The authors use three-dimensional live-cell imaging of colorectal carcinoma organoids to show that chromosomal instability is ... A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution ... including microsatellite instability. Cell-fate tracking showed that, although mitotic errors are frequently followed by cell ... Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids. *Ana C. F. Bolhaqueiro1 na1, ...
The role of gene flow and chromosomal instability in shaping the bread wheat genome. In: Nature Plants. 2021 ; Vol. 7, No. 2. ... The role of gene flow and chromosomal instability in shaping the bread wheat genome. Nature Plants. 2021 Feb 1;7(2):172-183. ... The role of gene flow and chromosomal instability in shaping the bread wheat genome. / Przewieslik-Allen, Alexandra M; ... Dive into the research topics of The role of gene flow and chromosomal instability in shaping the bread wheat genome. ...
A new chromosomal instability disorder confirmed by complementation studies.. R D Wegner, M Metzger, F Hanefeld, N G Jaspers, C ... and combined immunodeficiency together with spontaneous chromosomal instability and cellular hypersensitivity to X-rays and ...
Chromosomal InstabilityGenomic InstabilityAneuploidyChromosome AberrationsJoint InstabilityMicrosatellite InstabilityHelix-Loop ... Chromosomal InstabilityGenomic InstabilityAneuploidyChromosome AberrationsJoint InstabilityMicrosatellite InstabilityChromosome ... These chromosomal instability signatures were ... Chromosomal instability is a common feature of cancer, occurring in around 80 ... Two genomic instability pathways, chromosomal instability pathway and microsatellite instability pathway, are known as the main ...
Chromosomal instability (CIN) is the increasing rate in which cells acquire new chromosomal alterations. Depending on the type ... chromosomal instability acute myeloid leukemia cytogenetic heterogeneity aneuploidy complex karyotype TP53 centrosome ... Bakhoum, S.F.; Cantley, L.C. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment. Cell 2018, ... Bach, D.-H.; Zhang, W.; Sood, A.K. Chromosomal Instability in Tumor Initiation and Development. Cancer Res. 2019, 79, 3995-4002 ...
Chromosomal instability drives immunosuppression and metastatic dissemination * FSP1 oxidizes NADPH to suppress ferroptosis ...
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Pathologic Processes - Chromosomal Instability PubMed MeSh Term *Overview. Overview. subject area of * Prolonged Mek1/2 ...
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CANINE LATENT PAPILLOMAVIRUS INFECTION AND CHROMOSOMAL INSTABILITY STUDIES IN PERIPHERAL BLOOD LYMPHOCYTES AND TUMORS CELLS ... Canine latent papillomavirus infection and chromosomal instability studies in peripheral blood lymphocytes and tumors cells ... To investigate the chromosomal fragility, we researched by cytogenetic technique in the peripheral blood lymphocytes cultures ...
Inactivation of AP4 in CRC cell lines resulted in increased spontaneous and c-MYC-induced DNA damage, chromosomal instability ( ... formation assays were used to determine the effects of AP4 inactivation and target gene regulation on chromosomal instability ( ... AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and ... AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and ...
found that rearrangements involving telomere regions are associated with chromosomal instability in human fibroblasts that ... "Chromosomal instability". Nature. 357 (6379): 548. Bibcode:1992Natur.357..548S. doi:10.1038/357548a0. PMID 1608466. S2CID ... Genomic instability has been observed both in vitro and in vivo in the progeny of cells that are irradiated with heavy ions in ... In fact, only a small fraction of the initial damage is transduction of late chromosomal damage has also been measured in the ...
N2 - Recent molecular genetic studies have revealed that two major types of genomic instabilities, chromosomal instability and ... AB - Recent molecular genetic studies have revealed that two major types of genomic instabilities, chromosomal instability and ... Recent molecular genetic studies have revealed that two major types of genomic instabilities, chromosomal instability and ... chromosomal instability and microsatellite instability, exist in the colorectal carcinomas. To clarify the relationship between ...
