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*  Frontiers | Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable...
FH18-20/Fc bound weakly to three of the strains but did not promote complement dependent killing. Outer-membrane protein P5 has ... FH18-20/Fc bound weakly to three of the strains but did not promote complement dependent killing. Outer-membrane protein P5 has ... Chimeric proteins containing the regions that most FH-binding bacteria use to engage human FH, domains 6 and 7 (FH6,7/Fc) and/ ... Chimeric proteins containing the regions that most FH-binding bacteria use to engage human FH, domains 6 and 7 (FH6,7/Fc) and/ ...
https://www.frontiersin.org/articles/10.3389/fcimb.2016.00040/full
*  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway | JEM
The protein is known to inhibit C1s and C1r, two subcomponents of the complement protein C1. It is for these properties that it ... Studies on human plasma C1-inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin and trypsin. J. Clin ... Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway. Haixiang Jiang, Eric Wagner, Huamei Zhang, Michael ... Complement 1 inhibitor (C1-INH)* is a critically important protein that controls activation of multiple plasma mediator ...
http://jem.rupress.org/content/194/11/1609
*  Complement c1 inactivator proteins facts | Factolex
... protein, the main function of which is the inhibition of the complement system to prevent spontaneous activation. fact lexicon ... Complement c1 inactivator proteins (C1-inhibitor) -- a serine protease inhibitor (serpin) ... Complement c1 inactivator proteins (C1-inhibitor) C1-inhibitor. also called Complement c1 inactivator proteins and has 6 more ... a serine protease inhibitor (serpin) protein, the main function of which is the inhibition of the complement system to prevent ...
http://en.factolex.com/Complement_c1_inactivator_proteins:complement_system
*  Berinert P Study of Subcutaneous Versus Intravenous Administration - Full Text View - ClinicalTrials.gov
Complement C1s. Complement C1 Inhibitor Protein. Complement C1 Inactivator Proteins. Immunologic Factors. Physiological Effects ... Drug Information available for: SERPING1 protein, human Genetic and Rare Diseases Information Center resources: Hereditary ... and C1-Inhibitor antigen in normal or elevated concentration of dysfunctional protein). ...
https://clinicaltrials.gov/ct2/show/NCT00748202
*  Clinical review of hereditary angioedema: diagnosis and management.
0/Complement C1 Inactivator Proteins; 0/Complement C1 Inhibitor Protein; 0/Estrogen Antagonists; 0/SERPING1 protein, human; ... Complement C1 Inactivator Proteins / adverse effects, therapeutic use. Complement C1 Inhibitor Protein / metabolism. Danazol / ...
http://www.biomedsearch.com/nih/Clinical-review-hereditary-angioedema-diagnosis/19940422.html
*  Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2.
Complement C1 Inactivator Proteins / analysis, immunology*. Enzyme-Linked Immunosorbent Assay. Female. Follow-Up Studies. ... 0/Antibodies, Anti-Idiotypic; 0/Complement C1 Inactivator Proteins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M ... We studied the clinical features, complement profiles, and associated diseases in 19 new patients with diagnosed acquired ... angioedema type 2. SUBJECTS AND METHODS: Plasma concentrations and functional activity of complement components were measured ...
http://www.biomedsearch.com/nih/Prevalence-monoclonal-gammopathy-in-patients/12208377.html
*  Ex vivo perfusion of mouse hearts expressing the human complement regulatory protein CD59. - UCL Discovery
Animals, Antigens, CD, CD59 Antigens, Complement Inactivator Proteins, Graft Rejection, Heart, Heart Rate, Humans, In Vitro ... Ex vivo perfusion of mouse hearts expressing the human complement regulatory protein CD59. Transplant Proc , 26 (3) 1245-. ... Ex vivo perfusion of mouse hearts expressing the human complement regulatory protein CD59. ... Ex vivo perfusion of mouse hearts expressing the human complement regulatory protein CD59.. ...
http://discovery.ucl.ac.uk/91434/
*  Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks - Full Text View -...
