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*  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway | JEM
The protein is known to inhibit C1s and C1r, two subcomponents of the complement protein C1. It is for these properties that it ... The Human Complement System in Health and Disease. J.E. Volanakis and M.M. Frank, editors. Marcel Dekker, Inc., New York, NY. ... Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway. Haixiang Jiang, Eric Wagner, Huamei Zhang, Michael ... Complement 1 inhibitor (C1-INH)* is a critically important protein that controls activation of multiple plasma mediator ...
http://jem.rupress.org/content/194/11/1609
*  C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms | Biochemical Journal
C1q, the first component of the classical pathway of the complement system, interacts with various cell types and triggers a ... C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms. E. A. Leonora LEIGH, ... Previously, it has been shown that C1q-mediated oxidative burst by neutrophils is not linked to G-protein-coupled fMet-Leu-Phe- ... gC1qR, a C1q-binding protein, has recently been reported to participate in C1q-mediated chemotaxis of murine mast cells and ...
http://www.biochemj.org/content/330/1/247
*  Molecular Vision: Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B...
In contrast to the therapeutic potential of inhibiting the complement pathways, deficiencies within the complement system can ... Whaley K. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human ... of all complement pathways [18,19]. While the scaffold protein, complement component 3 (C3), and serine proteases factor B and ... and the complement system plays an important role in the pathogenesis of AMD. Inhibition of complement factor B, a key ...
http://www.molvis.org/molvis/v23/561/
*  Structural and functional characterization of human and murine C5a anaphylatoxins (Journal Article) | SciTech Connect
Complement is an ancient part of the innate immune system that plays a pivotal role in protection against invading pathogens ... Whereas A8{sup Δ71-73} adopts a three-helix bundle conformation similar tomore » human C5a-desArg, the two murine proteins form ... Upon complement activation, a cascade of proteolytic events generates the complement effectors, including the anaphylatoxins ... Signalling through their cognate G-protein coupled receptors, C3aR and C5aR, leads to a wide range of biological events ...
https://www.osti.gov/scitech/biblio/22347767-structural-functional-characterization-human-murine-c5a-anaphylatoxins
*  LACTOBACILLUS ACIDOPHILUS NUCLEIC ACID SEQUENCES ENCODING CARBOHYDRATE UTILIZATION-RELATED PROTEINS AND USES THEREFOR - Patent...
168 PTS system mannose-specific factor IID 876 169, 170 PTS system enzyme II protein 879 171, 172 Phosphotransferase system ... or a complement thereof, c) a nucleotide sequence comprising a fragment of a nucleotide sequence as set forth in any of SEQ ID ... proteins, including proteins of the phosphotransferase system (PTS), ABC transporters, and other proteins involved in transport ... Group translocation system proteins are also included, including enzyme I, enzyme II, and HPr proteins. [0158]Methods are known ...
http://www.patentsencyclopedia.com/app/20090093021
*  Complement receptor - Wikipedia
... part of the innate immune system. Complement receptors bind proteins of the complement system, and can thus detect pathogens ... Immune system Humoral immunity Janeway, CA Jr; Travers P; Walport M; et al. (2001). "The complement system and innate immunity ... A complement receptor is a receptor of the complement system, ... All four complement receptors bind to fragments of complement ... Peter Parham, The Immune System (2nd ed.), Taylor&Francis "Complement Receptor Deficiency: eMedicine Dermatology". Retrieved ...
https://en.wikipedia.org/wiki/Complement_receptor
*  Complement System Proteins - Complement Summary | CureHunter Mobile
Also Known As: Complement; Complement, Hemolytic; Complement Protein; Protein, Complement; Proteins, Complement System Show All ... Complement System Proteins (Complement) Summary Description: Serum glycoproteins participating in the host defense mechanism of ... Key Diseases for which Complement System Proteins is Relevant. * Infection : 87 outcomes 156 studies in 2347 results ... CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).. ...
http://www.curehunter.com/m/keywordSummaryD003165.do
*  Complement System Proteins - Semantic Scholar
This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of ... The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine ... Complement System Proteins. Known as: Proteins, Complement System, Complement, Complement Component Protein (More). ... The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine ...
https://www.semanticscholar.org/topic/Complement-System-Proteins/1546
*  INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM | JEM
INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM. Joan Siegel, Rosemarie Rent, Henry Gewurz ... We conclude that CRP is a potent activator of the C system at the level of C1, and that polycations such as protamine sulfate ... It seems not unlikely that one role of CRP in health and disease involves its ability to interact with the C system. ... It was mediated by a heat-stable nondialyzable factor which separated with C-reactive protein (CRP) during fractionation and ...
