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*  Nonsense-Mediated Decay of ash1 Nonsense Transcripts in Saccharomyces cerevisiae | Genetics
Effects of nonsense and missense mutations on ASH1 mRNA localization. (A) Nonsense codons affect the intracellular distribution ... The nonsense codons created by base substitution were followed by an A residue, which results in optimal translation ... Nonsense-Mediated Decay of ash1 Nonsense Transcripts in Saccharomyces cerevisiae. Wei Zheng, Jonathan S. Finkel, Sharon M. ... Nonsense-Mediated Decay of ash1 Nonsense Transcripts in Saccharomyces cerevisiae. Wei Zheng, Jonathan S. Finkel, Sharon M. ...
http://www.genetics.org/content/180/3/1391.long
*  Plus it
2000) Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103:1121 ... Several GABAAreceptor subunit missense and nonsense premature translation-termination codon (PTC)-generating mutations have ... and the nonsense stop codon caused by the α1 subunit mutation, 975delC, S326fs328X, is located at the middle of exon 8 (Bb). An ... 1Ba,b). The stop codon for the wild-type α1 subunit minigene is located at the end of exon 9 (Fig. 1Ba), and the PTC for the ...
http://www.jneurosci.org/content/29/9/2833
*  Mutation at Tyrosine in AMLRY (GILRY Like) Motif of Yeast eRF1 on Nonsense Codons Suppression and Binding Affinity to eRF3 ...
The stop codons suppression of the mutant was analyzed in vivo using PGK-stop codon-LACZ gene fusion and showed that the ... Mutation at Tyrosine in AMLRY (GILRY Like) Motif of Yeast eRF1 on Nonsense Codons Suppression and Binding Affinity to eRF3 ... Keywords: eRF1, eRF3, Saccharomyces cerevisiae, termination translation, nonsense codon suppression, binding affinity ... The suppression on UAG codon was the highest increased among the stop codons by comparing the suppression of the wild type ...
http://www.ijbs.com/v04p0087
*  Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open...
In addition to triggering nonsense-mediated mRNA decay (NMD), premature translation-termination codons (PTCs) frequently induce ... Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open ... Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open ... NAS is induced because the nonsense mutation alters a splicing signal, such as inactivating an exonic splicing enhancer. ...
http://edoc.unibas.ch/1615/
*  The Impact of Selection at the Amino Acid Level on the Usage of Synonymous Codons | G3: Genes | Genomes | Genetics
... codon usage can also result from selection for translational accuracy to reduce the costs of both missense and nonsense errors ... This model is expounded by a codon to codon transition probability matrix Furthermore, every codon to codon substitution is ... is the observed frequency of a 4FD codon si with a nucleotide i at the third codon position, and is the frequency of all codons ... for the Thr, Pro and Ala codons increases with A+G frequency, whereas for the Gly codons decreases. This measure for Val codons ...
http://www.g3journal.org/content/7/3/967
*  British Library EThOS: Post-transcriptional regulation of gene expression by the (PSI) prion of Saccharomyces cerevisiae
The efficiency of stop codon recognition by eRF1 is influenced by the surrounding nucleotide context of the stop codon, and in ... eRF3 in the [PSI+], prion state forms insoluble high molecular weight aggregates that cause inefficient termination (nonsense ... Consistent with this hypothesis, the [PSI+] state was found to enhance suppression of all stop codons, with those in weak ... PSI] is thus a context sensitive suppressor of all three stop codons. Using computer screening, yeast genes whose open reading ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395144
*  New functions in translation termination uncovered for NMD factor UPF3B | The EMBO Journal
Nonsense‐mediated mRNA decay (NMD) is a cellular surveillance pathway recognizing and degrading mRNAs that fail to terminate ... However, at which termination codons (TCs) and under which circumstances NMD is triggered, and how normal translation ... Despite a wealth of biochemical data, the mechanism by which targets of the nonsense‐mediated mRNA decay (NMD) pathway are ... Ribosomal occupancy at the termination codon can be visualized at single nucleotide resolution by the toeprinting technique, ...
http://emboj.embopress.org/content/36/20/2928
*  Nonsense Codon - Nonsense Mutation Summary Report | CureHunter
A nonsense mutation is one that converts an amino acid-specific codon to a stop codon. ... An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is ... Nonsense Codon, Ochre; Nonsense Codon, Opal; Nonsense Codons; Nonsense Codons, Amber; Nonsense Codons, Ochre; Nonsense Codons, ... Unassigned Codon; Codon, Nonsense; Amber Nonsense Codon; Amber Nonsense Mutation; Nonsense Codon, Amber; Ochre Nonsense Codon; ...
http://www.curehunter.com/public/keywordSummaryD018389-Nonsense-Codon-Nonsense-Mutation.do
*  A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation | Disease...
