., Kuzin, A., Zhu, ... Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase. Wirschell, M. ...
Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference. Estelle, A. B., George, A., Barbar ...
DrugE3CRLs: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant). Ciulli, A. ... The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of ... Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System. Cell Chemical Biology. ... Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System. In: Cell Chemical ...
... the protein CD4, which adorns the surface of helper T cells, and the protein CD8, found on killer T cells. The findings, ... Schwartz and Cullen set Littman on an ambitious project to unravel the interaction, and he tore into it with the enthusiasm of ... For the Harvard team, the target of the tool is a gene called CCR5, which encodes a protein that adorns the surface of the ... "I had the naive idea that by putting the viral antigen and MHC protein in lipid vesicles and monitoring whether the vesicles ...
Targeting NEU protein in melanoma cells with non-thermal atmospheric pressure plasma and gold nanoparticles. Choi, B. B., Kim, ... The Multivalent Polyampholyte Domain of Nst1, a P-Body-Associated Saccharomyces cerevisiae Protein, Provides a Platform for ...
Cullin protein, neddylation domain; Cullin, N-terminal.... 0.02. OrthoFinder. Transcript_contig_54372. 54372. Cullin protein, ... Description : Cullin protein, neddylation domain; Cullin, N-terminal [Interproscan].. Gene families : OG_01_0000229 ( ... neddylation domain; Cullin, N-terminal.... 0.05. OrthoFinder. Transcript_contig_54536. 54536. Cullin protein, neddylation ... modification-dependent protein catabolic process. None. Extended. MF. GO:0031625. ubiquitin protein ligase binding. IEA. ...
... by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. ... Stat3 mRNA and stat3 morpholino suggest that Ambra1b could indirectly regulate this protein through CUL4-DDB1 interaction. ... AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, ... The cullin protein family. Genome Biol. 2011. https://doi.org/10.1186/gb-2011-12-4-220. ...
Other Desigationscullin-3. *Gene Typeprotein-coding. *NCBI Gene ID100483591 ...
Cullin-3 [Source:UniProtKB/TrEMBL;Acc:G4N0J9]. 0.03. OF. POW16012. No alias. Cullin, N-terminal;Cullin protein, neddylation ... Cullin protein, neddylation domain. 0.02. OF. EED54600. No alias. SCF ubiquitin ligase complex subunit CulA, putative. 0.03. OF ... modification-dependent protein catabolic process. None. Extended. MF. GO:0031625. ubiquitin protein ligase binding. IEA. ... ubiquitin-like protein ligase binding. None. Extended. BP. GO:0051603. proteolysis involved in cellular protein catabolic ...
Kelch-like protein 3. A. 277. Homo sapiens. Mutation(s): 3 Gene Names: KLHL3, KIAA1129. ... Cullin-3. B. 386. Homo sapiens. Mutation(s): 3 Gene Names: CUL3, KIAA0617. ...
... a wiki resource centered on human protein-protein interactions ... G protein pathway suppressor 1. cullin 2. Image. GO Annotations ...
AMP-activated protein kinase; ANXA5: annexin A5; CP: cytogenetic response; CML: chronic myeloid leukemia; CUL3: cullin 3; GAPDH ... Kelch-like protein 20; LRMP: lymphoid-restricted membrane protein; MAP1LC3/LC3: microtubule associated protein 1 light chain 3 ... GCA (grancalcin) is usually a cytosolic protein that is translocated to the granule membrane upon neutrophil activation [26,27 ... It belongs to a group of EF-hand Ca2+?binding proteins including CAPN (calpain), ALG2, and SRI (sorcin), which show structural ...
... a wiki resource centered on human protein-protein interactions ... G protein pathway suppressor 1. cullin 4A. Image. GO ...
cullin-RING ubiquitin ligase complex. GO:0000307 cyclin-dependent protein kinase holoenzyme complex. ... BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like homodimer (mouse). ... Protein Ontology Hierarchy. (Note that the implicit relationship is is_a, whereas indicates derives_from relationship.). ...
cullin-RING ubiquitin ligase complex. GO:0000307 cyclin-dependent protein kinase holoenzyme complex. ... BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like homodimer (mouse). ... Protein Ontology Hierarchy. (Note that the implicit relationship is is_a, whereas indicates derives_from relationship.). ...
Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAPK [mitogen- ... activated protein kinases] and JNKs [c-Jun N-terminal kinases]) and promotes fibrosis in various tissues. Here, we determined ... Meijles DN., Cull JJ., Markou T., Cooper STE., Haines ZHR., Fuller SJ., OGara P., Sheppard MN., Harding SE., Sugden PH., Clerk ... Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) ...
Cullen M, He J, Burdette L, Yeager M, Chanock SJ, Parry DM, Goldstein AM, Yang XR. Characterization of T gene sequence variants ... Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol. 2010 Jun 28; 189 ... "Fetal Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Fetal Proteins" by people in this website by year, and whether ...
