Core Binding Factor Alpha 1 Subunit | Profiles RNS
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... Core Binding Factor Alpha 2 Subunit. *Core Binding Factor Alpha 3 Subunit ... "Core Binding Factor Alpha 1 Subunit" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... This graph shows the total number of publications written about "Core Binding Factor Alpha 1 Subunit" by people in this website ...
RUNX2 gene: MedlinePlus Genetics
SL3/AKV core-binding factor alpha A subunit. Additional Information & Resources. Tests Listed in the Genetic Testing Registry. ... The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the ... 2013 Jan;24(1):130-3. doi: 10.1097/SCS.0b013e3182636b7e. Citation on PubMed ...
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes - PubMed
Although numerous transcription factors involved in chondrocyte and osteoblast differentiation have been identified, lit … ... Core Binding Factor Alpha 1 Subunit Actions. * Search in PubMed * Search in MeSH ... Regulation of osteoblast differentiation by transcription factors. Komori T. Komori T. J Cell Biochem. 2006 Dec 1;99(5):1233-9 ... Although numerous transcription factors involved in chondrocyte and osteoblast differentiation have been identified, little is ...
Publication Detail
SALL1 regulates commitment of odontoblast lineages by interacting with RUNX2 to remodel open chromatin regions - PubMed
The differentiation of neural crest cells into odontoblasts is orchestrated by transcription factors regulating the expression ... Core Binding Factor Alpha 1 Subunit / genetics Actions. * Search in PubMed * Search in MeSH ... Yuxiu Lin 1 , Yao Xiao 1 , ChuJiao Lin 1 , Qian Zhang 1 , Shu Zhang 1 , Fei Pei 1 , Huan Liu 1 2 , Zhi Chen 1 ... Yuxiu Lin 1 , Yao Xiao 1 , ChuJiao Lin 1 , Qian Zhang 1 , Shu Zhang 1 , Fei Pei 1 , Huan Liu 1 2 , Zhi Chen 1 ...
Medical Dictionary, Dictionary of medicine and human biology, medical, biological and chemical terminology
... caused by mutation in the transcription factor gene (CBFA1) encoding core-binding factor, runt domain, alpha-subunit 1 on 6p. ... Applying to factors that have a detrimental effect upon hereditary qualities, physical or mental. dysgerminoma (dis-jer-mi-no′ ... primary d. d. due to a functional disturbance and not due to inflammation, new growths, or anatomic factors. SYN: functional d ... caused by mutation in the transforming growth factor, beta-induced, gene (TGFB1) encoding keratoepithelin on 5q. Leyden-Möbius ...
RUNX2 - Wikipedia
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... Zinc finger protein 521 (ZFP521) and activating transcription factor 4 (ATF4) are cofactors of Runx2. Binding of the ...
RUNX3 - Early...
SL3/AKV core-binding factor alpha C subunit. Description. RUNX3 is a member of the runt domain-containing family of ... transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5- ... It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or ... we will perform a multi-center study of FISH and hypermethylation markers as possible prognostic factors in BE. The centers ...
Recombinant Human RUNX2 protein (ab112259) | Abcam
SL3/AKV core binding factor alpha A subunit. *SL3/AKV core-binding factor alpha A subunit ... CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, ... Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of ... alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. ...
MeSH Browser
Core Binding Factors [D12.776.930.155] * Core Binding Factor alpha Subunits [D12.776.930.155.200] * Core Binding Factor Alpha 1 ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... Core Binding Factor Alpha 1 Subunit Preferred Term Term UI T623663. Date12/13/2004. LexicalTag NON. ThesaurusID NLM (2006). ...
MeSH Browser
Core Binding Factors [D12.776.930.155] * Core Binding Factor alpha Subunits [D12.776.930.155.200] * Core Binding Factor Alpha 1 ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... Core Binding Factor Alpha 1 Subunit Preferred Term Term UI T623663. Date12/13/2004. LexicalTag NON. ThesaurusID NLM (2006). ...