http://jem.rupress.org/content/140/3/631
*  Protein that foils complement system may be key to smallpox virulence | CIDRAP
... smallpox virus has a protein that inhibits the human complement system far more effectively than does its counterpart protein ... in the closely related vaccinia virus, used in smallpox vaccine, according to researchers who compared the two proteins. This ... Protein that foils complement system may be key to smallpox virulence. Filed Under: ... Jun 10, 2002 (CIDRAP News) The smallpox virus has a protein that inhibits the human complement system far more effectively than ...
http://www.cidrap.umn.edu/news-perspective/2002/06/protein-foils-complement-system-may-be-key-smallpox-virulence
*  Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic...
Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic ... Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic ... Membrane cofactor protein (MCP) is a complement regulatory protein that is expressed on human cells and cell lines as two ... indicated that MCP was a type 1 membrane glycoprotein and a member of the regulators of complement activation gene/protein ...
http://jem.rupress.org/content/174/1/93
*  Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures |...
Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures. S J ... Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures ... Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures ... Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures ...
http://www.biochemj.org/content/295/1/109
*  Targeting Complement Activation in Antineutrophil Cytoplasmic Autoantibodies (ANCA)-Vasculitis - Eculizumab - Full Text View -...
Immune System Diseases. Complement System Proteins. Autoantibodies. Immunologic Factors. Physiological Effects of Drugs. ... Change in complement levels between groups from baseline to week 12. *change in complement levels 2 [ Time Frame: up to 52 ... Complement levels elevation [ Time Frame: up to 52 weeks ]. Evaluation of complement levels at study entry to determine which ... Normalisation of complement activation [ Time Frame: up to 52 weeks ]. Normalization of complement activation at 4 weeks, 8, 12 ...
https://clinicaltrials.gov/ct2/show/NCT01275287?recr=Open&cond=%22Vasculitis%22&rank=6
*  Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury - Full...
Change in urine protein biomarkers (urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of ... Change in urine protein biomarkers (urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of ... Change from baseline in urine protein biomarkers at 4 hours after surgery [ Time Frame: Baseline, 4 hours after surgery ]. ... Change from baseline in urine protein biomarkers at postoperative day 1 [ Time Frame: Baseline, day 1 after surgery ]. ...
https://www.clinicaltrials.gov/ct2/show/NCT02114138
*  Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation - Full Text View - ClinicalTrials.gov
complement protein. eculizumab. Kidney transplantation. Additional relevant MeSH terms: Complement System Proteins. Immunologic ... Eculizumab is an antibody that has been developed to inhibit the complement protein C5. Eculizumab will be delivered via IV ... Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation. The safety and scientific validity of this ... Number of circulating endothelial cells with evidence of injury and bound antibody and/or complement [ Time Frame: baseline, 3, ...
https://clinicaltrials.gov/ct2/show/NCT01327573
*  Coversin in Paroxysmal Nocturnal Haemoglobinuria (PNH) - Full Text View - ClinicalTrials.gov
Coversin, a small protein complement C5 inhibitor which prevents the cleavage of C5 by C5 convertase into C5a and C5b, will be ... If at any point in treatment complement inhibition falls to less than 50% of baseline a further ablating dose of 0.57mg/kg ... If this is insufficient to maintain complement inhibition at ≤10% of baseline (pre-treatment) level after 5 days of treatment ... Thereafter the daily repeat dose will be titrated according to clinical response and complement inhibition determined by CH50 ...
https://clinicaltrials.gov/ct2/show/NCT02591862?term=Coversin&rank=1
*  Immunological study of vulvar lichen sclerosus: preliminary considerations.
Complement System Proteins / analysis*. Female. Humans. Immunoglobulins / blood*. Lymphocyte Subsets / pathology*. Middle Aged ... 0/Autoantibodies; 0/Immunoglobulins; 9007-36-7/Complement System Proteins From MEDLINE®/PubMed®, a database of the U.S. ...
http://www.biomedsearch.com/nih/Immunological-study-vulvar-lichen-sclerosus/8471134.html
*  Structural insights into the recognition properties of human ficolins.