Given our previous work showing that protein scavenging by tumor cells can be utilized as a nutrient delivery mechanism, we set ... Madeleine M. LaRue, Jane Cullis, Dafna Bar-Sagi; Abstract PR22: Collagen scavenging alters macrophage phenotype in pancreatic ... Citation Format: Madeleine M. LaRue, Jane Cullis, Dafna Bar-Sagi. Collagen scavenging alters macrophage phenotype in pancreatic ... the functional modulation of tumor-associated macrophages through the coupling of extracellular matrix remodeling to protein ...
Recombinant Human CUL4A/RBX1/DDB1/CRBN Complex Protein, CF (E3-650) is manufactured by R&D Systems. Reproducible results in ... Cullin-4A/RING Box Protein 1/Damage Specific DNA Binding Protein 1/Cereblon Complex ... Cullin-4A (CUL4A) is a core component of multiple cullin-RING type Ubiquitin ligase complexes that mediate the ubiquitination ... Custom Protein Services Custom Simple Plex Services Custom Targeted Protein Degradation Services ...
It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations ... a web resource for human protein-protein interactions. ... protein kinase, cAMP-dependent, catalytic, alpha. cullin 5. ... Protein-Protein Interactions. 181 interactors: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 ADRBK1 AKAP13 AKAP14 AKAP8L AKIP1 ANXA7 APC ... Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway. *Negative Regulation Of ...
CUL3 E3 complicated and a proteomic analysis through the Deshaies group indicated that UBA-UBX protein are from the p97-cullin ... 5a), and improved proteins amounts and nuclear translocation of NRF2, as proven by immunofluorescence assay (Fig. 5b). Since ... Reduced degrees of the p97 cofactors UFD1 and NPL4 as well as the UBA-UBX proteins UBXN7 result in increased appearance of NRF2 ... Knockdown of UBXN7 (a UBA-UBX proteins) resulted in raises of NRF2, GCLM, and HO-1 by both immunoblot evaluation (Fig. 5a) and ...
Post-Translational Protein Modification Chemical Compounds 100% * Cullin Proteins Medicine & Life Sciences 94% ... keywords = "Cullin-RING E3 ligase, Macrophages, MLN4924, Neddylation, Proliferation and survival",. author = "Lihui Li and ... The well-identified targets of neddylation are cullins, which serve as essential components of Cullin-RING E3 ligases (CRL). It ... The well-identified targets of neddylation are cullins, which serve as essential components of Cullin-RING E3 ligases (CRL). It ...
cullin family protein binding(GO:0097602). Gene overrepresentation in curated gene sets: canonical pathways category:. Log- ... guanine nucleotide binding protein (G protein), alpha 11a (Gq class) chr20_-_46362606 Show fit 0.42. ENSDART00000153087 bmf2 ... mitogen-activated protein kinase associated protein 1 chr23_-_24483311 Show fit 0.43. ENSDART00000185793 ENSDART00000109248 ... positive regulation of protein ubiquitination(GO:0031398). 0.0. 0.7. GO:0007193. adenylate cyclase-inhibiting G-protein coupled ...
... and cullin 4A (CUL4A) in its NEDD8-modified form is essential for repressive chromatin formation. We found that DNMT3b ... NEDD8 is a ubiquitin-like protein modifier that is conjugated to target proteins, such as cullins, to regulate their activity, ... NEDD8 is a ubiquitin-like protein modifier that is conjugated to target proteins, such as cullins, to regulate their activity, ... NEDD8 is a ubiquitin-like protein modifier that is conjugated to target proteins, such as cullins, to regulate their activity, ...
Cullin Proteins Medicine & Life Sciences 26% * Ubiquitin-Protein Ligases Medicine & Life Sciences 20% ... N2 - Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of ... AB - Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of ... Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of ...
... and cullin 4A (CUL4A) in its NEDD8-modified form is essential for repressive chromatin formation. We found that DNMT3b ... NEDD8 is a ubiquitin-like protein modifier that is conjugated to target proteins, such as cullins, to regulate their activity, ... NEDD8 is a ubiquitin-like protein modifier that is conjugated to target proteins, such as cullins, to regulate their activity, ... NEDD8 is a ubiquitin-like protein modifier that is conjugated to target proteins, such as cullins, to regulate their activity, ...
... was studied both biochemically and immunochemically to determine the nature of its core protein ... A J Sant, S E Cullen, K S Giacoletto, B D Schwartz; Invariant chain is the core protein of the Ia-associated chondroitin ... indicating that the core protein and invariant chain were structurally similar. The purified CSPG and its core protein were ... Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan. A J Sant, A J Sant ...
Thomas Cullen says: at 2:39 am. thank you for this. That mix you made seems like it would be amazing. Going to the store now to ... everything has protein. protein is just chains of aminos. a banana has around 1-1.5g protein, etc. the protein you take ... kidney beans only have 8g of protein/100g red lentils and chickpeas only 6g of protein/100g which is very little protein. nuts ... you do not need beans to have protein. peas, hemp hearts, spirulina, etc. are all very high in protein. ...
The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), ... The SMAD proteins are a family of transcription factors consisting of 8 members, SMAD1-8, which are further subdivided into 3 ... This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin- ... Figure 1. Cells have a protein on their surface called PD-1 (in orange above). When PD-1 binds to PD-L1 (yellow) on another ...