DeCS
Core Binding Factor Alpha 2 Subunit [D12.776.930.155.200.200] Core Binding Factor Alpha 2 Subunit ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... Core Binding Factor Alpha 1 Subunit Descriptor Spanish: Subunidad alfa 1 del Factor de Unión al Sitio Principal Spanish from ...
Runx-2 gene expression is associated with age-related changes of bone mineral density in the healthy young-adult population
Absorptiometry, Photon; Adolescent; Adult; Aging; Bone Density; Core Binding Factor Alpha 1 Subunit; Female; Gene Expression; ... Heredity factors are important for BMD, and Runx-2 is accepted as a regulator of osteoblasts and bone formation. The aim of our ... Heredity factors are important for BMD, and Runx-2 is accepted as a regulator of osteoblasts and bone formation. The aim of our ... of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. ...
Target Information | Therapeutic Target Database
PEBP2-alpha C; PEA2-alpha C; Oncogene AML-2; Core-binding factor subunit alpha-3; CBFA3; CBF-alpha-3; Acute myeloid leukemia 2 ... SL3/AKV core-binding factor alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; Polyomavirus enhancer-binding protein 2 ... CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding ... while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of ...
RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug...
... level interferon and TNF signaling were deregulated in primary RUNX1mut CML cells and stem cell and B-lymphoid factors ... also known as core binding factor subunit alpha (CBFA2), is a transcription factor (TF) and an essential component of the core ... d GSEA of TNF, IFN-alpha, IFN-gamma, and CBF-AML pathways upregulated in RUNX1mut compared with RUNX1wt patients. e GSEA of ... binding factor complex that plays a key role in hematopoiesis [1]. Somatic and germline alterations involving RUNX1 gene are ...
Bony Callus | Profiles RNS
NEW (2006) MESH HEADINGS WITH SCOPE NOTES (UNIT RECORD FORMAT; 9/3/2005
CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding ... A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. ... HN - 2006(1987) BX - Core Binding Factor alpha Proteins MH - Core Binding Factor beta Subunit UI - D050658 MN - D12.776.930.155 ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ...
Early gene regulation of osteogenesis in embryonic stem cells. - Immunology
Msx2 and Runx2 in mouse embryonic stem cells were monitored over a 48 hour period after exposure to the growth factors BMP2 and ... Animals, Base Sequence, Bone Morphogenetic Protein 2, Cell Differentiation, Cell Line, Core Binding Factor Alpha 1 Subunit, ... If you click Reject all non-essential cookies only necessary cookies providing core functionality such as security, network ... Msx2 and Runx2 in mouse embryonic stem cells were monitored over a 48 hour period after exposure to the growth factors BMP2 and ...
Core Binding Factor (CBF) Primary Acute Myeloid Leukemia
... the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to ... Cite this: Core Binding Factor (CBF) Primary Acute Myeloid Leukemia: Biology and Clinical Implications - Medscape - Mar 22, ... An alternative scenario could be that the CBFbeta/MYH11 protein binds to the CBF-alpha subunit to form a complex that in turn ... Core Binding Factor (CBF) Primary Acute Myeloid Leukemia: Biology and Clinical Implications. MedGenMed 2(2), 2000 [formerly ...
John Frater - Research output - Research Profiles at Washington University School of Medicine
Core Binding Factor beta Subunit 67% * Lymphoma 60% * Ventricular Myosins 50% * Chromosomes, Human, Pair 16 50% ... proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha ... Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells. Capoccia, B. J., Lennerz, J. K. M., ... Combined core needle biopsy and fine-needle aspiration with ancillary studies correlate highly with traditional techniques in ...
The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal...
Core Binding Factor alpha Subunits; DNA Primers; Gene Expression Regulation; Genes, Regulator; Neoplasm Proteins; Osteocalcin; ... Animals; Base Sequence; Cell Line; Chromatin; Core Binding Factor Alpha 1 Subunit; ... Together our results support a stepwise model for chromatin remodeling of the OC promoter and show that binding of the liganded ... These findings indicate that binding of liganded VDR in the distal promoter directly impacts the chromatin structure of the ...
