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The tumor suppressor gene FHIT spans the FRA3B fragile site, the most active common chromosome fragile site of the human genome ... Ohta M, Inoue H, Cotticelli MG, et al The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated ... a chromosome region that spans the common fragile site FRA16D (8, 9, 10, 11) . Several studies have revealed alterations of ... This gene maps at the location of FRA16D, one of the most active common chromosomal fragile sites (8, 9, 10, 11) . The WWOX ...
http://clincancerres.aacrjournals.org/content/10/7/2459
*  Changing the Paradigms of Treatment in Peripheral T-cell Lymphoma: From Biology to Clinical Practice | Clinical Cancer Research
... leading to the juxtaposition of the DUSP22 phosphatase gene on chromosome 6p25.3 with the fragile site FRA7H on 7q32.3, ... The sites of primary anatomic origin are not intended to be seen as the exclusive site of disease, but rather should be ... PTCL, NOS, and ALCL, ALK− share karyotypic abnormalities, including gains of chromosomes 1q and 3p and losses on chromosome 6q ... Chromosome abnormalities in peripheral T-cell lymphoma. Cancer Genet Cytogenet 2000;117:71-9. ...
http://clincancerres.aacrjournals.org/content/20/20/5240.full
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... a gene mutated in autosomal recessive juvenile Parkinsonism and mapped to the common fragile site FRA6E on human chromosome ... another TSG located in a fragile site (FRA16D), is deleted/truncated in several types of cancers, including NSCLC (23) . ... Orphanos V, McGown G, Hey Y, et al Allelic imbalance of chromosome 6q in ovarian tumours. Br J Cancer, 71: 666-9, 1995. ... Morita R, Saito S, Ishikawa J, et al Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer ...
http://clincancerres.aacrjournals.org/content/10/8/2720
*  Molecular Genetic Evidence for the Independent Origin of Multifocal Papillary Tumors in Patients with Papillary Renal Cell...
... contains the aphidicolin-inducible fragile site FRA7G. D9S171 includes regions of the putative tumor suppressor gene p16. ... Trisomy of chromosome 17 was also observed in 12 of 13 tumors. The one patient with a tumor showing disomy of chromosome 17 ( ... Detection of X-chromosome inactivation. X-chromosome inactivation analysis was done on papillary tumors from three female ... FISH analysis was done on 13 tumors from 6 patients showing LOH at loci on chromosome 7 and/or chromosome 17 (Fig. 3). Trisomy ...
http://clincancerres.aacrjournals.org/content/11/20/7226.full
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... of UPD regions were localized to or formed part of a previously identified fragile site (27). Fragile sites correspond to known ... Left, chromosome ideograms showing exemplary UPD of chromosome 6 detected by (upper portion) 250K Affymetrix array (CNAG ... Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A ... Common fragile sites associated with the breakpoints of chromosomal aberrations in hematologic neoplasms. Cancer Genet ...
http://clincancerres.aacrjournals.org/content/17/12/3913
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CML Progenitor cells have chromosomal instability and display increased DNA damage at DNA fragile sites. Blood (Suppl) 2005;106 ... The Philadelphia chromosome (Ph1) translocation t(9;22)(q34;q11), the main feature and the sole cytogenetic alteration observed ... Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006;354:2542-51. ... Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006;354:2531-41. ...
http://clincancerres.aacrjournals.org/content/13/6/1638
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Many of these sites cover regions that have been reported previously to exhibit frequent chromosomal losses in NSCLC: 6q12, ... Testa J. R., Liu Z., Feder M., Bell D. W., Balsara B., Cheng J. Q., Taguchi T. Advances in the analysis of chromosome ... and fragile histidine triad have been positively identified as contributors to the tumorigenic process. Additional ... Turunen O., Wahlstrom T., Vaheri A. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family ...
http://clincancerres.aacrjournals.org/content/8/4/1127
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... than any other chromosome after correction for number of CpG sites (P , 0.0001; Supplementary Fig. S7). Chromosome 21 ... Concerning the role of X-inactivation and DNA methylation in fragile X syndrome. Am J Med Genet 1992;43:291-8. ... Sites outside CpG islands measured a decrease (Student's t test, P = 0.0095) in average CpG site methylation reaching 18.5% in ... Chromosome 21 was the main target for methylation changes. This chromosome confers protection against cancer in trisomy 21 ...
http://clincancerres.aacrjournals.org/content/17/17/5582
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Exposure of cells to high levels of ROS leads to oxidative stress and may cause DNA damage, especially to the fragile ... Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. ... Germline mutations in the phosphatase and tensin homolog deleted on chromosome 10 tumor suppressor gene [PTEN (MIM 601728)] are ... has been reported to specifically target ubiquinone-binding sites in the SDH complex (30, 31) and causes rapid production of ...
http://clincancerres.aacrjournals.org/content/18/18/4954