"Crystallographic studies of snake venom proteins from Taiwan cobra (Naja nana atra). Cardiotoxin-analogue III and phospholipase ... The Chinese cobra (Naja atra), also called the Taiwan cobra, is a species of cobra in the family Elapidae, found mostly in ... The Chinese cobra is a highly venomous member of the true cobras (genus Naja). The murine LD50 values of its venom are 0.29 mg/ ... The Chinese cobra is sometimes confused with the Monocled cobra (Naja kaouthia). But it can be easily distinguished by virtue ...
... the cobra is the quintessential venomous snake. Cobras discussed in this article include species in the genus Naja and other ... similar venomous snakes, such as Ophiophagus hannah (king cobra), Hemachatus haemachatus (ringhals), Walterinnesia aegyptia ( ... desert black snake), Boulengerina species (water cobras), and Pseudohaje speci... ... Complement-activating proteins. Complement-depleting cobra venom factor (CVF) activates the alternative complement pathway ...
Cobra Neurotoxins. Cobra Neurotoxin Proteins. Direct Lytic Factors. Cobra Cardiotoxin Proteins. D23 - Biological Factors. Shiga ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Protein Isoprenylation. Protein Prenylation. G09 - Circulatory and Respiratory Physiology. Hemodynamic Processes. Hemodynamics ... Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ...
Cobra Neurotoxins. Cobra Neurotoxin Proteins. Direct Lytic Factors. Cobra Cardiotoxin Proteins. D23 - Biological Factors. Shiga ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Protein Isoprenylation. Protein Prenylation. G09 - Circulatory and Respiratory Physiology. Hemodynamic Processes. Hemodynamics ... Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ...
In addition, by employing electron paramagnetic resonance (EPR) and protein nuclear magnetic resonance (1H-NMR) spectroscopy ... By studying cardiotoxin from Naja mossambica mossambica cobra (cardiotoxin VII4), a basic three-fingered S-type cardiotoxin, we ... Finally, molecular dynamics simulations and in silico docking studies identified CL binding sites in cardiotoxin VII4 and ... By performing confocal analysis, we observed that red-fluorescently tagged cardiotoxin rapidly translocates to mitochondria in ...
The major components in the venom are cytotoxins/cardiotoxins (~75.6% of total venom proteins) and alpha-neurotoxins (~7.4%), ... Neurological effects and intubation were significantly more common after a monocled cobra bite than after a spitting cobra bite ... Previous studies characterized the protein composition of its venom, with phospholipase A2 (PLA2) proteins the most abundant. ... Although antivenom is available for treatment of cobra envenomation, its neutralization potency against cobra-induced necrosis ...
Kaneda N, Hamaguchi M, Kojima K, Kaneshima H, Hayashi K. Action of cobra venom cardiotoxin on chick embryonal fibroblasts ... 0.075 U/mg protein), followed by C.V (0.077 U/mg protein), and E.C (0.078 U/mg protein), respect to their control (0.087 U/mg ... 0.071 U/mg protein), followed by E.P (0.076 U/mg protein), and E.C (0.081 U/mg protein). No significant differences were ... 0.083 U/mg proteins). Level 1/50 IC50 of E.P showed significant decline in GSH content (0.073 U/mg protein), followed by C.C ( ...
King cobras, found in South-East Asia, are the worlds longest venomous snake, reaching lengths up to nearly six meters - ... Now batrachotoxin is an insanely potent neuro- and cardiotoxin, which means it sucker punches you in your brain and in your ... They all evolved through the mutation of protein genes. Some venoms are closely related to digestive enzymes, like those found ... And yet the king cobras venom pales in comparison to that of the Australian inland taipan. Largely recognized as the most ...
Snake venoms are complex substances, chiefly proteins, with enzymatic activity. Although enzymes play an important role, the ... cardiotoxin, myotoxin) are misleading and can lead to errors in clinical judgment. ...
