Loading...
*  CpG Islands | SpringerLink
... volume examines bioinformatic and molecular biological methods useful to identify and to explore the functions of CpG islands, ... Prediction of CpG Islands as an Intrinsic Clustering Property Found in Many Eukaryotic DNA Sequences and Its Relation to DNA ... Authoritative and practical, CpG Islands: Methods and Protocols aims to provide readers with the information and methodologies ... Methods for the Measurement of DNA Methylation at CpG Islands. * Front Matter Pages 81-81 ...
https://link.springer.com/book/10.1007/978-1-4939-7768-0
*  CpG island hypermethylation - Wikipedia
... called CpG island methylator prototype, or CIMP. Higher levels of CpG island hypermethylation are found in CIMP. The frequent ... the CpG island is hypomethylated, and the rest of the genome is methylated. It is evident that the hypomethylation of the CpG ... A CpG island is a Cytosine and Guanine linked by a phosphate in a repeated sequence. These are genetic hotspots as they are ... Hypermethylated CpG islands also act as biomarkers, as they can help distinguish cancer from normal cells in the same sample. ...
https://en.wikipedia.org/wiki/CpG_island_hypermethylation
*  CpG Islands and DNA Methylation
Methylated CpG dinucleotides at position 5 of cytosine are associated with transcriptional repression and an inactive chromatin ... Figure 3. Chromatin structure of CpG islands. The distribution of methylated and nonmethylated CpG dinucleotides is shown at ... 2010) CpG islands influence chromatin structure via the CpG‐binding protein Cfp1. Nature 464: 1082-1086. ... genes are associated with CpG islands, as is clearly shown by the high density of CpG dinucleotides around their 5′ ends. In ...
http://www.els.net/WileyCDA/ElsArticle/refId-a0005027.html
*  Comparative Analysis of CpG Islands in Four Fish Genomes
CpG islands are usually unmethylated in a genome, especially in the promoter regions [2], in contrast, ~80% of CpG ... There has been much interest in CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, because they are ... F. Antequera and A. P. Bird, "Number of CpG islands and genes in human and mouse," Proceedings of the National Academy of ... CpG islands in this table were identified by Takai and Jones' algorithm [7]. The number of genes in each fish genome was based ...
https://www.hindawi.com/journals/ijg/2008/565631/
*  7.2 Hypermethylation of CpG islands in cancer - Week 7 - Cancer Epigenetics | Coursera
this methylation at CpG islands that's found in cancer.. So this is, tends to be called CpG island hypermethylation, or CGI ... CPG island, so you don't see methylation in general at CPG islands. ... 7.2 Hypermethylation of CpG islands in cancer. To view this video please enable JavaScript, and consider upgrading to a web ... CpG island spread throughout the genome in general are hypomethylated.. And so what's unusual to find is one that's ...
https://www.coursera.org/learn/epigenetics/lecture/AnWDn/7-2-hypermethylation-of-cpg-islands-in-cancer
*  British Library EThOS: Contribution of CpG islands to ubiquitous gene expression
The effect of CpG islands on transgene expression was first tested in cultured cells. In transient transfection it was ... Transgenic mice were used to study the effect of CpG islands on the level and pattern of transgene expression in vivo. ... Even when integrated into the genome of cultured cells, CpG islands are not able to confer position-independent, copy number- ... However, the results from bulk analysis of primary clones suggest that CpG islands improve the level of expression in cultured ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654021
*  Functional Relevance of CpG Island Length for Regulation of Gene Expression | Genetics
Functional Relevance of CpG Island Length for Regulation of Gene Expression Message Subject (Your Name) has forwarded a page to ... Functional Relevance of CpG Island Length for Regulation of Gene Expression. Navin Elango and Soojin V. Yi ... Functional Relevance of CpG Island Length for Regulation of Gene Expression. Navin Elango and Soojin V. Yi ... Functional Relevance of CpG Island Length for Regulation of Gene Expression. Navin Elango and Soojin V. Yi ...
http://www.genetics.org/content/187/4/1077.supplemental
*  Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer | Cancer Research
2) ⇓ . The CpG island at MGMT was methylated in a single case of the primary prostate cancers (1%; Fig. 2C ⇓ ). CpG islands at ... In this study, by using a Kaplan-Meier analysis, we found that of all of the CpG islands tested, only PTGS2 CpG island ... A, NIM at 16 CpG islands for normal prostate tissues taken from 13 transplant tissue donors. B, NIM at 16 CpG islands for tumor ... For instance, hypermethylation at the GSTP1 CpG island in combination with hypermethylation at the MDR1 CpG island yields a ...
