Loading...
*  Eculizumab blocks vaccine-induced opsonophagocytic killing of meningococci by whole blood from immunized adults | Blood Journal
... that blocks the alternative complement pathway (AP) and is in phase 2 development for treatment of PNH. In the absence of ... Blocking the alternative pathway with ACH-4471, a small molecule in development for PNH, had much less effect on meningococcal ... blocks the terminal complement pathway required for serum bactericidal activity (SBA). Because treated patients are at ,1000- ... Eculizumab, an anti-complement C5 mAb, blocked killing of meningococci by whole blood from healthy immunized adults. ...
http://www.bloodjournal.org/content/early/2017/06/19/blood-2017-05-781450?sso-checked=true
*  KAKEN - Research Projects | Elucidation of activation mechanism of the lectin complement pathway (KAKENHI-PROJECT-08670372)
... expressed by alternative polyadenylation is a component of the lectin complement pathway.' Int. Immunol.(in press).. *. ... expressed by alternative polyadenylation is a component of the lectin complement pathway.' Int.Immunol.(in press).. *. ... Publications] Matsushita, M.: 'The lectin pathway of the complement system.' Microbiol. Immunol.40. 887-893 (1996). *. ... Publications] Matsushita, M.: 'The lectin pathway of the complement system.' Microbiol. Immunol.40. 887-893 (1996). *. ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670372/
*  Properdin
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune ... can directly interact with neutrophil myeloperoxidase resulting in activation of alternative pathway of complement. ... A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme ... tubular HS as a novel docking platform for alternative pathway activation via properdin, which might play a role in proteinuric ...
https://pharos.nih.gov/idg/targets/P27918
*  Oxidative Stress Sensitizes RPE Cells To Complement-Mediated Injury In A Lectin Pathway- And Malondialdehyde Epitope-Dependent...
Purpose: : Uncontrolled activation of the alternative complement pathway is thought to be associated with age-related macular ... While the effect required alternative pathway (AP) activation, the AP was not sufficient, since elimination of MBL/MASP ... Using a combination of complement-depletion and reconstitution strategies, we have shown that the lectin pathway (LP) is ... Oxidative Stress Sensitizes RPE Cells To Complement-Mediated Injury In A Lectin Pathway- And Malondialdehyde Epitope-Dependent ...
http://iovs.arvojournals.org/article.aspx?articleid=2353899
*  Frontiers | Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable...
FH18-20/Fc bound weakly to three of the strains but did not promote complement dependent killing. Outer-membrane protein P5 has ... FH binding is a common property of many respiratory tract pathogens and FH/Fc chimeras may represent promising alternative or ... FH18-20/Fc bound weakly to three of the strains but did not promote complement dependent killing. Outer-membrane protein P5 has ... FH6,7/Fc bound strongly to each of seven NTHi clinical isolates tested and efficiently promoted complement-mediated killing by ...
https://www.frontiersin.org/articles/10.3389/fcimb.2016.00040/full
*  Plus it
... permits activation of the alternative pathway but inhibits activation of the classical complement pathway. Sera in the presence ... The results are consistent with a role for the alternative pathway of complement in the inhibition of growth of rat primary ... These results suggested that activation of the alternative pathway of complement might be involved in the observed antitumor ... prevents activation of both the alternative and classical complement pathways. [Ethylenebis(oxyethylenenitrilo)]tetraacetic ...
http://cancerres.aacrjournals.org/content/46/8/3886
*  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway | JEM
... we studied the role of the C1-INH in inhibition of the alternative complement pathway. In the alternative complement pathway, ... as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, ... Because the alternative complement pathway has many features in common with the classical complement pathway, and because many ... Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway. Haixiang Jiang, Eric Wagner, Huamei Zhang, Michael ...
http://jem.rupress.org/content/194/11/1609
*  Molecular Vision: Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B...
Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus ... Whaley K. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human ... for formation of the alternative pathway convertase, several complement proteins, including complement factor H (CFH), act as ... Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci USA. 1997; 94:8720 ...
http://www.molvis.org/molvis/v23/561/
*  Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin. ... Three pathways of complement activation are known: the classical, lectin, and alternative pathways. Although each uses its own ... a positive regulator of the alternative pathway of complement, has been shown to bind to surfaces and promote complement ... Inhibition of complement alternative pathway function with anti-properdin monoclonal antibodies. Mol. Immunol. 37:191-201. [ ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3028849/?lang=en-ca
*  An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae |...