Cobra Cardiotoxin Targets Mitochondria to Disrupt Mitochondrial Membrane Structure and Function. Toxin. 2019; 11(3): 152. Doi: ... protein chemistry (protein structure/function, molecular mobility, subcellular localization, and stereochemistry), transgenic ... oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic. Three-Fingered ... Khomenko T, Deng XM, Jadus MR, Szabo S. Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal ...
Cobra Cardiotoxin Targets Mitochondria to Disrupt Mitochondrial Membrane Structure and Function. Toxin. 2019; 11(3): 152. Doi: ... protein chemistry (protein structure/function, molecular mobility, subcellular localization, and stereochemistry), transgenic ... oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic. Three-Fingered ... Khomenko T, Deng XM, Jadus MR, Szabo S. Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal ...
Endocytotic Routes of Cobra Cardiotoxins Depend on Spatial Distribution of Positively Charged and Hydrophobic Domains to Target ... In case of proteins for which it is possible to identify the secondary structure, symbols are given in the Stride ...
Cobra Neurotoxins. Cobra Neurotoxin Proteins. Direct Lytic Factors. Cobra Cardiotoxin Proteins. D23 - Biological Factors. Shiga ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Protein Isoprenylation. Protein Prenylation. G09 - Circulatory and Respiratory Physiology. Hemodynamic Processes. Hemodynamics ... Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ...
Applying a protein decomplexation approach, [...] Read more. Naja nivea (Cape Cobra) is endemic to southern Africa. Envenoming ... The major components in the venom are cytotoxins/cardiotoxins (~75.6% of total venom proteins) and alpha-neurotoxins (~7.4%), ... small-sized and spherical particles with high Bothrops jararaca venom protein association efficiency. The high protein loading ... Surprisingly, the protein was found to be located in the cytoplasm, and gene deletion in A. flavus resulted in defective growth ...
Cobra Cardiotoxin Proteins / metabolism Actions. * Search in PubMed * Search in MeSH * Add to Search ... Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models. Wang Y, Lu J, Liu Y. Wang Y, et al. Int J Mol Sci. ... Following cardiotoxin-induced injury, SelN expression was strongly up-regulated in wild-type muscles and, for the first time, ...
Cobra Cardiotoxin Cobra Cytotoxin Proteins Cobra Toxin Gamma Cobra Venom Cardiotoxin D Cytotoxin-Like Basic Protein (Cobra ... Proteins [D12.776] * Reptilian Proteins [D12.776.831] * Cobra Cardiotoxin Proteins [D12.776.831.222] * Cobra Neurotoxin ... Cardiotoxin I Cardiotoxin II Cardiotoxin VII 4 Cardiotoxin VII2 Cardiotoxin-Like Basic Polypeptide Cardiotoxins, Elapid ... Cobra Cardiotoxin Proteins Preferred Concept UI. M0006549. Registry Number. 0. Scope Note. Most abundant proteins in COBRA ...
Cobra Cardiotoxin Cobra Cytotoxin Proteins Cobra Toxin Gamma Cobra Venom Cardiotoxin D Cytotoxin-Like Basic Protein (Cobra ... Proteins [D12.776] * Reptilian Proteins [D12.776.831] * Cobra Cardiotoxin Proteins [D12.776.831.222] * Cobra Neurotoxin ... Cardiotoxin I Cardiotoxin II Cardiotoxin VII 4 Cardiotoxin VII2 Cardiotoxin-Like Basic Polypeptide Cardiotoxins, Elapid ... Cobra Cardiotoxin Proteins Preferred Concept UI. M0006549. Registry Number. 0. Scope Note. Most abundant proteins in COBRA ...
Cobra Neurotoxins. Cobra Neurotoxin Proteins. Direct Lytic Factors. Cobra Cardiotoxin Proteins. D23 - Biological Factors. Shiga ... SHP1 Protein Tyrosine Phosphatase. Protein Tyrosine Phosphatase, Non-Receptor Type 6. Thioredoxin Reductase (NADPH). ... Protein Isoprenylation. Protein Prenylation. G09 - Circulatory and Respiratory Physiology. Hemodynamic Processes. Hemodynamics ... Ca(2+)-Calmodulin Dependent Protein Kinase. Calcium-Calmodulin-Dependent Protein Kinases. Cholesterol Esterase. Sterol Esterase ...
