core binding factor alpha Summary Report | CureHunter
... core binding factor plays a key role in several development pathways and in human disease; has been sequenced ... Transcription Factors: 20597*Core Binding Factors: 223*Core Binding Factor alpha Subunits: 18*core binding factor alpha: 16 ... core binding factor alpha. Subscribe to New Research on core binding factor alpha ... 11/07/2000 - "Binding of CBFalpha/AML/PEBP2alpha (core binding factor alpha/acute myelogenous leukemia/polyoma enhancer binding ...http://www.curehunter.com/public/keywordSummaryC406688-core-binding-factor-alpha.do
"Runx-dependent expression of PKC is critical for cell survival in the " by Carrie Dickey-Sims, Anthony J. Robertson et al.
Inhibition or knockdown of SpPKC1 also causes apoptosis, while cell survival is rescued in SpRunt-1 morphant embryos coinjected ... RESULTS: We report here that SpRunt-1 deficiency leads to ectopic cell proliferation and extensive apoptosis. Suppression of ... Chromatin immunoprecipitation indicates that SpRunt-1 interacts physically with SpPKC1 in vivo, and cis-regulatory analysis ... Runx transcription factors play critical roles in the developmental control of cell fate and contribute variously as ...https://uknowledge.uky.edu/physiology_facpub/33/
basal cell carcinoma of eyelid disorder 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Core Binding Factor Alpha 1 Subunit / metabolism. Eyelid Neoplasms / metabolism. Osteoblasts / metabolism ... Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Core Binding Factor Alpha 1 Subunit ... In this review, we discuss the risk factors, pathology, molecular biology, clinical features, and management of eyelid basal ... 1. Jankovic I, Kovacevic P, Visnjic M, Jankovic D, Binic I, Jankovic A: Does incomplete excision of basal cell carcinoma of the ...http://www.bmlsearch.com/?kwr=basal+cell+carcinoma+of+eyelid+disorder+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Schematic illustration of the putative signaling pathwa | Open-i
... to runt-related transcription factor 2 (RUNX2) in the mDE6 cells. Several s ... Core Binding Factor Alpha 1 Subunit/genetics*/metabolism. *Epithelial Cells/metabolism*. *Proto-Oncogene Proteins c-akt/ ... and can induce the expression of runt-related transcription factor 2 (RUNX2) during the development of the tooth germ.The ... and can induce the expression of runt-related transcription factor 2 (RUNX2) during the development of the tooth germ. RUNX2 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4380193_IJMM-35-05-1169-g05&req=4
Osteogenic differentiation of hMSCs. (A) Differentiatio | Open-i
Core Binding Factor Alpha 1 Subunit/genetics. *DNA Primers. *Flow Cytometry. *Gene Expression Profiling ... Role of Slug transcription factor in human mesenchymal stem cells. Torreggiani E, Lisignoli G, Manferdini C, Lambertini E, ... Role of Slug transcription factor in human mesenchymal stem cells. Torreggiani E, Lisignoli G, Manferdini C, Lambertini E, ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3822845_jcmm0016-0740-f6&req=4
"Runx2 mediates epigenetic silencing of the bone morphogenetic protein-" by Manish Tandon, Karthiga Devi Gokul et al.
The transforming growth factor beta (TGF-beta) family member bone morphogenetic protein-3B (BMP-3B/GDF10) is regarded as a ... The ectopic expression of Runx2, but not DNA binding mutant Runx2, in normal lung fibroblast cells and lung cancer cells ... The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several ... Core Binding Factor Alpha 1 Subunit; Bone Morphogenetic Protein 3; Lung Neoplasms ...https://escholarship.umassmed.edu/oapubs/2320/
Core-binding factor subunit alpha-1; Short=CBF-alpha-1;AltName: Full=Oncogene AML-3;AltName: Full=Osteoblast-specific ... the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993 May;194(1):314-31 ... J:19082 Ogawa E, et al., PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila ... J:49076 Xiao ZS, et al., Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. ...http://www.informatics.jax.org/sequence/Q08775
"Crystallization and preliminary X-ray analysis of a domain in the Runx" by Carola Bruna, Gloria Arriagada et al.