The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132. ... Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation. Infect. Immun. 55: 174-180. ... Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement. J. Biol. Chem. 259: ... B, Serum P binds to Neisseriae in the presence of the alternative pathway of complement. P binding to unencapsulated N. ...
http://www.jimmunol.org/content/185/1/507.long
*  Barraquer-Simons syndrome - Wikipedia
C3 nephritic factor is a serum immunoglobulin G that interacts with the C3bBb alternative pathway convertase to activate C3. C3 ... Complement dysfunction may predispose some patients to bacterial infections. The diagnosis of the disease is mainly clinical ( ... Around 83% of APL patients had low complement 3 (C3) levels and the presence of polyclonal immunoglobulin C3 nephritic factor. ... Lipodystrophy is often associated with glomerulonephritis, low C3 serum complement levels, and the presence of a C3 nephritic ...
https://en.wikipedia.org/wiki/Barraquer%E2%80%93Simons_syndrome
*  Alternative complement pathway - Wikipedia
The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the ... "Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus ... The alternative pathway of the complement system is an innate component of the immune system's natural defense against ... The C5-convertase of the alternative pathway consists of (C3b)2BbP (sometimes referred to as C3b2Bb). After the creation of C5 ...
https://en.wikipedia.org/wiki/Alternative_complement_pathway
*  The alternative complement pathway regulates pathological angiogenesis in the retina. - PubMed - NCBI
... our data implicate the alternative complement pathway in facilitating neovessel clearance by down-regulating the complement ... The alternative complement pathway regulates pathological angiogenesis in the retina.. Sweigard JH1, Yanai R1, Gaissert P1, ... We used alternative complement pathway-deficient (Fb(-/-)) mice and age- and strain-matched control mice to assess neovessel ... We investigated the role of the alternative complement pathway during the formation and resolution of aberrant ...
https://www.ncbi.nlm.nih.gov/pubmed/24668752
*  Physiopathological implications of genetic variability in the complement alternative pathway | HSTalks
Santiago Rodríguez de Córdoba on Physiopathological implications of genetic variability in the complement alternative pathway, ... Other Talks in the Series: The Complement System. The evolution of complement and the alternative pathway ... Physiopathological implications of genetic variability in the complement alternative pathway. *Prof. Santiago Rodríguez de ... Physiopathological Implication of Genetic Variability in the Complement Alternative Pathway. My name is Santiago Rodriguez de ...
https://hstalks.com/t/3765/physiopathological-implications-of-genetic-variabi/
*  Alternative-complement-pathway C3/C5 convertase - Wikipedia
Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme ... complement C 3(C 5) convertase (amplification), alternative complement pathway C3(C5) convertase, C5 convertase, CVF,Bb, (CVF)- ... Alternative complement pathway Kerr, M.A. (1981). "Human factor B". Methods Enzymol. 80: 102-112. doi:10.1016/s0076-6879(81) ... Alternative-complement-pathway C3/C5 convertase at the US National Library of Medicine Medical Subject Headings (MeSH) ...
https://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase
*  Kidney Diseases Associated With Alternative Complement Pathway Dysregulation and Potential Treatment Options☆,☆☆
Genetic mutations affecting the alternative complement pathway regulating proteins (complement factor H, I, membrane cofactor ... Kidney Diseases Associated With Alternative Complement Pathway Dysregulation and Potential Treatment Options☆,☆☆. ... are characterized as inappropriate activation of the alternative complement pathway. ... Recent advances in targeted complement inhibitor therapy resulted in significant improvement in disease remission, renal ...
https://insights.ovid.com/ajmeds/201712000/00000441-201712000-00002
*  Alternative Pathway Complement Activation in Vitreous and Bruch's-Choroid Interface | IOVS | ARVO Journals
Alternative Pathway Complement Activation in Vitreous and Bruch's-Choroid Interface L. E. DeForge; K. M. Loyet; L. Sturgeon; K ... Alternative Pathway Complement Activation in Vitreous and Bruch's-Choroid Interface You will receive an email whenever this ... Purpose: : While both genetic and pathophysiological studies point to a role for the Alternative Pathway (AP) of complement in ... Alternative Pathway Complement Activation in Vitreous and Bruch's-Choroid Interface. Invest. Ophthalmol. Vis. Sci. 2010;51(13): ...
https://iovs.arvojournals.org/article.aspx?articleid=2374801
*  Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement...
