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*  Evolution of sex chromosomes and sex-biased gene expression | Department of Biology
Sex chromosomes have evolved from non-sex-determining chromosomes (autosomes) many times throughout the tree of life. Ever ... Second, the neo-sex chromosome is homologous to the sex chromosomes of mammals, which makes it possible - for the first time - ... We are now exploring this remarkable neo-sex chromosome system to understand the evolution of sex chromosomes in terms of ... a neo-sex chromosome, which has been formed by a fusion between an autosome and the ancestral sex chromosomes. This neo-sex ...
https://www.biology.lu.se/research/research-groups/genetics-of-sex-differences/research-projects/evolution-of-sex-chromosomes-and-sex-biased-gene-expression
*  Scandinavian Journal of Work, Environment & Health - Acute myeloid leukemia and clonal chromosome aberrations in relation to...
Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solvents ... No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher ... were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes.. Methods Consecutively ...
https://www.sjweh.fi/show_abstract.php?abstract_id=572
*  Avian sex chromosome dimorphism | Biology Letters
The avian Z chromosome is remarkably preserved across taxa [4]. Usually, it is 4-6th in size among all the chromosomes and has ... 2006 Comparison of the chicken and zebra finch Z chromosomes shows evolutionary rearrangements. Chromosome Res. 14, 805-815. ... 2008 Molecular cloning of zebra finch W chromosome repetitive sequences: Evolution of the avian W chromosome. Chromosoma 117, ... 2007 The molecular basis of chromosome orthologies and sex chromosomal differentiation in palaeognathous birds. Chromosome Res. ...
http://rsbl.royalsocietypublishing.org/content/8/4/636
*  Chromosome segregation control by Escherichia coli ObgE GTPase - Foti - 2007 - Molecular Microbiology - Wiley Online Library
The defects in chromosome partitioning were accompanied by changes in chromosome organization at oriC and ter, visualized by ... Studies of chromosome organization in bacterial cells show that the chromosome is an exquisitely organized and dynamic ... Our results are consistent with a role for ObgE in chromosome partitioning, with defects in chromosome segregation observed ... A reasonable hypothesis is that ObgE is required to license chromosome segregation and, in its absence, chromosomes are ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2007.05811.x/full
*  Dawson, Dean
Proper chromosome segregation requires the co-ordination of chromosome behavior with other cellular events, and the assembly of ... A second project in our laboratory explores the basis of chromosome segregation errors in meiosis. In meiosis I, chromosomes ... Our goal is to elucidate fundamentals of chromosome behavior that will provide insights into the origins of chromosome ... The improper partitioning of chromosomes is responsible for a many human maladies. Errors in mitotic chromosome segregation ...
http://omrf.org/research-faculty/scientists/dawson-dean/
*  Department of Biological Sciences
Oxidative Damage Leads to Errors in Meiotic Chromosome Segregation. Submitted by Ann Lavanway on Sun, 10/30/2016 - 1:03pm ... Read more about Oxidative Damage Leads to Errors in Meiotic Chromosome Segregation ... lab has demonstrated that oxidative damage causes a premature loss of sister chromatid cohesion and an increase in chromosome ... oxidative damage contributes to maternal age effect then reducing oxidative damage could be a strategy for reducing chromosome ...
http://biology.dartmouth.edu/node/
*  UC Davis Health System Feature Story: 22q11.2 deletion syndrome...
The condition's name describes a location on the 22nd chromosome, where a tiny bit of genetic information is missing: a ... Tony Simon runs a clinic dedicated to supporting children with chromosome 22q11.2 deletion syndrome and educating health-care ... the often baffling chromosome 22q11.2 deletion syndrome (22q11.2DS). ... More about chromosome 22q11.2DS. Further information about the laboratory may be found on the Web at http://cabil.mindinstitute ...
http://www.ucdmc.ucdavis.edu/welcome/features/2010-2011/07/20100714_22q112DS.html
*  Sex Chromosomes: Genetics, Abnormalities, and Disorders
Sex chromosomes determine the sex of an organism. A human somatic cell has two sex chromosomes: XY in male and XX in female. A ... Most XX men who lack a Y chromosome do still have a copy of the SRY gene on one of their X chromosomes (moved there by ... Combination of a Y-sperm and an egg will produce a male.Usually, a woman has two X chromosomes (XX) and a man one X and one Y ( ... Chapter 1. Sex Chromosomes, Gender Differences and Disease, pp. 1-24 (Lopes AM, Sargent CA, Affara NA, Amorim A, Instituto de ...
https://www.novapublishers.com/catalog/product_info.php?products_id=9697
*  A Conserved Checkpoint Monitors Meiotic Chromosome Synapsis in Caenorhabditis elegans | Science
Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated ... A Conserved Checkpoint Monitors Meiotic Chromosome Synapsis in Caenorhabditis elegans Message Subject. (Your Name) has ... This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also ... We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic ...