The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1alpha,25 dihydroxy vitamin D3 ... Absorptiometry, Photon; Animals; Core Binding Factor Alpha 1 Subunit; Crystallization; Mice; Protein Binding; Protein Structure ... The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1alpha,25 dihydroxy vitamin D3 ... Crystallization and preliminary X-ray analysis of a domain in the Runx2 transcription factor that interacts with the 1alpha,25 ...https://escholarship.umassmed.edu/gsbs_sp/135/
Osteo-Promoter Database (OPD) - Promoter analysis in skeletal cells | BMC Genomics | Full Text
The analysis leads to a better insight of proteins that bind to DNA, regulate DNA, and function in chromatin remodeling. The ... The study summarizes transcriptional regulation factors interacting and cooperating at promoter regions that regulate gene ... Core-binding factor alpha-subunit 1. Osteoblast-specific transcription factor. Cleidocranial dysplasia murine Cbfa1+/- ... Transcription factors bind to regulatory elements upstream of transcription start sites and interact with other factors to ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-6-46
RETINOBLASTOMA-RELATED Protein Stimulates Cell Differentiation in the Arabidopsis Root Meristem by Interacting with Cytokinin...
... bone differentiation depends on pRb coactivation of the RUNT-RELATED TRANSCRIPTION FACTOR2/CORE-BINDING FACTOR SUBUNIT ALPHA-1 ... pRB is known to promote cell cycle exit by binding to members of the E2F family of transcription factors, thus interfering with ... pRB acts as a transcriptional regulator primarily via a mechanism that consists of binding to the main transcription factor ... a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ...http://www.plantcell.org/content/25/11/4469.long
Search Articles | University of Toronto Libraries
core binding factor alpha 1 subunit - genetics (2) 2 Filter by. Remove filter. core binding factor alpha 1 subunit - metabolism ... Core Binding Factor Alpha 1 Subunit - metabolism , Young Adult , Bone and Bones - metabolism , Adult , Female , Aged , Cell ... Core Binding Factor Alpha 1 Subunit - genetics , Osteogenesis - genetics ... POPULATION , OCTREOTIDE , DIAGNOSIS , RISK-FACTORS , MANAGEMENT , ABNORMALITIES , RECOMMENDATIONS , ENDOCRINOLOGY & METABOLISM ...https://query.library.utoronto.ca/index.php/search/q?kw=Author:Dav%C3%AC,%20Maria%20Vittoria
Potential of RAS Inhibition to Improve Metabolic Bone Disorders
... core-binding factor subunit alpha-1 (Cbfa1) and receptor activator of nuclear factor kappa-B ligand (RANKL), which is regulated ... Aliskiren is a drug of the second generation of renin inhibitors, and it binds to the binding site of renin essential for its ... Renin inhibitors bind to the active site of renin and inhibit its binding to angiotensinogen, which is the rate-determining ... Aliskiren binds to the binding site of renin essential for its activity thereby reducing plasma renin activity and suppressing ...https://www.hindawi.com/journals/bmri/2013/932691/
Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental...
... core-binding factor alpha subunit 1 (Cbfa1; 7.2-fold), osteocalcin (OC; 430-fold), and BSP (BSP; 5.7-fold) transcripts (Fig. 1 ... Synapse-boosting factors in young blood. Proteins in the blood of mice may underlie the cognition-enhancing properties of young ... B and C) Newly formed vessels, identified by CD31+ endothelial cells, penetrated the outer matrix and reached the inner core in ... an inner hypertrophic core (B, D, and F) rich in GAG, Col II, and Col X, and an outer mineralized rim (B, H, J, and L) with a ...https://www.pnas.org/content/107/16/7251?ijkey=cc69a45ac0e8341f2d8a4f46dc54319290c86c42&keytype2=tf_ipsecsha
Chondrogenic potential of articular chondrocytes depends on their original location
Core Binding Factor Alpha 1 Subunit, DNA, Gene Expression Regulation, Glycosaminoglycans, Humans, Immunohistochemistry ...https://dspace.library.uu.nl/handle/1874/314336
RUNX2 - Wikipedia
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. Interestingly, the Runx2 DNA-binding activity is ...https://en.wikipedia.org/wiki/RUNX2
"A Cbfa1-dependent genetic pathway controls bone formation beyond embry" by P Ducy, M Starbuck et al.
