Coproporphyrins | Profiles RNS
Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA. ... "Coproporphyrins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Coproporphyrins" by people in this website by year, and ... Below are the most recent publications written about "Coproporphyrins" by people in Profiles. ...
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Stool coproporphyrin and protoporphyrin are the most commonly measured porphyrins in feces. The ratio of fecal coproporphyrin ... Urinary ALA and coproporphyrin levels are markedly increased. Molecular genetic studies of the ALAD gene reveal the mutated ... Hereditary coproporphyria results in most cases from half-normal activity (50%) of coproporphyrin oxidase. [17] The disease is ... For example, fecal protoporphyrin always exceeds coproporphyrin (P , C = V) in variegate porphyria, whereas the reverse is true ...
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... and coproporphyrin; zinc: extracellular increase of coproporphyrin; benzene: a tendency to extracellular increase of ... and copro-porphyrin; mercury: extracellular decrease of heptacarboxyporphyrin and intracellular increase of coproporphyrin; ... copper: extracellular decrease of uro-, coproporphyrin and protoporphyrin IX, extracellular increase of heptacarboxyporphyrin ...
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Significantly increased coproporphyrin suggests HCP or VP, even if PBG is negative. Urine tests are irrelevant to the diagnosis ... Fecal porphyrin excretion is normal or slightly elevated in AIP; excretion of coproporphyrin III is markedly increased in HCP, ... and both coproporphyrin and protoporphyrin excretion is increased in VP. Fecal porphyrin analysis also can support the initial ...
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Variegate porphyria
In VP, the ratio of uroporphyrins to urinary coproporphyrin is usually 1:1 (or uroporphyrins , coproporphyrin), whereas in PCT ... the ratio of uroporphyrins to urinary coproporphyrin is 3-8:1. ...