TY - JOUR. T1 - Modulation of forskolin binding to rat brain membranes. AU - Seamon, K. B.. AU - Vaillancourt, R.. AU - Daly, J. W.. PY - 1985/12/1. Y1 - 1985/12/1. N2 - High affinity binding sites for [3H]forskolin have been identified in rat brain membranes. These sites have a K(d) of 15 nM and a B(max) of about 200 fmol/mg protein. The binding of [3H]forskolin to those high affinity sites in rat brain membranes is increased about two-fold by addition of MgCl2 or MnCl2. Smaller increases are observed in the presence of calcium, sodium, or potassium. The binding of [3H]forskolin is also increased in the presence of NaF or GppNHp, agents that are known to activate adenylate cyclase through the stimulatory guanine nucleotide regulatory protein (N(s)). The increase in [3H]forskolin binding in the presence of NaF or GppNHp is due to an increase in the number of binding sites with no change in the apparent K(d) for the binding sites. The NaF- and GppNHp-stimulated binding ...
Bonow, R. O., Brown, A. S., Gillam, L. D., Kapadia, S. R., Kavinsky, C. J., Lindman, B. R., Mack, M. J., Thourani, V. H., Dehmer, G. J., Beaver, T. M., Bradley, S. M., Carabello, B. A., Desai, M. Y., George, I., Green, P., Holmes, D. R., Johnston, D., Leipsic, J., Mick, S. L., Passeri, J. J. & 22 othersPiana, R. N., Reichek, N., Ruiz, C. E., Taub, C. C., Thomas, J. D., Turi, Z. G., Doherty, J. U., Bailey, S. R., Bhave, N. M., Daugherty, S. L., Dean, L. S., Duvernoy, C. S., Hendel, R. C., Kramer, C. M., Lindsay, B. D., Manning, W. J., Mehrotra, P., Patel, M. R., Sachdeva, R., Wann, L. S., Winchester, D. E. & Allen, J. M., Feb 1 2018, In : European Journal of Cardio-thoracic Surgery. 53, 2, p. 306-308 3 p., ezx410.. Research output: Contribution to journal › Article ...
TY - JOUR. T1 - The in vitro activation of cyclic AMP production by either forskolin or isoproterenol in the syrian hamster pineal during the day is not accompanied by an increase in melatonin production. AU - Santana, Celsa. AU - Guerrero, Juan M.. AU - Reiter, Russel J. AU - Troiani, Maureen E.. PY - 1988/12/30. Y1 - 1988/12/30. N2 - The role of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Forskolin markedly increased cyclic AMP production in pineal glands collected either late in the light period or in the dark period. The effect of forskolin was synergistically enhanced by 3-isobutylmethylxanthine, a phosphodiesterase inhibitor; however, increase in cyclic AMP after isoproterenol was only apparent in the presence of 3-isobutylmethylxanthine. Since β-adrenergic agonists are able to stimulate melatonin production late ...
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Two other antibiotics, ledipasvir and colforsin, were chosen as test pharmaceutical compounds. Pharmacokinetics in single bolus ...
Colforsin (INN) is a water-soluble derivative of forskolin. Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yokoyama M ( ...
Room 309, 10/16/2000 2: 00 PM - 3: 30 PM (PD) Intraveous Colforsin Daropate Prevents Thiamylal-Fentanyl-Induced ... Room 309, 10/16/2000 2: 00 PM - 3: 30 PM (PD) Intraveous Colforsin Daropate Prevents Thiamylal-Fentanyl-Induced ... Room 309, 10/16/2000 2: 00 PM - 3: 30 PM (PD) Intraveous Colforsin Daropate Prevents Thiamylal-Fentanyl-Induced ... Intraveous Colforsin Daropate Prevents Thiamylal-Fentanyl-Induced Bronchoconstriction : A-1344. Anesthesiology 2000;93(3A):A- ...
"Colforsin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Colforsin" by people in this website by year, and whether " ... Below are the most recent publications written about "Colforsin" by people in Profiles. ...
Colforsin*Colforsin. *N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1- ... "Colforsin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Colforsin" by people in this website by year, and whether " ... Below are the most recent publications written about "Colforsin" by people in Profiles. ...
