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*  Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation | Journal of Cell Science
Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation Message Subject (Your Name) has sent ... Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation. Nunu Mchedlishvili, Samuel Wieser, ... Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation. Nunu Mchedlishvili, Samuel Wieser, ... Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation. Nunu Mchedlishvili, Samuel Wieser, ...
http://jcs.biologists.org/content/early/2012/03/07/jcs.091967
*  DNA damage response during mitosis induces whole chromosome mis-segregation | Cancer Discovery
DNA damage response during mitosis induces whole chromosome mis-segregation. Samuel F Bakhoum, Lilian Kabeche, John P. Murnane ... DNA damage response during mitosis induces whole chromosome mis-segregation. Samuel F Bakhoum, Lilian Kabeche, John P. Murnane ... DNA damage response during mitosis induces whole chromosome mis-segregation. Samuel F Bakhoum, Lilian Kabeche, John P. Murnane ... DNA damage response during mitosis induces whole chromosome mis-segregation Message Subject (Your Name) has forwarded a page to ...
http://cancerdiscovery.aacrjournals.org/content/early/2014/08/08/2159-8290.CD-14-0403
*  Errors in chromosome segregation during oogenesis and early embryogenesis - WRAP: Warwick Research Archive Portal
Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome ... Hultén, Maj A., Smith, Edward M. and Delhanty, Joy D. A. (2010) Errors in chromosome segregation during oogenesis and early ... It is also clear that superimposed on the maternal meiotic chromosome segregation errors, there are a large number of mitotic ... In this chapter, we summarise current knowledge of errors in chromosome segregation during oogenesis and early embryogenesis, ...
http://wrap.warwick.ac.uk/3796/
*  Aurora Kinases as Anticancer Drug Targets | Clinical Cancer Research
Aurora kinases in spindle assembly and chromosome segregation. Exp Cell Res 2004;301:60-7. ... It is therefore thought likely that aurora C has a specific role in the regulation of chromosome segregation during male ... which act in concert with many other proteins to control chromosome assembly and segregation during mitosis. Aurora dysfunction ... Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 2003;161: ...
http://clincancerres.aacrjournals.org/content/14/6/1639.long
*  Pol : A DNA Polymerase Required for Sister Chromatid Cohesion
Here we report that TRF4, an evolutionarily conserved gene necessary for chromosome segregation, encodes a DNA polymerase with ...
http://www.bio.net/bionet/mm/cellbiol/2000-August/012919.html
*  Mislocalization of the Drosophila centromere-specific histone CIDpromotes formation of functional ectopic kinetochores -...
Analysis of mitoses in living and fixed cells reveals that mitotic delays, anaphase bridges, chromosome fragmentation, and cell ... The presence of microtubule motors and binding proteins, spindle attachments, and aberrant chromosome morphologies demonstrate ... We conclude that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes ... chromosome missegregation, aneuploidy, and growth defects. Thus, CENP-A mislocalization is one possible mechanism for genome ...
https://digital.library.unt.edu/ark:/67531/metadc882613/
*  Microtubule cross-linking activity of She1 ensures spindle stability for spindle positioning | JCB
S2, A-C); characterizations of spindle and chromosome segregation defects in she1 mutants (Fig. S2, D-H; Fig. S3, A-D; and ... Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation. Curr. Biol. 23:2423-2429. ... Given the observed spindle defects, we wondered whether loss of She1 could lead to elevated chromosome segregation errors. We ... SHE1 deletion reduced spindle-associated Bim1 and increased spindle MT dynamics contributing to chromosome segregation errors. ...
http://d2j7maqgsavdlx.cloudfront.net/content/early/2017/08/08/jcb.201701094
*  The Kinetochore Receptor for the Cohesin Loading Complex
... a phenomenon with wide-ranging importance in chromosome segregation and, in multicellular organisms, transcription regulation. ... A similar mechanism targets cohesin to chromosomes in vertebrates. These findings represent a complete molecular description of ...
https://dash.harvard.edu/handle/1/34492077
*  DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric...