http://cancerres.aacrjournals.org/content/64/6/1975
*  Abstract 5004: CpG island methylator phenotype in bladder cancer | Cancer Research
Abstract 5004: CpG island methylator phenotype in bladder cancer. Woonbok Chung, Jolanta Bondaruk, Nianxiang Zhang, Jaroslav ... Abstract 5004: CpG island methylator phenotype in bladder cancer. Woonbok Chung, Jolanta Bondaruk, Nianxiang Zhang, Jaroslav ... Abstract 5004: CpG island methylator phenotype in bladder cancer. Woonbok Chung, Jolanta Bondaruk, Nianxiang Zhang, Jaroslav ... Abstract 5004: CpG island methylator phenotype in bladder cancer Message Subject (Your Name) has forwarded a page to you from ...
http://cancerres.aacrjournals.org/content/72/8_Supplement/5004
*  CpG Islands Undermethylation in Human Genomic Regions under Selective Pressure
CpG island coordinates CGIs genomic coordinates were obtained from the UCSC GB CpgIslandExt track. In this track CpG islands ... To estimate the methylation of each CpG island we calculated the mean of all CpGs methylation values into a CpG island. We were ... Additionally, by analyzing SNP frequency in CpG islands, we demonstrated that CpG islands in regions under selective pressure ... Additionally, by analyzing SNP frequency in CpG islands, we demonstrated that CpG islands in regions under selective pressure ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3149076/?lang=en-ca
*  Can these CpG islands be representative? - DNA Methylation, Histone and Chromatin Study
I use CpG Island Explorer to predicate CpG islands,but in one gene I did not get CpG island in the promoter region adjacent to ... I only get one CpG island about 4kb upstream the ATG codon, does the CpG region could be representative for study? If it is not ... Can these CpG islands be representative? - (Jul/11/2005 ). I get the DNA sequence 5kb upstream from exon1 and exon1 to ... If the CpG island is far away from the promoter or transcriptional start site, it is hard to say whether its methylation has ...
http://www.protocol-online.org/biology-forums/posts/7851.html
*  Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype | PNAS
A) Methylation of multiple CpG islands detected by methylated CpG island amplification. Methylated CpG island amplification ... status of the same six CpG islands used to define the CIMP phenotype in cancers was determined by methylated CpG island ... CpG island methylator phenotype;. SSCP,. single-stranded conformational polymorphisms;. LOH,. loss of heterozygosity;. MSP,. ... CIMP+ tumors have a high degree of CpG island methylation and a high frequency of classical genetic changes such as MSI, K-RAS ...
http://www.pnas.org/content/97/2/710?ijkey=c75cf64d82fe6cafc5fce373900194b130cf4f07&keytype2=tf_ipsecsha
*  CpG islands influence chromatin structure via the CpG-binding protein Cfp1
... John P. Thomson,1,* Peter J. Skene,1,* Jim ... CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base composition and high density of CpG ... A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol. 2008;6:e22. [PMC free ... Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 1994;8:2282-2292. [ ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3730110/?lang=en-ca
*  CPGI22964 (CpG island 22964) - KOMP (Knockout Mouse Project)
CpG island 22964. Synonyms: CGI22964. Gene nomenclature, locus information, and GO, OMIM, and PMID associations are updated ...
https://www.komp.org/geneinfo.php?geneid=158115
*  CpG Island Methylation in Sporadic and Neurofibromatis Type 2-Associated Schwannomas | Clinical Cancer Research
C in CpG islands that were methylated remains unaffected. Asterisks show two CpG islands not methylated. ... CpG Island Methylation in Sporadic and Neurofibromatis Type 2-Associated Schwannomas. Pilar Gonzalez-Gomez, M. Josefa Bello, M ... CpG Island Methylation in Sporadic and Neurofibromatis Type 2-Associated Schwannomas. Pilar Gonzalez-Gomez, M. Josefa Bello, M ... CpG Island Methylation in Sporadic and Neurofibromatis Type 2-Associated Schwannomas. Pilar Gonzalez-Gomez, M. Josefa Bello, M ...
http://clincancerres.aacrjournals.org/content/9/15/5601
*  Methyl-CpG island-associated genome signature tags - Energy Innovation Portal
... and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and ... and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and ...
http://techportal.eere.energy.gov/patent.do/ID=27511
*  The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. -...
