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*  Nijmegen Breakage Syndrome Publications and Abstracts | PubFacts.com
Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients.. * ... Some of these functional abnormalities can be explained by aberrant DNA damage response and chromosomal instability. It has ... Nijmegen breakage syndrome (NBS, MIM #251260) is an autosomal recessive chromosomal instability disorder. Majority of patients ... Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosomal instability disorder characterized by microcephaly, ...
https://www.pubfacts.com/search/Nijmegen+Breakage+Syndrome
*  Fanconi anemia group F protein elisa and antibody
At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased ... Chromosomal Location of Human Ortholog: 11p15. Cellular Component: nucleoplasm. Molecular Function: protein binding. Disease: ...
https://www.mybiosource.com/protein_family.php?root=fanconi-anemia-group-f-protein
*  Telomere length : dynamics and role as a biological marker in malignancy
Age Factors, Aged, Breast Neoplasms/*blood/*mortality, Chromosomal Instability, Female, Humans, Middle Aged, Odds Ratio, ... They are essential for maintaining chromosomal stability by preventing damage and degradation of the chromosome ends. Telomeres ... Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:570563
*  Centrosomes - NCBES
Aneuploidy and chromosomal instability are highly correlated with the appearance of multiple centrosomes. ...
http://ncbes.nuigalway.ie/research/centre-for-chromosome-biology/centrosomes/
*  A novel Leu153Ser mutation of the Fanconi anemia FANCD2 gene is associated with severe chemotherapy toxicity in a pediatric T...
... predisposition to cancers and chromosomal instability. We report the clinical and molecular features of a patient initially ... predisposition to cancers and chromosomal instability. We report the clinical and molecular features of a patient initially ... Cells from this patient showed a moderate chromosomal instability, increasing sensitivity to DNA crosslinking agents but normal ... Cells from this patient showed a moderate chromosomal instability, increasing sensitivity to DNA crosslinking agents but normal ...
https://iris.unicampania.it/handle/11591/189372
*  A mechanism linking extra centrosomes to chromosomal instability. - PubMed - NCBI
Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the presence of extra centrosomes. However, a ... A mechanism linking extra centrosomes to chromosomal instability.. Ganem NJ1, Godinho SA, Pellman D. ...
https://www.ncbi.nlm.nih.gov/pubmed/19506557?dopt=Abstract
*  Link Unraveled Between Chromosomal Instability, Centrosome Defects In Cancer Cells - Redorbit
According to Pellman, chromosomal instability, it turns out, "is actually a side effect of the cells' ability to cluster their ... Link Unraveled Between Chromosomal Instability, Centrosome Defects In Cancer Cells. by Sam Savage ... but the correction process creates other problems that result in chromosomal instability." ... "Such instability may be a double-edged sword. It may confer a survival benefit on cancer cells by enabling them to adapt to a ...
http://www.redorbit.com/news/health/1701466/link_unraveled_between_chromosomal_instability_centrosome_defects_in_cancer_cells/
*  Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in...
Chromosomal instability in mouse metastatic pancreatic cancer--it's Kras and Tp53 after all. [Cancer Cell. 2005] ... Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ... The primary carcinomas and metastases demonstrate a high degree of genomic instability manifested by nonreciprocal ...
https://www.ncbi.nlm.nih.gov/pubmed/15894267?access_num=15894267&link_type=MED&dopt=Abstract
*  Olga Tšuiko „Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics" | University...
Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics ... Olga Tšuiko „Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics". ... Olga Tšuiko „Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics" ... On 26 November at 15 Olga Tšuiko will defend her doctoral thesis „Unravelling chromosomal instability in mammalian ...
https://www.ut.ee/en/events/olga-tsuiko-unravelling-chromosomal-instability-mammalian-preimplantation-embryos-using
*  Cancers | Free Full-Text | Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid...
Genomic instability may play an essential role in leukemogenesis by promoting the accumulation of genetic lesions responsible ... Clearly, genetic instability and clonal evolution are driving forces for leukemic transformation. Understanding the mechanisms ... Chromosomal instability (CIN) is a characteristic feature of cancer. In this review, we concentrate on mechanisms leading to ... and advanced MDS and underlined the important role of dysfunctional telomeres in the development of genetic instability and ...
http://mdpi.com/2072-6694/5/3/857
*  Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability | Molecular...
