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*  Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi...
... chromosome breakage and DNA cross-linker sensitivity. Surprisingly, male and female mutant mice had reduced numbers of germ ... Fanconi anemia (FA) is an autosomal recessive chromosome instability syndrome characterized by progressive bone marrow (BM) ...
https://digital.lib.washington.edu/researchworks/handle/1773/4433
*  Fibroblast Fanconi Anemia Breakage - Seattle Children's Hospital
Chromosome breakage analysis is a test for assessing genomic instability. The most common syndrome for which this test is ... Test Code SK FANC UM Fibroblast Fanconi Anemia Breakage Clinical System Name. Fibroblast Fanconi Anemia Breakage ... In such a case, breakage analysis of skin fibroblasts is necessary to detect the increased breakage and radial formation. This ... The first step in FA diagnosis is to perform a breakage analysis on peripheral blood. However, some FA patients undergo a self- ...
http://seattlechildrenslab.testcatalog.org/show/SK-FANC-UM-1
*  Fanconi anemia group F protein elisa and antibody
... increased chromosome breakage) and defective DNA repair.. Protein type: DNA repair, damage. Chromosomal Location of Human ... May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).. ... May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCF ...
https://www.mybiosource.com/protein_family.php?root=fanconi-anemia-group-f-protein
*  New light shed on chromosome fragility
Why are certain chromosome regions prone to breakages? The answer is crucial, as this fragility is involved in the development ... New light shed on chromosome fragility. December 26, 2011 Why are certain chromosome regions prone to breakages? The answer is ... Scientists identify molecular basis for DNA breakage. July 19, 2011 Scientists from the Hebrew University have identified the ... Laszlo Tora and his colleagues have discovered that breakages in the longest human genes are due to a phenomenon previously ...
https://phys.org/news/2011-12-chromosome-fragility.html
*  Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae - UCL Discovery
... chromosome segregation, and (v) cytokinesis. The analyses suggest that chromosome breakage within RSZs requires the actions of ... The Rrm3 helicase and Psy2 phosphatase complex were found to suppress chromosome breakage at RSZs in a manner dependent on Tel1 ... may alter chromosome structure. Mammalian common fragile sites are the best-characterised, naturally occurring breakage-prone ... in mec1-ts mutants results in replication fork stalling followed by chromosome breakage at RSZs. Interestingly, inhibition of ...
http://discovery.ucl.ac.uk/16125/
*  "Assessing DNA Damage and Repair in Various Chromatin States in Tetrahy" by Steven Anton Hill
... and telomeres are added at chromosome breakage sites (CBS). The aim of this research was to investigate NER in T. thermophila ... and telomeres are added at chromosome breakage sites (CBS). The aim of this research was to investigate NER in T. thermophila ...
https://bearworks.missouristate.edu/theses/1857/
*  Chromosome segregation control by Escherichia coli ObgE GTPase - Foti - 2007 - Molecular Microbiology - Wiley Online Library
Replication fork inhibition inseqAmutants ofEscherichia colitriggers replication fork breakage, Molecular Microbiology, 2014, ... The defects in chromosome partitioning were accompanied by changes in chromosome organization at oriC and ter, visualized by ... Studies of chromosome organization in bacterial cells show that the chromosome is an exquisitely organized and dynamic ... Our results are consistent with a role for ObgE in chromosome partitioning, with defects in chromosome segregation observed ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2007.05811.x/full
*  Fanconi Anemia; Anemia, Fanconi
Spontaneous chromosome breakage is a feature of this disease along with predisposition to leukemia. There are at least 7 ...
https://lookfordiagnosis.com/mesh_info.php?term=Fanconi+Anemia&lang=1
*  Chromosome centric fusion synonyms, chromosome centric fusion antonyms - FreeThesaurus.com
Antonyms for chromosome centric fusion. 1 synonym for centric: centrical. What are synonyms for chromosome centric fusion? ... Synonyms for chromosome centric fusion in Free Thesaurus. ... Chromosome banding. *Chromosome banding. *chromosome breakage ... redirected from chromosome centric fusion). Also found in: Dictionary, Medical, Legal, Encyclopedia. #vtZoom,.vt-link{cursor: ... Chromosome centric fusion synonyms, chromosome centric fusion antonyms - FreeThesaurus.com https://www.freethesaurus.com/ ...
