Table of contents | Archives of Disease in Childhood
Zonal Colonic Aganglionosis, a Variant of Hirschsprungs Disease (1 April, 1972) Free A. G. MacIver, R. Whitehead ... Coeliac disease. Some still controversial aspects. (1 April, 1972) Free C M Anderson, M Gracey, V Burke ... Coeliac Disease and IgA Deficiency (1 April, 1972) Free E. Savilahti, P. Pelkonen, J. K. Visakorpi ... Neuronal Ceroid Lipofuscinosis (Battens Disease) (1 April, 1972) Free N. S. Gordon, H. B. Marsden, M. J. Noronha ...
Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease | Journal of Clinical Pathology
Background: Colonic diverticular disease (diverticulosis) is a common disorder in Western countries. Although its pathogenesis ... Conclusions: Interstitial cells of Cajal and glial cells are decreased in colonic diverticular disease, whereas enteric ... Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease ... Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease ...
Colonic wall thickness, pancreatic enzyme dose and type of preparation in cystic fibrosis | Archives of Disease in Childhood
Apart from one patient with a possible early colonic stricture, we found no evidence of subclinical disease in CF patients ... Colonic wall thickness of a control group was also measured. The average thickness in all colonic regions was higher in the CF ... 1995) Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes [letter]. Lancet 345:499-500. ... 1996) Colonic wall thickening is related to age and not to the use of high strength pancreatin preparations in cystic fibrosis. ...
Pathology reports solve "new bowel disease" riddle | The BMJ
"The increase of colonic lymphoid aggregates found in severely constipated patients may represent a protective mucosal mechanism ... MMR and bowel disease-how events unfurled *. 1997-8: After broadly normal results from the Royal Free hospital pathology ... "They had to create a new disease, and when Susan Davies got normal results they were in trouble," argues Tom MacDonald, a ... Pathology reports solve "new bowel disease" riddle BMJ 2011; 343 :d6823 doi:10.1136/bmj.d6823 ...
Strictures in Crohn's disease are characterised by an accumulation of mast cells colocalised with laminin but not with...
Distribution of mast cells in the muscularis propria in colonic strictures in Crohns disease. (A) Mast cells are shown by ... Numbers of mast cells in colonic strictures in Crohns disease compared with normal colon. Mast cells were detected by staining ... Deposition of fibronectin and vitronectin in the muscularis propria in colonic strictures in Crohns disease. (A) Fibronectin ( ... 1995) Pathogenesis of intestinal strictures in Crohns disease: an update. Inflammatory Bowel Disease 1:220-227. ...
Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial...
A decrease in expression of DEFB1 has been shown in colonic Crohns disease, but not in UC.33 Using larger cohorts of patients ... Assessment of disease activity. Clinical and histological disease activity was assessed using the total Mayo score,16 and the ... The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis. ... Ulcerative colitis (UC) is an idiopathic chronic disease of the colon characterised by periods of active disease followed by ...
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative...
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative ... Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative ...
Efficacy of etanercept for treatment of Crohn's related spondyloarthritis but not colitis | Annals of the Rheumatic Diseases
... had a diagnosis of juvenile HLA-B27 positive ankylosing spondylitis and a subsequent diagnosis of colonic Crohns disease. He ... A short-term study of chimeric monoclonal antibody cA2 to tumour necrosis factor alpha for Crohns disease. Crohns disease cA2 ... Sandborn WJ, Hanauer SB, Katz S, Safdi M, Wolf DG, Baerg RD, et al. Etanercept for active Crohns disease: a randomised, double ... Patient 1, a 27 year old HLA-B27 positive man, had a 10 year history of large bowel Crohns disease (fig 1) which had been ...
A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease |...
2 The risk of developing a fistula depends on disease location, being most frequent in colonic disease with rectal involvement. ... Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohns disease. Clin Imaging 2011;35:360-5. ... Usual therapy improves perianal Crohns disease as measured by a new disease activity index. McMaster IBD Study Group. J Clin ... MRI provides additional detailed information on luminal disease location, disease severity, and fluid collections. ...
Increased expression of interleukin 17 in inflammatory bowel disease | Gut
Results: IL-17 expression was not detected in samples from normal colonic mucosa, infectious colitis, or ischaemic colitis. In ... Crohns disease (CD) (n=20), infectious colitis (n=5), ischaemic colitis (n=8), and normal colorectal tissues (n=15). IL-17 ... we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease ( ...