... comprising colforsin daropate. Advantageous Effects [0012] The pharmaceutical composition including colforsin daropate ... commercially available colforsin daropate may be used. In the present invention, a precursor of colforsin daropate, forskolin ... Test of Bone Density-Improving Effect of Colforsin in Laboratory Animal [0050] Many studies have been made in order to ... 0044] As a result, colforsin daropate showed no cytotoxicity at the active concentration (FIG. 1). EXAMPLE 2 Osteoclast ...
ANTIINFLAMMATORY EFFECT OF COLFORSIN DAROPATE HYDROCHLORIDE AFTER CARDIOPULMONARY BYPASS. Hayashida, N.; Chihara, S.; Tayama, E ...
Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. In: ... Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. / Suzuki, ... Suzuki S, Ito O, Sayama T, Goto K. Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after aneurysmal ... Suzuki, S, Ito, O, Sayama, T & Goto, K 2010, Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after ...
Colforsin / pharmacology * Cyclic AMP / analogs & derivatives * Cyclic AMP-Dependent Protein Kinases / physiology* ...
Colforsin / pharmacology * In Vitro Techniques * Isoproterenol / pharmacology * Kinetics * Norepinephrine / pharmacology * ...
DB02587. Colforsin. Polymorphism and mutation databases. BioMuta curated single-nucleotide variation and disease association ...
Intravenous colforsin daropate, a water-soluble forskolin derivative, prevents thiamylal-fentanyl-induced bronchoconstriction ...
Topical forskolin (colforsin) and aqueous flow in humans. Arch Ophthalmol 1987;105:637-41. View abstract. ... Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76 ... Antiinflammatory effects of colforsin daropate hydrochloride, a novel water-soluble forskolin derivative. Ann Thorac.Surg. 2001 ... Colforsin, Colforsine, Forskohlii, Forskolin, Forskolina, Forskoline, HL-362, L-75-1362B, Plectranthus barbatus.,br/,,br/, ...
0 (Fusion Regulatory Protein 1, Heavy Chain); 0 (Large Neutral Amino Acid-Transporter 1); 1F7A44V6OU (Colforsin). ...
Colforsin daropate hydrochloride View Synonyms. View Structure. Description:. Acts as direct activator of adenyl cyclase; ...
Colforsin. The serum concentration of Umeclidinium can be increased when it is combined with Colforsin.. Experimental, ...
7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one; Coleonol; Colforsin ...
Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after ... ... Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated ... vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin ...
Colforsin (Forskolin) Colforsin (Forskolin, Coleonol, Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) ...
Colforsin (Forskolin) Colforsin (Forskolin, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide ...
Suzuki S, Ito O, Sayama T, Goto K. Intra-arterial colforsin daropate for the treatment of cerebral vasospasm after aneurysmal ...
Colforsin dapropate hydrochloride multiple interactions. ISO. RGD:68944. 6480464. Mibefradil inhibits the reaction [[Colforsin ... Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I ... Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of ... Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of ...
Colforsin (pharmacology) *Cyclic AMP (metabolism) *Glucocorticoids (pharmacology) *Nerve Growth Factors (pharmacology) * ...
Colforsin (pharmacology) *Cricetinae. *Cyclic AMP (metabolism, pharmacology) *Electrophoresis, Polyacrylamide Gel. *Embryo, ...
colforsin ( 3 ) References. 1 Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer ...
colforsin ( 2 ) References. 1 Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular ...
studied the effects of dry colforsin powder in 16 asthmatics. Colforsin or forskolin is a derivative of Coleus forskholii. ... colforsin. The dry powdered colforsin (forskolin) showed measurable bronchodilation in asthmatics by elevated FEV-1 values. ... After 30 min, colforsin showed 16 - 2% changes in FEV, as compared to fenoterol MDI and capsules (29 - 3% and 30 - 3%, ... Colforsin capsule and placebo-treated groups experienced less severe side effects. A decrease in potassium levels was noted ...
1993) Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin. Pharmacol. Ther. ...
Sometimes its also referred to as Colforsin; 7-beta-acetoxy-8, 13-epoxy-1-alpha, 6-beta, 9-alpha-trihydroxylabd-14-en-11-one; ...