Finally, we demonstrate that loss of CENP-C or DNMT3B leads to elevated chromosome misalignment and segregation defects during ... Centromeric and pericentromeric regions are essential for chromosome condensation and the fidelity of segregation. Centromere ... Centromeric and pericentromeric regions are essential for chromosome condensation and the fidelity of segregation.... ... Compelling links exist between DNMT3B and chromosome stability as emphasized by the mitotic defects that are a hallmark of ICF ...
http://oxfordindex.oup.com/view/10.1093/hmg/ddp256
*  BIOL1020 Genetics blog: Cortical dynein and RanGTP in Mitotic Spindle Orientation
... spindle is an important framework of microtubules which align the chromosomes of the cell to maintain even DNA segregation ... at the chromosome [3]. A RanGEF (guanine-nucleotide exchange factor), called RCC1, binds to the chromosomes which locally ... 3] Kiyomitsu, T & Cheeseman, IM, 2012, Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle ... in the vicinity of chromosomes [3]. This dynamic stabilizes the mitotic spindle lateral axis, as forces from the top and bottom ...
http://biol1020-2012-1.blogspot.com/2012/04/cortical-dynein-and-rangtp-in-mitotic.html
*  Chromosome Segregation and Structure
Chromosome Segregation; Centrosomes and Centrioles; Ploidy, Chromosome Segregation Errors, and Disease; Asymmetric Cell ... Organizing Chromosomes during Segregation. Noncanonical Biogenesis of Centrioles and Basal Bodies. Catarina Nabais, Sónia Gomes ... Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer. Erich A. Nigg, Dominik Schnerch, ... The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our ...
https://cshlpress.com/default.tpl?action=full&cart=15338965171120545917&--eqskudatarq=1229&typ=ps&newtitle=Chromosome%20Segregation%20and%20Structure
*  Small GTPase Controls Chromosome Segregation | Science Signaling
Knockdown of Gie in Drosophila cells also blocked normal sister chromosome segregation but did not block the progression of ... Named Gie1 and Gie2 (GTPases indispensible for equal segregation of chromosomes), the new members share about 30% amino acid ... Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. J. Cell Sci. 117, 4705 ... may localize to the spindle mid-zone and mid-body to control chromosome segregation. ...
http://stke.sciencemag.org/content/2004/251/tw337
*  Small GTPase Controls Chromosome Segregation | Science Signaling
Thank you for your interest in spreading the word about Science Signaling.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://stke.sciencemag.org/content/2004/251/tw337/tab-article-info
*  Discovery of a novel chromosome segregation mechanism during cell division | EurekAlert! Science News
Abnormal segregation can cause cell death or diseases like Down syndrome and cancer. Filamentous spindle fibers must bind to ... For the spindle fiber to be correctly joined, the chromosome must have heterochromatin. However, the mechanism for forming this ... chromosomes need to be evenly segregated. This equal distribution is important to accurately pass genetic information to the ... The chromosome centromere is an essential area for chromosome movement and accurate segregation in which a kinetochore ...
https://www.eurekalert.org/pub_releases/2017-03/ku-doa032217.php
*  Spindle asymmetry drives non-Mendelian chromosome segregation
Cortical CDC42 depends on polarization directed by chromosomes, which are positioned near the cortex to allow the asymmetric ... from the cell cortex regulated microtubule tyrosination to induce spindle asymmetry and that non-Mendelian segregation depended ...
https://insights.ovid.com/pubmed?PMID=29097549
*  Live Cell Imaging of Chromosome Segregation During Mitosis | Protocol
This protocol describes an easy and convenient method to label and visualize live chromosomes in mitotic cells using Histone2B- ... Cell cycle control checkpoints that ensure accurate chromosome segregation prevent aneuploidy and cell transformation 1,2,3. In ... Live Cell Imaging of Chromosome Segregation During Mitosis. Prajakta Varadkar1, Kazuyo Takeda2, Brenton McCright1 ... Varadkar, P., Takeda, K., McCright, B. Live Cell Imaging of Chromosome Segregation During Mitosis. J. Vis. Exp. (133), e57389, ...
https://www.jove.com/video/57389/live-cell-imaging-of-chromosome-segregation-during-mitosis
*  Chromosome Segregation and Kinetochore research - Istituto Europeo di Oncologia
Hence, the segregation of the genome is coordinated in time and space.. To study chromosome segregation we implement a multi- ... generating offspring with a correct number of chromosomes. Errors made during chromosome segregation e.g., due to a lack or ... As chromosome segregation and the proteins involved are evolutionary conserved we study them in the yeast Saccharomyces ... To identify new proteins involved in chromosome segregation we perform protein affinity purifications and yeast two-hybrid ...
