Clathrin is a protein that assembles into a lattice structure to form coated pits on the cell membrane. The clathrin light ... Clathrin-coated vesicles are responsible for transporting various molecules, including receptors, from the cell surface to the ... From cancer research to immunology, neuroscience to cell biology, we have antibodies tailored to your specific needs. ... MYF6, along with other MRFs, helps orchestrate the differentiation of myoblasts (precursor cells) into mature muscle fibers. ...
... coated with clathrin on the cytoplasmic surface, that pinch off to form clathrin coated vesicles enclosing the ligands in ... small receptor bearing pits in the plasma membrane, ... from the outside by engulfing it with their cell membrane. It ... coated pits. small receptor-bearing pits in the plasma membrane, coated with clathrin on the cytoplasmic surface, that pinch ... costal pit. Look at other dictionaries:. *. coated pits - coated pits, spezialisierte Bereiche der Plasmamembran, aus denen ...
We unravel a coincident mechanism of lipid-induced activation of PI3KC2α at membranes that involves large-scale repositioning ... Depletion of PI3KC2α from Cos7 cells resulted in reduced levels of PI(3,4)P2 at endocytic plasma membrane coated pits and a ... 5: Conformational control of PI3KC2α activity in vitro and at endocytic clathrin-coated pits in living cells.. ... d,e, Conformational control of local PI(3,4)P2-synthesis mediated by PI3KC2α at endocytic clathrin-coated pits in living cells ...
Cell membrane, Coated pit, Cytoplasm, Developmental protein, Disulfide bond, EGF-like domain, Endocytosis, Glycoprotein, ... cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ... cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_ ... org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_ ...
Clathrin-coated pit. *. Cleavage furrow. *. Coated pit. *. COPII-coated vesicle membrane. *. Cyanelle. ...
Membrane. Membrane , clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits. ... Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle ... is required for sorting of membrane proteins to the basolateral surface of epithelial cells.. The NPXY sequence motif found in ... moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or ...
In order for cells to become fully polarized, it is necessary to grow them on a permeable membrane filter; however, the ... and are distinct from caveolae and clathrin-coated pits. SNAP-23 partially colocalizes with both syntaxin 3 and 4 clusters. ... Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. ... Syntaxins 3 and 4 localize to the apical and basolateral plasma membrane, respectively, of epithelial cells where they mediate ...
... cell growth, proliferation, and survival. Less is known regarding its critical role in neuronal physiology, neuronal metabolism ... which locally produce phosphoinositide in growing clathrin-coated pits [106]. In PC12 cells, activation of PI3K-C2α enhances ... the endosome to the trans-Golgi network or the plasma membrane determine the concentration of important molecules at the cell ... in immune cells, such as macrophages and dendritic cells. However, in regard to the role of activation of different isoforms of ...
However, AM-1 cultured directly on calcium phosphate-coated plates formed resorption pits, and this was inhibited by ... were detected on the surface of AM-1 cells by plasma membrane biotinylation and immunofluorescence analysis. ... cells than in highly metastatic oral squamous cell carcinoma (HSC-3) cells. Experiments coculturing mouse macrophages (RAW264.7 ... cells than in highly metastatic oral squamous cell carcinoma (HSC-3) cells. Experiments coculturing mouse macrophages (RAW264.7 ...
... and at the endocytic clathrin coated pits. It can also translocate to plasma membrane ruffles upon stimulation with growth- ... cell migration, cell polarity, and phagocytosis. Cytokine defects have also been reported in mammalian cell lines lacking OCRL1 ... where it is found in the clathrin-coated pits, clathrin-coated vesicles, variable functioning endosomes (early, signaling, ... Phosphoinositides as regulators of membrane trafficking in health and disease. Cell Mol Life Sci. 2008 Sep. 65(18):2833-41. [ ...
... and at the endocytic clathrin coated pits. It can also translocate to plasma membrane ruffles upon stimulation with growth- ... cell migration, cell polarity, and phagocytosis. Cytokine defects have also been reported in mammalian cell lines lacking OCRL1 ... where it is found in the clathrin-coated pits, clathrin-coated vesicles, variable functioning endosomes (early, signaling, ... Phosphoinositides as regulators of membrane trafficking in health and disease. Cell Mol Life Sci. 2008 Sep. 65(18):2833-41. [ ...
