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*  Properdin
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme ... This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune ... can directly interact with neutrophil myeloperoxidase resulting in activation of alternative pathway of complement. ... This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in ...
https://pharos.nih.gov/idg/targets/P27918
*  Frontiers | Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable...
FH6,7/Fc efficiently promoted binding of C3 to NTHi exposed to mouse serum, and intranasal delivery of FH6,7/Fc resulted in ... FH18-20/Fc bound weakly to three of the strains but did not promote complement dependent killing. Outer-membrane protein P5 has ... FH binding is a common property of many respiratory tract pathogens and FH/Fc chimeras may represent promising alternative or ... FH6,7/Fc efficiently promoted binding of C3 to NTHi exposed to mouse serum, and intranasal delivery of FH6,7/Fc resulted in ...
https://www.frontiersin.org/articles/10.3389/fcimb.2016.00040/full
*  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway | JEM
This cleavage leads to the activation of the alternative pathway convertase and formation of a C3-cleaving enzyme. In the ... we studied the role of the C1-INH in inhibition of the alternative complement pathway. In the alternative complement pathway, ... as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, ... Because the alternative complement pathway has many features in common with the classical complement pathway, and because many ...
http://jem.rupress.org/content/194/11/1609
*  Molecular Vision: Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B...
C3), and serine proteases factor B and factor D are required and sufficient for formation of the alternative pathway convertase ... The initial step in the alternative pathway is proteolysis of complement C3, which plays a central role in the activation of ... Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus ... Whaley K. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human ...
http://www.molvis.org/molvis/v23/561/
*  Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation
... due to its role as a stabilizer of the C3 and C5 convertases of the alternative pathway. This suggests that an inhibitor in ... The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin. ... pneumoniae directly or as a stabilizer of the C3 and C5 convertases of the alternative pathway, or by amplifying deposition of ... pneumoniae and accelerate activation of the alternative pathway of complement, as measured by C3 and C9 deposition. This is the ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3028849/?lang=en-ca
*  Complement C3-C5 Convertases - C3 Convertase Summary Report | CureHunter
These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. ... Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A ... Complement 5 Convertase; Complement C3 Convertases; Complement C5 Convertases; Activator, C3; C3 Convertases, Complement; C3-C5 ... Convertase, C3; Convertase, C3-C5; Convertase, Complement 3; Convertases, Complement C3; Convertases, Complement C3-C5; ...
http://www.curehunter.com/public/keywordSummaryD050577-Complement-C3-C5-Convertases-C3-Convertase.do
*  An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae |...
The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132. ... Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation. Infect. Immun. 55: 174-180. ... Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement. J. Biol. Chem. 259: ... B, Serum P binds to Neisseriae in the presence of the alternative pathway of complement. P binding to unencapsulated N. ...
http://www.jimmunol.org/content/185/1/507.long
*  Barraquer-Simons syndrome - Wikipedia
C3 nephritic factor is a serum immunoglobulin G that interacts with the C3bBb alternative pathway convertase to activate C3. C3 ... due to complement activation and consumption of C3). Low C3 levels may impair complement-mediated phagocytosis and bacterial ... Around 83% of APL patients had low complement 3 (C3) levels and the presence of polyclonal immunoglobulin C3 nephritic factor. ... Lipodystrophy is often associated with glomerulonephritis, low C3 serum complement levels, and the presence of a C3 nephritic ...
https://en.wikipedia.org/wiki/Barraquer%E2%80%93Simons_syndrome
*  Alternative-complement-pathway C3/C5 convertase - Wikipedia
Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme ... C5 convertase, (C3b)n,Bb, complement C 3(C 5) convertase (amplification), alternative complement pathway C3(C5) convertase, C5 ... Alternative-complement-pathway C3/C5 convertase at the US National Library of Medicine Medical Subject Headings (MeSH) ... Alternative complement pathway Kerr, M.A. (1981). "Human factor B". Methods Enzymol. 80: 102-112. doi:10.1016/s0076-6879(81) ...
https://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase
*  Natural pattern recognition mechanisms at epithelial barriers and potential use in nanomedicine : European Journal of...
The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J Biol Chem 2006;281:2128-32. ... and the alternative pathway (Figure 2). All pathways converge in the activation of a C3 convertase, a serine protease that is ... Both the classical and the lectin pathway result in the formation of the C4bC2a C3-convertase. Right: the alternative pathway ... In the bloodstream C3 is hydrolyzed at low but constant rate promoting the formation of the C3 convertase C3H2O Bb.The ...
https://www.degruyter.com/view/j/ejnm.2014.6.issue-3/ejnm-2014-0020/ejnm-2014-0020.xml
*  Properdin - Wikipedia
Hourcade D (2006). "The Role of Properdin in the Assembly of the Alternative Pathway C3 Convertases of Complement". J Biol Chem ... It binds to preformed alternative pathway C3-convertases. Properdin also inhibits the Factor H - mediated cleavage of C3b by ... or Factor P is the only known positive regulator of complement activation that stabilizes the alternative pathway convertases. ... The alternative pathway is not dependent on antibodies. This branch of the complement system is activated by IgA immune ...
https://en.wikipedia.org/wiki/Properdin
*  Eosinophil colony-stimulating factor | definition of eosinophil colony-stimulating factor by Medical dictionary
C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases. ... enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases. ...