Ficolins are oligomeric proteins assembled from collagen-like stalks and fibrinogen- ... Complement System Proteins / immunology. Humans. Immunity, Innate. Lectins / chemistry, immunology*. N-Acetylneuraminic Acid / ... Protein Multimerization. Protein Structure, Quaternary. Protein Structure, Tertiary. Receptors, Pattern Recognition / ... Ficolins are oligomeric proteins assembled from collagen-like stalks and fibrinogen-like domains that have the ability to sense ...
http://www.biomedsearch.com/nih/Structural-insights-into-recognition-properties/20375619.html
*  Pathophysiology and treatment of septic shock in neonates.
0/Intercellular Signaling Peptides and Proteins; 0/Opsonin Proteins; 9007-36-7/Complement System Proteins; WI4X0X7BPJ/ ... Complement System Proteins / immunology. Endothelium, Vascular / immunology. Genomics / methods. Humans. Hydrocortisone / ... Opsonin Proteins / immunology. Proteomics / methods. Resuscitation / methods*. Risk Factors. Shock, Septic / immunology, ... Acute-Phase Proteins / immunology. Anti-Infective Agents / therapeutic use. Blood Coagulation Disorders / immunology, ...
http://www.biomedsearch.com/nih/Pathophysiology-treatment-septic-shock-in/20569817.html
*  Multicentric Prospective Study of Genetic and Physiopathology Concerning Dysregulation of Complement During Repeated Fetal...
complement. antiangiogenic factors. Repeated fetal losses. Additional relevant MeSH terms: Complement System Proteins. ... The aim of the study is to assess the role of complement dysregulation and its impact on antiangiogenic factors (soluble Flt1 ... serum levels of sFlt1 and endoglin and their link to complement activation [ Time Frame: 8 weeks post pregnancy start ]. To ... serum levels of sFlt1 and endoglin and their link to complement activation [ Time Frame: 16 weeks post pregnancy start ]. To ...
https://clinicaltrials.gov/ct2/show/NCT01690858
*  A case of unusual SLE related syndrome characterized by erythema multiforme, angioneurotic edema, marked hypocomplementemia,...
Complement C1 / analysis*. Complement System Proteins / analysis*, deficiency*. Erythema Multiforme / immunology*. Female. ... 0/Antibodies, Antinuclear; 0/Complement C1; 0/Precipitins; 9007-36-7/Complement System Proteins ...
http://www.biomedsearch.com/nih/case-unusual-SLE-related-syndrome/1082447.html
*  Search | IOVS | ARVO Journals
TAGS: adenovirus infections, adenoviruses, antigens, cd55, complement system proteins, complement membrane attack complex, age- ... CD46, CD55, And CD59-mediated Attenuation Of Complement-induced Damage On Murine RPE Cells In-vitro And In-vivo: Therapeutic ... Decay Accelerating Factor (CD55)-Mediated Attenuation of Complement: Therapeutic Implications for Age-Related Macular ...
https://iovs.arvojournals.org/solr/searchresults.aspx?author=Kelly+N.+Ma
*  Letter from Michael Heidelberger to Enrique E. Ecker, Western Reserve University (April 24, 1945)
Complement System Proteins Exhibit Category: Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry ... He proved that complement was made up of a group of specific chemical substances that could be isolated in the laboratory, and ... and guinea pig complement. The letter illustrates Heidelberger's role as arbitrator, critic, and guardian of a uniform ... the only two of our complement team left, will fight it out until some agreement is reached. Otherwise, I fear the same ...
https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/DHBBGJ
*  Participants at the National Academy of Sciences Conference on Complement] [1950]
Complement System Proteins Exhibit Category: Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry ... National Academy of Sciences Conference on Complement (March 1951) Box Number: 4. Folder Number: 10. Unique Identifier: DHBBMZ ... Participants at the National Academy of Sciences Conference on Complement]. High resolution version (8,264,364 Bytes) ... This photograph is of attendees at an interdisciplinary conference on complement organized by Heidelberger (9th from the left) ...
https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/DHBBMZ
*  Letter from Felix Haurowitz to Michael Heidelberger (January 9, 1943)
Complement System Proteins Exhibit Category: Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry ... In this letter Haurowitz discussed his and Heidelberger's research on complement, a complex system of over twenty serum ... I have read very attentatively your three papers on complement determination. Please allow me the following remarks. On page ... I've repeated now my earlier work about the gravimetric determination of complement, modifying the message according to your ...
https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/DHBBJF