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The tumor suppressor gene FHIT spans the FRA3B fragile site, the most active common chromosome fragile site of the human genome ... Ohta M, Inoue H, Cotticelli MG, et al The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated ... a chromosome region that spans the common fragile site FRA16D (8, 9, 10, 11) . Several studies have revealed alterations of ... This gene maps at the location of FRA16D, one of the most active common chromosomal fragile sites (8, 9, 10, 11) . The WWOX ...
http://clincancerres.aacrjournals.org/content/10/7/2459
*  New light shed on chromosome fragility
Why are certain chromosome regions prone to breakages? The answer is crucial, as this fragility is involved in the development ... They studied the replication process in these genes and found out that replication in the fragile site region takes place at ... New light shed on chromosome fragility. December 26, 2011 Why are certain chromosome regions prone to breakages? The answer is ... known to exhibit DNA breaks called common fragile sites . They hypothesized that, since the time required for the transcription ...
https://phys.org/news/2011-12-chromosome-fragility.html
*  Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae - UCL Discovery
Interestingly, inhibition of ATR, the mammalian homologue of Mec1, also leads to chromosome instability at common fragile sites ... RSZs and mammalian common fragile sites and to assess whether yeast RSZs as a suitable system for studying common fragile sites ... may alter chromosome structure. Mammalian common fragile sites are the best-characterised, naturally occurring breakage-prone ... One example of a yeast fragile site is the replication slow zone (RSZ), so called because the rate of replication fork ...
http://discovery.ucl.ac.uk/16125/
*  Fragile site | Article about fragile site by The Free Dictionary
Find out information about fragile site. The chromosomal position of a deoxyribonucleic acid sequence predisposed to ... sometimes contains short repetitive sequences Explanation of fragile site ... Indeed, one fragile site under suspicion--a long string of DNA on human chromosome 3 called FRA3B--is often disrupted in breast ... Fragile site , Article about fragile site by The Free Dictionary https://encyclopedia2.thefreedictionary.com/fragile+site ...
http://encyclopedia2.thefreedictionary.com/fragile+site
*  Biofyzikální ústav AV ČR
Both give rise to chromosomal fragile sites, as their replication is intrinsically problematic. However, at the same time, both ... Telomeres and genes encoding 45S ribosomal RNA (rDNA) are frequently located adjacent to each other on eukaryotic chromosomes. ...
http://www.ibp.cz/cs/oddeleni/radiobiologie-a-bunecna-biologie/publication-4893/
*  Male Sex Chromosome Losing Genes By Rapid Evolution, Study Reveals, page 1
The Above Top Secret Web site is a wholly owned social content community of The Above Network, LLC. This content community ... Fragile Earth: 7 hours ago, 25 flags * And the winners of the #FakeNewsAwards are..... Political Mud-Pit: 7 hours ago, 24 flags ... the Y chromosome, has evolved at a much more rapid pace than its partner chromosome, the X chromosome, which both males and ... Instead, a new pair of non-sex chromosomes likely will start on the path to becoming sex chromosomes."" Interesting... So men ...
http://www.abovetopsecret.com/forum/thread483076/pg1
*  Transcription-replication conflicts at chromosomal fragile sites-consequences in M phase and beyond | Springer for Research &...
Certain transcribed regions known as chromosomal fragile sites... ... Durkin SG, Glover TW (2007) Chromosome fragile sites. Annu Rev ... Fragile sites at the centromere of Chinese hamster chromosomes: a possible mechanism of chromosome loss. Mutat Res 397:239-246 ... Hecht F, Glover TW (1984) Cancer chromosome breakpoints and common fragile sites induced by aphidicolin. Cancer Genet Cytogenet ... fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites ...
https://rd.springer.com/article/10.1007/s00412-016-0617-2
*  A novel approach to simultaneously scan genes at fragile sites | BMC Cancer | Full Text
Chromosome 3 short arm was present in normal copy number indicating that deletions were site specific. In contrast WWOX was not ... The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing ... The presence of site specific deletions of FHIT in these cell lines and primary tumors support its possible role in South ... Fragile sites are regions of the genome sensitive to replication stress and to exposure to environmental carcinogens. ...