Long-term risk of cardiovascular and cerebrovascular disease after removal of the colonic microbiota by colectomy: a cohort...
... chronic ischaemic heart disease, cardiac arrhythmias, heart failure, cerebrovascular diseases and other arterial diseases) and ... Inflammatory bowel disease and risk of coronary heart disease. Trends Cardiovasc Med 2015;25:699-704. doi:10.1016/j.tcm.2015.03 ... Risk of cardiovascular disease in inflammatory bowel disease. World J Gastrointest Pathophysiol 2014;5:359-65. doi:10.4291/wjgp ... Long-term risk of cardiovascular and cerebrovascular disease after removal of the colonic microbiota by colectomy: a cohort ...
Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary | Gut
The PUCAI correlates well with endoscopic appearance of the colonic mucosa with a concordance of ~80%.17 For benchmarking the ... In Crohns disease (CD), baseline disease activity should include ileocolonoscopy for drugs of new categories (using the Simple ... Crohns disease. Multi-item measures of disease activity, a concept incorporating symptoms, signs and biomarkers, have, until ... Narrow eligibility criteria regarding age, disease severity, disease location or previous treatments will present additional ...
A prospective study of colonoscopy practice in the UK today: are we adequately prepared for national colorectal cancer...
Approximately two thirds of colonic disease is within reach of a 60 cm flexible sigmoidoscope and many diagnoses are within ... followed by diverticular disease (14.9%). Inflammatory bowel disease was recorded in 13.9% and carcinoma in 3.8%. Only half of ... followed by diverticular disease (14.9%). Inflammatory bowel disease was recorded in 13.9% and carcinoma in 3.8%. ... diverticular disease 1053/1376 (76.5%), and inflammatory bowel disease 1010/1285 (78.6%). The proportion of normal examinations ...
Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate...
Khoo UY, Bjarnason I, Donaghy A, et al. Antibodies to colonic epithelial cells from the serum and colonic washings in ... Snook JA, Lowes JR, Wu KC, et al. Serum and tissue autoantibodies to colonic epithelium in ulcerative colitis. Gut1991;32:163-6 ... Sadlack B, Merz H, Schorle H. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell1993;75:253-61. ... Three of the nine patients were women and the group had an mean age of 59 years (range 49-90). Mean duration of disease was 8.4 ...
Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse...
... is it the coexistence of colonic diverticulosis and inflammatory bowel disease?. Ann Gastroenterol. 2017;30:257-261. 5411375. ... Restaging imaging at that point revealed stable disease on ipilimumab. She had been off ICI for 8 weeks due to irEC and it was ... Restaging scans were obtained at the time and showed ongoing progression of disease burden in the abdomen. The severity of his ... Subsequently she was treated with pembrolizumab for a total of 5 months without adverse events but then stopped due to disease ...
PTH-126 Azathioprine, steroids and the presence of inflammatory bowel disease before liver transplantation influence transplant...
Crohns disease, indeterminate colitis), duration from diagnosis and colonic extent, IBD activity in the last 5 years, IBD ... Data was collected retrospectively and Cox-regression analysis was used to evaluate factors known to affect disease severity: ... Introduction Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease, progressive in the majority of cases ... 246 (67%) were diagnosed with IBD: 208 ulcerative colitis, 30 Crohns disease, 8 indeterminate colitis. 20 had colon cancer, 13 ...
Does Mycobacterium avium subspecies paratuberculosis cause Crohn's disease? | Gut
... more commonly detected in colonic than ileal disease and was not more frequently found in early onset or stricturing disease.12 ... Crohns disease and the mycobacterioses: a review and comparison of two disease entities. Clin Microbiol Rev1989;2:90-117. ... Is Crohns disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johnes disease. Lancet Infect Dis ... Crohns disease certainly has environmental and host genetic influences that interact to cause clinically evident disease. It ...
Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis? ...
... and inflammatory bowel disease were excluded. ... 1967) Histopathology of the large colonic polyp. Dis Colon ... Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis? ... Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis? ...
Effects of probiotics on atopic dermatitis: a randomised controlled trial | Archives of Disease in Childhood
... there has been growing speculation that normal human immune development may have been affected by alterations in colonic flora ... Archives of Disease in Childhood 2005; 90 881-882 Published Online First: 19 Aug 2005. doi: 10.1136/adc.2005.073114 ... Although the children in our study were recruited from the general community, they had more severe disease compared to the two ... Children with AD are also at increased risk (up to 80%) of developing persistent respiratory tract disease (allergic rhinitis ...