We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding ... To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain ( ... Core Binding Factor Alpha 1 Subunit, DNA, Complementary, Down-Regulation, Gene Expression, Humans, Mice, Mice, Transgenic, ... We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding ...https://digitalcommons.library.tmc.edu/uthdb_docs/21/
RUNX2 monoclonal antibody (M03), clone 1C10 - (H00000860-M03) - Products - Abnova
SL3/AKV core-binding factor alpha A subunit,acute myeloid leukemia 3 protein,core-binding factor, runt domain, alpha subunit 1, ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this ... This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain ... CBF-alpha 1,OTTHUMP00000016533,SL3-3 enhancer factor 1 alpha A subunit, ...http://www.abnova.com/products/products_detail.asp?catalog_id=H00000860-M03
RUNX1 - TA325833 | acris-antibodies.com
... is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. ... CBF-alpha-2, CBFA2, Core-binding factor subunit alpha-2, EVI-1, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Polyomavirus enhancer- ... Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and ... binding protein 2 alpha B subunit, Runt-related transcription factor, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core- ...https://www.acris-antibodies.com/antibodies/primary-antibodies/runx1-ta325833.htm
Switch to Europe/Worldwide website
CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, ... CBF-alpha-2, CBFA2, Core-binding factor subunit alpha-2, EVI-1, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Polyomavirus enhancer- ... binding protein 2 alpha B subunit, Runt-related transcription factor, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core- ... The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes ...https://www.acris-antibodies.com/antibodies/primary-antibodies/runx1-ap55801pu-s.htm
Runx2 and dental development. - PubMed - NCBI
Core Binding Factor Alpha 1 Subunit/genetics*. *Core Binding Factor Alpha 1 Subunit/physiology ... The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for ... Control is complex, with involvement of a multitude of factors, thereby regulating the expression and activity of this gene ... Camilleri S1, McDonald F.. Author information. 1. Department of Orthodontics, Dental Institute of Kings College London, London ...https://www.ncbi.nlm.nih.gov/pubmed/17026500
Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and...
Core Binding Factor Alpha 1 Subunit/genetics*. *Core Binding Factor Alpha 1 Subunit/metabolism ... DNA binding was measured by phosphor analysis of labelled bands in gel shift assays after 5% PAGE. A difference in binding ... B. There was no detectable difference in the affinity of [35S] RUNX2 Q-variants for binding labelled VDR protein in in vitro ... C. The ability of in vitro translated RUNX2 Q-variants to bind a RUNX2 DNA element from the mouse osteocalcin promoter (known ...https://www.ncbi.nlm.nih.gov/pubmed/22912713
A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. - Nuffield...
The expression of DDR-2, a key factor in OA, was increased. DDR-1-deficient chondrocytes from the TMJ were positively ... Discoidin domain receptor 1 (DDR-1)-deficient mice exhibited a high incidence of osteoarthritis (OA) in the temporomandibular ... Chondrocytes isolated from the TMJs of DDR-1-deficient mice maintained their osteoarthritic characteristics when placed in ... the DDR-1 knock-out mouse can serve as a novel model for temporomandibular disorders, such as OA of the TMJ, and will help to ...https://www.ndorms.ox.ac.uk/publications/652047
Experts and Doctors on cell lineage in Ōsaka, Japan
core binding factor beta subunit*core binding factors*picryl chloride*croton oil*b lymphocyte gene rearrangement*immunoglobulin ... Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell ... Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002;32:633-8 pubmed ... Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002;32:633-8 pubmed ...http://www.labome.org/locale/japan/experts-and-doctors-on-cell-lineage-in---saka--japan-836924.html
Experts and Doctors on mice in Tokyo, Japan
core binding factor alpha 2 subunit*osteopetrosis*lymphocyte antigen 96*core binding factor alpha 1 subunit*ly antigens* ... Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide. Biochim Biophys Acta. ... tnf receptor associated factor 6*neurologic mutants mice*obese mice*ige receptors*interleukin 17*bombesin receptors*inbred nzb ... Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain. J Neurosci. 2011;31: ...http://www.labome.org/locale/japan/experts-and-doctors-on-mice-in-tokyo--japan-2688.html