The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after ... The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases.. Cohen ... The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases ... The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases ...
https://www.ncbi.nlm.nih.gov/pubmed/28469732
*  Control of gene expression by CpG island methylation in normal cells | Biochemical Society Transactions
Control of gene expression by CpG island methylation in normal cells. G. Strathdee, A. Sim, R. Brown ... Methylation, targeted at CpG islands, is an important part of the mechanisms that govern X-chromosome inactivation; it is also ... Control of gene expression by CpG island methylation in normal cells Message Subject (Your Name) has forwarded a page to you ... partly due to the critical role of CpG island methylation in the inactivation of tumour suppressor genes during the development ...
http://www.biochemsoctrans.org/content/32/6/913
*  Prediction of CpG Islands as an Intrinsic Clustering Property Found in Many Eukaryotic DNA Sequences and Its Relation to DNA...
... of all genes in the human genome is overlapped by a CpG island (CGI). CGIs have known functions in the transcription initiation ... Hackenberg M, Barturen G, Carpena P et al (2010) Prediction of CpG-island function: CpG clustering vs. sliding-window methods. ... CpG islands Clustering DNA words DNA methylation Virtual machine This is a preview of subscription content, log in to check ... Gardiner-Garden M, Frommer M (1987) CpG islands in vertebrate genomes. J Mol Biol 196:261-282CrossRefPubMedGoogle Scholar ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-7768-0_3
*  Why can the MSP represent the methylation of CpG island? - DNA Methylation, Histone and Chromatin Study
There are so many CpG sites in one CpG island ,and the CpG sites investigated by a MSP are so limited. Only less than 10 CpG ... There are so many CpG sites in one CpG island ,and the CpG sites investigated by a MSP are so limited. Only less than 10 CpG ... There are so many CpG sites in one CpG island ,and the CpG sites investigated by a MSP are so limited. Only less than 10 CpG ... Why so little CpG sites mehtylation informatiom can repsent the whole CpG island ??? ...
http://www.protocol-online.org/biology-forums/posts/6128.html
*  Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation | Molecular and Cellular Biology
Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation. Scott A. Foster, David J. Wong, Michael T. ... C) p16 promoter CpG island methylation assay. U and M indicate the primer pair specific for unmethylated and methylated p16 ... 1996) Methylation-specific PCR: a novel assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93:9821-9826. ... 1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human ...
https://mcb.asm.org/content/18/4/1793?ijkey=111057786d3d27d8a437142a6ed6e1033e00e025&keytype2=tf_ipsecsha
*  Genome-Wide CpG Island Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas | Clinical Cancer Research
... chip-on-chip microarray contains 195K CpG island probes and 50K non-CpG island probes and interrogates 27,800 CpG islands ... In this study, we used methylated CpG island amplification (MCA) coupled with genome-wide CpG island microarrays (MCAM) ... genome-wide CpG island methylation profiling of IPMNs reveals that IPMNs harbor aberrant methylation of hundreds of CpG islands ... the CpG island methylation profiles of six IPMNs to normal primary pancreatic duct samples using methylation CpG island ...
http://clincancerres.aacrjournals.org/content/18/3/700
*  Putative zinc finger protein binding sites are over-represented in the boundaries of methylation-resistant CpG islands in the...
Understanding about mechanisms that may lead to the methylation resistance of CpG islands is still very poor. ... but most CpG islands are resistant to such epigenetic modification. ... Majority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, ... BACKGROUND: Majority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are ...
https://www.rti.org/publication/putative-zinc-finger-protein-binding-sites-are-over-represented-boundaries-methylation
*  Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs
... ... Gona, Saideep, Sanders, Alison P., Miranda, Marie Lynn, et al.. "Prenatal exposure to cadmium and cotinine and CpG island DNA ... In prior work, we analyzed CpG island methylation levels within gene promoters (nᅠ=ᅠ16,421) in leukocytes collected from ... The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and ...
https://scholarship.rice.edu/handle/1911/88822
*  CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer | Gut
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer ... CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer ...
https://gut.bmj.com/content/58/1/90.alerts