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*  RETARDATION | SBIR.gov
AND DETERMINE THE FINE STRUCTURE GENETIC MAP OF THE REGION OF THE MOUSE X CHROMOSOME HOMOLOGOUS TO THE HUMAN FRAGILE SITE AND ... THIS PROJECT DESCRIBES THE ISOLATION OF DNA PROBES LINKED TOTHE SITE IN THE HUMAN X CHROMOSOME INVOLVED IN FRAGILITY OF THE ... CHROMOSOME UNDER SOME GROWTH CONDITIONS ("FRAGILE X SITE") AND KNOWN TO BE ASSOCIATED WITH A HIGH INCIDENCE OF MENTAL ... THE NEW METHODS OF CHROMOSOME "WALKING" WILL THEN BE USED TO ISOLATE SEQUENCES THAT SPAN THS SITE ITSELF. ...
https://www.sbir.gov/sbirsearch/detail/82045
*  Plus it
The tumor suppressor gene FHIT spans the FRA3B fragile site, the most active common chromosome fragile site of the human genome ... Ohta M, Inoue H, Cotticelli MG, et al The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated ... a chromosome region that spans the common fragile site FRA16D (8, 9, 10, 11) . Several studies have revealed alterations of ... This gene maps at the location of FRA16D, one of the most active common chromosomal fragile sites (8, 9, 10, 11) . The WWOX ...
http://clincancerres.aacrjournals.org/content/10/7/2459
*  X chromosome reactivation could treat Rett syndrome, other X-linked disorders | EurekAlert! Science News
... those caused by mutations in the X chromosome -- in females. ... the site of several serious X-linked diseases - could be safely ... including fragile X, CDKL5 disorder and a number of other neurodevelopmental syndromes. For Rett Syndrome, we are actively ... But that cure is locked up by a life-long process called X-chromosome inactivation. Our goal has been to unlock the inactive X ... Females carry two copies of the X chromosome, but within each cell only one copy is active, the other being silenced by an RNA ...
https://www.eurekalert.org/pub_releases/2018-01/mgh-xcr010418.php
*  Trinucleotide Repeat Expansion | Harvard Catalyst Profiles | Harvard Catalyst
Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs. ... Free, web-based electronic data capture tools to support clinical and research studies. ... The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Trinucleotide%20Repeat%20Expansion
*  ZNF19 - Wikipedia
"Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 ( ... This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.. *v ... By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia ... This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16.[5] ...
https://en.wikipedia.org/wiki/ZNF19
*  SCHWESTERCHROMATIDENAUSTAUSCH (sister chromatid exchanges): Topics by WorldWideScience.org
Relationships between fragile sites, chromosome breakages and sister chromatid exchanges: preliminary data ... Chromosome duplications and deletions and their mechanisms of origin Michaelis, R.C.; Wilroy, Jr., R.S.; Velagaleti, G.V.N. ... Sister Chromatid Exchanges in Mammalian Meiotic Chromosomes Allen, J. W.; Walters, C.; Health Effects Research Lab., Research ... Variability in chromosome aberrations, sister chromatid exchanges, and mitogen-induced blastogenesis in peripheral lymphocytes ...
https://worldwidescience.org/topicpages/multi/DE/s/sister+chromatid+exchanges.html
*  Saldivar J[au] - PubMed - NCBI
Citations may include links to full-text content from PubMed Central and publisher web sites. ... Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability. ... Genes Chromosomes Cancer. 2019 May;58(5):317-323. doi: 10.1002/gcc.22684. Epub 2018 Nov 18. Review. ... Genes Chromosomes Cancer. 2013 Nov;52(11):1017-29. doi: 10.1002/gcc.22097. Epub 2013 Aug 9. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Saldivar+J%5Bau%5D&dispmax=50
*  Long-range regulation is a major driving force in maintaining genome integrity | BMC Evolutionary Biology | Full Text
We postulate that long-range transcriptional regulation strongly influences chromosome break fixation. In many regions, the ... Large-scale genome rearrangement events modify the order of genes and non-coding conserved regions on chromosomes. While ... rare fragile sites are present in a small proportion of individuals whereas common fragile sites are present in all individuals ... Fragile sites are regions of the genome which appear as gaps or breaks on metaphase chromosome when exposed to inhibitor of DNA ...