http://www.freethesaurus.com/chromosome+centric+fusion
*  Chromosome breakage syndromes | definition of Chromosome breakage syndromes by Medical dictionary
What is Chromosome breakage syndromes? Meaning of Chromosome breakage syndromes medical term. What does Chromosome breakage ... Looking for online definition of Chromosome breakage syndromes in the Medical Dictionary? Chromosome breakage syndromes ... redirected from Chromosome breakage syndromes). Also found in: Dictionary, Encyclopedia.. Related to Chromosome breakage ... Chromosome breakage syndromes , definition of Chromosome breakage syndromes by Medical dictionary https://medical-dictionary. ...
https://medical-dictionary.thefreedictionary.com/Chromosome+breakage+syndromes
*  Statistics about Thrombocytopenia -- chromosome breakage - RightDiagnosis.com
... chromosome breakage as a medical condition including prevalence, incidence, death rates, and social and hospital statistics. ... Thrombocytopenia -- chromosome breakage: Rare Disease Status. Thrombocytopenia -- chromosome breakage is listed as a "rare ... Thrombocytopenia -- chromosome breakage: Rare Disease Status. Thrombocytopenia -- chromosome breakage is listed as a "rare ... Statistics about Thrombocytopenia -- chromosome breakage. *Prevalence and Incidence of Thrombocytopenia -- chromosome breakage ...
http://www.rightdiagnosis.com/t/thrombocytopenia_chromosome_breakage/stats.htm
*  JCI - Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease
Impairments in chromosome maintenance are linked to rare chromosome breakage disorders. Here, we have identified a chromosome ... Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. Saskia N. van der Crabben,1 Marije ... This work associates missense mutations in NSMCE3 with an autosomal recessive chromosome breakage syndrome that leads to ... In summary, our work describes what we believe to be a novel autosomal recessive chromosome breakage syndrome, resulting from ...
https://www.jci.org/articles/view/82890
*  JCI - Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease
Impairments in chromosome maintenance are linked to rare chromosome breakage disorders. Here, we have identified a chromosome ... with an autosomal recessive chromosome breakage syndrome that leads to defective T and B cell function and acute respiratory ... Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. ... Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. ...
https://jci.org/articles/view/82890/figure/1
*  Bloom syndrome: multiple retinopathies in a chromosome breakage disorder | British Journal of Ophthalmology
Results: A 39 year old man with a rare autosomal recessive "chromosome breakage" syndrome was followed. A variety of ocular ... Bloom syndrome is an archetypal "chromosome breakage syndrome." A recessively inherited mutation in the BLM gene leads to an ... Gibbons B, Scott D, Hungerford JL, et al. Retinoblastoma in association with chromosome breakage syndromes Fanconi's anaemia ... "chromosome breakage syndrome."7 Owing to excessive chromosomal rearrangements in all cell types, somatic mutations occur at a ...
http://bjo.bmj.com/content/88/3/354
*  Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in...
Chromosomal breakage occurs during apoptosis and chromosome rearrangement. Chromosomal breakages tend to cluster in certain ... Chromosomal breakage is an early event in both apoptotic DNA fragmentation and chromosome rearrangement. Previous studies ... These data have been published in our previous report [26]. Chromosomal breakage resulting from chromosome loop excision is an ... IPCR detection of chromosome breaks mediated by H2O2-induced apoptosis in NP69 cells. To detect chromosome breaks within the ...
https://rd.springer.com/article/10.1186%2Fs12867-018-0116-5
*  Chromosome-breakage genomic instability and chromothripsis in breast cancer | BMC Genomics | Full Text
Genomic instability dependent on chromosomal breakage events is not stochastic, targeting some chromosomes clearly more than ... suggesting a particular proclivity of this chromosome for breaks. We also observed chromothripsis affecting various chromosomes ... We describe the number of chromosomal breaks as well as the patterns of breaks on individual chromosomes in each tumor. There ... although the highest density of breaks occurred at chromosome 17 in all subtypes, ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-579
*  "A study in the relation between chromosome breakage and gene mutation " by Evelyn Ackerman
Ackerman, Evelyn, "A study in the relation between chromosome breakage and gene mutation in Drosophila melanogaster." (1961). ... A study in the relation between chromosome breakage and gene mutation in Drosophila melanogaster. ...
