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*  RETARDATION | SBIR.gov
AND DETERMINE THE FINE STRUCTURE GENETIC MAP OF THE REGION OF THE MOUSE X CHROMOSOME HOMOLOGOUS TO THE HUMAN FRAGILE SITE AND ... THIS PROJECT DESCRIBES THE ISOLATION OF DNA PROBES LINKED TOTHE SITE IN THE HUMAN X CHROMOSOME INVOLVED IN FRAGILITY OF THE ... CHROMOSOME UNDER SOME GROWTH CONDITIONS ("FRAGILE X SITE") AND KNOWN TO BE ASSOCIATED WITH A HIGH INCIDENCE OF MENTAL ... THE NEW METHODS OF CHROMOSOME "WALKING" WILL THEN BE USED TO ISOLATE SEQUENCES THAT SPAN THS SITE ITSELF. ...
https://www.sbir.gov/sbirsearch/detail/82045
*  Welcome to CDC stacks | Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome -...
Fragile X is the most common inherited cause of mental retardation with a prevalence of 1 in 4000 for males and 1 in 5000 to ... Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome ... Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often ... To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women ...
https://stacks.cdc.gov/view/cdc/40463
*  Genome Medicine | PHI
HumCFS: A database of fragile sites in human chromosome.. *imRNA: Prediction of Immunomodulatory RNAs. ... DrugMint: A web server for identification of drug like molecules.. *EbolaVCR: A web-based resource for designing therapeutics ... External Links to web servers developed/mainatined by Indian groups. This section provides URL/links to important websites ... Home » Genomics » Genome Medicine. Genome Medicine. Personalised medicine is a new concept in the field of drug or vaccine ...
http://webs.iiitd.edu.in/genomics/medicine
*  Fragile-X syndrome | chromosomal disorder | Britannica.com
Fragile-X syndrome, a chromosomal disorder associated with a fragile site on the end of the X chromosome. The major symptom of ... Fragile-X syndrome, a chromosomal disorder associated with a fragile site on the end of the X chromosome. The major symptom of ... The X chromosome is one of two sex chromosomes (the other being the Y chromosome). Males have one X and one Y chromosome; ... which is located in the fragile site of the X chromosome and encodes FMRP. FMR1 contains a repetitive sequence of ...
https://www.britannica.com/science/fragile-X-syndrome
*  Human Chromosomes | Orlando J. Miller | Springer
This is the fourth edition of an acclaimed introductory textbook on the structure and function of human chromosomes. The ... Fragile Sites, Trinucleotide Repeat Expansion, and the Fragile X Syndrome. Pages 295-308 ... This is the fourth edition of an acclaimed introductory textbook on the structure and function of human chromosomes. The ... Download Product Flyer Request Instructor Sample on Partner Site macmillanihe.com Download High-Resolution Cover ...
https://www.springer.com/gp/book/9780387950310?utm_medium=referral&utm_source=mihe&utm_campaign=3_pier05_ppbuybutton&utm_content=en_09012018
*  FHIT monoclonal antibody (M05), clone 2G3 - (H00002272-M05) - Products - Abnova
The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations ...
http://www.abnova.com/products/products_detail.asp?catalog_id=H00002272-M05
*  2.1 Children with Genetic Disorders: Fragile X Syndrome - ECI - Module 2: Special Needs and Conditions
Results from chromosomal analyses (see full Glossary) often find a partially broken ('fragile') site on some X chromosomes; ... Category - 2.1 Children with Genetic Disorders: Fragile X Syndrome. Children with Fragile X Syndrome. by Natasha Boskic ... To learn about Fragile X syndrome in the middle childhood years, please visit the six to 12 part of this course:. [1] Source: ... Fragile X is the most common known cause of autism (ASD) and is the most common known inherited cause of cognitive delays. ...
http://blogs.ubc.ca/earlychildhoodintervention2/category/2-1-children-with-genetic-disorders-fragile-x-syndrome/
*  Statistics & Downloads for chromosome 1 | HUGO Gene Nomenclature Committee
fragile site. 13. readthrough. 9. region. 1. unknown. 25. virus integration site. 1. ... Click on a chromosome below to see a statistics & download page for the chosen chromosome. The table below contains the number ... The old file format can still be found on our FTP site and will continue to be updated in the short term. If you use the old ... Site maintained by the External Services team at EMBL-EBI , Terms of Use , Privacy , Cookies ...
https://www.genenames.org/cgi-bin/statistics?c=1
*  Statistics & Downloads for chromosome X | HUGO Gene Nomenclature Committee
fragile site. 6. readthrough. 2. region. 2. unknown. 18. Total Approved Symbols. 1848. ... Click on a chromosome below to see a statistics & download page for the chosen chromosome. The table below contains the number ... The old file format can still be found on our FTP site and will continue to be updated in the short term. If you use the old ... Site maintained by the External Services team at EMBL-EBI , Terms of Use , Privacy , Cookies ...