SMART: PH domain annotation
The entire sequence was 83% similar to centaurin alpha, another PtdIns(3,4,5)P3-binding protein. The protein bound PtdIns(3,4,5 ... The core of the molecule is an antiparallel beta-sheet consisting of seven strands. The C terminus is folded into a long alpha- ... The PH domain in beta-adrenergic receptor kinase may be involved in binding to the beta gamma subunits of a trimeric G-protein ... A family of NMR solution structures of the growth factor receptor-bound protein 2 (Grb2) SH2 domain has been determined by ...
Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis | Nature Communications
An ANY-box core was used, which contained a light-gray base and an adjustable perpendicular stick holding a camera and an ... S)-lacosamide binding to collapsin response mediator protein 2 (CRMP2) regulates CaV2.2 activity by subverting its ... 1a), the mitochondrial indicators ATP synthase-subunit c (SCMAS) and heat-shock protein-60 (HSP60) co-localized with the ... governed by the neuron-specific22 calcium/calmodulin-dependent protein kinase II alpha (CaMKIIa) promoter (CaMKIIaCre-mCATLoxP ...
Search | Global Index Medicus
Adolescent , Female , Humans , Cell Nucleus , Metabolism , Cleidocranial Dysplasia , Genetics , Core Binding Factor Alpha 1 ... Female , Humans , DNA-Binding Proteins , Genetics , Fingers , Congenital Abnormalities , Frameshift Mutation , Hair Diseases , ... Novel Mutation of Cleidocranial Dysplasia-related Frameshift Runt-related Transcription Factor 2 in a Sporadic Chinese Case / 中 ... Previous studies reported a connection between CCD and the haploinsufficiency of runt-related transcription factor 2 (RUNX2). ...
Somatic SETBP1 mutations in myeloid neoplasms
SETBP1 is a SET-binding protein regulating self-renewal potential through HOXA-protein activation. Somatic SETBP1 mutations ... Core Binding Factor Alpha 2 Subunit / genetics * Core Binding Factor Alpha 2 Subunit / metabolism ... In general, somatic SETBP1 mutations have a significant clinical impact on the outcome as poor prognostic factor, due to ... SETBP1 is a SET-binding protein regulating self-renewal potential through HOXA-protein activation. Somatic SETBP1 mutations ...
The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok - PubMed
Core Binding Factor Alpha 3 Subunit / metabolism Actions. * Search in PubMed * Search in MeSH ... Mechanistically, Thpok- bound genes encoding the transcription factors Blimp1 and Runx3 and acted by antagonizing their ... The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok Thomas Ciucci 1 , Melanie S ... The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok Thomas Ciucci et al. ...
NDF-RT Code NDF-RT Name
Core Binding Factor Alpha 2 Subunit N0000169997 Core Binding Factor Alpha 3 Subunit N0000169995 Core Binding Factor alpha ... Subunits N0000169994 Core Binding Factor beta Subunit N0000169993 Core Binding Factors N0000005782 Corn Oil N0000011299 Corpus ... Gi2 N0000170554 GTP-Binding Protein alpha Subunits N0000170556 GTP-Binding Protein alpha Subunits, G12-G13 N0000170558 GTP- ... Binding Protein alpha Subunits, Gi-Go N0000170557 GTP-Binding Protein alpha Subunits, Gq-G11 N0000170555 GTP-Binding Protein ...
Pesquisa | Portal Regional da BVS
PI3K catalytic subunit alpha (PIK3CA), and silencing information regulator 2 related enzyme 1 (SIRT1) may the core targets of ... nuclear factor erythroid 2-related factor (NFE2L2), nitric oxide synthase 3 (NOS3), nuclear receptor subfamily 3 group C member ... Radioligand binding assays demonstrated that the EDG-1 receptors expressed in Pichia pastoris have specific and saturation ... HIF1A, NFE2L2, NOS3, NR3C1, PIK3CA, and SIRT1 might be core targets of metformin for the treatment of NAFLD. ...