Kozak, M (31 January 1986). "Point mutations define a sequence flanking the AUG initiator codon that modulates translation by ... Kozak, M (January 1986). "Point mutations define a sequence flanking the AUG initiator codon that modulates translation by ... Kozak, M (1981). "Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes". ... Kozak, Marilyn (1981-10-24). "Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ...

In 14 of the mutations that were mapped to the PRKAR1A locus, they found a premature stop codon; one altered the initiator ATG ... codon. The messenger ribonucleic acids (mRNAs) resulting from this mutation were unstable, and they rapidly decayed. In ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

A missense mutation of the initiator methionine codon prevents translation12. PTENP1 possesses a 39 UTR that is 1 kilobase ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

Kozak, M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J. Mol. Biol. 1987 ... eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons. Nucleic Acids ... Codon optimized/protamine RNA. Mice: i.d./20 μg, 80 μg.. Ferrets: i.m./20, 80, 250 ug. Pigs: i.d./250 μg. [119]. ... Codon optimized/unmodified/LNPs. Mice: i.m./0.5, 5 μg. NHPs: i.m./10 μg. [121]. ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

In 14 of the mutations that were mapped to the PRKAR1A locus, they found a premature stop codon; one altered the initiator ATG ... codon. The messenger ribonucleic acids (mRNAs) resulting from this mutation were unstable, and they rapidly decayed. In ...

The methionine codon of VP2 was located upstream of glycine-rich sequence (GGGARAGGVG). An unusual serine-rich sequence ( ... We also identified 2 conserved replication initiator motifs 127EFHIHVLLW135 and 187VLQYKHSQTR196. Potential splicing signals to ... which we selected as the start codon. The Walker loop 396GPATTGKS403 [GXXXXGK(T/S)], which is an ATP- or GTP-binding motif, was ... Tusavirus has a potential upstream start codon MSS in a weaker Kozak consensus sequence than MAQ (Figure, panel A), ...

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44 ... Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes. Proc. Natl. Acad. Sci. U.S. ... We found that mutating the start codon of uORF1 (uAUG1) to CUG reduced the FLUC activity, whereas mutating the start codon of ... Guenther, U. P. et al. The helicase Ded1p controls use of near-cognate translation initiation codons in 5 UTRs. Nature 559, ...

Translation begins with the codon AUG, and an initiator tRNA that carries the amino acid Methionine or, the chemically modified ... If translation were to begin one nucleotide before or after the start codon, every codon that follows in the mRNA will be ... During this scan, the nucleotides adjacent to the start codon affect the efficiency of codon recognition. If the recognition ... First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The ...

Mitchell GA, Brody LC, Looney J, Steel G, Suchanek M, Dowling C, Der Kaloustian V, Kaiser-Kupfer M, Valle D. An initiator codon ...

... residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon ... and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex 00: ... model Active yeast ribosome preparation using monolithic anion exchange chromatography Structural Changes Enable Start Codon ...

Synthesis of modified terminator (UGA) and initiator (AUG) codons containing some hydroxyalkyl analogues of nucleosides S. N. ... Effect of substitution of halogen or N3-methyl derivatives of uridine for uridine in trinucleotide codons on their recognition ...

The agnoprotein initiator codon and overlapping open reading frame thus act as strong barriers to further ribosome scanning and ... Suppression of a VP1 mutant of simian virus 40 by missense mutations in serine codons of the viral agnogene. Margolskee, R.F., ... Of six independently isolated pseudorevertants, all had a missense mutation in a serine codon, near the beginning of the ... effects of upstream initiation codons. Perez, L., Wills, J.W., Hunter, E. J. Virol. (1987) [Pubmed] ...

Narrower terms initiator codon, start codon, stop codon, terminator codon. complementary RNA cRNA: Synthetic RNA produced by ... FAO Related terms: initiation codon; initiator stop codon: Termination codon A set of three nucleotides for which there is no ... the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon. MeSH, 1995 Related or ... complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE). MeSH, 1991. Coined by Sydney ...

The initiator codon - whether it is AUG, CTG, TTG or something else, - is by default translated as methionine (Met, M). The ... Alternative initiation codons:. ATA, GTG and TTG (Yokobori et al. 1999). ATT is the start codon for the CytB gene in ... Alternative Initiation Codons:. In rare cases, translation in eukaryotes can be initiated from codons other than AUG. A well ... Detailed information on codon usage can be found at the Codon Usage Database. ...

Both vectors carry a deletion of the AUG initiator codon (Aug(-)) in the Hyg sequence downstream of the RRE. A vector that has ... The downstream Hyg sequence contained a deletion of the initiator AUG codon (Aug(-)). Control vectors encoded a single copy of ... First the Hyg sequence lacking the AUG codon was positioned downstream of the RRE and between BamHI and XhoI sites. Next the SV ... The downstream Hyg lacked the AUG initator codon. All three of these mutations, when tested individually in vectors, were found ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

Initiator Codon 100% * Open Reading Frames 78% * Binding Sites 62% * Escherichia coli 57% ...

initiator_codon_variant. A codon variant that changes at least one base of the first codon of a transcript. ... initiator_codon_variant, incomplete_terminal_codon_variant, stop_lost, stop_retained_variant, stop_gained, NMD_transcript_ ... incomplete_terminal_codon_variant. A sequence variant where at least one base of the final codon of an incompletely annotated ... A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened ...

Stop codons can be thought of as periods ending a sentence, whereas the initiator codon is like a capital letter, sometimes ... For example the sequence UGA is a stop codon, indicating that the gene has ended and processing of the chain is to stop. AUG is ... A change from CTC to CAT in the DNA sequence of the sixth codon of the gene coding for beta globin will result in substitution ...

Initiator Codon Medicine & Life Sciences 54% * Cell Biology Medicine & Life Sciences 38% ... mGFP/H2B-mCherry into the start codon of Tnnt2 and Myh6. nlacZ (nuclear lacZ) and mGFP (membrane GFP) are flanked by two LoxP ... mGFP/H2B-mCherry into the start codon of Tnnt2 and Myh6. nlacZ (nuclear lacZ) and mGFP (membrane GFP) are flanked by two LoxP ... mGFP/H2B-mCherry into the start codon of Tnnt2 and Myh6. nlacZ (nuclear lacZ) and mGFP (membrane GFP) are flanked by two LoxP ...

Initiator Codon Medicine & Life Sciences 100% * Terminator Codon Medicine & Life Sciences 97% ... Then we study the extent to which start codons and stop codons in the human sequence are conserved in other species, showing ... Then we study the extent to which start codons and stop codons in the human sequence are conserved in other species, showing ... Then we study the extent to which start codons and stop codons in the human sequence are conserved in other species, showing ...

... by preventing the formation of initiation complexes containing a non-initiator tRNA and/or a non-canonical mRNA start codon. ... that contains an initiator transfer RNA (tRNA) and is primed for formation of the first peptide bond. During 50S subunit ... by preventing the formation of initiation complexes containing a non-initiator tRNA and/or a non-canonical mRNA start codon. ... that contains an initiator transfer RNA (tRNA) and is primed for formation of the first peptide bond. During 50S subunit ...

Kozak M. 1987; At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. Journal of ...

Codon, Initiator (MeSH) * DNA Mutational Analysis (MeSH) * Female (MeSH) * Genetic Testing (MeSH) ... One mutation altered the translation initiation codon from ATG to ATA (HBD c.3G>A), and another changed the canonical splice ...