https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-9-203
*  Indmedica - Current Pediatric Research
Fragile - sites are non ran-dom distributed loci on chromosomes which are prone to form breaks/gaps at metaphase stage of cell- ... The dysmorphology of chromosome including high incidences of fragile sites induced by 5-azacytidine in the present study is due ... Saxena AK, Srivastava AK, Singh G .Unexpected seg-regation of chromosome and common fragile site ex-pression induced by 5- ... Sutherland GR, Backer E. The clinical significance of fragile sites on human chromosomes. Clinical Genetics 2000; 58: 157-164. ...
http://www.indmedica.com/journals.php?journalid=13&issueid=144&articleid=1932&action=article
*  Structures of Naturally Evolved CUP1 Tandem Arrays in Yeast Indicate That These Arrays Are Generated by Unequal Nonhomologous...
2014 Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. ... In yeast, which has small chromosomes (,2 Mb), synthesis could continue to the end of the chromosome. This type of event ( ... fragile sites). In yeast, DNA sequences with the ability to form secondary structures (Voineagu et al. 2008) or to perturb the ... The CUP1 repeats are located on the right arm of chromosome VIII, and there are no flanking Ty elements on this arm in S288c. ...
http://www.g3journal.org/content/4/11/2259
*  The 2013 Thomas Hunt Morgan Medal | Genetics
2005 Chromosomal translocations in yeast induced by low levels of DNA polymerase: a model for chromosome fragile sites. Cell ... Though this began with simply monitoring SNPs that altered restriction sites on the relevant chromosome, the second key ... and Tom's initial project was to clone chromosome III by classic chromosome walking. When it became clear that the walk was ... 1988 Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III. Mol. Cell. Biol. 8: ...
http://www.genetics.org/content/194/1/1
*  Visiting Lecture Series | College of Graduate Studies |SUNY Upstate Medical University
We also develop novel methods using NextGen sequencing to identify chromosome fragile sites in the human genome. ... Chromosome fragility: When Replication Goes Awry. We are interested in the mechanisms of how replication defects lead to DNA ...
http://upstate.edu/grad/faculty/lecture-series.php
*  Chromosomal fragile site - Wikipedia
"Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression". American Journal ... "Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23". American ... The FRAXA site is perhaps most famous for its role in Fragile X syndrome, but fragile sites are clinically implicated in many ... Based on their frequency, fragile sites are classified as "common" or "rare". To date, more than 120 fragile sites have been ...
https://en.wikipedia.org/wiki/Chromosomal_fragile_site
*  HOXD8 - Wikipedia
"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1-2 ... This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.. *v ... By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia ... This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD ...
https://en.wikipedia.org/wiki/HOXD8
*  Table of Contents - October 01, 2011, 12 (10) | EMBO Reports
Endogenous fragile sites in chromosomes can only be detected after their breakage. In this report, the authors find that ... Lac operator repeats generate a traceable fragile site in mammalian cells *Ariana Jacome1 and ... This website is best viewed using the latest versions of all modern web browsers. Older browsers may not display correctly. ... insertion of lac operator repeats generate fragile sites that can be followed throughout the cell cycle and show that oncogenes ...
http://embor.embopress.org/content/12/10
*  Method for the molecular cytogenetic visualization of fragile site FRAXA | SpringerLink
Fragile X syndrome is one of the most common reasons for human hereditary mental retardation. It is associated with the ... The presence of a fragile site FRAXA on the X chromosome is typical for patients with this pathology. We developed a method of ... Excess thymidine induced folate sensitive fragile sites. Am. J. Med. Genet. 22, 433-443.CrossRefPubMedGoogle Scholar ... Rare fragile sites. Cytogenet. Genome Res. 100, 77-84.CrossRefPubMedGoogle Scholar ...