Binding of a ligand leads to internalization via clathrin-coated pits (3) and prolonged retention in the cell. PSMA antibody- ... Prostate-specific membrane antigen expression as a predictor of prostate cancer progression. Hum Pathol. 2007;38:696-701. ... Blood cell count was checked every 2 wk after the first and every 4 wk after succeeding cycles. Prostate-specific antigen (PSA ... The 497-keV β-energy of 177Lu corresponds to a mean and maximum tissue range of only 0.5 and 2 mm (i.e., 10-50 cell diameters ...
This study provides the first in vivo evidence of trapped SD proteins in clathrin-coated pits at the plasma membrane when this ... In Drosophila, although the importance of clathrin-mediated endocytosis in cell-cell signaling and cell morphogenesis is well ... cofactor in the disassembly of clathrin coats from clathrin-coated vesicles in Notch-bearing cell ... J. Cell Biol. 79: 336-342. PubMed ID: 10887964 Ungewickell, E., et al. (1995). Role of auxilin in uncoating clathrin-coated ...
Lamellipodial protrusion and directional migration of carcinoma cells towards chemoattractants, such as epidermal growth factor ... Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. ... In cells treated with U73122, but not cells treated with the control drug U73343, EGF neither induced a drop in the membrane- ... Cell culture MTLn3 (rat mammary adenocarcinoma cell line) cells were maintained, starved as described previously (Song et al., ...
Cell Membrane [A11.284.149] * Cell Membrane Structures [A11.284.149.165] * Coated Pits, Cell-Membrane [A11.284.149.165.175] * ... Cells [A11] * Cellular Structures [A11.284] * Cell Membrane [A11.284.149] * Cell Membrane Structures [A11.284.149.165] * ... Caveolar coats are composed of CAVEOLINS.. Entry Term(s). Caveola Previous Indexing. Cell Membrane (1971-2000). See Also. ... Endocytic/exocytic CELL MEMBRANE STRUCTURES rich in glycosphingolipids, cholesterol, and lipid-anchored membrane proteins that ...
These so-called coated pits are the locations of the membrane receptors which permit the uptake into cells of such important ... that the membrane which covers a cell is a dynamic structure through which essential chemicals enter and leave the cell. As ... NIGMS focuses on the cell and chromosomes and genes.. I am intrigued with this. Back in my previous reincarnation on the House ... In the past few years, the virtual explosion of knowledge about the hereditary material contained within the cell has made it ...
Flat clathrin is present in all cells and spontaneously curves into coated pits without additional energy sources or recruited ... Animals, Mice, Humans, Models, Biological, Cell Line, Cell Membrane, Male, Rats, Cryoelectron Microscopy, Cholesterol, ... It is characterized by a polyhedral clathrin lattice that coats budding membranes. The mechanism and control of lattice ... We show that clathrin sites maintain a constant surface area during curvature across multiple cell lines. ...
... activation of platelets is associated with microvesiculation as a none-selective mechanism which leads to the loss of membrane ... When a clathrin-coated pit forms on the inner surface of the cell membrane, it then buds inside the cell and forms a coated ... Endocytosis by random initiation and stabilizatio of clathrin-coated pits. Cell Press. 2004;118(5):591-605. ... during membrane fragmentation which might be mechanistically different from calcium dependent budding of cell membrane in ...
Recent developments in cancer biology have identified the existence of a sub-poplulation of cells - cancer stem cells (C... ... 2002). Curvature of clathrin-coated pits driven by epsin. Nature 419:361-366. Frank-Kamenetsky M, Zhang XM, Bottega S, et al. ( ... Pantarotto D, Briand JP, Prato M, Bianco A. (2004). Translocation of bioactive peptides across cell membranes by carbon ... 2009). Cancer stem cells: Controversial or just misunderstood. Cell Stem Cell 4:203-205. Kamata K, Lu Y, Xia Y. (2003). ...