The katun mutation introduces a nonsense codon into the Zic3 transcript that conforms to the rule for PTC recognition in ... 1998). A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends ... A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation ... A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation ...
http://dmm.biologists.org/content/6/3/755
*  Messenger RNA Transcripts of the Hepatocyte Nuclear Factor-1α Gene Containing Premature Termination Codons Are Subject to...
... are nonsense or frameshift and lead to the production of premature termination codons (PTCs) (4). The most common HNF-1α ... The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons. Hum Mol ... PTC, premature termination codon. Maturity-onset diabetes of the young (MODY) is a subtype of diabetes characterized by early ... The nonsense mutations R171X, I414G415ATCG→CCA, and P291fsinsC showed reduced mutant mRNA expression to 40% (P = 0.009), ,0.01 ...
http://diabetes.diabetesjournals.org/content/53/2/500
*  What Is the Difference Between Replication and Transcription? | Reference.com
What Is the Function of Nonsense Codon?. A: A nonsense codon has the effect of prematurely stopping the transcription of RNA or ...
https://www.reference.com/education/difference-between-replication-transcription-708162c4db5645b9
*  What are some characteristics of Codon? | Reference.com
A codon is a series of three nucleotides used to specify a specific an amino acid. These nucleotides are labeled with G, C, and ... What is the function of nonsense codon?. A: A nonsense codon has the effect of prematurely stopping the transcription of RNA or ... The nucleotides found in codons determine what purpose that codon has in the DNA or RNA sequence. Each codon indicates which ... What is a codon and what does it represent?. A: A codon is a set of three nucleotides that code for an amino acid or act as a ...
https://www.reference.com/science/characteristics-codon-872169ece61a7826
*  A conserved role for cytoplasmic poly(A)‐binding protein 1 (PABPC1) in nonsense‐mediated mRNA decay | The EMBO Journal
Position effects of nonsense codons in D. melanogaster. To gain further insights into the mechanism of PTC recognition in D. ... Nagy E, Maquat LE (1998) A rule for termination‐codon position within intron‐containing genes: when nonsense affects RNA ... The 50 nt boundary rule is not absolute and in some mRNAs the spacing between the nonsense codon and the boundary can be ... The ability of a nonsense codon to trigger mRNA degradation is modulated by changing its distance to the 3′ UTR. The positional ...
http://emboj.embopress.org/content/26/6/1591
*  Hemoglobinopathy Flashcards by Victor Redmon | Brainscape
Translation errors (frameshift or nonsense codons). *Gene deletion rare. 42 How are β thalassemias classified? ...
https://www.brainscape.com/flashcards/hemoglobinopathy-3100327/packs/4897288
*  Suppression of nonsense mutations in cell culture and mice by multimerized suppressor tRNA genes. - Semantic Scholar
... for tRNA suppression employed as gene therapy for nonsense defects. ... We demonstrate here the first experimental suppression of a premature termination codon in vivo by using an ochre suppressor ... Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons. Zixian Lu ... Therapeutics based on stop codon readthrough.. Kim M. Keeling, Xiaojiao Xue, Gwen Gunn, David M. Bedwell ...
https://www.semanticscholar.org/paper/Suppression-of-nonsense-mutations-in-cell-culture-Buvoli-Buvoli/5e0e3931c6da6e1932086c99510efdb6ca7bd94e
*  Emerging Drugs for Duchenne Muscular Dystrophy - CADTH Issues in Emerging Health Technologies - NCBI Bookshelf
... nonsense mutation suppression), eteplirsen (exon 51 skipping), and idebenone (adenosine triphosphate [ATP] modulation). ... Stop-Codon Read-Through Nonsense Suppression Therapy. This treatment is applicable to approximately 10% to 15% of males with ... Ataluren's mechanism selects only premature stop codons; it does not interfere with normal stop codons.15 ... It is indicated for the treatment of DMD in ambulatory patients five years and older with nonsense mutations.10 In Canada, the ...
