Studies of Telomere Structure Using Yeast Model Systems - Jack Griffith
2011) Evolution of linear chromosomes and multipartite genomes in yeast mitochondria. Nucleic Acids Res 39:4202-19 ... Studies of Telomere Structure Using Yeast Model Systems Griffith, Jack D. University of North Carolina Chapel Hill, Chapel Hill ... Studies of Telomere Structure Using Yeast Model Systems. Griffith, Jack D. / University of North Carolina Chapel Hill. $30,585 ... Studies of Telomere Structure Using Yeast Model Systems. Griffith, Jack D. / University of North Carolina Chapel Hill. $38,231 ...
Telomere G- and C-strand synthesis: mechanisms and regulation - Neal Lue
Telomeres are specialized nucleoprotein structures located at the termini of linear eukaryotic chromosomes that are critical ... Telomeres are specialized nucleoprotein structures located at the termini of linear eukaryotic chromosomes that are critical ... Therefore, strategies for manipulating telomere lengths and structures are expected to find applications in multiple clinical ...
Epigenetic and Metabolic Regulation of Gene Silencing in Saccharomyces - Jasper Rine
This research is directed to understand how disease processes can be impacted by heritable changes in chromosome structure that ...
Epigenetic control of meiotic recombination in mammals. - Roberto Pezza
Errors in homologous chromosome segregation during meiosis are the leading cause of birth defects, spontaneous abortions, and ... Proper chromosome segregation requires pairwise associations of maternal and paternal homologous chromosomes via crossovers, ... Experiments in Aim 1 and 2 will also inform the molecular aspects of how changes in chromatin structure influence meiotic ... and ultimately the association of meiotic chromosomes, which is of paramount importance in preventing the chromosome ...
Monoalleleic autosomal spreading of a novel family of nucleolus-localized ncRNAs - Prasanth Kannanganattu
... model that ncRNA-coating of chromosomes are not restricted only to sex chromosomes. The proposed research will be of strong ... Perturbations in nucleolus structure and rDNA expression have been associated with aging related diseases such as progeria. ... The objectives of this proposal are to identify the determinants underlying allele-specific chromosome coating of SNULs, and to ... In the first aim, PI will characterize SNULs and will test whether SNULs display monoallelic chromosome coating utilizing ...
Elucidating the Structure and the Function of Non-Coding RNA-LSD1 Interactions - Nicholas Reiter
... structure and RNA-chromatin associated protein interactions play crucial roles i... ... An ncRNA, termed TERRA, enables LSD1 to interact with a DNA double strand break repair enzyme at the ends of chromosomes ( ... Elucidating the Structure and the Function of Non-Coding RNA-LSD1 Interactions Reiter, Nicholas J. Marquette University, ... Elucidating the Structure and the Function of Non-Coding RNA-LSD1 Interactions. Reiter, Nicholas J. / Marquette University. ...
Cancer Gene Discovery to Identify Targetable Targets - Carlo Croce
This view was shattered by my discovery in 2002 that CLL is caused by the loss of two microRNA genes on chromosome 13q14, miR- ... Its dysregulation in cancer affects chromatin structure. I also discovered the partial duplication of ALL1 (MLL1) in AML. I ...
Aneuploid Cells in the Human Placenta - Heinz-Ulrich Weier
Two placental structures facilitate these functions: floating and anchoring villi. The genetic makeup of floating villi has ... We hypothesize that in the absence of mutations, genomic changes in CTBs such as gains or losses of chromosomes are normal ... Baumgartner, Adolf; Weier, Jingly Fung; Weier, Heinz-Ulrich G (2006) Chromosome-specific DNA repeat probes. J Histochem ... At the end of this project, we will have developed the technology to accurately score all 24 human chromosomes in interphase ...
Polyoma Virus Replication - Robert Garcea
2015) Physical limits on kinesin-5-mediated chromosome congression in the smallest mitotic spindles. Mol Biol Cell 26:3999-4014 ... 2017) Three-Dimensional Structure of the Ultraoligotrophic Marine Bacterium ""Candidatus Pelagibacter ubique"". Appl Environ ...
Pathogenesis and treatment studies in patients with NOMI - Peter Lipsky
The gene that is mutated in the CIAS1 associated diseases encodes a protein, cryopyrin that has similarities in structure and ... a gene located on chromosome 1. The other two diseases being familial cold induced autoinflammatory syndrome (FCAS) or Muckle ...
Mechanism of Renal Tubular Anion Transport - Peter Aronson
... examine structure-function relationships by use of chimeric constructs; and estimate the contribution of the transporter to ... Project 1: Chromosome Inheritance. *Assessing the power of primary drug-screens to predict clinical response. ...
Bruker AVANCE III HD 500 MHz NMR - Jonathan Sessler
Unlocking sequence-structure-function-disease relationships in large protein super-families. *High Resolution Characterization ... Mitotic transmission of acentric chromosome fragments. *MIRA: The biological basis of paternal care in stickleback fish ... that new molecules have been made as per design expectations and to analyze whether a given structure exists in the ...
Generating Evidence on Deprescribing Safety - Elizabeth Bayliss
Unlocking sequence-structure-function-disease relationships in large protein super-families. *High Resolution Characterization ... Mitotic transmission of acentric chromosome fragments. *MIRA: The biological basis of paternal care in stickleback fish ...
Development of Virtual Tumor - Thomas Deisboeck
Unlocking sequence-structure-function-disease relationships in large protein super-families. *High Resolution Characterization ... Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation ... To accomplish these goals over the proposed three years, the team is structured into three cores: A) the administrative core, B ...
The Role of LncRNAs in Pulmonary Fibrosis - Lin Liu
Dissecting the impact of RNA on DNA replication and chromatin structure. *Perinatal Research Society Annual Meeting ... Function of the Subunits of Eukaryotic Chromosomes. Recently added grants:. *Novel Reagents for Monitoring Sulfation Patterns ...
Sigma-1 Receptor Provides Neuroprotection Against Optic Neuropathy - Kathryn Bollinger
Unlocking sequence-structure-function-disease relationships in large protein super-families. *High Resolution Characterization ... Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation ...
Mechanisms of DNA Replication - Kenneth Marians
2011) Structure of the SSB-DNA polymerase III interface and its role in DNA replication. EMBO J 30:4236-47 ... Every time a cell divides a complete and accurate copy of the genetic information stored in the chromosomes must be passed to ... In this proposal we study the mechanisms that ensure that the chromosomes are copied completely by studying the enzymatic ...
Upar-Upa Binding Stoichiometry in Live Cells - Valeria Caiolfa
2014) Enhanced emission of fluorophores on shrink-induced wrinkled composite structures. Opt Mater Express 4:753-763 ... fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures. ...