When the total cell surface is considered, there is little preferential association with coated pits; when only the nonvillous ... 100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding ... binding to villi followed by redistribution to the nonvillous portion of the cell containing coated pits). These events ... a preferential association with coated pits is found and is quantitatively increased in the absence of rebinding of the ligand ...
Plasma membrane domain organization regulates EGFR signaling in tumor cells. J Cell Biol 179, 341-356 ... The galectin lattice (i) regulates flow of receptors and solute transporters to coated-pit endocytosis and/or caveolin domains ... another microfilament-anchored cell-cell connection between T cells and antigen-presenting cells. Gal-3 interactions with ... promotes turnover at cell-substratum and cell-cell adhesions. The enzymes Mgat1, 2 ,4 and 5 compete for UDP-GlcNAc as donor ...
Felberbaum-Corti M, Van Der Goot FG, Gruenberg J: Sliding doors: clathrin-coated pits or caveolae?. Nat Cell Biol. 2003, 5 (5 ... Caveolin-Stabilized Membrane Domains as Multifunctional Transport and Sorting Devices in Endocytic Membrane Traffic. Cell. 2004 ... Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem. 1996, 271 (46 ... Polo S, Fiore PPD: Endocytosis conducts the cell signaling orchestra. Cell. 2006, 124 (5): 897-900. 10.1016/j.cell.2006.02.025 ...
Cell Membrane Structures. *Cell-Matrix Junctions. *Coated Pits, Cell-Membrane. *Glycocalyx. *Intercellular Junctions ... Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl- ... "Membrane Microdomains" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Membrane Microdomains" by people in this website by year, and ...
J. Cell Biol. 86: 199-211.. Pfeiffer, J.R., Oliver, J.M. and Berlin, R.D. 1980. Surface topography of coated pits. Nature 286: ... J.Cell Biol. 101: 1492-1500.. Regula, C.S., Sager, P.R. and Berlin, R.D. 1986. Membrane Tubulin. Ann. N.Y. Acad. Sci. 466: 832- ... J. Cell Biology 89: 45-53.. Melmed, R.M., Karanian, P. and Berlin, R.D. 1981. Cell volume regulation: roles for microtubules ... J. Cell Biol. 71: 921-932.. Fernandez, S. and Berlin, R.D. 1976. Cell surface distribution of lectin receptors determined by ...
... of endosomal clathrin-coated membrane pits Involved in HIV-1 nef-mediated removal ofMHC-I from the cell surface to the TGN. ... Coat protein that is involved in the localization oftrans-Golgi network (TGN) membrane proteins that contain acidiccluster ... Nef mediated downregulation of MHC class I complex cell surface expression.. Down-regulation of MHC class I involves Nef- ... Down-regulation of MHC I protects HIV-infected cells from host CTL response. ...
Cell Membrane * Cell Membrane Structures * Coated Pits, Cell-Membrane * Intercellular Junctions * Desmosomes ... The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the ...
... to eliminate any cell membrane-bound ANG II (2 12 16 34 ANG II was extracted from PTCs within a buffer containing 20 mM Tris · ... of clathrin-coated pits cytoskeleton microtubules or tyrosine phosphatases in AT1 receptor-mediated ANG II endocytosis in PTCs ... ANG II plus 400 mM sucrose which depletes clathrin-coated pits (2 9 10 ANG II in addition to the cytoskeleton microtubule ... Ramifications of inhibitors of clathrin-coated pits cytoskeleton microtubules and tyrosine NBI-42902 phosphatase on ...
... on the breast cancer cells membrane. Intriguingly, we discovered that the selectively enrichment of nanoprobe particles in ... The breast cancer targeting diagnostic capacity was evaluated by normal/tumor cell co-culture assay, tumor cells targeting ... moiety to distinguish tumor cells from normal cells and RuPEP act as a light-emitting element to highlight breast cancer cells ... This study produce a potent nanoprobe can be used as a convenient tool to highlight and distinguish tumor cells in vivo, and ...