https://www.genenames.org/cgi-bin/statistics?c=X
*  Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability
"Stably transfected common fragile site sequences exhibit instability at ectopic sites," Genes Chromosomes and Cancer, vol. 47, ... S. G. Durkin and T. W. Glover, "Chromosome fragile sites," Annual Review of Genetics, vol. 41, pp. 169-192, 2007. View at ... F. Hecht and T. W. Glover, "Cancer chromosome breakpoints and common fragile sites induced by aphidicolin," Cancer Genetics and ... H. Zhang and C. H. Freudenreich, "An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome ...
https://www.hindawi.com/journals/bmri/2013/730714/ref/
*  DIP2B gene - Genetics Home Reference - NIH
... promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome ... This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the ... The resources on this site should not be used as a substitute for professional medical care or advice. Users with questions ... Molecular Location: base pairs 50,504,985 to 50,748,667 on chromosome 12 (Homo sapiens Annotation Release 109, GRCh38.p12) ( ...
https://ghr.nlm.nih.gov/gene/DIP2B
*  Genotoxicity reduction in bagasse waste of sugar industry by earthworm technology | SpringerPlus | Full Text
2008). Breaks in chromosomes results from the fragile site breakage (Lukusa and Fryns 2008). Vagrant in chromosomes indicates ... 1999). Bridges in the chromosome may be due to the stickiness or by dicentric chromosome formation (Jabee et al. ... By using this website, you agree to our Terms and Conditions, Privacy statement and Cookies policy. Manage the cookies we use ... Stickiness in the chromosomes may be due to DNA condensation or entanglement of chromatin fibers (Osterberg et al. 1984; ...
https://springerplus.springeropen.com/articles/10.1186/s40064-016-2882-1
*  Frontiers | CRL Ubiquitin Ligases and DNA Damage Response | Oncology
... compromised DDR and destabilized chromosomes, such as chromosomal breaks at fragile sites (Cangi et al., 2008). Therefore, it ... transfer to substrates from the active E2 site and by positioning the active E2 site closer to ubiquitin accepting sites of ... Therefore, it seems that active Chk1 phosphorylates S76 of Cdc25A in response to DNA damage, which creates a priming site for ... S82 of Cdc25A is a primary phosphorylation site in the phospho-degron motif of Cdc25A. Several kinases have been reported to ...
https://www.frontiersin.org/articles/10.3389/fonc.2012.00029/full
*  Changing the Paradigms of Treatment in Peripheral T-cell Lymphoma: From Biology to Clinical Practice | Clinical Cancer Research
... leading to the juxtaposition of the DUSP22 phosphatase gene on chromosome 6p25.3 with the fragile site FRA7H on 7q32.3, ... The sites of primary anatomic origin are not intended to be seen as the exclusive site of disease, but rather should be ... PTCL, NOS, and ALCL, ALK− share karyotypic abnormalities, including gains of chromosomes 1q and 3p and losses on chromosome 6q ... Chromosome abnormalities in peripheral T-cell lymphoma. Cancer Genet Cytogenet 2000;117:71-9. ...
http://clincancerres.aacrjournals.org/content/20/20/5240.full
*  Chromosome VII History
Raveendranathan M, et al. (2006) Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast. ... Hiraga SI, et al. (2012) TFIIIC localizes budding yeast ETC sites to the nuclear periphery. Mol Biol Cell 23(14):2741-54. ... Current and past versions can be obtained from SGD's Download site.. SEQUENCE CHANGES, including any resulting annotation ... for providing the following Chromosome VII ORFs: YGL014C-A, YGL041W-A and YGR035W-A.. Basrai MA, et al. (1999) NORF5/HUG1 is a ...
https://www.yeastgenome.org/cgi-bin/chromosomeHistory.pl?currentAnnotSortBy=annotDateDown&chr=7&annotFeatSort=1
*  Karyological evidence for diversification of Italian slow worm populations (Squamata, Anguidae)
Our analysis showed the presence of a fragile site on chromosomes of this pair, suggesting its propensity for structural ... Comparison with literature data on Central European populations showed a difference on the morphology of the 10th chromosome ... The presence of a fragile site on the tenth chromosome suggests the propensity for this chromosome for structural ... Our analysis showed the presence of a fragile site on chromosomes of this pair, suggesting its propensity for structural ...
https://compcytogen.pensoft.net/article_preview.php?id=1796
*  MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells | BMC Cancer | Full Text
To gain insight into the role of miR-143 in colon cancer, we used a microarray-based approach in combination with seed site ... As expected, transcripts down-regulated upon miR-143 overexpression had a significant enrichment of miR-143 seed sites in their ... miR-143 is located at a fragile site on chromosome 5 frequently deleted in cancer, and has been reported to be down-regulated ... miR-143 is located at a fragile site on chromosome 5 frequently deleted in cancer, and has been reported to be down-regulated ...
