Unanue performed important work on MHC class II antigen processing and clarified the role of antigen-presenting cells in ... She also pioneered the use of immune checkpoint therapy, such as anti-CTLA-4 therapy, prior to surgery in order to evaluate the ... providing the first evidence of the H-2 complex and later reporting that antigen II is a major histocompatibility antigen. ... He was the first to show that adoptive transfer of T cells could cure cancer in mice, and that human antigen-specific T cell ...
... and a class I antigen derived from the human cytomegalovirus (HCMV). pp65 protein. MT-8421, its ETB targeting CTLA-4, along ...
Inhibition of CTLA-4 signaling can also reduce T-regulatory cell function, which may contribute to a general increase in T-cell ... Yervoy is a recombinant, human monoclonal antibody that binds to the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4). CTLA ... Yervoy binds to CTLA-4 and blocks the interaction of CTLA-4 with its ligands, CD80/CD86. Blockade of CTLA-4 has been shown to ... PD-1 and CTLA-4) to help destroy tumor cells: Yervoy helps activate and proliferate T cells, while Opdivo helps existing T ...
5. Patients who are human leukocyte antigen (HLA)-A2 positive.. 6. Patients with an Eastern Cooperative Oncology Group (ECOG) ... 2. Patients with prior treatment with compounds targeting PD-1, PD-L1, CTLA-4, or similar compounds where general resistance ... E.4. Principal exclusion criteria. 1. Patients treated with dexamethasone , 2 mg/day or equivalent (i.e. 13 mg/day of ... D.3.11.4. Combination product that includes a device, but does not involve an Advanced Therapy. No ...
Inhibition of CTLA-4 signaling can also reduce T-regulatory cell function, which may contribute to a general increase in T-cell ... Yervoy is a recombinant, human monoclonal antibody that binds to the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4). CTLA ... Yervoy binds to CTLA-4 and blocks the interaction of CTLA-4 with its ligands, CD80/CD86. Blockade of CTLA-4 has been shown to ... These complications may occur despite intervening therapy between PD-1 or CTLA-4 receptor blockade and allogeneic HSCT. ...
Checkpoint signaling pathways, such as cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), ... anti-CTLA-4), have dramatically changed the treatment of advanced cancers over the past decade. ICIs block T cell inhibition, ... December 4, 2020. Immune checkpoint inhibitors effectively treat malignancy in ways that were not possible just a few years ago ...
Common checkpoints that these inhibitors affect are the PD-1/PD-L1 and CTLA-4 pathways. Small molecules, such as cytokines, ... Monoclonal antibodies are large molecules which bind to specific antigens on the surface of cancer cells, marking them for ... 22,4(2022):12. Opinions expressed are solely those of the author. This article is for general information, education and ... In the US, the cost of oncology medicines increased over a five-year period by 73%4, and this was primarily driven by targeted ...
... anti CTLA-4), anti- programmed cell death 1 (anti-PD-1), anti- programmed cell death ligand 1 (anti-PD-L1), and anti-programmed ... other anti cytotoxic T-lymphocyte-associated antigen 4 ( ... of the bone marrow or with a wide field of radiation within 4 ... weeks; major surgery within 4 weeks; *- Current or prior use of immunosuppressive medication within 14 days before the first ...
CTLA-4) antibody ipilimumab versus sunitinib showed a statistically significant OS prolongation, significantly improved ORR and ... comparing the anti-PD-1 inhibitor nivolumab in combination with the anti-cytotoxic T-lymphocyte antigen-4 ( ... CTLA-4, dendritic cell vaccines, anti VEGF), which are subjects of effective clinical investigations. ... Seventeen of the remaining 23 patients died from various reasons (4 from cardiac decompensation, 3 from pneumonia and cardiac ...
B cells between the MZ and the B-cell follicle enables them to efficiently capture and deliver blood-borne antigens and antigen ... CTLA-4), and the anti-programmed-death 1 Mouse monoclonal to MYST1 (anti-PD1) antibodies nivolumab and pembrolizumab, have ... B cells between the MZ and the B-cell follicle enables them to efficiently capture and deliver blood-borne antigens and antigen ... B cells between the MZ and the B-cell follicle enables them to efficiently capture and deliver blood-borne antigens and antigen ...