Replaced for 2008 by Cobra Cardiotoxin Proteins). Discrete Subaortic Stenosis C14.280.955.249.70.210. DNA Adducts G5.180.104. ... Cobra Neurotoxins D12.776.831.244. (Replaced for 2008 by Cobra Neurotoxin Proteins). Cocaine D2.145.74.722.388. D4.75.80.875. ... Protein Isoprenylation G6.535.797.500. (Replaced for 2008 by Protein Prenylation). Protein-Tyrosine-Phosphatase D8.811.277.352. ... HIV Envelope Protein gp160 D12.776.964.775.325.380 D12.776.964.775.325.164.374. D12.776.964.970.880.325.380 D12.776.964.775. ...
Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, ... "Cobra Venoms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cobra Venoms" by people in Harvard Catalyst Profiles by year, ... Below are the most recent publications written about "Cobra Venoms" by people in Profiles. ...
N0000167592 Lysine Carboxypeptidase N0000167593 Glutamate Carboxypeptidase II N0000171448 Cobra Cardiotoxin Proteins ... SNARE Proteins N0000168728 Munc18 Proteins N0000169000 Amphibian Proteins N0000169001 Xenopus Proteins N0000169025 Eye Proteins ... Proteins N0000168231 Protein Kinase C N0000168232 Protein Kinase C-alpha N0000168234 Protein Kinase C-delta N0000168233 Protein ... Wnt3A Protein N0000183504 Wnt3 Protein N0000183531 Axin Protein N0000183533 Wnt4 Protein N0000169872 Y-Box-Binding Protein 1 ...
Replaced for 2008 by Cobra Cardiotoxin Proteins) Discrete Subaortic Stenosis C14.280.955.249.70.210 DNA Adducts G5.180.104 DNA ... D4.75.80.875.99.221.750.625.150 Cobra Neurotoxins D12.776.831.244 (Replaced for 2008 by Cobra Neurotoxin Proteins) Cocaine ... E7.695.680 Protein Isoprenylation G6.535.797.500 (Replaced for 2008 by Protein Prenylation) Protein-Tyrosine-Phosphatase D8.811 ... E5.478.594.385 HIV Core Protein p24 D12.776.964.775.350.400 D12.776.964.775.350.362.500 D12.776.964.970.600.850.350.400 D12.776 ...
Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic ... the role of stress proteins ERdj5 and ERp57.. Corazzari M; Lovat PE; Armstrong JL; Fimia GM; Hill DS; Birch-Machin M; Redfern ...
atra cardiotoxin 1 (CTX-1), produced by Chinese cobra snakes, belonging to Elapidae family, is included in the three-finger ... BoHV-4 ORF45 has been suggested to be a tegument protein; however, its structure and function have not yet been experimentally ... Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. ... As a result, the sequence NCP-0 (Naja Cardiotoxin Peptide-0) was designed as ancestor and subsequently 4 other variant ...
Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast ... Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in ... After serum-starved MDA-MB-231 cells were treated with EGF (50 ng/mL) for 12 h, CCR1 protein expression on the cell surface was ... The protein extracts (20 μg each) were separated by SDS-polyacrylamide gel electrophoresis and transferred to nitrocellulose ...
Sun, Y.J. et al., Crystal structure of cardiotoxin V from Taiwan cobra venom: pH-dependent conformational change and a novel ... membrane-binding motif identified in the three-finger loops of P-type cardiotoxin. Biochemistry (1997) Release Date. 1997-04-21 ...
Beta-cardiotoxin (β-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel β-adrenergic blocker ... Investigators characterized the mechanism of action of the MoMo30 protein, as well as the sequence of the protein-coding gene. ... Moreover, mutations induced in non-structural protein 6 (nsp6) in addition to the S protein were sufficient to restate the ... The investigators identified IQGAP1, a scaffold protein, as a gasdermin D (GSDMD)-interacting protein through a nonbiased ...