... or to chromosomal loss. These findings reveal a mechanism by which HR genes suppress CIN and how DNA breaks that persist ... Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. ... transgenerational end-resection leads to fold-back inversion of single-stranded centromeric repeats and to stable chromosomal ... Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. ...
Role of chromosomal instability and clonal heterogeneity in Breast Cancer: a pilot study.. *Martinez Aguero, Magdalena Maria ( ... Chromosomal instability (CI), defined as cell-to-cell variability in the number or structure of chromosomes, has been ...
... is a rare autosomal recessive condition of chromosomal instability that is clinically characterized by microcephaly, a distinct ... A new chromosomal instability disorder: the Nijmegen breakage syndrome. Acta Paediatr Scand. 1981 Jul. 70 (4):557-64. [QxMD ... A new chromosomal instability disorder confirmed by complementation studies. Clin Genet. 1988 Jan. 33(1):20-32. [QxMD MEDLINE ... Wegner RD, German JJ, Chrzanowska KH, Digweed M, Stumm M. Chromosomal instability syndromes other than ataxia-telangiectasia. ...
... co-activators cooperated in the regulation of a gene signature that indicated the presence of chromosomal instability (CIN). A ... Tóth, M., Wehling, L., Thiess, L. et al. Co-expression of YAP and TAZ associates with chromosomal instability in human ... Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma. *Marcell Tóth1, ... Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. A signature of chromosomal instability inferred from gene expression ...
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. In: Oncogene. ... Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Oncogene. 2008 ... Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. / Wang, P.; ... Dive into the research topics of Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth ...
Induction of chromosomal instability in mouse hemopoietic cells by fetal irradiation. / Devi, P. U.; Hossain, M. In: Mutation ... Devi, P. U. ; Hossain, M. / Induction of chromosomal instability in mouse hemopoietic cells by fetal irradiation. In: Mutation ... Devi PU, Hossain M. Induction of chromosomal instability in mouse hemopoietic cells by fetal irradiation. Mutation Research - ... Devi, P. U., & Hossain, M. (2000). Induction of chromosomal instability in mouse hemopoietic cells by fetal irradiation. ...
A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome? Genome ... A genome-wide analysis of common fragile sites : What features determine chromosomal instability in the human genome?. In: ... A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome? / ... A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?. ...
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes and ... Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. In: Genes ... Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. / Donehower ... title = "Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability", ...
Chromosomal instability (CIN), the numerical and structural alterations of chromosomes resulting from ongoing errors of ... From: Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid ...
The increased chromosomal instability seems to be an intrinsic feature for tumours that metastasise and should be further ... Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with ... Our study shows that increased chromosomal instability, including chromothripsis and deregulated kinetochore and cell cycle ...
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias ... Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias ... Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias ... title = "Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive ...
T1 - Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI ... Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI tumors ... Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI tumors ... Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI tumors ...
Purpose: Chromosomal instability (CIN) is a common phenomenon in colorectal cancer, but its role and underlying cause remain ... N2 - Purpose: Chromosomal instability (CIN) is a common phenomenon in colorectal cancer, but its role and underlying cause ... AB - Purpose: Chromosomal instability (CIN) is a common phenomenon in colorectal cancer, but its role and underlying cause ... abstract = "Purpose: Chromosomal instability (CIN) is a common phenomenon in colorectal cancer, but its role and underlying ...
Aging-induced nucleolar decline and chromosomal instability. * Award Number: R01GM075240 * ORGANIZATION: NATIONAL INSTITUTE OF ... Interestingly, the replicatively aging cells also have a chromosome instability (CIN) phenotype that is driven by the rDNA ... This results in deterioration of the rDNA heterochromatin and instability of the array. ... instability. Overexpression of the Mcd1 subunit of cohesin suppresses the age-induced rDNA and CIN phenotypes, and strongly ...
Chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: a fluorescent in situ hybridization study using ... of the gastrointestinal tract have been known to have characteristic chromosomal aberrations including trisomies of chromosomes ... of the gastrointestinal tract have been known to have characteristic chromosomal aberrations including trisomies of chromosomes ...
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by ... Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by ...