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Clinical protocols.. Phenotyping is performed on two separate visits to the University of Southern California General Clinical ... Subject recruitment for the BetaGene Study is ongoing, and for this report we describe only those clinical protocols and assays ... All protocols for the BetaGene Study have been approved by the institutional review boards of the participating institutions. ... the families who participated in the BetaGene Study and the support of the University of Southern California General Clinical ...
http://diabetes.diabetesjournals.org/content/56/5/1481
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The consensus protocol addressed two major clinical questions:. *. Primary prevention: Will an intensive treatment program ... Clinical evaluation of vascular damage in diabetes mellitus. J Am Med Assoc 1947;134:1289-1291pmid:20253941. ... The clinical goals of conventional therapy (CONV) were absence of symptoms of hyperglycemia and avoidance of severe or frequent ... Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/ ...
http://diabetes.diabetesjournals.org/content/62/12/3976
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The assessment of clinical human islet grafts in a comprehensive manner would allow the refinement of isolation protocols and ... Implications for Predicting Long-Term Clinical Outcome. Abstract. The success of the Edmonton Protocol for islet ... Islet Graft Assessment in the Edmonton Protocol. Implications for Predicting Long-Term Clinical Outcome. ... A.M.J.S. is a clinical investigator of the Alberta Heritage Foundation for Medical Research and holds the Clinical Research ...
http://diabetes.diabetesjournals.org/content/53/12/3107
*  Pathogenesis of A−β+ Ketosis-Prone Diabetes | Diabetes
Subjects underwent four stable isotope protocols in the General Clinical Research Center. For 2 days prior to each study, they ... and the nursing staff of the Baylor College of Medicine General Clinical Research Center for meticulous attention to protocol ... Protocol 4.. After baseline blood and breath sampling, a priming dose of NaH13CO3 (4 µmol/kg) was given, and then 2,4-13C-β- ... Protocol 2.. After baseline blood sampling, 2H2-citrulline (prime 1.0 µmol/kg, constant 1.0 µmol/kg/h), 15N1-amide-glutamine ( ...
http://diabetes.diabetesjournals.org/content/62/3/912.full
*  Insulin Resistance and Microalbuminuria | Diabetes
The Ethical Committee of the Clinical Research Centre approved the study protocol. ... The main clinical and laboratory features of type 2 diabetic patients included in the main study and in the substudy are given ... 2Department of Clinical and Experimental Medicine, University of Padova, Italy. *. 3Unit of Diabetology, Azienda Ospedaliera, ... 1Clinical Research Centre for Rare Diseases "Aldo e Cele Daccò," Mario Negri Institute for Pharmacological Research, Villa ...
http://diabetes.diabetesjournals.org/content/55/5/1456?ijkey=d62f347f401bb8b5161cbe06f3093e79dfc43755&keytype2=tf_ipsecsha
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The study protocol was approved by the clinical research ethics board of the University of British Columbia. Parents of all ... Clinical Systems, Milwaukee). A total of 24 HLA-A*0201-positive (age [mean ± SD] 9.9 ± 5.1 years, range 1.4-17.7 years, 54% ...
http://diabetes.diabetesjournals.org/content/55/11/3068
*  Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor | Diabetes
Protocol.. The subjects were admitted the previous night to the General Clinical Research Center at the Johns Hopkins Hospital ... Joint Committee on Clinical Investigation) approved the protocol, and written consent was obtained from all participants. ... It bears, for example, on the utility of continuous sensing in providing a real-time indication of clinical hypoglycemia or ... Two sensors were placed subcutaneously by the clinical investigator into the abdomen within 2 inches of each other. After ...
http://diabetes.diabetesjournals.org/content/52/11/2790.full
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The DCCT and the EDIC protocols were approved by the institutional review boards at all participating clinical sites and the ... the Genetic Clinical Research Centers Program (1993-2007), and Clinical Translational Science Center Program (2006 to present ... Clinical neuropathy was not assessed with a frequency that permitted similar analyses of the patterns of incidence over time. ... Clinical characteristics of the former DCCT INT and CONV participants at DCCT baseline, DCCT closeout, and EDIC years 15-18 ...