http://science.sciencemag.org/content/310/5754/1683
*  The influence of sex chromosome aneuploidy on brain asymmetry. - Department of Psychiatry
The findings suggest that the number of sex chromosomes influences the development of brain asymmetry not simply to modify the ... We therefore applied a novel image analysis technique to investigate the relationship between sex chromosome dosage and ... as a function of sex chromosome dosage, be respectively decreased in TS women and increased in KS men, relative to ... who have only one X-chromosome exhibit deficits of spatial ability whereas males with Klinefelter's syndrome (KS) who possess a ...
https://www.psych.ox.ac.uk/publications/139803
*  Sex chromosome recombination suppression | Philosophical Transactions of the Royal Society B: Biological Sciences
2. Do chromosomes carrying sex-determining genes evolve suppressed recombination more frequently than other chromosomes? ... Evolution of recombination rates between sex chromosomes. Deborah Charlesworth. Published 6 November 2017.DOI: 10.1098/rstb. ... Evolution of recombination rates between sex chromosomes Message Subject (Your Name) has sent you a message from Philosophical ... In species with genetic sex-determination, the chromosomes carrying the sex-determining genes have often evolved non- ...
http://rstb.royalsocietypublishing.org/content/372/1736/20160456
*  Meiotic Behavior of an Asymmetric Neo-Sex Bivalent in Caenorhabditis elegans: Synaptic Adjustment and Crossover Redistribution ...
In Caenorhabditis elegans males carrying mnT12, an X;IV fusion chromosome, mnT12 and IV form an asymmetric bivalent: chromosome ... Heteromorphic sex chromosomes, such as the X/Y pair in mammals, differ in size and DNA sequence yet function as homologs during ... Here, we investigate the meiotic behavior of this asymmetric neo-X/Y chromosome pair in C. elegans. Through immunolocalization ... propose that redistribution of crossovers triggered by bivalent asymmetry may be an important driving force in sex chromosome ...
http://www.genetics.org/content/early/2011/01/06/genetics.110.124958
*  History
Chromosomes are number 1 through 22; the 23rd pair are called sex chromosomes because they determine a person's sex (male or ... If the lock is missing from one of the pair of chromosomes 22s, only one chromosome 22 will light up in the area in question ( ... This may include a whole extra chromosome, as in Down syndrome (an extra number 21), a whole missing chromosome, as in Turner ... which is also called the long arm of the chromosome. (Chromosomes are divided into two parts, the top half being called the 'p ...
http://www.cbil.upenn.edu/VCFS/history.html
*  Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic PathologyHighlights | Arteriosclerosis,...
Conclusions-An XY sex chromosome complement mediates diffuse aortic pathology, whereas an XX sex chromosome complement ... Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic PathologyHighlights. Yasir Alsiraj, Sean E ... To define mechanisms for these sex differences, we determined the role of sex chromosome complement and testosterone on the ... Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic PathologyHighlights ...
http://atvb.ahajournals.org/content/38/1/143?download=true
*  Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control | Science
At early passages of the A9/CX donor cells, the hamster X chromosome was highly active, inducing senescence in 100% of the ... Transfer of a normal Chinese hamster X chromosome (carried in a mouse A9 donor cell line) to a nickel-transformed Chinese ... These results suggest that a senescence gene or genes, which may be located on the Chinese hamster X chromosome, can be ... Full senescing activity of the intact hamster X chromosome was restored by treatment of the donor mouse cells with 5- ...
http://science.sciencemag.org/content/251/4995/796
*  Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary...
... of which 94 displayed lagging chromosomes, for a total of 130 chromosome loss events for the two chromosomes under study. The ... Chromosome loss events during mitosis can be visualized in anaphase cells as lagging chromosomes left near the spindle equator ... Lagging chromosomes appear during anaphase. To test the possibility that cells showing lagging chromosomes at anaphase were ... Laggin chromosomes are seen left behind at the spindle equator during anaphase only, after metaphase chromosome congression, as ...
http://jcs.biologists.org/content/115/3/507
*  Importance of TEX19.1 in chromosome segregation in murine ES cells
Cells possessing the incorrect number of chromosomes (referred to as aneuploid) can arise as a result of chromosome mis- ... Importance of TEX19.1 in chromosome segregation in murine ES cells. Download. Relovska2016.docx (25.40Mb) ... In both meiosis and mitosis, accurate chromosome segregation relies on the correct orientation of sister chromatids during ... I compared the incidence of errors commonly associated with chromosome mis-segregation between Tex19.1-/- and control cells, ...
