... heterogeneity and clonal evolution of cancer cells when challenged with targeted therapy, the inconsistency between expected ...
For highlighting the biologic underpinnings of pediatric leukemia onset and clonal evolution, and for demonstrating how ...
The 2021 edition of the congress focused on the molecular characterisation and clonal evolution of solid tumours, mechanisms ...
Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy. Nat Commun. 2016 Apr 5;7:11111. ... time and spatial modelling of cancer evolution, 3) mutation signatures and genome scaring algorithms and 4) visualization of ...
Jiao W, Vembu S, Deshwar AG, Stein L, Morris Q. Inferring clonal evolution of tumors from single nucleotide somatic mutations. ... McGranahan N, Swanton C. Clonal heterogeneity and tumor evolution: past, present, and the future. Cell. 2017; 168(4):613-28. ... Assumption (1) follows from the clonal evolution theory of tumor growth [22]. Assumption (2) is automatically satisfied because ... The clonal evolution of tumor cell populations. Science. 1976; 194(4260):23-8. ...
Greaves M, Maley CC: Clonal evolution in cancer. Nature 2012, 481: 306-313. 10.1038/nature10762 ...
... is focusing on understanding the molecular mechanisms that underlie the genesis of the bone marrow failure and clonal evolution ...
Genetic Resources and Crop Evolution 50:101-114. doi:10.1023/A:1022972320696 ... Figure 1. Clonal and environmental variabilities of xylem vulnerability to cavitation in rubber clones. P50 was measured on (A ... Clonal variability for vulnerability to cavitation and other drought-related traits in ,em,Hevea brasiliensis,/em, Müll. Arg. ... cavitation clonal variability drought embolism Hevea brasiliensis hydraulics leaf shedding stomatal conductance xylem. ...
Clonal/subclonal architecture and tumor evolution were reconstructed. Then, stereo-sequencing were performed on one slide of ... Reconstruction of tumor evolution in ASCs. To further explore the evolution routes of ASC, we reconstructed phylogeny trees ... we confirmed that these components shared clonal origins and could disseminate separately during tumor evolution. We also ... Krause, A. et al.Deciphering the clonal relationship between glandular and squamous components in adenosquamous carcinoma of ...
Clonal evolution of glioblastoma under therapy. Nat Genet. 2016;48:768-76. https://doi.org/10.1038/ng.3590. ... Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment. ... Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the glioma longitudinal analysis consortium. Neuro ... Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in ...
Clonal Evolution Medicine & Life Sciences 77% * OSCE Social Sciences 74% * Candida glabrata Medicine & Life Sciences 74% ...
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity. 3. ... Individual foci and germinal centers represent discrete pauciclonal populations that apparently undergo somatic evolution in ... are sites of intraclonal clonal competition between mutated sister lymphocytes. ...
2006) Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli Genetics 172:2093-2100. ... 1997) Evolution of high mutation rates in experimental populations of E. coli Nature 387:703-705. ... 2006) Ploidy controls the success of mutators and nature of mutations during budding yeast evolution Current Biology 16:1581- ... 2009) Genome evolution and adaptation in a long-term experiment with Escherichia coli Nature 461:1243-1247. ...
Our results suggest that within-host evolution plays a minor role in the generation of diversity compared to independent ... while one-quarter of variants appeared to have arisen from within-host evolution. Several isolates encode putative virulence ... even though this is pertinent to understanding bacterial evolution and ecology and their role in infection. We isolated and ... within-host evolution can generate clouds of intra-clonal diversity, where genotypes differ by just a handful of SNPs (Dixit et ...
Layla Oesper , Tumor Evolution: Methods for Comparing, Summarizing and Visualizing Clonal Trees , CGSI 2023. ...
Inferring clonal evolution of tumors from single nucleotide somatic mutations. no code implementations • 11 Oct 2012 • Wei Jiao ... Comparing Nonparametric Bayesian Tree Priors for Clonal Reconstruction of Tumors. no code implementations • 11 Aug 2014 • Amit ... Reconstructing subclonal composition and evolution from whole genome sequencing of tumors. no code implementations • 27 Jun ... have become increasingly popular to infer clonal population structure of tumors. ...
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic ...
He is leading an investigator-initiated clinical trial examining the clonal evolution of bladder cancer following targeted ... but is generally interested in all aspects of evolution including but not limited to longitudinal studies of therapy response ... a cancer genomics laboratory focused on utilizing state-of-the-art genomic approaches to study the development and evolution of ... to studying bladder cancer as a model disease for dissecting the fundamental biological mechanisms that drive the evolution of ...
... and analysis of intratumoral heterogeneity during therapy demonstrated differential clonal evolution within tumors and putative ... The mechanisms by which immune checkpoint blockade modulates tumor evolution during therapy are unclear. We assessed genomic ...
"Spectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative ... from peripheral blood or bone marrow has the potential to prospectively identify RUNX1 carriers at higher risk for evolution to ... Asymptomatic carriers of RUNX1 germline pathogenic variants develop detectable clonal haematopoiesis prior to malignant ... as well as the finding of clonal hematopoiesis with a TET2 mutant clone in 1 of the patients. It is critical to consider ...
"Of critical need is the ability to understand cancer therapy resistance through sub-clonal tumor evolution and heterogeneity," ...
Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors - Artículo de Revista ...
Institute of Systematics and Evolution of Animals, Polish Academy of Sciences ... Regulation of the clonal cycle in the Paramecium aurelia species complex. 41 pages, 16 figures, paperback, ISBN 83-919407-3-X. ... The clonal cycle begins with fertilization preceded by meiosis. The conditionings of meiosis induction were precisely studied ... Institute of Systematics and Evolution of Animals Polish Academy of Sciences. This website is WCAG and W3C standards compliant. ...
... newly arising FLT3 point mutations during clonal evolution, as for example D835Y and D835G, have prognostic impact as being ... Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood. 2013; 122:100-8. https://doi.org/10.1182/blood-2013-01 ... Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute ... B) Number of detected FLT3-ITDs per method, comparing HTAS to fragment analysis according to clonal size. HTAS (high-throughput ...
Sequencing normal colorectal cells provides quantitative insights into the genomic and clonal evolution of cancer. ... sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal ... Sequencing normal colorectal cells provides quantitative insights into the genomic and clonal evolution of cancer. ... sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal ...
Thus, a better understanding of their developmental pathways is highly relevant to chordate evolution. Previous work in our ... The coelomic epithelium transcriptome from a clonal sea star, Coscinasterias muricata Jonatan L. Gabre, P. Martinez, Helen ... Thus, a better understanding of their developmental pathways is highly relevant to chordate evolution. Previous work in our ... Large-scale gene expression study in the ophiuroid Amphiura filiformis provides insights into evolution of gene regulatory ...
Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST. (2020) Genes, 11 (5), . ... "Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST" (2020) Genes. ... leading to an understanding of the clonal evolution within this patient. These data suggest that multi-regional sampling may be ...
Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma. Russo, M ...
... from the first mutation and epimutation through clonal selection and tumor recurrence, using next-generation sequencing to ... MRI-guided tumor biopsies and treatment data with longitudinal genomics to allow the reconstruction of tumor evolution in the ...
Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young ... radiotherapy and systemic therapy with good evolution. ... radiotherapy and systemic therapy with good evolution.. 2. Case ...