core binding factor alpha
     Summary Report | CureHuntercore binding factor alpha Summary Report | CureHunter

... core binding factor plays a key role in several development pathways and in human disease; has been sequenced ... Transcription Factors: 20597*Core Binding Factors: 223*Core Binding Factor alpha Subunits: 18*core binding factor alpha: 16 ... core binding factor alpha. Subscribe to New Research on core binding factor alpha ... 11/07/2000 - "Binding of CBFalpha/AML/PEBP2alpha (core binding factor alpha/acute myelogenous leukemia/polyoma enhancer binding ...
more infohttp://www.curehunter.com/public/keywordSummaryC406688-core-binding-factor-alpha.do

Runx-dependent expression of PKC is critical for cell survival in the  by Carrie Dickey-Sims, Anthony J. Robertson et al."Runx-dependent expression of PKC is critical for cell survival in the " by Carrie Dickey-Sims, Anthony J. Robertson et al.

Inhibition or knockdown of SpPKC1 also causes apoptosis, while cell survival is rescued in SpRunt-1 morphant embryos coinjected ... RESULTS: We report here that SpRunt-1 deficiency leads to ectopic cell proliferation and extensive apoptosis. Suppression of ... Chromatin immunoprecipitation indicates that SpRunt-1 interacts physically with SpPKC1 in vivo, and cis-regulatory analysis ... Runx transcription factors play critical roles in the developmental control of cell fate and contribute variously as ...
more infohttps://uknowledge.uky.edu/physiology_facpub/33/

basal cell carcinoma of eyelid disorder 2005:2010[pubdate] *count=100 - BioMedLib™ search enginebasal cell carcinoma of eyelid disorder 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Core Binding Factor Alpha 1 Subunit / metabolism. Eyelid Neoplasms / metabolism. Osteoblasts / metabolism ... Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Core Binding Factor Alpha 1 Subunit ... In this review, we discuss the risk factors, pathology, molecular biology, clinical features, and management of eyelid basal ... 1. Jankovic I, Kovacevic P, Visnjic M, Jankovic D, Binic I, Jankovic A: Does incomplete excision of basal cell carcinoma of the ...
more infohttp://www.bmlsearch.com/?kwr=basal+cell+carcinoma+of+eyelid+disorder+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Schematic illustration of the putative signaling pathwa | Open-iSchematic illustration of the putative signaling pathwa | Open-i

... to runt-related transcription factor 2 (RUNX2) in the mDE6 cells. Several s ... Core Binding Factor Alpha 1 Subunit/genetics*/metabolism. *Epithelial Cells/metabolism*. *Proto-Oncogene Proteins c-akt/ ... and can induce the expression of runt-related transcription factor 2 (RUNX2) during the development of the tooth germ.The ... and can induce the expression of runt-related transcription factor 2 (RUNX2) during the development of the tooth germ. RUNX2 ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4380193_IJMM-35-05-1169-g05&req=4

Osteogenic differentiation of hMSCs. (A) Differentiatio | Open-iOsteogenic differentiation of hMSCs. (A) Differentiatio | Open-i

Core Binding Factor Alpha 1 Subunit/genetics. *DNA Primers. *Flow Cytometry. *Gene Expression Profiling ... Role of Slug transcription factor in human mesenchymal stem cells. Torreggiani E, Lisignoli G, Manferdini C, Lambertini E, ... Role of Slug transcription factor in human mesenchymal stem cells. Torreggiani E, Lisignoli G, Manferdini C, Lambertini E, ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3822845_jcmm0016-0740-f6&req=4

Runx2 mediates epigenetic silencing of the bone morphogenetic protein- by Manish Tandon, Karthiga Devi Gokul et al."Runx2 mediates epigenetic silencing of the bone morphogenetic protein-" by Manish Tandon, Karthiga Devi Gokul et al.

The transforming growth factor beta (TGF-beta) family member bone morphogenetic protein-3B (BMP-3B/GDF10) is regarded as a ... The ectopic expression of Runx2, but not DNA binding mutant Runx2, in normal lung fibroblast cells and lung cancer cells ... The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several ... Core Binding Factor Alpha 1 Subunit; Bone Morphogenetic Protein 3; Lung Neoplasms ...
more infohttps://escholarship.umassmed.edu/oapubs/2320/

Sequence DetailSequence Detail

Core-binding factor subunit alpha-1; Short=CBF-alpha-1;AltName: Full=Oncogene AML-3;AltName: Full=Osteoblast-specific ... the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993 May;194(1):314-31 ... J:19082 Ogawa E, et al., PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila ... J:49076 Xiao ZS, et al., Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. ...
more infohttp://www.informatics.jax.org/sequence/Q08775

Crystallization and preliminary X-ray analysis of a domain in the Runx by Carola Bruna, Gloria Arriagada et al."Crystallization and preliminary X-ray analysis of a domain in the Runx" by Carola Bruna, Gloria Arriagada et al.

