Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy
developed water-soluble iron oxide (WSIO) nanocrystals using DMSA as coating materials . The DMSA formed a stable coating ... Chitosan is a hydrophilic and biocompatible natural polymer that is popular as a theranostic nanocarrier material . In a ... On the other hand, gold provides several advantages as a coating material due to its inertness and its unique ability to absorb ... This section describes the use of several coating molecules as shielding materials. The optimal surface densities of the ...http://thno.org/v02p0003.htm
Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic...
Certain coating materials like PEG and peptides could significantly reduce the potential toxicity of gold nanoparticles on cell ... There are studies of new kinds of high-density lipoprotein (HDL)-like nanoparticles that are completely biocompatible and ... al. , which consisted of nanoclusters composed of closely spaced gold-coated SPION. These nanoclusters were coated with ... Targeted gold-coated iron oxide nanoparticles for CD163 detection in atherosclerosis by MRI. Sci Rep. 2015;5:17135 ...http://www.thno.org/v08p4710.htm
3D Cell Printed Tissue Analogues: A New Platform for Theranostics
PEG is biocompatible, and the Food and Drug Administration (FDA)-approved material has been widely used in the field of ... a) Enhanced in vivo bone regeneration treated by bdECM-coated scaffolds that were evaluated via micro-CT (scale bars=4 mm). (b ... Calvert P. Inkjet Printing for Materials and Devices. Chemistry of Materials. 2001;13:3299-305 ... Journal of Materials Chemistry B. 2015;3:5415-25 70. Kundu J, Shim J-H, Jang J, Kim S-W, Cho D-W. An additive manufacturing- ...http://thno.org/v07p3118.htm
Single-Molecule Tracking in Living Cells Using Single Quantum Dot Applications
Handbook of Nanostructured Materials and Nanotechnology, Organics, Polymers, and Biological Materials, 1st ed. Sandego: ... Synthesis of silica-coated semiconductor and magnetic quantum dots and their use in the imaging of live cells. Angew Chem Int ... Biocompatible luminescent silicon quantum dots for imaging of cancer cells. ACS Nano. 2008;2:873-8 ... The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating. ...http://thno.org/v02p0655.htm
Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing
Materials and Methods. Results. Discussion. Conclusions. Abbreviations. Supplementary Material. Acknowledgements. References. ... We compared gelatin-coated PVA (equally treated with 0.1 N HCl solution) and 1 mg/mL ciprofloxacin-treated PVA (PVA/Cipro) ... a novel skin patch combining both antibiotic ciprofloxacin and cell-derived ECM was fabricated via coupling with biocompatible ... Supplementary Material. Supplementary figures.. Acknowledgements. The authors would like to thank Cininta Savitri, MD for her ...http://thno.org/v08p5025.htm
Sustained Release of Immunosuppressant by Nanoparticle-anchoring Hydrogel Scaffold Improved the Survival of Transplanted Stem...
Materials and Methods. Results. Discussion. Abbreviations. Supplementary Material. Acknowledgements. References. Global reach, ... A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med ... biocompatible, and degradable hydrogel, which is promising for 3-D cell culture and in situ transplantation [17-19]. Based on ... Materials and Methods. Materials and animals. Poly (lactic-co-glycolic acid) (PLGA, lactic acid: glycolic acid = 50:50; ...http://thno.org/v08p0878.htm
Pharmacokinetics, Metabolism and Toxicity of Carbon Nanotubes for Biomedical Purposes
Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman ... In vivo biomodification of lipid-coated carbon nanotubes by Daphnia magna. Environ Sci Technol. 2007;41:3025-3029 ... CNTs can be used as tissue engineering materials for cell growth. After implanting subcutaneously, CNTs exhibited very good ... Schipper et al. reported that PEG-SWCNTs and PEG-PL/SWCNTs were nontoxic and biocompatible . Although both SWCNTs retained ...http://thno.org/v02p0271.htm
Incorporating gold nanoclusters and target-directed liposomes as a synergistic amplified colorimetric sensor for HER2-positive...