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in...
... mast cells and colonic endothelial cells respectively. Briefly, total RNA from cells and colonic specimens was extracted using ... Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol 2010;10:103-10. ... In contrast, disease severity in irradiated wild-type mice that were reconstituted with bone marrow cells from St2−/− (KO→WT) ... Consistently, the colonic mucosa of St2-deficient mice showed lowered production of KC (figure 3D) as compared with their WT ...
Histological and molecular diversity and heterogeneity of precancerous lesions associated with inflammatory bowel diseases |...
... and analysed for a key panel of colonic cancer-related molecular markers. ... Aims Inflammatory bowel disease (IBD)-associated precancerous lesions may be adenomatous or non-adenomatous with various ... Histological and molecular diversity and heterogeneity of precancerous lesions associated with inflammatory bowel diseases ... Histological and molecular diversity and heterogeneity of precancerous lesions associated with inflammatory bowel diseases ...
Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease? | World...
Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease? ... Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease? ...
Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. | The BMJ
The intake of anti-inflammatory drugs by 268 patients with colonic or small bowel perforation or haemorrhage was compared with ... The association between complicated lower bowel disease and intake of anti-inflammatory drugs may be causal. ... that by a group of patients, matched for age and sex, with uncomplicated lower bowel disease. Patients with perforation or ...
Richard Lehman's journal review-11 January 2016 - The BMJ
... ileal Crohns disease, colonic Crohns disease, and ulcerative colitis) than by Crohns disease and ulcerative colitis as ... Disease location is an intrinsic aspect of a patients disease, in part genetically determined, and the major driver to changes ... were associated with subphenotypes of inflammatory bowel disease, mainly disease location (essentially fixed over time; median ... Globulin for graft v host disease. 43 The NEJM has printed a lot of strangely worded abstract conclusions so far this year. ...
Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative...
INFLAMMATORY BOWEL DISEASE. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non ... Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative ... Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative ... by a significant increase in the proliferating cell nuclear antigen labelling index of the CD44 cells of the colonic mucosa (p= ...
015 Gut microbiota and nutritional profiles of Parkinson's disease patients | BMJ Neurology Open
... the limited literature indicates a reduction in short-chain fatty-acid-producing bacteria that negatively influence colonic ... Objectives Imbalances in the composition of the gut microbiome (GM) from Parkinsons disease (PD) patients have been reported ...
Positioning intestinal ultrasound in a UK tertiary centre: significant estimated clinical role and cost savings | Frontline...
... and isolated colonic (n=6) inflammation. In one case of a new diagnosis of Crohns being investigated for small bowel disease ... Diagnostic delay in Crohns disease is associated with a complicated disease course and increased operation rate. Am J ... Ultrasound use to assess Crohns disease in the UK: a survey of British Society of gastroenterology inflammatory bowel disease ... Gastrointestinal ultrasound in inflammatory bowel disease care: patient perceptions and impact on disease-related knowledge. ...
1930 A joint MDT clinic may improve adherence to surgery in adolescents and young adults (AYA) with refractory to medical...
Objectives IBD is a chronic inflammatory disease of the GI tract which in 25% of cases presents in the paediatric age group and ... The majority of patients (7 with UC and 18 with refractory colonic and perianal Crohns) would need to have a potentially ... 7 (18%) had refractory ulcerative colitis and the rest had refractory Crohns disease. ... nature and phenotype of their disease and the rationale and details of the recommended surgery. The CNS connects them with ...
Table of contents | Gut
Simplified method for the measurement of segmental colonic transit time. (1 July, 1994) A Notghi, R Hutchinson, D Kumar, N B ... Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. (1 July, 1994) A Theodossi, D J ... Secretion of urokinase and plasminogen activator inhibitor-1 by normal colonic epithelium in vitro. (1 July, 1994) P Gibson, O ... Lymphocyte and macrophage interleukin receptors in inflammatory bowel disease: a more selective target for therapy? (1 July, ...
XIAP deficiency is a mendelian cause of late-onset IBD | Gut
Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease. ... recurrent colonic strictures, severe perianal fistulas as well as pancolitis and ulcerations affecting stomach and small bowel ... coeliac-like disease with blunted villi, lymphocytic infiltrates, but without coeliac disease-associated antibodies. This may ... In six out of seven patients, CD was the chief complaint at onset of disease and only one patient had previously experienced ...