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-6-205
*  Adelaide Research & Scholarship: Molecular basis of p(CCG)n repeat instability at the FRA16A fragile site locus
Chromosome Fragile Sites; Models, Genetic; Molecular Sequence Data; Asian Continental Ancestry Group; European Continental ... Rare, folate-sensitive fragile sites are the result of the unstable expansion of trinucleotide p(CCG)n repeats, which are ... Differences in the number and frequency of alleles of the fragile site FRA16A p(CCG)n repeat were observed between different ... Perfect repeat configuration therefore appears to be a necessary precondition for the instability associated with fragile site ...
https://digital.library.adelaide.edu.au/dspace/handle/2440/7355
*  Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing | Nature Methods
Chromosome fragile sites. . Annu. Rev. Genet. 41, 169-192 (2007).. **CAS*PubMed*Article*Google Scholar*27.. Zhang, H. & ... An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae. . Mol. ... ATR regulates fragile site stability. . Cell 111, 779-789 (2002).. **CAS*PubMed*Article*Google Scholar*24.. Benjamini, Y. & ... Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. . Nat. Struct. Mol. Biol. 17, 299- ...
https://www.nature.com/articles/nmeth.2408?error=cookies_not_supported&code=7cb81b1e-2c06-417e-9dd3-08256b692688
*  Host-induced aneuploidy and phenotypic diversification in the Sudden Oak Death pathogen Phytophthora ramorum | BMC Genomics |...
Common fragile sites as targets for chromosome rearrangements. DNA Repair. 2006;5(9-10):1126-35.View ArticlePubMedGoogle ... Chromosome fragile sites. Annu Rev Genet. 2007;41:169-92.View ArticlePubMedGoogle Scholar. ... These include breakage of chromosomes at common fragile sites under replication stress, followed by repair of the double-strand ... Chromosome size differences in Phytophthora palmivora, a pathogen of cocoa. Nature. 1975;255(5511):704-5.View ArticlePubMed ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2717-z
*  Genome instability - Wikipedia
Durkin, Sandra G.; Glover, Thomas W. (Dec 2007). "Chromosome Fragile Sites". Annual Review of Genetics. 41 (1): 169-192. doi: ... These sites are called fragile sites, and can occur commonly as naturally present in most mammalian genomes or occur rarely as ... Rare fragile sites can lead to genetic disease such as fragile X mental retardation syndrome, myotonic dystrophy, Friedrich's ... Although, seemingly harmful, these common fragile sites are conserved all the way to yeast and bacteria. These ubiquitous sites ...
https://en.wikipedia.org/wiki/Genome_instability
*  Chromosomal localization and evolution of satellite DNAs and heterochromatin in grasses (Poaceae), especially tribe Aveneae -...
All satellite DNAs (satDNA) tested are situated predominantly subtelomerically in the chromosomes, but occur also colocalized ... and GC-rich regions in the chromosomes of 32 species of the grass family Poaceae have been established by means of fluorescence ... Functional repetitive sequences and fragile sites in chromosomes of Lolium perenne L.. *Laiane Corsini Rocha, Fernanda de ... Chromosome evolution in wild oat grasses (Aveneae) revealed by molecular phylogeny.. *Grit Winterfeld, Elke Döring, Martin ...
https://www.semanticscholar.org/paper/Chromosomal-localization-and-evolution-of-satellite-Winterfeld-R%C3%B6ser/12fbe40d540578580c2789987d44b5587069b1f8
*  Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication | G3: Genes | Genomes |...
2007 Chromosome fragile sites. Annu. Rev. Genet. 41: 169-192.. OpenUrlCrossRefPubMedWeb of Science ... indicating correct chromosomes segregation, in line with the previous observation that chromosomes segregate correctly in the ... 1995 DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes. J. Biol. Chem. 270: 26766-26769. ... The role of Clb2 in chromosome segregation is unlikely, by itself, to explain this strong synergistic effect. First, as shown ...
http://www.g3journal.org/content/8/2/737
*  Induction of Folate Sensitive Chromosomal Fragile Sites by Fudr in Pakistani Lohi Sheep (Ovis aries) | Korea Science
Induction of Folate Sensitive Chromosomal Fragile Sites by Fudr in Pakistani Lohi Sheep (Ovis aries) - Folate Sensitive; ... Analysis of aphidicolineinduced chromosome fragile sites in domestic pig (Sus scrofa) Cytogenet cell Genet. 62:110-116. ... FUdR with no fragile sites. The sex comparison for the distribution of fragile sites across the Lohi genome did not reveal any ... Folate sensitive common fragile sites in chromosomes of the domestic pig (Sus scrofa). Res. Vet. Sci. 55:231-235. ...
http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1DMBP_2008_v21n8_1103
*  Ch9: Genetics Flashcards by | Brainscape
reversal of the normal order of genes in a chromosome segment involving only the part of a chromosome at one side of the ... Brainscape is a web and mobile study platform that helps you learn things faster. Our mission is to create a smarter world by ... Fragile X syndrome. Ocular albinism. Chronic granulomatous disease. Menkes syndrome. Testicular feminization. X-linked SCID. X- ... Male hypogonadism that occurs when there are two or more X chromosomes and at least one Y chromosome (needed for the male ...