http://diabetes.diabetesjournals.org/content/64/2/631
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During protocol 2, diabetic patients were admitted to the clinical research facility at ∼12:00 A.M. on the day before the study ... On the first study day, nondiabetic and diabetic subjects in protocol 1 were admitted to the clinical research facility at ∼7: ... protocol 1) and once during improved glycemic control by variable intravenous insulin infusion (protocol 2). ... control subjects), but improved during protocol 2 (P = 0.011 vs. insulin-infused and P , 0.05 vs. control subjects) (Fig. 4B). ...
http://diabetes.diabetesjournals.org/content/50/2/392
*  A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans | Diabetes
All procedures and protocols took place at the General Clinical Research Center (GCRC) and were approved by the Human Subjects ... 233 to D.E.C.), the National Institutes of Health (RO1-DK-55460 to D.S.W. and K23-DK-02689 to J.Q.P.), a General Clinical ... Diet and GCRC protocols.. Before blood sampling, subjects were placed for 2 weeks on an outpatient diet prepared by the ... Ghigo E, Arvat E, Camanni F: Orally active GH secretagogues: state of the art and clinical perspectives. Ann Med 30:159-168, ...
http://diabetes.diabetesjournals.org/content/50/8/1714.full
*  Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection | Diabetes
Thus, variations in dosing protocol can impact the therapeutic dose window and pose a significant challenge for clinical ... Daniel protocol; blue, Kobayashi protocol; green, von Herrath protocol). A single representative VM is shown. ... It is important to note here that simulated responses to alternate protocols provide insight into which protocols are most ... 9-23 peptide immunizations in vivo according to both protocols showed that indeed in live NOD mice the low-frequency protocol ...
http://diabetes.diabetesjournals.org/content/59/12/3148?patientinform-links=yes&legid=diabetes
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1). The study protocol was approved by the Royal Adelaide Hospital Research Ethics Committee and registered as a clinical trial ... Study protocol. Scintigraphic measurements of gastric emptying were performed over 4 h both from T = 0 h to T = 4 h and T = 24 ... The clinical relevance of our study will require confirmatory studies comparing GLP-1 agonists in type 2 patients that have ... for participation in multicentric clinical trials. M.A.N. has also received consulting fees or/and honoraria for membership in ...
http://diabetes.diabetesjournals.org/content/63/2/785
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The Institutional Review Board of the Clinical Research Institute in SNUH approved the study protocol, and informed consent for ... The clinical characteristics of the subjects are summarized in Table 1. Table 2 showed the meta-analyses of type 2 diabetes ... Clinical studies.. All study subjects were examined in the morning after an overnight fast. Anthropometric parameters and blood ... The study protocol was approved by the Ethics Committee of the KHGS and Ajou University Medical Center. ...
http://diabetes.diabetesjournals.org/content/57/8/2226
*  Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss | Diabetes
... were recruited as a control group in the same clinical protocol. These subjects had abdominal programmed surgery (inguinal ... Clinical and biological parameters.. In obese subjects, body composition was estimated by whole-body fan-beam dual energy X-ray ... This clinical work was supported by the Programme Hospitalier de Recherche Clinique, Assistance Publique-Hôpitaux de Paris (AOR ... In humans, the nature of WAT fibrosis and its clinical relevance are poorly documented and have been addressed mostly by gene ...
http://diabetes.diabetesjournals.org/content/59/11/2817?ijkey=02f90f9ecdfa889637686585c4dd5fe151cab559&keytype2=tf_ipsecsha
*  Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in...
As previously described, this study was registered as a clinical trial (19). All protocol and consent documents were approved ... Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest 2015;125: ... Anti-CD3 clinical trials in type 1 diabetes mellitus. Clin Immunol 2013;149:268-278pmid:23726024. ... As per the clinical trials agreement between Amgen and the NIH and separately between Sanofi and the University of Florida, ...
https://diabetes.diabetesjournals.org/content/68/6/1267
*  Improvement in β-Cell Secretory Capacity Following Human Islet Transplantation According to the CIT07 Protocol | Diabetes
The Clinical Islet Transplantation 07 (CIT07) protocol utilizes anti-thymocyte globulin and etanercept induction, islet culture ... These data indicate that engrafted islet β-cell mass is markedly improved with the CIT07 protocol, especially given more ... Improvement in β-Cell Secretory Capacity Following Human Islet Transplantation According to the CIT07 Protocol ... Improvement in β-Cell Secretory Capacity Following Human Islet Transplantation According to the CIT07 Protocol ...
