Nguyen, Tri (2006) HIGH RESOLUTION STUDY OF THE CONFORMATIONAL LANDSCAPE OF BIOMOLECULES IN THE GAS PHASE. Doctoral ... Lucas, Joshua Michael (2006) Technology Mapping for Circuit Optimization Using Content-Addressable Memory. Masters Thesis, ... Protective immunity provided by HLA-A2 epitopes for fusion and hemagglutinin proteins of measles virus. Virology, 352 (2). 390 ... Park, Chisung (2006) Collaboration Among Human Service Nonprofit Organizations: Mapping Formal and Informal Networks of ...

Knowledge FlowProcess Mapping How is knowledge shared and stored. Resonance effects in a spherical shell were studied in [25], ... The conformational distributions thus esti- forwx for 14 (Tab. Communicating with Blissym- bolics. [Part (b) from A. 10 937. 2 ... Persistent infection with Theilers virus leads to CNS autoimmunity via epitope spreading. 5 CAMB cylinders were immersed into ...

Figure 1. Maps and expression of ARG8m under the control of the ATP9 promoter.. (A) Map of ARG8m fused to the 5′ UTR of ATP9 ... drives the conformational changes necessary for the synthesis of ATP by the F1 portion (Boyer, 1997; Stock et al, 2000). Cox6, ... a strain expressing Cox6 tagged with hemagglutinin followed by a protein C epitope from the nuclear COX6-HAC gene, and of the ... B) Map of the MRS/sA9R in which part of the ATP9 promoter region of MRS/A9R was spontaneously deleted. (C) Spot growth tests of ...

The electron density map unequivocally proved the presence of an iron atom with the coordination by the two protein ligands of ... That docking is limited to one segment of MHC-bound peptide offers an explanation for epitope recognition and altered peptide ... transferrins undergo a large scale conformational transition: the apo structure with an opening of the interdomain cleft is ...

A conformational change, or an angular motion in the tiny protein molecule, would manifest as a visible motion of the probe. ... The PAR-2 effect was mediated by activation of the MAP kinases Erk1/2 and JNK.\n\nConclusion: This study is the first to ... strain-specific neutralizing antibodies (Abs). Most of these Abs target highly variable immunodominant epitopes in the globular ... For direct observation of conformational changes, an extra-liposomal site(s) of the target protein is bound to a glass surface ...

Detection of bax conformational change. Whole-cell lysates were extracted by lysis buffer, and then proteins were analyzed by ... Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. ... Exposure of an N-terminal epitope of Bax seems to induce apoptotic cell death by controlling this mitochondrial membrane ... For detection of Bax conformational change, proteins were detected using specific primary antibody for the active form of Bax ( ...

Genetic mapping: To create a mapping population, the mutant was crossed to Ler, and a total of 99 F2 individuals displaying the ... To determine whether cul1-7 is af-fected in RBX1 binding, we synthesized epitope-tagged versions of wild-type and mutant CUL1, ... Upon illumination with red light, Prundergoes a conformational change to the ac-tive far-red light-absorbing form (Pfr), ... Several alleles ofCUL1in Arabidopsis have been re-ported previously, and in contrast tocul1-7, their changes map to the N- ...

Therapeutic epitopes and uses thereof. Amyloid beta protein (globular assembly and uses thereof). Modulation of the ... Computerized national online parcel-level map data portal. Seamless wireless phone access service. IOTA software download via ... Prevention and treatment of HCV infection employing antibodies directed against conformational epito.... Device and method for ...

... to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at ... Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation. ... which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein ...

We have characterized multiple conformational epitopes recognized by monoclonal antibodies against the P1 adhesin of S. mutans ... Maps, Parking & Directions * Interior Building Maps * Special Care Instructions for Cancer Patients ... Characterization of epitopes Recognized by Anti-P1 Streptococcus mutans Monoclonal Antibodies, FEMS Immunology and Medical ... including induced changes in antigen conformation and exposure of cryptic epitopes and subsequent alterations in antigen ...