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-232
*  Indmedica - Current Pediatric Research
These fragile sites are confined to almost all chromosomes except the Y chro-mosome. Identification of these fragile sites ... Karyogram showed folate sensitive common fragile sites in A, B, C and D group of chromosomes. In A group frag-ile sites were ... Fragile sites were seen in the form of chromosome breaks in 13(thirteen) cases, chromosome loss in 03 (three) case, triradial/ ... Fragile sites were seen in 22 cases in the form of chromosome breaks/gaps,chromosome loss ,triradial/quadriradial configuration ...
http://www.indmedica.com/journals.php?journalid=13&issueid=147&articleid=1990&action=article
*  Plus it
The tumor suppressor gene FHIT spans the FRA3B fragile site, the most active common chromosome fragile site of the human genome ... Ohta M, Inoue H, Cotticelli MG, et al The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated ... a chromosome region that spans the common fragile site FRA16D (8, 9, 10, 11) . Several studies have revealed alterations of ... This gene maps at the location of FRA16D, one of the most active common chromosomal fragile sites (8, 9, 10, 11) . The WWOX ...
http://clincancerres.aacrjournals.org/content/10/7/2459
*  Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth | Molecular Cancer...
hsa-miR-10a is localized in 17q21.32 genome region, which is not a chromosome fragile site or a commonly deleted chromosome ... Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A ... containing the putative target site of USF2 3′-UTR into XbaI-NotI site of the Renilla reporter vector (pRL-SV40, Promega). ... Furthermore, a defined CpG island could not be found near the hsa-miR-10a chromosome localization, making unlikely that an ...
http://mcr.aacrjournals.org/content/6/12/1830.long
*  Strong Association of Chromosome 1p12 Loci with Thyroid Cancer Susceptibility | Cancer Epidemiology, Biomarkers & Prevention
Fragile sites and neuroblastoma: fragile site at 1p13.1 and other points on lymphocyte chromosomes from patients and family ... Strong Association of Chromosome 1p12 Loci with Thyroid Cancer Susceptibility. Aida Baida, Mounaim Akdi, Eddy González-Flores, ... Strong Association of Chromosome 1p12 Loci with Thyroid Cancer Susceptibility. Aida Baida, Mounaim Akdi, Eddy González-Flores, ... Strong Association of Chromosome 1p12 Loci with Thyroid Cancer Susceptibility. Aida Baida, Mounaim Akdi, Eddy González-Flores, ...
http://cebp.aacrjournals.org/content/17/6/1499.long
*  TES Full-Length MS Protein Standard - Creative Proteomics
This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a ... Cancer-associated chromosomal changes often involve regions containing fragile sites. ... Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site ... Home > Products > Stable Isotope Labeled Full Length MS Protein Standard > TES Full-Length MS Protein Standard ...
https://www.creative-proteomics.com/product/detail-cpfl300205_104.htm
*  Research
Role of DNA secondary structures in fragile site breakage along human chromosome 10. Hum Mol Genet. 2013 Apr 1;22(7):1443-56. ... We have developed a protocol can narrow down sites of true fragility within the current cytogenetically-defined fragile sites, ... We demonstrated that fragile sites participate in the generation of RET/PTC rearrangement in thyroid cells, and this allows ... The role of fragile sites in sporadic papillary thyroid carcinoma. J Thyroid Res. 2012;2012:927683. PubMed PMID: 22762011; ...
https://yhwanglab.wordpress.com/about-2/
*  Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma | BMC Medical Genomics | Full Text
WWOX is located at chromosome 16q23.3-q24.1, spanning common fragile site FRA16D [3]. WWOX is detected as functional loss or ... By using this website, you agree to our Terms and Conditions, Privacy statement and Cookies policy. Manage the cookies we use ... Gene Chromosome Canc. 2004, 39 (1): 11-21. 10.1002/gcc.10291.View ArticleGoogle Scholar. ... Gene Chromosome Canc. 2003, 38 (3): 215-225. 10.1002/gcc.10273.View ArticleGoogle Scholar. ...
https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-6-56
*  Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells | BMC Biology ...
Whilst it has long been known that low folate levels can induce fragile sites in both human and mouse chromosomes [29-31], ... Sutherland GR: Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture. Am J Hum ... Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes. Genome Res. 2006, ... Rozier L, El-Achkar E, Apiou F, Debatisse M: Characterization of a conserved aphidicolin-sensitive common fragile site at human ...
https://preview-bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-8-6