https://www.brainscape.com/flashcards/ch9-genetics-1109503/packs/1923500
*  Difference between revisions of "CH391L/S2013" - OpenWetWare
Chromosome Fragile Sites. * Replication-Transcription Conflicts. * Replication-Collapse at Interstrand Cross Links ... Course web page: The course web site on the OpenWetWare (OWW) Wiki will be used to complete assignments. Participants will be ... The class will be notified of any changes in class and on the OpenWetWare course web site. ... you are required to complete a written report by creating a new page on the course web site that is an in-depth discussion of ...
https://openwetware.org/wiki/?title=CH391L/S2013&diff=prev&oldid=668045
*  A Study With RO4917523 in Patients With Fragile X Syndrome
FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X ... followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g ... Chromosome Fragile Sites. Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a ... Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs. ...
https://www.bioportfolio.com/resources/trial/70731/A-Study-With-RO4917523-in-Patients-With-Fragile-X-Syndrome.html
*  Difference between revisions of "CH391L/S2013" - OpenWetWare
Chromosome Fragile Sites. −. −. * Replication-Transcription Conflicts. −. −. * Replication-Collapse at Interstrand Cross Links ... Course web page: The course web site on the OpenWetWare (OWW) Wiki will be used to complete assignments. Participants will be ... Course web page:''' The [http://openwetware.org/wiki/CH391L/2013 course web site] on the [http://openwetware.org/wiki/Main_Page ... Course web page:''' The [http://openwetware.org/wiki/CH391L/2013 course web site] on the [http://openwetware.org/wiki/Main_Page ...
https://openwetware.org/wiki/?title=CH391L/S2013&curid=129031&diff=668156&oldid=668015
*  ASMscience | DNA Recombination Strategies During Antigenic Variation in the African Trypanosome
... can be changed by recombination-based and transcription-based processes that focus on telomeric VSG gene transcription sites. ... Chromosome fragile sites. Annu Rev Genet 41:169-192. [PubMed][CrossRef]. 177. Ozeri-Galai E, Lebofsky R, Rahat A, Bester AC, ... DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in african trypanosomes. ... Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites. Mol Cell 43:122- ...
http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MDNA3-0016-2014
*  Cytogenetic and Genome Research 2016, Vol. 149, No. 4 - Karger Publishers
Interstitial NORs, Fragile Sites, and Chromosome Evolution: A Not So Simple Relationship - The Example of Melolontha melolontha ... Mixed-Up Sex Chromosomes: Identification of Sex Chromosomes in the X1X1X2X2/X1X2Y System of the Legless Lizards of the Genus ... JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. ... For Manuscript Submission, Check or Review Login please go to Submission Websites List. ...
https://www.karger.com/Journal/Issue/273468
*  Chromosomal fragile site - Wikipedia
"Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression". American Journal ... "Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23". American ... The FRAXA site is perhaps most famous for its role in Fragile X syndrome, but fragile sites are clinically implicated in many ... Based on their frequency, fragile sites are classified as "common" or "rare". To date, more than 120 fragile sites have been ...
https://en.wikipedia.org/wiki/Chromosomal_fragile_site
*  SKY/FISH | Roswell Park Comprehensive Cancer Center
... and fragile site analysis as well as more specialized techniques such as Spectral karyotyping (SKY) and fluorescent in situ ... Services include conventional chromosome analysis such as G-banding (Human tissue only) ... Services include conventional chromosome analysis such as G-banding (Human tissue only) and fragile site analysis as well as ... Chromosome aberration and fragile site analysis. *Planning of inter-disciplinary projects utilizing SKY/FISH technology, data ...
https://www.roswellpark.org/shared-resources/pathology-network/services-and-fees/skyfish
*  Fragile X syndrome
In Renpenning's syndrome, there is no fragile site on the X chromosome. Renpenning's cases have short stature, moderate ... "marker X chromosome" in association with mental disability.[3] In 1970 Frederick Hecht coined the term "fragile site". ... There are four generally accepted states of the chromosome region involved in Fragile X syndrome which relate to the length of ... Fragile X syndrome (FXS), or Martin-Bell syndrome, is a genetic syndrome which results in a spectrum of characteristic physical ...
http://www.princeton.edu/~achaney/tmve/wiki100k/docs/Fragile_X_syndrome.html
*  DCB - DNA and Chromosome Aberrations Research - National Cancer Institute
Mechanisms involved in mitotic chromosome segregation and chromosome imbalance, translocations, and fragile sites ... Role of DNA fragile sites, which are regions of the chromosome that are prone to breakage and are hotspots for translocations ... Role of nonconventional DNA structures in generating fragile sites. Emerging research areas include understanding the role of ... An emerging area of interest is the role that chromosome translocations play in driving tumorigenesis and cancer progression. ...
https://www.cancer.gov/about-nci/organization/dcb/research-portfolio/dcar