https://medical-dictionary.thefreedictionary.com/eosinophil+colony-stimulating+factor
*  Progressive Lipodystrophy: Background, Pathophysiology, Etiology
C3 nephritic factor is a serum immunoglobulin G that interacts with the C3bBb alternative pathway convertase to activate C3. ... Adipocytes synthesize factor D, the limiting component of the alternative complement pathway, which cleaves C3-bound factor B ... Adipocytes synthesize factor D, the limiting component of the alternative complement pathway, which cleaves C3-bound factor B ... prevents the alternative complement C3-convertase C3Bb from dissociative inactivation, resulting in adipocyte lysis. ...
https://emedicine.medscape.com/article/1082489-overview
*  Neutrophils and Immunity: From Bactericidal Action to Being Conquered
"Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal ... "Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases," Nature Immunology, vol. 6, no. 9, pp. 920 ... "Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion," The Journal of Immunology, ... "Convertase inhibitory properties of staphylococcal extracellular complement-binding protein," Journal of Biological Chemistry, ...
https://www.hindawi.com/journals/jir/2017/9671604/ref/
*  Complement factor B - Wikipedia
... components of the alternative-pathway C3 convertase of complement". The Biochemical Journal. 253 (3): 667-75. PMC 1149358 . ... The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is ... This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in ... Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the ...
https://en.wikipedia.org/wiki/Complement_factor_B
*  Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen...
Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous ... Complement factor D (Df) then cleaves factor B into fragments Ba and Bb with formation of the AP initiation C3 convertase C3(H2 ... Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody- ... generating the same C3 convertase as the CP. The AP is activated by low-grade spontaneous hydrolysis of C3 in plasma to form C3 ...
http://www.jimmunol.org/content/197/9/3680
*  B cell stimulatory factor II | definition of B cell stimulatory factor II by Medical dictionary
C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases. ... enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases. ...
http://medical-dictionary.thefreedictionary.com/B+cell+stimulatory+factor+II
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Further experiments revealed that TRX regulated the alternative complement pathway by inhibiting C3 convertase activity and ... These new findings indicated that S. zooepidemicus used SzP to recruit TRX and regulated the alternative complement pathways to ... To reduce the CO2 emission derived from dung use, the proportion of dung combustion should be reduced and alternative renewable ... TRX inhibited C3 deposition on the bacterial surface when it was recruited by SzP. ...
https://www.jove.com/visualize?author=Junxi+Wu
*  Acquired Partial Lipodystrophy: Background, Pathophysiology, Epidemiology
Adipocytes synthesize factor D, the limiting component of the alternative complement pathway, which cleaves C3-bound factor B ... prevents the alternative complement C3-convertase C3Bb from dissociative inactivation, resulting in adipocyte lysis. ... due to complement activation and consumption of C3). Low C3 levels may impair complement-mediated phagocytosis and bacterial ... in which subendothelial deposits of immunoglobulin and C3 are probably due to a deregulated alternative complement pathway. ...
https://emedicine.medscape.com/article/123039-overview
*  Tissue factor | definition of tissue factor by Medical dictionary
C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases. ... factor H a complement system regulatory protein that inhibits the alternative pathway of complement activation. ... factor B a complement component that participates in the alternative complement pathway. ...
https://medical-dictionary.thefreedictionary.com/tissue+factor
*  List of EC numbers (EC 3) - Wikipedia
... complement factor I EC 3.4.21.46: complement factor D EC 3.4.21.47: alternative-complement-pathway C3/C5 convertase EC 3.4. ... classical-complement-pathway C3/C5 convertase EC 3.4.21.44: Transferred entry: complement component C5 convertase. Now EC 3.4. ... 21.43, classical-complement-pathway C3/C5 convertase EC 3.4.21.45: ... Proprotein convertase 1 EC 3.4.21.94: Proprotein convertase 2 EC 3.4.21.95: Snake venom factor V activator EC 3.4.21.96: ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_3)
*  Complement component 3 - Wikipedia
In the alternative complement pathway, C3 is cleaved by C3bBb, another form of C3-convertase composed of activated forms of C3 ... The resultant complex, C3bBb, is called the alternative pathway (AP) C3 convertase. C3bBb is deactivated in steps. First, the ... Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are ... "Entrez Gene: C3 complement component 3". Sahu A, Lambris JD (Apr 2001). "Structure and biology of complement protein C3, a ...
https://en.wikipedia.org/wiki/Complement_component_3
*  Genome-wide association study - Wikipedia
... a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases". Blood ... A suggested alternative to linkage studies was the genetic association study. This study type asks if the allele of a genetic ... A common alternative to case-control GWA studies is the analysis of quantitative phenotypic data, e.g. height or biomarker ... An alternative application is therefore the potential for GWA studies to elucidate pathophysiology. One such success is related ...
https://en.wikipedia.org/wiki/Genome-wide_association_study
*  Factor H (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)
... and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement ... Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation ... Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in ... Zipfel PF, et al. (2008) The complement fitness factor H: role in human diseases and for immune escape of pathogens, like ...
http://cn.sinobiological.com/Complement-Factor-H-Protein-Antibody-a-1140.html
*  AID 334193 - Inhibition of alternative complement pathway activation by complement modulation test - PubChem
BioAssay record AID 334193 submitted by ChEMBL: Inhibition of alternative complement pathway activation by complement modulation test.
https://pubchem.ncbi.nlm.nih.gov/bioassay/334193