https://www.ieo.it/it/ricerca/Ricerca-di-base/Dipartimento-di-Oncologia-Sperimentale/Chromosome-Segregation-and-Kinetochore-research-Unit/
*  Genetic Analysis of Hybrid Cells Using Isozyme Markers as Monitors of Chromosome Segregation | SpringerLink
Genetic Analysis of Hybrid Cells Using Isozyme Markers as Monitors of Chromosome Segregation. ... and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome 1p, Proc. Natl. Acad. Sci. USA 75:2382-2386.PubMed ... Genetic Analysis of Hybrid Cells Using Isozyme Markers as Monitors of Chromosome Segregation. In: Shay J.W. (eds) Techniques in ... McKusick, V. A., and Ruddle, F. H., 1977, The status of the gene map of human chromosomes, Science 196:390-405.PubMedCrossRef ...
https://link.springer.com/chapter/10.1007/978-1-4684-4271-7_35
*  Chromosome segregation control by Escherichia coli ObgE GTPase - Foti - 2007 - Molecular Microbiology - Wiley Online Library
Our results are consistent with a role for ObgE in chromosome partitioning, with defects in chromosome segregation observed ... A reasonable hypothesis is that ObgE is required to license chromosome segregation and, in its absence, chromosomes are ... The mechanism of bacterial chromosome segregation is still mysterious, although the demonstration of segregation defects ... loss of sister cohesion triggers global chromosome movement and mediates chromosome segregation. Cell 121: 899-911. *CrossRef ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2007.05811.x/full
*  Mitotic Centromere-associated Kinesin Is Important for Anaphase Chromosome Segregation | JCB
... as more is known about the basic mechanisms of cell cycle regulation and chromosome segregation, certain lagging chromosome ... Mitotic Centromere-associated Kinesin Is Important for Anaphase Chromosome Segregation. Todd Maney, Andrew W. Hunter, Mike ... Effect of endogenous MCAK depletion on chromosome segregation. Mitotic cells triple-labeled with anti-MCAK (A, D, G, J, M); ... 1994) Video time-lapse study of mitosis in binucleate V79 cells: chromosome segregation and cleavage. Mutagenesis 9:117-123, ...
http://jcb.rupress.org/content/142/3/787
*  Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors | Development
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors Message Subject (Your Name) has sent ... Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Sofia B. Lizarraga, Steven P. ... Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Sofia B. Lizarraga, Steven P. ... Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Sofia B. Lizarraga, Steven P. ...
http://dev.biologists.org/content/137/11/1907
*  Chromosome segregation - Wikipedia
After the first chromosome segregation in meiosis I is complete, there is further chromosome segregation during the second ... Both proper initial segregation of chromosomes in prophase I and the next chromosome segregation during equational division in ... Improper chromosome segregation can result in aneuploid gametes having either too few or too many chromosomes. The second stage ... This segregation process occurs during both mitosis and meiosis. During mitosis chromosome segregation occurs routinely as a ...
https://en.wikipedia.org/wiki/Chromosome_segregation
*  Site-specific recombination and circular chromosome segregation - Enlighten: Publications
Site-specific recombination and circular chromosome segregation. Philosophical Transactions of the Royal Society B: Biological ... functions in Escherichia coli to ensure that circular plasmids and chromosomes are in the monomeric state prior to segregation ... Two recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E. coli chromosome and to sites ...
http://eprints.gla.ac.uk/133505/
*  The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes | Journal of Cell Science
The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes Message Subject (Your Name) has sent you a ... The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes. Muriel D. David, Dominique Petit, Jacques ... The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes. Muriel D. David, Dominique Petit, Jacques ... The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes. Muriel D. David, Dominique Petit, Jacques ...
http://jcs.biologists.org/content/early/2013/11/12/jcs.135079
*  Nilsson group provides new insight into chromosome segregation in Nature Communications - University of Copenhagen
The researches now aim to use this novel model to better understand other aspects of chromosome segregation and investigate if ... "This work provides a novel unifying model for the function of BubR1 in chromosome segregation that can explain previous ... Nilsson group provides new insight into chromosome segregation in Nature Communications. The accurate distribution of the ... Nilsson group provides new insight into chromosome segregation in Nature Communications - University of Copenhagen. ...
http://www.cpr.ku.dk/selected-publications/2016_1/nilsson-group-provides-new-insight-into-chromosome-segregation-in-nature-communications/