The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1alpha,25 dihydroxy vitamin D3 ... Absorptiometry, Photon; Animals; Core Binding Factor Alpha 1 Subunit; Crystallization; Mice; Protein Binding; Protein Structure ... The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1alpha,25 dihydroxy vitamin D3 ... Crystallization and preliminary X-ray analysis of a domain in the Runx2 transcription factor that interacts with the 1alpha,25 ...
more infohttps://escholarship.umassmed.edu/gsbs_sp/135/

Osteo-Promoter Database (OPD) - Promoter analysis in skeletal cells | BMC Genomics | Full TextOsteo-Promoter Database (OPD) - Promoter analysis in skeletal cells | BMC Genomics | Full Text

The analysis leads to a better insight of proteins that bind to DNA, regulate DNA, and function in chromatin remodeling. The ... The study summarizes transcriptional regulation factors interacting and cooperating at promoter regions that regulate gene ... Core-binding factor alpha-subunit 1. Osteoblast-specific transcription factor. Cleidocranial dysplasia murine Cbfa1+/- ... Transcription factors bind to regulatory elements upstream of transcription start sites and interact with other factors to ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-6-46

RETINOBLASTOMA-RELATED Protein Stimulates Cell Differentiation in the Arabidopsis Root Meristem by Interacting with Cytokinin...RETINOBLASTOMA-RELATED Protein Stimulates Cell Differentiation in the Arabidopsis Root Meristem by Interacting with Cytokinin...

... bone differentiation depends on pRb coactivation of the RUNT-RELATED TRANSCRIPTION FACTOR2/CORE-BINDING FACTOR SUBUNIT ALPHA-1 ... pRB is known to promote cell cycle exit by binding to members of the E2F family of transcription factors, thus interfering with ... pRB acts as a transcriptional regulator primarily via a mechanism that consists of binding to the main transcription factor ... a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ...
more infohttp://www.plantcell.org/content/25/11/4469.long

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

core binding factor alpha 1 subunit - genetics (2) 2 Filter by. Remove filter. core binding factor alpha 1 subunit - metabolism ... Core Binding Factor Alpha 1 Subunit - metabolism , Young Adult , Bone and Bones - metabolism , Adult , Female , Aged , Cell ... Core Binding Factor Alpha 1 Subunit - genetics , Osteogenesis - genetics ... POPULATION , OCTREOTIDE , DIAGNOSIS , RISK-FACTORS , MANAGEMENT , ABNORMALITIES , RECOMMENDATIONS , ENDOCRINOLOGY & METABOLISM ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Dav%C3%AC,%20Maria%20Vittoria

Potential of RAS Inhibition to Improve Metabolic Bone DisordersPotential of RAS Inhibition to Improve Metabolic Bone Disorders

... core-binding factor subunit alpha-1 (Cbfa1) and receptor activator of nuclear factor kappa-B ligand (RANKL), which is regulated ... Aliskiren is a drug of the second generation of renin inhibitors, and it binds to the binding site of renin essential for its ... Renin inhibitors bind to the active site of renin and inhibit its binding to angiotensinogen, which is the rate-determining ... Aliskiren binds to the binding site of renin essential for its activity thereby reducing plasma renin activity and suppressing ...
more infohttps://www.hindawi.com/journals/bmri/2013/932691/

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental...Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental...

... core-binding factor alpha subunit 1 (Cbfa1; 7.2-fold), osteocalcin (OC; 430-fold), and BSP (BSP; 5.7-fold) transcripts (Fig. 1 ... Synapse-boosting factors in young blood. Proteins in the blood of mice may underlie the cognition-enhancing properties of young ... B and C) Newly formed vessels, identified by CD31+ endothelial cells, penetrated the outer matrix and reached the inner core in ... an inner hypertrophic core (B, D, and F) rich in GAG, Col II, and Col X, and an outer mineralized rim (B, H, J, and L) with a ...
more infohttps://www.pnas.org/content/107/16/7251?ijkey=cc69a45ac0e8341f2d8a4f46dc54319290c86c42&keytype2=tf_ipsecsha

Chondrogenic potential of articular chondrocytes depends on their original locationChondrogenic potential of articular chondrocytes depends on their original location

Core Binding Factor Alpha 1 Subunit, DNA, Gene Expression Regulation, Glycosaminoglycans, Humans, Immunohistochemistry ...
more infohttps://dspace.library.uu.nl/handle/1874/314336

RUNX2 - WikipediaRUNX2 - Wikipedia

Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. Interestingly, the Runx2 DNA-binding activity is ...
more infohttps://en.wikipedia.org/wiki/RUNX2

A Cbfa1-dependent genetic pathway controls bone formation beyond embry by P Ducy, M Starbuck et al."A Cbfa1-dependent genetic pathway controls bone formation beyond embry" by P Ducy, M Starbuck et al.

