As faithful chromosome segregation is essential for maintaining the genomic integrity of cells, and deficient chromosome ... that is responsible for a correct chromosome attachment to the spindle poles, thus ensuring proper chromosome segregation; and ... segregation leads to aneuploidy and cancer, we wanted to observe and deepen on what is happening in chromosomes segregation in ... "Next steps would be to study whether other subtypes of B-ALL with abnormal chromosome numbers, such as hypodiploid B-ALL, a ...

Most people are familiar with the well-known X shape of chromosomes, but in fact chromosomes only take on this shape when the ... The consistent segregation of these regions, in the same way in every cell, suggests that these processes could drive ... Each of the cells 20 chromosomes is colored differently. view more Credit: University of Cambridge and MRC Laboratory of ... In a second video regions of the chromosomes where genes are active are coloured blue, and the regions that interact with the ...