https://link.springer.com/article/10.1134/S0026893317040069
*  DIP2B Gene - GeneCards | DIP2B Protein | DIP2B Antibody
CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. (PMID: 17236128) ... This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects ... transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011] ... Binding Sites for Transcription Factors within promoters. ENSR00000051774. 416. 2800. HDGF ARNT ARID4B SIN3A YY1 CBX5 ZNF143 ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=DIP2B
*  ZNF66 Gene - GeneCards | ZNF66 Pseudogene
Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) ... Binding Sites for Transcription Factors within promoters. ENSR00000108313. 430. 1401. PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 YY1 ELK1 ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH19G021019. 1.3. Ensembl ENCODE 14.6. +246.0. ... Chromosome:. 19. Start:. 20,776,270 bp from pter. End:. 20,837,476 bp from pter. Size:. 61,207 bases. Orientation:. Plus strand ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZNF66
*  Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1...
Human chromosomes contain fragile sites susceptible to different damages, resulting in specific chromosomal rearrangements ... 2F). The propensity for chromosome loss was greater than that for chromosome gain (Fig. 2F, 2G). As cancer cell lines, such as ... The chromosomal aberrations at these fragile sites may have selective advantages in vivo and thus contribute to HCV oncogenesis ... F and G, Percentages of chromosome loss (F) and gain (G) of individual chromosomes in HCV-infected Raji cells at 180 d ...
http://www.jimmunol.org/content/185/11/6985.long
*  Long-range heterochromatin association is mediated by silencing and double-strand DNA break repair proteins | JCB
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and ... Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. Cell. 120:587 ... We did not observe any significant association between HMR on chromosome VI and HML at its native site on chromosome III (Fig. ... HML and HMR proximity when placed on chromosome VI. (A) Schematic of chromosome III and chromosome VI. A 64× LacO array was ...
http://jcb.rupress.org/content/201/6/809?ijkey=7930300f2a0d896a9ff117e4bd0d1d6f6069d2f6&keytype2=tf_ipsecsha
*  Nuclear Enzymes, Fragile Sites, and Cancer
Asterisks indicate chromosome fragile sites. Dots indicate locations of select oncogenes. Discussion [abbreviated]. In 1983 the ... The finding of a large number of recurrent fragile sites on human chromosomes provides suggestive evidence for the origin of ... In addition, 26 of 36 oncogenes that had been mapped to a chromosome band or subband had a corresponding fragile site ( ... Fifty of the 110 fragile sites coincided with the location of 50 of 75 recurrent chromosome breakpoints observed in more than ...
https://mbbnet.ahc.umn.edu/hoff/hoff_fs2.html
*  Remarkably Long-Tract Gene Conversion Induced by Fragile Site Instability in Saccharomyces cerevisiae | Genetics
All diploids contain fragile site FS2 on the MS71-derived homolog of chromosome III. Both experimental diploids are homozygous ... Models of repair by homologous recombination at yeast fragile site FS2. (A) The right arm of one homolog of yeast chromosome ... Gene conversions are stimulated by instability at fragile site FS2 during S phase. The MS71-derived homolog of chromosome III ... indicates a restriction site exists, ● indicates lack of the site. Numbers are the approximate chromosome coordinate in kb. On ...
http://www.genetics.org/content/204/1/115.figures-only
*  WikiGenes - FHIT - fragile histidine triad
Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX. Ishii, H., Mimori, K., ... The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in ... The FHIT gene, located at the FRA3B fragile site of chromosome 3p14.2, encodes a 16.8 kD homologue of the yeast enzyme ... The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in ...
https://www.wikigenes.org/e/gene/e/2272.html
*  Pemetrexed Disodium and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Non-Small...
Correlate the fragile site on chromosome 12 within the SMRT gene with metastasis after definitive treatment with this regimen ... Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial Neoplasms. ... We are updating the design of this site. Learn more. Show more ... About Site. *ClinicalTrials.gov Background. *About the Results ...
https://clinicaltrials.gov/ct2/show/NCT01731626?cond=%22Lung+Neoplasms%22&rank=16