https://www.era.lib.ed.ac.uk/handle/1842/25724
*  The region 3′ to Xist mediates X chromosome counting and H3 Lys‐4 dimethylation within the Xist gene | The EMBO Journal
A counting process senses the X chromosome/autosome ratio and ensures that X chromosome inactivation (XCI) initiates in the ... Rastan S, Robertson EJ, Rasmussen TP, Mastrangelo MA, Eden A, Pehrson JR, Jaenisch R (1985) X‐chromosome deletions in embryo‐ ... Panning B, Dausman J, Jaenisch R, Avner P, Brockdorff N, Turner BM (1997) X chromosome inactivation is mediated by Xist RNA ... Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N (1996) Requirement for Xist in X chromosome inactivation. Nature 379: ...
http://emboj.embopress.org/content/23/3/594
*  Errors in chromosome segregation during oogenesis and early embryogenesis - WRAP: Warwick Research Archive Portal
Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome ... Analysis of nine chromosome probes in first polar bodies and metaphase II oocytes for the detection of aneuploidies. Eur J Hum ... Hultén, Maj A., Smith, Edward M. and Delhanty, Joy D. A. (2010) Errors in chromosome segregation during oogenesis and early ... Differences in chromosome susceptibility to aneuploidy and survival to first trimester. Reprod Biomed Online 2004;8(1):81-90. ...
http://wrap.warwick.ac.uk/3796/
*  Genetic Diversity on the Human X Chromosome does not Support a Strict Pseudoautosomal Boundary | Genetics
Unlike the autosomes, recombination between the X chromosome and Y chromosome is often thought to be constrained to two small ... The PAR1 spans the first 2.7 Mb of the proximal arm of the human sex chromosomes, while the much smaller PAR2 encompasses the ... Genetic Diversity on the Human X Chromosome does not Support a Strict Pseudoautosomal Boundary. Daniel J. Cotter, Sarah M. ... Genetic Diversity on the Human X Chromosome does not Support a Strict Pseudoautosomal Boundary. Daniel J. Cotter, Sarah M. ...
http://www.genetics.org/content/early/2016/03/21/genetics.114.172692
*  Plus it
... attachments to chromosomes through Aurora-A and Plk1 kinases, thereby increasing the frequency of lagging chromosomes during ... DNA damage response during mitosis induces whole chromosome mis-segregation. Samuel F Bakhoum, Lilian Kabeche, John P. Murnane ... DNA damage response during mitosis induces whole chromosome mis-segregation. Samuel F Bakhoum, Lilian Kabeche, John P. Murnane ... DNA damage response during mitosis induces whole chromosome mis-segregation. Samuel F Bakhoum, Lilian Kabeche, John P. Murnane ...
http://cancerdiscovery.aacrjournals.org/content/early/2014/08/08/2159-8290.CD-14-0403
*  Transitions Between Male and Female Heterogamety Caused by Sex-Antagonistic Selection | Genetics
This effect can entirely prevent a new w chromosome from invading, or it may slow down the spread of W as the y chromosome ... For example, a mutation that changes an X chromosome (recessive to Y) to a W chromosome (dominant and feminizing over Y) will ... The second difference is that the mutant female carries a w chromosome, instead of an x chromosome. This results in a fitness ... Deleterious recessive mutations completely linked to the ancestral Y chromosome can prevent invasion of a neo-W chromosome or ...
http://www.genetics.org/content/186/2/629
*  Small supernumerary marker chromosome - Wikipedia
47th autosomal chromosome called a small supernumerary marker chromosome (sSMC). These small supernumerary marker chromosomes ... Humans typically have 22 pairs of autosomal chromosomes in their cells, and a pair of sex chromosomes. About 2.7 million ... Small supernumerary marker chromosomes (sSMC) in humans. Cytogenet Genome Research, 2004; 107: 55-67 Liehr et al. Small ... can originate from any of the 24 different human chromosomes. About 70% of the cases with sSMC are de novo (new mutations), 30 ...
https://en.wikipedia.org/wiki/Small_supernumerary_marker_chromosome
*  HUMARA assay - Wikipedia
... that is located on X chromosome. Considering the fact that once one X chromosome is inactivated in a cell, all other cells ... The method is based on X chromosome inactivation and it takes the advantage of having different methylation status of a gene ... 1-) The gene is located on X chromosome and it goes through inactivation by methylation in normal embryogenesis of a female ... The fact that most-but not all-genes on X chromosome undergo inactivation, this feature becomes an important one. 2-) Human ...
https://en.wikipedia.org/wiki/HUMARA_assay
*  Homologous chromosome - Wikipedia
The additional 23rd pair is the sex chromosomes, X and Y. If this pair is made up of an X and Y chromosome, then the pair of ... It reduces the chromosome number in a germ cell by half by first separating the homologous chromosomes in meiosis I and then ... Homologous chromosomes are chromosomes which contain the same genes in the same order along their chromosomal arms. There are ... Therefore, when two chromosomes of the exact structure exist, they are able to pair together to form homologous chromosomes. ...
https://en.wikipedia.org/wiki/Homologous_chromosome