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*  New light shed on chromosome fragility
... as this fragility is involved in the development of tumors. A team from the Institut de Génétique et de Biologie Moleculaire et ... Why are certain chromosome regions prone to breakages? The answer is crucial, ... New light shed on chromosome fragility. December 26, 2011 Why are certain chromosome regions prone to breakages? The answer is ... crucial, as this fragility is involved in the development of tumors. A team from the Institut de Génétique et de Biologie ...
https://phys.org/news/2011-12-chromosome-fragility.html
*  Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae - UCL Discovery
Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae. Doctoral thesis , UCL ( ... Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae ... Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae. ... Next, the mechanism underlying chromosome fragility at RSZs was investigated by examining the contribution of various ...
http://discovery.ucl.ac.uk/16125/
*  Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer. | IRIS Univ. Cagliari
Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer. ... Aim: We aimed to verify whether familial fPTC patients show an increased spontaneous chromosome fragility. Methods: To this ... Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer. ... Aim: We aimed to verify whether familial fPTC patients show an increased spontaneous chromosome fragility. Methods: To this ...
https://iris.unica.it/handle/11584/109399
*  Fragile site | Article about fragile site by The Free Dictionary
Indeed, one fragile site under suspicion--a long string of DNA on human chromosome 3 called FRA3B--is often disrupted in breast ...
http://encyclopedia2.thefreedictionary.com/fragile+site
*  Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome
Chromosome fragility and the abnormal replication of theFMR1locus in fragile X syndrome. ... Our data suggest a model for chromosome fragility in FXS in which the repeat impairs replication from an origin of replication ... The molecular basis of the chromosome fragility is unknown. Previous work has suggested that the stable intrastrand structures ... Such alleles are associated with a fragile site, FRAXA, a gap or constriction in the chromosome that is coincident with the ...
https://insights.ovid.com/hmoge/201406010/00008563-201406010-00012
*  Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae - pdf...
Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae. . ... Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae - Descarga ... Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae. ... From this data, we propose a model for a replication-dependent mechanism of chromosomal fragility at the site of inverted ...
http://libros.duhnnae.com/2017/jun7/149815427652-Replication-Dependent-Mechanism-of-Chromosome-Fragility-at-the-Site-of-Inverted-Repeats-in-Saccharomyces-cerevisiae.php
*  Method for the molecular cytogenetic visualization of fragile site FRAXA | SpringerLink
Human chromosome fragility. Biochim. Biophys. Acta. 1779, 3-16.CrossRefPubMedGoogle Scholar ... Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome. Human Mol. Genetics. 23, 2940-2952. ... The role of DNA damage response pathways in chromosome fragility in fragile X syndrome. Nucleic Acids Res. 37, 4385-4392. ... fragile X syndrome mental retardation chromosome fragility FRAXA FMR1 fluorescent in situ hybridization ...
https://link.springer.com/article/10.1134/S0026893317040069
*  Visiting Lecture Series | College of Graduate Studies |SUNY Upstate Medical University
Chromosome fragility: When Replication Goes Awry. We are interested in the mechanisms of how replication defects lead to DNA ... We also develop novel methods using NextGen sequencing to identify chromosome fragile sites in the human genome. ...
http://upstate.edu/grad/faculty/lecture-series.php
*  Andre Nussenzweig, Ph.D. | Center for Cancer Research - National Cancer Institute
Genome Organization Drives Chromosome Fragility. Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon K, Pekowska A ... In 2005, we devised a method to monitor chromosome translocations between c-myc and IgH in vitro. We then performed a series of ...
https://ccr.cancer.gov/Laboratory-of-Genome-Integrity/andre-nussenzweig?qt-staff_profile_tabs=15
*  Frontiers in Bioscience: A virtual library of medicine
Chromosome fragility: molecular mechanisms and cellular consequences. Catherine H. Freudenreich. [Frontiers In Bioscience, ... Hairpin- and cruciform-mediated chromosome breakage: causes and consequences in eukaryotic cells. Kirill S. Lobachev, Alison ...
https://www.bioscience.org/landmark/12l/2007
*  Evolutionary stability of topologically associating domains is associated with conserved gene regulation | BMC Biology | Full...
Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. ... Genome organization drives chromosome fragility. Cell. 2017;170(3):1-15.Google Scholar. ... Comparative analysis of chicken chromosome 28 provides new clues to the evolutionary fragility of gene-rich vertebrate regions ... For each chromosome, we placed the same number of actual breakpoints at a random position of the chromosome. For each ...
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0556-x
*  A Study With RO4917523 in Patients With Fragile X Syndrome
These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific ... and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It ... Chromosome Fragile Sites. Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a ... Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs. ...
https://www.bioportfolio.com/resources/trial/70731/A-Study-With-RO4917523-in-Patients-With-Fragile-X-Syndrome.html
*  Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast | G3: Genes |...