http://diabetes.diabetesjournals.org/content/early/2013/04/22/db12-1802.long?patientinform-links=yes&legid=diabetes
*  The 30-Year Natural History of Type 1 Diabetes Complications | Diabetes
... clinical exam protocol showing the presence of two or more of the following: symptoms, sensory and/or motor signs, and/or ... Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA: A practical two-step quantitative clinical and ... and neuropathy were assessed at 20 and 25 years on the subset of participants with a clinical examination. There was a ...
http://diabetes.diabetesjournals.org/content/55/5/1463.long
*  In Vivo Evidence for Increased Oxidation of Circulating LDL in Impaired Glucose Tolerance | Diabetes
Experimental protocol.. Blood samples were centrifuged within 20 min at 4°C. Serum, citrate, and EDTA plasma was separated from ... 4Institute and Policlinic of Clinical Metabolic Research, Carl Gustav Carus Medical School, University of Technology Dresden, ... Baseline clinical and biochemical characteristics of NGT, IGT, and diabetic (DM) subjects ... newly diagnosed diabetes in our study versus clinical diabetes in the others) accounts for differences in PON activities. In ...
http://diabetes.diabetesjournals.org/content/51/10/3102.long
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Clinical measurements and procedures.. The IRAS protocol required two visits, 1 week apart, of ∼4 h each. Participants were ... 1Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas. ... The IRAS protocol was approved by local institutional review committees, and all participants provided written informed consent ... Three models were constructed for each liver marker: in model A, adjustments were made for age, sex, ethnicity, clinical center ...
http://diabetes.diabetesjournals.org/content/53/10/2623
*  The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in...
Clinical characteristics of these subjects are given in Table 1. Requirement for insulin therapy in the UKPDS was protocol ... We conclude that the different clinical features of LADA and type 1 diabetes cannot be explained by an absence of IDDM2-encoded ... However, the later age of onset (after the peak of type 1 diabetes incidence) and less aggressive clinical course (no immediate ... 5School of Clinical Medical Sciences, University of Newcastle, Newcastle, U.K. ...
http://diabetes.diabetesjournals.org/content/55/6/1890?patientinform-links=yes&legid=diabetes%3B55%2F6%2F1890
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... differences in data collection methods and laboratory protocols over time may produce data-driven artifacts in clinical studies ... The clinical material was extensive from the cross-sectional phase, but the exact causes of death were not available for the ... The observations on clinical and biochemical characteristics were summarized by five model phenotypes. The five models do not ... Self-organizing map colorings of clinical features for men with type 1 diabetes. The map in Fig. 1 can be colored according to ...
http://diabetes.diabetesjournals.org/content/57/9/2480
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Volunteers, clinical and experimental study.. The study protocol was approved by the ethics committee of the University of ...
http://diabetes.diabetesjournals.org/content/52/3/621
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... yet relatively simple protocols to assess insulin action and β-cell function in epidemiological and large-scale clinical trials ... Ra of the reduced protocol well describes the full protocol Ra up to 120 min in both oral tests. Si estimates are shown in Fig ... A: Full protocol sampling schedule of OGTT (5 h, 11 samples) and meal (7 h, 21 samples). B: Reduced protocol sampling schedule ... The reduced protocol Si values are not significantly different and well correlated to those obtained with the full protocol: ( ...
http://diabetes.diabetesjournals.org/content/54/11/3265
*  Carboxyl-Ester Lipase Maturity-Onset Diabetes of the Young Is Associated With Development of Pancreatic Cysts and Upregulated...
For clinical and anatomical evaluation of the pancreas, a standard abdominal protocol was used: axial true fast imaging with ... Protocol for Pancreatic Imaging. Magnetic resonance imaging was performed on a 1.5 T Siemens Avanto running Syngo Magnetic ... Thus there seems to be a sequence of clinical characteristics over time that may reflect a pathogenic process taking place in ... We have previously reported various clinical characteristics for the CEL-mutation-carrying subjects (3). In this study, the ...
http://diabetes.diabetesjournals.org/content/63/1/259.long