MATCH trial
AACR Announces 2019 Class of Fellows of the AACR Academy - The ASCO Post
MAP 2021 Virtual
Artificial Intelligence and Knowledge Discovery (brAInworks) - Fakulta informatiky a informacnych technologii v Bratislave
Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy. Nat Commun. 2016 Apr 5;7:11111. ... time and spatial modelling of cancer evolution, 3) mutation signatures and genome scaring algorithms and 4) visualization of ...
Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time | Genome Medicine | Full Text
Jiao W, Vembu S, Deshwar AG, Stein L, Morris Q. Inferring clonal evolution of tumors from single nucleotide somatic mutations. ... McGranahan N, Swanton C. Clonal heterogeneity and tumor evolution: past, present, and the future. Cell. 2017; 168(4):613-28. ... Assumption (1) follows from the clonal evolution theory of tumor growth [22]. Assumption (2) is automatically satisfied because ... The clonal evolution of tumor cell populations. Science. 1976; 194(4260):23-8. ...
Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models...
D. Wade Clapp, M.D.: Member Biography: Indiana University Melvin & Bren Simon Cancer Center
... is focusing on understanding the molecular mechanisms that underlie the genesis of the bone marrow failure and clonal evolution ...
Clonal variability for vulnerability to cavitation and other drought-related traits in Hevea brasiliensis Müll. Arg. |...
Genetic Resources and Crop Evolution 50:101-114. doi:10.1023/A:1022972320696 ... Figure 1. Clonal and environmental variabilities of xylem vulnerability to cavitation in rubber clones. P50 was measured on (A ... Clonal variability for vulnerability to cavitation and other drought-related traits in ,em,Hevea brasiliensis,/em, Müll. Arg. ... cavitation clonal variability drought embolism Hevea brasiliensis hydraulics leaf shedding stomatal conductance xylem. ...
Clonal dynamics and stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma | Research Communities by...
Clonal/subclonal architecture and tumor evolution were reconstructed. Then, stereo-sequencing were performed on one slide of ... Reconstruction of tumor evolution in ASCs. To further explore the evolution routes of ASC, we reconstructed phylogeny trees ... we confirmed that these components shared clonal origins and could disseminate separately during tumor evolution. We also ... Krause, A. et al.Deciphering the clonal relationship between glandular and squamous components in adenosquamous carcinoma of ...
System-based approaches as prognostic tools for glioblastoma | BMC Cancer | Full Text
Clonal evolution of glioblastoma under therapy. Nat Genet. 2016;48:768-76. https://doi.org/10.1038/ng.3590. ... Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment. ... Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the glioma longitudinal analysis consortium. Neuro ... Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in ...
Moreno Lopez, R.<...
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of...
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity. 3. ... Individual foci and germinal centers represent discrete pauciclonal populations that apparently undergo somatic evolution in ... are sites of intraclonal clonal competition between mutated sister lymphocytes. ...
Selection on mutators is not frequency-dependent | eLife
2006) Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli Genetics 172:2093-2100. ... 1997) Evolution of high mutation rates in experimental populations of E. coli Nature 387:703-705. ... 2006) Ploidy controls the success of mutators and nature of mutations during budding yeast evolution Current Biology 16:1581- ... 2009) Genome evolution and adaptation in a long-term experiment with Escherichia coli Nature 461:1243-1247. ...
Genomic diversity of Escherichia coli from healthy children in rural Gambia [PeerJ]
Our results suggest that within-host evolution plays a minor role in the generation of diversity compared to independent ... while one-quarter of variants appeared to have arisen from within-host evolution. Several isolates encode putative virulence ... even though this is pertinent to understanding bacterial evolution and ecology and their role in infection. We isolated and ... within-host evolution can generate clouds of intra-clonal diversity, where genotypes differ by just a handful of SNPs (Dixit et ...