2007 Chromosome fragility: molecular mechanisms and cellular consequences. Front. Biosci. 12: 4911-4924. ... microsatellites are often sites of chromosome fragility, a phenomenon typically attributed to secondary structure formation and ... are shown at their chromosomal position for each of the 16 yeast chromosomes. Mutation number was plotted against chromosome ... per chromosome correlated with chromosome size (R2 = 0.91 and 0.87, respectively). ...
http://www.g3journal.org/content/3/9/1453.full
*  Adelaide Research & Scholarship: Molecular basis of p(CCG)n repeat instability at the FRA16A fragile site locus
Chromosomes, Human; Humans; Chromosome Fragility; Folic Acid; Polymerase Chain Reaction; Sequence Analysis, DNA; Base Sequence ... Repetitive Sequences, Nucleic Acid; Gene Frequency; Alleles; Chromosome Fragile Sites; Models, Genetic; Molecular Sequence Data ...
https://digital.library.adelaide.edu.au/dspace/handle/2440/7355
*  First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus...
13 Underlying inherited marrow failure disorders were excluded clinically and by chromosome fragility testing. Marrow ...
http://www.haematologica.org/content/99/12/1784
*  The Pattern of Gene Amplification Is Determined by the Chromosomal Location of Hairpin-Capped Breaks - Semantic Scholar
... equivalent to homogeneously staining regions in mammalian chromosomes) or extrachromosomal palindromic molecules (equivalent to ... Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae. *Clara ... The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification.. *Shay Covo, ... Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae.. *Vincent Pennaneach, Christopher D. Putnam, ...
https://www.semanticscholar.org/paper/The-Pattern-of-Gene-Amplification-Is-Determined-by-Narayanan-Mieczkowski/03ff7bb38744abfb736b2d7adc660526c86c3305
*  Precise karyotyping of carrot mitotic chromosomes using multicolour-FISH with repetitive DNA | SpringerLink
Here, mitotic chromosomes were subjected to multicolour fluorescence in situhybridization (mFISH) with probes... ... chromosomes are small and uniform in shape and length. ... Karyotype structure and chromosome fragility in the grass ... Carrot (Daucus carota L.) chromosomes are small and uniform in shape and length. Here, mitotic chromosomes were subjected to ... Kato, A., Lamb, J.C., Birchler, J.A.: Chromosome painting using repetitive DNA sequences as probes for somatic chromosome ...
https://link.springer.com/article/10.1007%2Fs10535-015-0558-2
*  Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication | G3: Genes | Genomes |...
2015 Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and ... indicating correct chromosomes segregation, in line with the previous observation that chromosomes segregate correctly in the ... 1995 DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes. J. Biol. Chem. 270: 26766-26769. ... The role of Clb2 in chromosome segregation is unlikely, by itself, to explain this strong synergistic effect. First, as shown ...
http://www.g3journal.org/content/8/2/737
*  Aplastic anemias - ONA
The diagnosis includes chromosome fragility, i.e. damage to chromosomes with exposure to the deoxyribonucleic acid (DNA) cross- ... Chromosome fragility test and detailed family history in patients less than 40 years old to investigate for Fanconi's anemia. ... Demonstration of specific clonal cytogenetic abnormalities, such as trisomies of chromosome 8 or 21 and deletions of 5, 7 and ...
https://www.oncologynurseadvisor.com/hospital-medicine/aplastic-anemias/article/601258/
*  Chromosomal fragile site - Wikipedia
"Human chromosome fragility", Biochimica et Biophysica Acta, 1779 (1): 3-16, doi:10.1016/j.bbagrm.2007.10.005, PMID 18078840 ... A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend ... Common fragile sites are considered part of normal chromosome structure and are present in all (or nearly all) individuals in a ... Sutherland, GR; Baker, E; Seshadri, RS (Jul 1980). "Heritable fragile sites on human chromosomes. V. A new class of fragile ...
https://en.wikipedia.org/wiki/Chromosomal_fragile_site
*  Hyun-Min Kim -BIO-PROTOCOL
Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. EMBO J 27(21): 2896- ...
https://bio-protocol.org/UserHome.aspx?id=1007160
*  Fanconi anemia - Wikipedia
Many FA patients (about 30%) do not have any of the classic physical findings, but Diepoxybutane chromosome fragility assay ... FANCB is the one exception to FA being autosomal recessive, as this gene is on the X chromosome. These genes are involved in ... Furthermore, cells will show chromosomal aberrations, the most frequent being monosomy 7 and partial trisomies of chromosome 3q ... which means that if the mother carries one mutated Fanconi anemia allele on one X chromosome, a 50% chance exists that male ...
https://en.wikipedia.org/wiki/Fanconi_anemia