Restriction endonuclease mapping of six novel deletions of the factor VIII gene in hemophilia A. 3139545 ... HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P. ... Detection of mutations in the factor VIII gene using single-stranded conformational polymorphism (SSCP). 1639429 ... an abnormal factor VIII with retention of function but modification of C2 epitopes. 9184393 ...

Further structural information provided by saturation transfer difference (STD) group epitope mapping, protein-based NMR, ... Abstract: The binding of a ligand to its target protein is often accompanied by conformational changes of both the protein and ... which are a consequence of conformational changes in both the protein and the ligand as well as the bound water network. ...

Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies ... The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion ... Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins. Quiroz ...

SARS-CoV-2 infects a cell as follows: SARS-CoV-2 Spike undergoes a conformational change where the S1 trimers flip up and ... or oxidation-specific epitopes. Also, oxidized lipids feed directly into pattern recognition receptors, triggering even more ... The remainder of the Spike undergoes a conformational change that causes it to unfold like an extension ladder, embedding ...

The major site of crosslinking of LARP6 to 5′SL RNA was mapped to this motif, as well. The RNK-motif is not found in other ... We propose a model in which the initial recognition of 5′SL by LARP6 is mediated by the RNK epitope and further stabilized by ... Conformational dynamics of non-native states of proteins and intrinsically unstructured proteins by NMR spectroscopy PhD Thesis ... The major site of crosslinking of LARP6 to 5′SL RNA was mapped to this motif, as well. The RNK-motif is not found in other ...

TL;DR: Combined pharmacophore mapping and molecular docking were used to identify the potential plant-based hits against the ... and molecular docking methods and indicated that PG induced conformational changes in the structure of HSA. ... Vaccinomics approach for developing multi-epitope peptide pneumococcal vaccine.. [...]. Hesam Dorosti1, Mahboobeh Eslami1, ...

Conformational control of Bax localization and apoptotic activity by Pro168.. J Cell Biol. 2004 Mar 29;164(7):1021-32. ... The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes. Mamm. Genome 8, ... The epitope recognized by rituximab. Blood. 2006 Sep15;108(6):1975-8. Pubmed16705086. ... Nowrouzi A, Dittrich M, Klanke C, Heinkelein M, Rammling M, Dandekar T, von Kalle C, Rethwilm A. Genome-wide mapping of foamy ...

Profiler tool available that will enable you to score individual peptide sequences based upon a relation epitope mapping ... They are a mixture of immunoglobulin molecules secreted against a specific antigen, each recognising a different epitope. ... carrier proteins to increase immunogenicity and provide T cell epitopes. Generally, the larger the immunogenic protein the ... potent adjuvant stimulates both cell mediated and humoral immunity with preferential induction of antibody against epitopes of ...

We expressed epitope-tagged DRL(DRL-HA) and SRC64B (SRC64B-MYC) proteins in Drosophila Kc cells,which express little, if any, ... WNT5 binding to DRL might result in subtle conformational changes to pre-existing DRL-SRC64B complexes,which were not detected ... establishment of the vertebrate retinotectal topographic map(Schmitt et al., 2005) and neurite outgrowth in vivo and in ...

... with the dominant responses directed against the HLA-B*57-epitope AISPRTLNAW and against a so-far-unknown epitope within Rev. ... Conformational transitions and secondary structure changes in F13 protein upon C2 binding show more native three-dimensional ... Genome-wide association studies (GWASs) are one of the most practical tools for mapping the patterns of inheritance for the ... Definition of a New HLA B*52-Restricted Rev CTL Epitope Targeted by an HIV-1-Infected Controller by Boutaina El Kenz ...

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles. Cell Host Microbe. 2020 Dec 9;28(6):880-91.e8. ... A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science. 2020 May 8;368(6491): ... Distinct conformational states of SARS-CoV-2 spike protein. Science. 2020 Sep 25;369(6511):1586-92. ... Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. 2020 Oct 2;370(6512):89-94. ...