Complement C1s. Complement C1 Inhibitor Protein. Complement C1 Inactivator Proteins. Immunologic Factors. Physiological Effects ... Complement C4 Serum Levels [ Time Frame: Pre-infusion to 1 hour post-infusion ]. Change in complement C4 serum levels from pre- ... Drug Information available for: SERPING1 protein, human Genetic and Rare Diseases Information Center resources: Hereditary ...
https://clinicaltrials.gov/ct2/show/NCT00438815?cond=%22hereditary+angioedema%22&rank=5
*  Complement control protein - Wikipedia
Complement Inactivator Proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... "regulators of complement activation (RCA)" or "complement control proteins (CCP)". Complement control proteins work in concert ... Complement control proteins also play a role in malignancy. Complement proteins protect against malignant cells- both by direct ... Most of the complement control proteins act on the convertases, C3b.Bb and C4b.2a, which are bimolecular complexes formed early ...
https://en.wikipedia.org/wiki/Complement_control_protein
*  PAGE analysis of native and polymerized C1-inh.A) Nativ | Open-i
Complement C1 Inactivator Proteins/genetics/metabolism*. Minor. *Animals. *Case-Control Studies. *Female ... Molecular weights of the marker proteins are depicted in kDa to the right. Proteins were visualized using silver staining. ... Molecular weights of the marker proteins are depicted in kDa to the right. Proteins were visualized using silver staining. ... Proteins were visualized using silver staining. B): SDS PAGE analysis of BS3 conjugated pC1-inh (lane 1), pC1-inh (lane 2), ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4219832_pone.0112051.g001&req=4
*  C1 Inhibitor Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Complement C1 Inactivator Proteins. Phase 4,Phase 3,Phase 2,Phase 1. ... Complement System Proteins. Phase 4,Phase 3,Phase 2,Phase 1. 7. Complement Inactivating Agents. Phase 4,Phase 3,Phase 2,Phase 1 ... Complement C1 Inhibitor Protein. Phase 4,Phase 3,Phase 2,Phase 1. ... Disease Ontology : 12 A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading ...
https://www.malacards.org/card/c1_inhibitor_deficiency
*  Apyrase activity from the crop soluble contents of Rhod | Open-i
Complement Inactivator Proteins/metabolism*. *Complement System Proteins/metabolism*. *Intestines/metabolism*. *Salivary Glands ... The most obvious function for these inhibitors would be the protection of the midgut against injury by the complement. To ... The existence of complement inhibitors may have important biological consequences which are discussed in detail. ... The most obvious function for these inhibitors would be the protection of the midgut against injury by the complement. To ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2698215_pone.0006047.g002&req=4
*  NAVER Academic > Search...
Aminocaproates, pharmacology, Animals, Complement Inactivator Proteins, Erythrocytes, immunology, Hemolysis, Humans, Sheep, ... Complement System Proteins, analysis, metabolism, Goats, Histamine Release,... ... Complement-mediated release of histamine from human leukocytes.. 1975 J A Grant et al. JOURNAL OF IMMUNOLOGY cited 15 times ... Inhibition by epsilon-aminocaproic acid of the activation of the first component of the complement system.. 1975 N A Soter et ...
https://academic.naver.com/search.naver?field=3&query=JOURNAL+OF+IMMUNOLOGY+114%EA%B6%8C+3%ED%98%B8
*  Internet Scientific Publications
If the C3b inactivator protein is impaired, the complement system gets completed and causes RBC destruction4. In PCH, the cold ... which lack proteolytically cleaved complement on their surface and inhibit complement-mediated lysis9. Steroid is beneficial in ... This binding time is sufficient to activate the complement cascade to stage C3b. Many C3b RBCs escape the macrophages in ... PCH - paroxysmal cold hemoglobinuria, DAT- direct antiglobulin test, C3 - complement third component, RBC -Red blood cell) ...
http://ispub.com/IJEICM/12/1/3616
*  Serpins Summary Report | CureHunter
... complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental ... plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than ... thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y ... protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates ...
http://www.curehunter.com/public/keywordSummaryD015843-Serpins.do
*  Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells. - Oxford Neuroscience
Animals, Antigens, CD, CD59 Antigens, Complement Inactivator Proteins, Gene Expression, Gene Transfer Techniques, Globins, ...