Materials and Methods. Materials and measurements. 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dodecanoyl (N-dod-PE) and 1, ... Fluorescent gold nanoclusters as a biocompatible marker for in vitro and in vivo tracking of endothelial cells. ACS Nano. 2011; ... Irinotecan delivery by lipid-coated mesoporous silica nanoparticles shows improved efficacy and safety over liposomes for ... Materials and Methods. Results and discussion. Conclusion. Supplementary Material. Abbreviations. Acknowledgements. References ...http://www.thno.org/v07p0899.htm
Integrin Targeting for Tumor Optical Imaging
reported a novel method for creating biocompatible and target-specific silica particles coated with a dense monolayer of ... The nano-sized materials show unique optical, magnetic, and other physicochemical properties. Importantly, many complex ... Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for ... Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality ...http://thno.org/v01p0102.htm
Gold Nanorods Based Platforms for Light-Mediated Theranostics
As a common strategy for preparing biocompatible nanomaterials, PEG coating helps prevent particle aggregation and non-specific ... Gold nanostructures: a class of multifunctional materials for biomedical applications. Chem Soc Rev. 2011;40:44-56 ... Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging. Opt ... Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater ...http://www.thno.org/v03p0223.htm
Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy...
v) The ODC-HPOC was composed of biosafe and biocompatible materials without side effects to normal tissues, offering a ... Preferential cancer cell self-recognition and tumor self-targeting by coating nanoparticles with homotypic cancer cell ... Supplementary Material. Supplementary figures and tables.. Competing Interests. The authors have declared that no competing ... Materials. Bovine hemoglobin (Hb), human serum albumin (HSA) and glutathione (GSH) were obtained from Hefei Bomei Biotechnology ...http://thno.org/v08p3584.htm
In Vitro Evaluation of Theranostic Polymeric Micelles for Imaging and Drug Delivery in Cancer
Materials and Methods. Materials. Lipids, 1,2-distearoyl-sn-glycero-3-phosphoe-thanolamine-N-[methoxy(polyethylene glycol)-2000 ... The specimens were prepared by drop-coating the sample dispersion onto an amorphous carbon coated 300 mesh copper grid followed ... the complicated methods for ligand displacement and further functionalization to render hydrophobic particles biocompatible and ... Electronic Materials Research Institute, Northeastern University, Boston MA USA.. This is an open access article distributed ...http://www.thno.org/v02p0714.htm
The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
Journal of Wide Bandgap Materials. 2002;9:261-272 26. Li QN, Xiu Y, Zhang XD. et al. Preparation of 99mTc-C60(OH)x and its ... Protein-mediated assembly of nanodiamond hydrogels into a biocompatible and biofunctional multilayer nanofilm. ACS Nano. 2008;2 ... In addition, the surface charge of ND influences its cellular uptake, as the uptake of poly-L-lysine-coated NDs is better than ... Biocompatible and detectable carboxylated nanodiamond on human cell. Nanotechnology. 2007;18:325102 ...http://thno.org/v02p0302.htm
Theranostics based on AIEgens
Selection of materials should be considered prior to designing appropriate theranostic agents. A variety of materials, in ... Highly stable organic small molecular nanoparticles as an advanced and biocompatible phototheranostic agent of tumor in living ... Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. Biomaterials. 2012;33:6408- ... In summary, a series of AIEgen-based theranostic materials have been explored for FLI-guided PDT. These materials generally ...http://www.thno.org/v08p4925.htm
Theranostic Nanodots with Aggregation-Induced Emission Characteristic for Targeted and Image-Guided Photodynamic Therapy of...
Materials and Methods. Materials. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (DSPE ... Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers. Nat ... these results indicate that the nanodots are highly biocompatible in live mice, which is crucial for in vivo biomedical ... Supplementary Material. Supplementary figures and tables.. Competing Interests. The authors have declared that no competing ...http://thno.org/v09p1264.htm
Analysis of Protease Activity Using Quantum Dots and Resonance Energy Transfer
Biocompatible fluorescent nanocrystals for immunolabeling of membrane proteins and cells. Anal Biochem. 2004;324:60-7 ... Medintz IL, Sapsford KE, Berti L. Materials for fluorescence resonance energy transfer analysis: Beyond traditional donor- ... QDs can be coated with organic molecules and macromolecules to provide aqueous solubility. These coatings can be broadly ...http://thno.org/v02p0127.htm
Porphyrin-grafted Lipid Microbubbles for the Enhanced Efficacy of Photodynamic Therapy in Prostate Cancer through Ultrasound...
Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery. J ... was prepared by immersing a formvar-coated copper grid into the PGL-NPs suspension (0.5 mg/mL). After 10 min of incubation, ... this strategy was biocompatible and imposed no significant toxic side effects on the treated mice. ... State-of-the-art materials for ultrasound-triggered drug delivery. Adv Drug Deliv Rev. 2014;72:3-14 ...http://thno.org/v08p1665.htm