CD152/CTLA-4 CD23 CD28 CD30 CD40 CD40 Ligand CD40L CD44 Club Cell Protein Cluster of Differentiation 14 Clusterin Connective ... Rat - Competitive ELISA, Immobilized antigen - Immunoassays. Product filter molecule 1,25OH2 Vitamin D 17α-Hydroxyprogesterone ... Competitive ELISA, Immobilized antigen type Competitive ELISA Competitive ELISA, Immobilized antibody Competitive ELISA, ... Antigen SARS-CoV-2 Anti-IgA IgG Anti-Muellerian hormone Anti-SARS-CoV-2 Apo B-48 APO-1/Fas Apolipoprotein A Apolipoprotein A2 ...
CTLA-4 Antigen; Immunotherapy; Adoptive; radioactive tracers; radionuclide imaging; CD8-Positive T-Lymphocytes ...
Through hereditary removal of one on one Big t cell priming by IECs, all of us found out that IEC-derived antigens ended up ... CTLA-4) one nucleotide polymorphism in contributors using. Posted on December 11, 2023. by admin ... Nonetheless, cross-presentation regarding IEC-derived antigen in order to CD8+ Big t cellular material simply in part depended ... Right here, we applied a hereditary program to demonstrate which simultaneous antigen expression along with inflammasome ...
深入研究「CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease」主題。共同形成了獨特的指紋。 ... CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease. ...
Dive into the research topics of Sustained complete response to CTLA-4 blockade in a patient with metastatic, castration- ... Sustained complete response to CTLA-4 blockade in a patient with metastatic, castration-resistant prostate cancer. ...
A biomimetic five-module chimeric antigen receptor (CAR) designed to target and eliminate antigen-specific T cells., Proc Natl ... Chambers, C. A., M. S. Kuhns, J. G. Egen, and J. P. Allison, CTLA-4-mediated inhibition in regulation of T cell responses: ... γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response., ... Egen, J. G., M. S. Kuhns, and J. P. Allison, CTLA-4: new insights into its biological function and use in tumor immunotherapy ...
Low expression and secretion of circulating soluble CTLA-4 in peripheral blood mononuclear cells and sera from type 1 diabetic ... Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and ... Esguerra, J., Bolmeson, C., Cilio, C. & Eliasson, L., 2011, In: PLoS ONE. 6, 4, e18613.. Research output: Contribution to ... 4, p. 250-260. Research output: Contribution to journal › Article › peer-review ...
Cytotoxic T-lymphocyte antigen 4 polymorphisms and breast cancer susceptibility: Evidence from a meta-analysis. Chang, H. Y., ... Fan, Y-C., Lin, S-F., Chou, C-C. & Bai, C-H., 2023, 於: International journal of environmental research and public health. 20, 4 ... In silico analysis to identify miR-1271-5p/PLCB4 (phospholipase C Beta 4) axis mediated oxaliplatin resistance in metastatic ... 4, p. 194-204 11 p.. 研究成果: 雜誌貢獻 › 文章 › 同行評審 ...
Dive into the research topics where Tanner Johanns is active. These topic labels come from the works of this person. Together they form a unique fingerprint ...
MINT Study II Group, 2020 8月, In: Tohoku Journal of Experimental Medicine. 251, 4, p. 287-294 8 p.. 研究成果: Article › 査読 ... for the MINT Study Group, 2022 4月, In: Cancer science. 113, 4, p. 1428-1434 7 p.. 研究成果: Article › 査読 ... 877-880 4 p.. 研究成果: Article › 査読 ... Chimeric Antigen Receptors 91% * Antigen 56% * T-Lymphocytes 41 ... 4, 350.. 研究成果: Article ›
Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies. Springuel, L., Lonez ... Sledge, G. W. & Roth, B. J., Jan 1 1989, In: Seminars in Oncology. 16, 4 SUPPL. 6, p. 110-115 6 p.. Research output: ... Foyil, K. V. & Bartlett, N. L., Apr 1 2011, In: Immunotherapy. 3, 4, p. 475-485 11 p.. Research output: Contribution to journal ... Morgensztern, D. & Govindan, R., Apr 2006, In: Expert Review of Anticancer Therapy. 6, 4, p. 545-551 7 p.. Research output: ...