Mapping of the corona virus membrane protein domains involved in interaction with the spike protein. J. Virol. 1999;73:7441- ... resistant to conformational changes induced by receptor recognition or proteolysis. Scientific reports, 8(1), 1-11. ... Glycan shield and epitope masking of a corona virus spike protein observed by cryo-electron microscopy. Nature structural & ... Angiotensin can lead to the mapping of "multiple respiratory distress", "myocardial injury", "renal failure", and "increased ...

H. Zhao, Y. Yang, Y. Lu, M. Mort, D. N. Cooper, and Y. Zhou, "Quantitative mapping of genetic similarity in human heritable ... J. Gao, E. Faraggi, Y. Zhou, J. Ruan, and L. Kurgan, "BEST: Improved Prediction of B-Cell Epitopes from Antigen Sequences", ... Y. Yang and Y. Zhou, "Effective protein conformational sampling based on predicted torsion angles", J. Comput. Chem. 37, 976- ... J. Hanson, K. Paliwal, T. Litfin, Y. Yang, and Y. Zhou, "Accurate prediction of protein contact maps by coupling residual two- ...

A novel ErbB2 epitope targeted by human antitumor immunoagents (415 views). Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): ... Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (495 views). J ... Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to ...

Şahin proves that immunization combining virus-like particles as antigen carriers with specific conformational epitopes of a ... Interest is also ranked by country and displayed on world map.[213] The first notable increase on the chart (March 2020) is ... Study co-authored by Uğur Şahin and Özlem Türeci on mutant major histocompatibility complex (MHC) class II epitopes concludes ... "Mutant MHC class II epitopes drive therapeutic immune responses to cancer". Nature. 520 (7549): 692-696. ISSN 1476-4687. doi ...

Characterization and comparison of polysaccharides from Lycium barbarum in China using saccharide mapping based on PACE and ... Using Infrared spectroscopy the conformational changes in the protein structure as a result of resin treatment was detected by ... Combined experimental data (analysis of guard cell wall epitopes and treatment of tissue with cell wall digesting enzymes, ... which suggested that saccharide mapping based on PACE and HPTLC analysis could be a routine approach for quality control of ...

A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist. The FEBS Journal 273(9): 1966-1974 ... 2008) deals with conformational changes of the KOR due to G protein coupling. Its thought that coupling with different G ... Post #39: Notes on Rasakhams Kappa opioid receptor regulation of ERK1/2 MAP kinase signaling cascade: molecular mechanisms ... A small warning: This one might be a little dull unless youre really into theoretical opioid binding epitopes. But before I ...

Mapping epitopes of anti-ligand antibodies; production of recombinant receptor for structural studies. 81,82. IL-2R IL-1OR. ... In addition, the hinge region is retained to provide conformational flexibility that can allow the Fc and receptor regions to ... CTLA-4 as a second receptor for B7 Inhibition of mast-cell binding of IgE as a treatment for allergic disease Mapping epitopes ... used a human erythropoietin receptor-based immunoadhesin to map a panel of anti-erythropoietin antibodies. Similar studies were ...

In 2017, two studies showed that autoreactive T cells could recognize specific α-Syn epitopes in PD patients [85, 86]. ... Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. ... and misfolding and/or neuronal internalization of α-Syn promote conformational template formation of endogenous α-Syn monocytes ... there is increasing evidence that misfolding and/or neuronal internalization of α-Syn promotes conformational template ...

The amino-terminal HA-epitope tag was detected using a fluorescein conjugate of the anti-HA antibody, clone 3F10 (Roche ... S1P receptor agonists with differing selectivity profiles will be useful tools to more completely map the physiological and ... 1 LPA between transmembrane domains may additionally impair the conformational change necessary for full agonist responses. ... and the haemagglutinin HA epitope tag (YPYDVPVYA, underlined) immediately after the initiator methionine, and the antisense ...