The alternative pathway was initially recognized to amplify complement activation triggered by the classical pathway. Properdin ... The alternative pathway of complement is thought to be activated following hydrolysis of C3, generation of C3b, and formation ... The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132. ... Properdin activates complement via an alternative pathway. A, Necrotic Jurkat cells were preincubated with or without properdin ...
http://www.jimmunol.org/content/180/11/7613?ijkey=4c7ecf4340af5dabcca70ddb98a75f3703f2602d&keytype2=tf_ipsecsha
*  Case report: lupus nephritis with autoantibodies to complement alternative pathway proteins and C3 gene mutation | BMC...
Serial sera samples were analyzed, and autoantibodies to complement alternative pathway proteins (Factor I, Factor B, C3 and ... Functional assays showed that these autoantibodies cause alternative pathway activation. This case is the first reported of a ... heterozygous C3 mutation associated with lupus nephritis and autoantibodies against complement alternative pathway proteins ( ... Factor I, Factor B, C3 and Properdin).These autoantibodies cause activation of this pathway and this fact could explain that ...
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-015-0032-6
*  Activation of the alternative complement pathway by intraocular lenses. | IOVS | ARVO Journals
Activation of the alternative complement pathway by intraocular lenses. You will receive an email whenever this article is ... B J Mondino, S Nagata, M M Glovsky; Activation of the alternative complement pathway by intraocular lenses.. Invest. Ophthalmol ... polymethylmethacrylate lenses with polypropylene loops generate C3a and C5a by activation of the alternative complement pathway ... known activators of the alternative pathway. Our results suggest that ...
https://iovs.arvojournals.org/article.aspx?articleid=2177108
*  Formation of High-Affinity C5 Convertases of the Alternative Pathway of Complement | The Journal of Immunology
Alternative pathway: activation and regulation. K. Rother, and G. O. Till, and G. M. Hänsch, eds. The Complement System 2nd Ed. ... Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of ... Reconstitution of C5 convertase of the alternative complement pathway with isolated C3b dimer and factors B and D. J. Immunol. ... Formation of High-Affinity C5 Convertases of the Alternative Pathway of Complement. Nenoo Rawal and Michael K. Pangburn ...
http://www.jimmunol.org/content/166/4/2635
*  Frontiers | The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct...
... of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin ... of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin ... mechanism that differs from previously described strategies used by other organisms to inhibit the AP of the host complement ... mechanism that differs from previously described strategies used by other organisms to inhibit the AP of the host complement ...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01065/full
*  Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular...
Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc. Natl. Acad. Sci. USA 94: 8720- ... Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin. J. Am. Soc. Nephrol. 4 ... Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular ... Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular ...
http://www.jimmunol.org/content/187/1/172?ijkey=f0b80d99e51fbd8960d5def308193e1de6266a23&keytype2=tf_ipsecsha
*  Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of...
Screening for complement deficiencies in the classical or alternative complement pathways has mainly been performed by ... Screening for complement deficiencies in the classical or alternative complement pathways has mainly been performed by ... Screening for complement deficiencies in the classical or alternative complement pathways has mainly been performed by ... Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of ...
https://lup.lub.lu.se/search/publication/956ec6ed-392c-4b96-914e-bd2d6f93cdf9
*  The Alternative Pathway The Complement System Part Ii Fl Immuno 14 - Qilin Music
Complement system , classical and alternative pathway of complement activation. Duration:21:36~ Size:29.66 MB~ Bitrate:192kbps ... The Alternative Pathway - The Complement System (Part II) (FL-Immuno/14). Duration:5:07~ Size:7.03 MB~ Bitrate:192kbps ... The Alternative Pathway The Complement System Part Ii Fl Immuno 14. Posted on April 17, 2018 by Tito. 92 out of 100 based on ... Complement system part 4 (Alternative pathway). Duration:28:54~ Size:39.69 MB~ Bitrate:192kbps ...
http://qilinmusic.com/the-alternative-pathway-the-complement-system-part-ii-fl-immuno-14