CGSI 2023 - CGSI
Quaid Morris | Papers With Code
Inferring clonal evolution of tumors from single nucleotide somatic mutations. no code implementations • 11 Oct 2012 • Wei Jiao ... Comparing Nonparametric Bayesian Tree Priors for Clonal Reconstruction of Tumors. no code implementations • 11 Aug 2014 • Amit ... Reconstructing subclonal composition and evolution from whole genome sequencing of tumors. no code implementations • 27 Jun ... have become increasingly popular to infer clonal population structure of tumors. ...
Plus it
Home - The American Society of Clinical Investigation
He is leading an investigator-initiated clinical trial examining the clonal evolution of bladder cancer following targeted ... but is generally interested in all aspects of evolution including but not limited to longitudinal studies of therapy response ... a cancer genomics laboratory focused on utilizing state-of-the-art genomic approaches to study the development and evolution of ... to studying bladder cancer as a model disease for dissecting the fundamental biological mechanisms that drive the evolution of ...
Salvador Mart��n. Curriculum. Universidad de Navarra
3905-RUNX1 - risk management | eviQ
"Spectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative ... from peripheral blood or bone marrow has the potential to prospectively identify RUNX1 carriers at higher risk for evolution to ... Asymptomatic carriers of RUNX1 germline pathogenic variants develop detectable clonal haematopoiesis prior to malignant ... as well as the finding of clonal hematopoiesis with a TET2 mutant clone in 1 of the patients. It is critical to consider ...
Epic Sciences to contribute to Cancer Moonshot Blood Profiling Atlas. - Epic Sciences
Información de la publicación
Books • The Institute of Systematics and Evolution of Animals of the Polish Academy of Sciences
Institute of Systematics and Evolution of Animals, Polish Academy of Sciences ... Regulation of the clonal cycle in the Paramecium aurelia species complex. 41 pages, 16 figures, paperback, ISBN 83-919407-3-X. ... The clonal cycle begins with fertilization preceded by meiosis. The conditionings of meiosis induction were precisely studied ... Institute of Systematics and Evolution of Animals Polish Academy of Sciences. This website is WCAG and W3C standards compliant. ...
Clonal heterogeneity of FLT3 -ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute...
... newly arising FLT3 point mutations during clonal evolution, as for example D835Y and D835G, have prognostic impact as being ... Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood. 2013; 122:100-8. https://doi.org/10.1182/blood-2013-01 ... Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute ... B) Number of detected FLT3-ITDs per method, comparing HTAS to fragment analysis according to clonal size. HTAS (high-throughput ...
The landscape of somatic mutation in normal colorectal epithelial cells.
Sequencing normal colorectal cells provides quantitative insights into the genomic and clonal evolution of cancer. ... sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal ... Sequencing normal colorectal cells provides quantitative insights into the genomic and clonal evolution of cancer. ... sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal ...
Olga Ortega-Martinez | University of Gothenburg
Thus, a better understanding of their developmental pathways is highly relevant to chordate evolution. Previous work in our ... The coelomic epithelium transcriptome from a clonal sea star, Coscinasterias muricata Jonatan L. Gabre, P. Martinez, Helen ... Thus, a better understanding of their developmental pathways is highly relevant to chordate evolution. Previous work in our ... Large-scale gene expression study in the ophiuroid Amphiura filiformis provides insights into evolution of gene regulatory ...
WashU weekly Neuroscience publications | Office of Neuroscience Research | Washington University in St. Louis
Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST. (2020) Genes, 11 (5), . ... "Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST" (2020) Genes. ... leading to an understanding of the clonal evolution within this patient. These data suggest that multi-regional sampling may be ...
Dajiang Liu - Research output - Penn State
Karos Pharmaceuticals - Products, Competitors, Financials, Employees, Headquarters Locations
... from the first mutation and epimutation through clonal selection and tumor recurrence, using next-generation sequencing to ... MRI-guided tumor biopsies and treatment data with longitudinal genomics to allow the reconstruction of tumor evolution in the ...