Neuromuscular transmission in the Chinese cobra Naja naja atra was not affected by its own toxin (cobrotoxin) at a conce... ... Neutralization of cobra venom by cocktail antiserum against venom proteins of cobra (Naja naja naja).. ... Preliminary crystallographic analysis of cardiotoxin V with major fusion activity from Taiwan cobra (Naja naja atra) venom.. ... Conformational prediction for snake venom toxins and laser Raman scattering of a cardiotoxin from Taiwan cobra (Naja naja atra ...
Snake venoms are complex substances, chiefly proteins, with enzymatic activity. Although enzymes play an important role, the ... cardiotoxin, myotoxin) are misleading and can lead to errors in clinical judgment. ...
They target specific proteins and toxins within the venom, such as PLA2, necrotoxins, myotoxins, cardiotoxins, the wasp kinins ... This wasnt actually a cobra, so I said that it was not going to work, but it was tried, and in fact, it did not work. We were ... Really, it comes down to these proteins. You find the protein and need to neutralize it from doing other things to the body. ... The proteins are so different geographically. If you have the same species in a different location or the food is a little bit ...
Cephalin Kaolin Cobra Toxin Gamma,Cobra Toxin Gamma Cobra Venom Cardiotoxin D,Cobra Venom Cardiotoxin D Coin Lesion, Pulmonary, ... Protein 27, Heat-Shock Protein 55,Protein 55 Protein AA,Protein AA Protein AA, Amyloid,Protein AA, Amyloid Protein ADP,ATP ... site unspecified Cardiotoxin I,Cardiotoxin I Cardiotoxin II,Cardiotoxin II Cardiotoxin VII 4,Cardiotoxin VII 4 Cardiotoxin VII2 ... HSV 1 Protein VP 16 HSV 1 Protein VP16,HSV 1 Protein VP16 HSV-1 Protein VP-16,HSV-1 Protein VP-16 HSV-1 Protein VP16,HSV-1 ...
Cobra Cardiotoxin Proteins Cobra Neurotoxin Proteins Cobra Venoms Coca Cocaine Cocaine-Related Disorders Cocarcinogenesis ... ADAMTS Proteins ADAMTS1 Protein ADAMTS13 Protein ADAMTS4 Protein ADAMTS5 Protein ADAMTS7 Protein ADAMTS9 Protein Adansonia ... ELAV Proteins ELAV-Like Protein 1 ELAV-Like Protein 2 ELAV-Like Protein 3 ELAV-Like Protein 4 Elbow Elbow Joint Elbow ... Adaptor Protein Complex 1 Adaptor Protein Complex 2 Adaptor Protein Complex 3 Adaptor Protein Complex 4 Adaptor Protein Complex ...
Cephalin Kaolin Cobra Toxin Gamma,Cobra Toxin Gamma Cobra Venom Cardiotoxin D,Cobra Venom Cardiotoxin D Coin Lesion, Pulmonary, ... Protein 27, Heat-Shock Protein 55,Protein 55 Protein AA,Protein AA Protein AA, Amyloid,Protein AA, Amyloid Protein ADP,ATP ... site unspecified Cardiotoxin I,Cardiotoxin I Cardiotoxin II,Cardiotoxin II Cardiotoxin VII 4,Cardiotoxin VII 4 Cardiotoxin VII2 ... HSV 1 Protein VP 16 HSV 1 Protein VP16,HSV 1 Protein VP16 HSV-1 Protein VP-16,HSV-1 Protein VP-16 HSV-1 Protein VP16,HSV-1 ...
... of protein accumulation (in %/hr) , i.e., to the rate of protein synthesis minus the rate of protein degradation. Division ... AB - We have investigated the action and substrate specificity of phospholipase A2 (EC 3.1.1.4) purified from cobra venom (Naja ... The identification of the final product as cardiotoxin was confirmed by thin-layer chromatography on silica gel, polyacrylamide ... B2, a labile protein of M.W. 220,000, was one of the few serum proteins precipitated by M.W. 5000,000 dextran sulfate at pH 8.0 ...