We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding ... To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain ( ... Core Binding Factor Alpha 1 Subunit, DNA, Complementary, Down-Regulation, Gene Expression, Humans, Mice, Mice, Transgenic, ... We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding ...
more infohttps://digitalcommons.library.tmc.edu/uthdb_docs/21/

RUNX2 monoclonal antibody (M03), clone 1C10 - (H00000860-M03) - Products - AbnovaRUNX2 monoclonal antibody (M03), clone 1C10 - (H00000860-M03) - Products - Abnova

SL3/AKV core-binding factor alpha A subunit,acute myeloid leukemia 3 protein,core-binding factor, runt domain, alpha subunit 1, ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this ... This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain ... CBF-alpha 1,OTTHUMP00000016533,SL3-3 enhancer factor 1 alpha A subunit, ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=H00000860-M03

RUNX1 - TA325833 | acris-antibodies.comRUNX1 - TA325833 | acris-antibodies.com

... is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. ... CBF-alpha-2, CBFA2, Core-binding factor subunit alpha-2, EVI-1, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Polyomavirus enhancer- ... Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and ... binding protein 2 alpha B subunit, Runt-related transcription factor, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core- ...
more infohttps://www.acris-antibodies.com/antibodies/primary-antibodies/runx1-ta325833.htm

Switch to Europe/Worldwide websiteSwitch to Europe/Worldwide website

CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, ... CBF-alpha-2, CBFA2, Core-binding factor subunit alpha-2, EVI-1, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Polyomavirus enhancer- ... binding protein 2 alpha B subunit, Runt-related transcription factor, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core- ... The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes ...
more infohttps://www.acris-antibodies.com/antibodies/primary-antibodies/runx1-ap55801pu-s.htm

Runx2 and dental development.  - PubMed - NCBIRunx2 and dental development. - PubMed - NCBI

Core Binding Factor Alpha 1 Subunit/genetics*. *Core Binding Factor Alpha 1 Subunit/physiology ... The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for ... Control is complex, with involvement of a multitude of factors, thereby regulating the expression and activity of this gene ... Camilleri S1, McDonald F.. Author information. 1. Department of Orthodontics, Dental Institute of Kings College London, London ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17026500

Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and...Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and...

Core Binding Factor Alpha 1 Subunit/genetics*. *Core Binding Factor Alpha 1 Subunit/metabolism ... DNA binding was measured by phosphor analysis of labelled bands in gel shift assays after 5% PAGE. A difference in binding ... B. There was no detectable difference in the affinity of [35S] RUNX2 Q-variants for binding labelled VDR protein in in vitro ... C. The ability of in vitro translated RUNX2 Q-variants to bind a RUNX2 DNA element from the mouse osteocalcin promoter (known ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/22912713

A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. - Nuffield...A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. - Nuffield...

The expression of DDR-2, a key factor in OA, was increased. DDR-1-deficient chondrocytes from the TMJ were positively ... Discoidin domain receptor 1 (DDR-1)-deficient mice exhibited a high incidence of osteoarthritis (OA) in the temporomandibular ... Chondrocytes isolated from the TMJs of DDR-1-deficient mice maintained their osteoarthritic characteristics when placed in ... the DDR-1 knock-out mouse can serve as a novel model for temporomandibular disorders, such as OA of the TMJ, and will help to ...
more infohttps://www.ndorms.ox.ac.uk/publications/652047

Experts and Doctors on cell lineage in Ōsaka, JapanExperts and Doctors on cell lineage in Ōsaka, Japan

core binding factor beta subunit*core binding factors*picryl chloride*croton oil*b lymphocyte gene rearrangement*immunoglobulin ... Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell ... Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002;32:633-8 pubmed ... Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002;32:633-8 pubmed ...
more infohttp://www.labome.org/locale/japan/experts-and-doctors-on-cell-lineage-in---saka--japan-836924.html

Experts and Doctors on mice in Tokyo, JapanExperts and Doctors on mice in Tokyo, Japan

core binding factor alpha 2 subunit*osteopetrosis*lymphocyte antigen 96*core binding factor alpha 1 subunit*ly antigens* ... Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide. Biochim Biophys Acta. ... tnf receptor associated factor 6*neurologic mutants mice*obese mice*ige receptors*interleukin 17*bombesin receptors*inbred nzb ... Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain. J Neurosci. 2011;31: ...
more infohttp://www.labome.org/locale/japan/experts-and-doctors-on-mice-in-tokyo--japan-2688.html

Cell Differentiation | Profiles RNSCell Differentiation | Profiles RNS

Core Binding Factor Alpha 1 Subunit. *Epigenesis, Genetic. *Histones. *Osteoblasts. *Osteocalcin. *Osteogenesis ...
more infohttps://profiles.umassmed.edu/display/114496