https://www.neuroscience.ox.ac.uk/publications/13780
*  Allosteric inhibition of complement function by a staphylococcal immune evasion protein. - PubMed - NCBI
Complement Factor B/metabolism. *Complement Inactivator Proteins/chemistry. *Complement Inactivator Proteins/metabolism* ... Allosteric inhibition of complement function by a staphylococcal immune evasion protein.. Chen H1, Ricklin D, Hammel M, Garcia ... Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A. 2010 Oct 12; ... Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A. 2010 Oct 12; ...
https://www.ncbi.nlm.nih.gov/pubmed/20876141
*  Jeremy P. Kamil, Ph.D.
Human papillomavirus E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein ... Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science 320: 797-799. ... Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. J Virol 81:10659-10668. ... One role of UL97 is to inactivate the retinoblastoma tumor suppressor protein (pRb), which is a key regulator of cellular genes ...
http://lsuhscmicrobiology.com/jeremy-p-kamil-phd
*  New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins | JEM
Carboxypeptidase R is an inactivator of complement-derived inflammatory peptides and an inhibitor of fibrinolysis. Immunol. Rev ... Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner. ... The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc. Natl. Acad ... Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J. ...
http://jem.rupress.org/content/196/5/561
*  C4bp complement protein - Semantic Scholar
It binds as a cofactor to COMPLEMENT FACTOR I which then hydrolyzes the COMPLEMENT C4B in the CLASSICAL PATHWAY C3 CONVERTASE ( ... A serum protein that regulates the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. ... C4bp complement protein. Known as: C4bC3bINA Cofactor, Complement C3b C4b Inactivator Cofactor, Protein, Complement C4b-Binding ... A serum protein that regulates the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It binds as a cofactor to COMPLEMENT FACTOR I which ...
https://www.semanticscholar.org/topic/C4bp-complement-protein/1286503
*  Atypical haemolytic uraemic syndrome and mutations in complement regulator genes | SpringerLink
Disulfide bonds are localized within the short consensus repeat units of complement regulatory proteins: C4b-binding protein. ... Pangburn MK, Schreiber RD, Muller-Eberhard HJ (1977) Human complement C3b inactivator: isolation, characterization, and ... Wiedmer T, Sims PJ (1991) Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane ... Richards A, Kemp EJ, Liszewski MK et al (2003) Mutations in human complement regulator, membrane cofactor protein (CD46), ...
https://link.springer.com/article/10.1007%2Fs00281-005-0003-2
*  Alternative complement pathway - Wikipedia
... there are several different kinds of regulatory proteins that disrupt the complement activation process: *Complement Receptor 1 ... "Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum ... CFHR5 (Complement Factor H-Related protein 5) is able to bind to act as a cofactor for factor I, has decay accelerating ... Factor I requires a C3b-binding protein cofactor such as complement factor H, CR1, or Membrane Cofactor of Proteolysis (MCP or ...
https://en.wikipedia.org/wiki/Alternative_complement_pathway
*  Complement factor I - Wikipedia
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement ... is a protein of the complement system, first isolated in 1966 in guinea pig serum, that regulates complement activation by ... Maga TK, Nishimura CJ, Weaver AE, Frees KL, Smith RJ (Jun 2010). "Mutations in alternative pathway complement proteins in ... this precursor protein is then cleaved by furin to yield the mature fI protein, which is a disulfide-linked dimer of heavy ...
https://en.wikipedia.org/wiki/Complement_factor_I
*  Is complement good or bad for cancer patients? A new perspective on an old dilemma. - PubMed - NCBI
Complement Inactivator Proteins/immunology*. *Complement Inactivator Proteins/metabolism. *Complement System Proteins/ ... Unbroken lines connect complement proteins to their functions in tumor growth. Broken lines connect complement proteins to ... Unbroken lines connect complement proteins to functions which inhibit tumor growth, whereas broken lines connect complement ... In addition, tumor cells are protected from co attack by membrane complement regulatory proteins (mCRPs) and soluble complement ...
https://www.ncbi.nlm.nih.gov/pubmed/19428302