https://mouseion.jax.org/strp/1620/
*  Barbara McClintock and the discovery of jumping genes | PNAS
Her studies of chromosome breakage in maize led her to discover a chromosome-breaking locus that could change its position ... She identified a particular chromosome breakage event that always occurred at the same locus on maize chromosome 9, which she ... and found that Ds chromosome breakage could be activated by an Ac element at a different site or even on a different chromosome ... 1981) Identifying P factors in Drosophila by means of chromosome breakage hotspots. Cell 26(3 Pt 1):421-428. ...
http://www.pnas.org/content/109/50/20198
*  A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency | eLife
Next, we monitored chromosome breakage in primary lymphocytes from the two patients and their mother. Baseline and DNA-damage ... Chromosome breakage analysis. Primary lymphocytes were cultured under standard conditions for karyotyping. Baseline and DNA ... A) Spontaneous and mitomycin C-induced chromosome breakage in primary lymphocytes from the mother and the two POI sisters. Data ... In line with a role of FANCM in the maintenance of genome stability, the occurrence of chromosome breakages and rearrangements ...
https://elifesciences.org/articles/30490
*  Andrea Beucher - Info zur Person mit Bilder, News & Links - Personensuche Yasni.de
Chromosome breakage after G2 checkpoint release , JCBjcb.rupress.org › Archive › 12 March. jcb.rupress.org ... An Imperfect G2M Checkpoint Contributes to Chromosome Instability ...https://www.tandfonline.com/doi/pdf cc www.tandfonline.com ...
http://www.yasni.de/andrea+beucher/person+information
*  Plus it
... radial chromosomes or chromatid breaks. D, quantification of abnormal chromosomes in chromosome breakage tests from peripheral ... Chromosome Breakage Studies. The lymphocyte cultures were established from whole blood as routinely applied to make chromosomal ... Upon treatment with diepoxybutane (DEB), proband lymphocytes showed increased chromosomal breakage and radial chromosome ... DEB was used at a final concentration of 0.1-0.22 μg/mL for chromosome fragility tests in lymphocytes and 0.1 μg/mL in ...
http://cancerdiscovery.aacrjournals.org/content/5/2/135
*  Browsing HMS Scholarly Articles by Keyword "Array CGH"
Chromosome-breakage genomic instability and chromothripsis in breast cancer  Przybytkowski, Ewa; Lenkiewicz, Elizabeth; ... Background: Chromosomal breakage followed by faulty DNA repair leads to gene amplifications and deletions in cancers. However, ...
https://dash.harvard.edu/handle/1/4454686/browse?type=subject&value=Array+CGH
*  Handbook of Genetic Counseling/Bloom Syndrome-1 - Wikibooks, open books for an open world
increased chromosome breakage. *increased rate of homologous chromosome exchange. *formation of quadriradial (QR) configuration ...
https://en.wikibooks.org/wiki/Handbook_of_Genetic_Counseling/Bloom_Syndrome-1
*  BCL11A | Cancer Genetics Web
Chromosome 2 Chromosome 3 Chromosome 7 Chromosome 8 Chromosome 9 FISH BCL6 ... Chromosome 14 Chromosome 2 FISH Chronic Lymphocytic Leukemia (CLL) CLL - Molecular Biology ZAP70 ... Chromosome Breakage. *Chromosome 14. *Gene Expression Profiling. *Immunoglobulin Heavy Chains. *Gene Amplification ... Chromosome 14 MicroRNAs Acute Lymphocytic Leukemia (ALL) Childhood Acute lymphoblastic leukaemia (ALL) ALL - Molecular Biology ...
http://www.cancerindex.org/geneweb/BCL11A.htm