https://www.ncbi.nlm.nih.gov/books/NBK476440/
*  mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans - Semantic Scholar
... not to mistranslation of the nonsense codons. mRNA surveillance, therefore, may mitigate potentially deleterious effects of ... the dominant-negative effects of nonsense alleles are likely to be due to expression of N-terminal nonsense-fragment ... animals can influence the phenotypic effects of heterozygous nonsense mutations. Certain nonsense alleles of a muscle myosin ... In Smg(+) genetic backgrounds, nonsense-mutant mRNAs are unstable, while in Smg(−) backgrounds such mRNAs are stable. Previous ...
https://www.semanticscholar.org/paper/mRNA-surveillance-mitigates-genetic-dominance-in-Cal%C3%AC-Anderson/c8b6e3f0a7d5eca1fad1fa631d21f16ff9976ffb
*  IthaGenes
Nonsense codon (Translation) Ethnic Origin:. Chinese, Japanese. Inheritance: Recessive. DNA Sequence Determined:. Yes. ... Chang JC, Kan YW, beta 0 thalassemia, a nonsense mutation in man., Proceedings of the National Academy of Sciences of the ...
https://ithanet.eu/db/ithagenes?ithaID=77
*  Effect of UPF1 overexpression on cwp gene expression.(A | Open-i
Messenger RNAs containing premature stop codons are rapidly degraded by a nonsense-mediated mRNA decay (NMD) system to avoid ... Messenger RNAs containing premature stop codons are rapidly degraded by a nonsense-mediated mRNA decay (NMD) system to avoid ... UPF1, a conserved nonsense-mediated mRNA decay factor, regulates cyst wall protein transcripts in Giardia lamblia. ... UPF1, a conserved nonsense-mediated mRNA decay factor, regulates cyst wall protein transcripts in Giardia lamblia. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2572189_pone.0003609.g004&req=4
*  Non parametric linkage analysis reveals a maximum LOD s | Open-i
Codon, Nonsense/genetics*. *Fingers/abnormalities*/pathology. *Homeodomain Proteins/genetics*. *Penetrance*. *Syndactyly/ ... Our results show the first nonsense mutation in the HOXD13 gene underlying a severe form of SPD in the homozygous state, and a ... Our results show the first nonsense mutation in the HOXD13 gene underlying a severe form of SPD in the homozygous state, and a ... A nonsense mutation in the HOXD13 gene underlies synpolydactyly with incomplete penetrance. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4296310_nihms300978f3&req=4
*  IthaGenes
Nonsense codon (Translation) Ethnic Origin:. Iranian. Inheritance: Recessive. DNA Sequence Determined:. Yes. ... A Novel Alpha-thalassemia Nonsense Mutation in HBA2: C.382 A > T globin Gene., Arch Iran Med , 17(7), 475-6, 2014 PubMed ...
https://ithanet.eu/db/ithagenes?ithaID=2519
*  mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts...
This study reveals that mRNA processing in the mutant background often produces transcripts that escape nonsense-mediated decay ... creb3l3asa18218 has a nonsense mutation in exon 2 of 10 (g.357C,T), which changes codon CAA to TAA, a PTC (Fig 5). PCR ... The association of nonsense codons with exon skipping. Mutat Res. 1998;411(2):87-117. PubMed pmid:9806422. * View Article ... A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem Sci. ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007105
*  Periventricular Nodular Heterotopia Summary Report | CureHunter
Nonsense Codon (Nonsense Mutation)IBA 09/01/2014 - "This detected a homozygous nonsense mutation in ARFGEF2 gene, at the DNA ... 09/01/2014 - "This detected a homozygous nonsense mutation in ARFGEF2 gene, at the DNA level c.388C,T in exon 4. The presence ...
http://www.curehunter.com/public/keywordSummaryD054091-Periventricular-Nodular-Heterotopia.do
*  Nonsense Codon - Biology As Poetry
generated and posted on 2016.02.06 ∞. String of three nucleotides in mRNA that encodes a stop in (termination of) translation. ...
http://www.biologyaspoetry.com/terms/nonsense_codon.html