In particular, antigen loss variant-tumor cells can be eliminated as bystanders as a secondary effect of destruction of the ... Antoni Ribas presented data demonstrating that ipilimumab, a CTLA-4-specific blocking antibody, induces a dense infiltrate of ... The context in which antigen presenting cells were exposed to GM-CSF at the site of immune priming greatly influenced the ... Hans Schreiber discussed the role of stromal cells in cross-presenting tumor antigens as a means of protecting from cancer ...
CTLA-4 is a co-inhibitory molecule mitigating T cell activation. In general, CTLA-4 inhibits T cell activation by three ... fusion protein consists of the extracellular and transmembrane domains of co-inhibitory molecule cytotoxic T-lymphocyte antigen ... Idelalisib as a single agent, or in combination with a CTLA-4 blocker, could also be effective in CTLA4-CD28 fusion gene- ... This suggests that the fusion protein can bind ligands with the affinity of CTLA-4 while mediating the T cell activating ...
... inhibition of antigen-presenting cell maturation by expressing cell surface suppressor receptors, such as CTLA-4, PD-1, TIGIT, ... 5 Inhibition of antigen-presenting cell maturation by selectively expressing cell surface suppressor receptors, such as CTLA-4 ... In the TME, self-antigens released by dying cancer cells induce the conversion of naïve Tregs to eTregs via TCR stimulation [42 ... Bullock W, Katz D, Benacerraf B. Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell ...
The increase in CTLA-4 expressing CD8+ T-cells was significantly higher after in vitro induction in older persons, while the ... Flow cytometry was used to quantitate the expression of PD-1, ICOS, CTLA-4 and Tim-3 in human T-cells from geriatric and ... In CD4+ T-cells, a greater increase in CTLA-4 expressing cells in older persons was the only difference between the age groups ... CTLA-4) plays a role in inhibitory regulation of T-cell activity, and T cell immunoglobulin and mucin protein 3 (Tim-3) has ...
We have studied the single nucleotide polymorphism at position +49 (A/G) of the CTLA-4 gene, in a cohort of 421 RA cases and ... We conclude that, although the importance of the B7-CTLA-4 interaction in the development of RA can not be excluded, the CTLA-4 ... Its role in the aetiology of rheumatoid arthritis (RA) however, remains unclear, as the functional studies of the B7-CTLA-4 ... with several autoimmune disorders showing association or linkage with the CTLA-4 locus. ...
CTLA-4. Cytotoxic T lymphocyte antigen 4. PD-1. Programmed death 1. PD-L1. Programmed death ligand 1. TIM-3. T-cell ... Cytotoxic T lymphocyte antigen 4. PD-1. Programmed death 1. PD-L1. Programmed death ligand 1. TIM-3. T-cell immunoglobulin ... Fragment antigen binding. Fc. Fragment crystallisable. FcγR. Fc gamma receptor. ADCC. Antibody dependent cellular cytotoxicity ... Fragment antigen binding. Fc. Fragment crystallisable. FcγR. Fc gamma receptor. ADCC. Antibody dependent cellular cytotoxicity ...
Immune checkpoint inhibitors (ICIs) that target cytotoxic T lymphocyte antigen 4 (CTLA-4) or the programmed cell death (ligand ... Monotherapy indicated monotherapy of CTLA-4, PD-1 or PD-L1 antibody; combination therapy indicated combination therapy of ... Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371(23):2189-99. ... Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science. 2015;350(6257):207-11. ...
Biomolecule/Target: N/ASynonyms: T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter- ... Biomolecule/Target: N/ASynonyms: T-lymphocyte activation antigen CD80; B7-1; Activation B7-1 antigen; BB1; CTLA-4 counter- ... Biomolecule/Target: N/ASynonyms: Soluble IL-2 receptor; TAC-antigen; CD25 antigen; CD25; Interleukin-2 receptor subunit ... Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to... ...