This type of chromosomal instability is by far the most frequent form of genetic instability among solid tumor cells and ... Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Sigrid A. ... Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 2001;3:433-8. ... 6E, arrow, and F), which provided further evidence for chromosomal instability (38). ...
http://mct.aacrjournals.org/content/7/7/2142
*  Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer - DTU Orbit
... basal-like phenotype and displayed the highest chromosomal structural complexity and chromosomal numerical instability. We ... Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer. Publication: Research - peer-review › ... Chromosomal instability (CIN) is associated with poor prognosis in human cancer. However, in certain animal tumor models ... which correlates with DNA-based measures of structural chromosomal complexity and numerical CIN in vivo, to gene expression ...
http://orbit.dtu.dk/en/publications/paradoxical-relationship-between-chromosomal-instability-and-survival-outcome-in-cancer
*  PLOS ONE: Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal...
Gene mutation rates (EGFR, KRAS, STK11, TP53), chromosomal instability, regional copy number, and genomewide DNA methylation ... Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, ...
http://journals.plos.org/plosone/article/email?id=10.1371/journal.pone.0036530
*  Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells | Cancer Discovery
Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells. Kristina M. Godek, Monica Venere, ... Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells. Kristina M. Godek, Monica Venere, ... Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells. Kristina M. Godek, Monica Venere, ... Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells Message Subject (Your Name) has ...
http://cancerdiscovery.aacrjournals.org/content/early/2016/04/13/2159-8290.CD-15-1154
*  Impact of chromosomal instability on colorectal cancer progression and outcome | BMC Cancer | Full Text
Two metrics of chromosomal instability were used; (i) Global Genomic Index (GGI), corresponding to the fraction of the genome ... Combining GGI and nbBP,we classified genomic profiles into 5 groups presenting distinct patterns of chromosomal instability and ... Our data show that CRC disease progression from stage 1 to stage 4 is not paralleled by increased levels of genetic instability ... We, also, asked whether the level of genomic instability was correlated to disease outcome in stage 2 and 3 CRCs. ...
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-121
*  Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer |...
Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 2002;99:1978-83. ... Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut 2008;57:941-50. ... Chromosomal instability detected by fluorescence in situ hybridization in Japanese breast cancer patients. Clin Chim Acta 2001; ... Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res 2011;71:3447-52. ...
http://cebp.aacrjournals.org/content/20/10/2183
*  Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability...
The chromosomal instability phenotype initiated by partial Bre1b knockdown (shBre1b1 cells grown without doxycycline) for 3 ... Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability ... Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability ... Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability ...
http://cancerres.aacrjournals.org/content/72/8/2111
*  Chromosomal Instability in Adult Retinal Stem Cells With High Proliferative Capacity and Differentiation Potentials | IOVS |...
Chromosomal Instability in Adult Retinal Stem Cells With High Proliferative Capacity and Differentiation Potentials ... Chromosomal Instability in Adult Retinal Stem Cells With High Proliferative Capacity and Differentiation Potentials ... M. Djojosubroto, M. Tekaya, D. Wanner, Y. Arsenijevic; Chromosomal Instability in Adult Retinal Stem Cells With High ... It is tempting to speculate that the higher genomic instability is related to cellular aging in adult RSCs. We are also ...
https://iovs.arvojournals.org/article.aspx?articleid=2388323
*  Supplementary Material for: Human BRCA1-Associated Breast Cancer: No Increase in Numerical Chromosomal Instability Compared to...
No Increase in Numerical Chromosomal Instability Compared to Sporadic Tumors ... Chromosomal instability (CIN) as part of genomic instability is an inherent characteristic of most solid tumors and is also ... Supplementary Material for: Human BRCA1-Associated Breast Cancer: No Increase in Numerical Chromosomal Instability Compared to ... BRCA1 participates in maintaining genomic integrity and protects the cell against genomic instability. ...
https://figshare.com/articles/Supplementary_Material_for_Human_BRCA1-Associated_Breast_Cancer_No_Increase_in_Numerical_Chromosomal_Instability_Compared_to_Sporadic_Tumors/5122861/1
*  Tumor suppressors, chromosomal instability, and hepatitis C vi...
... chromosomal instability, and hepatitis C virus-associated liver cancer.: Hepatitis C virus (HCV) is the only known RNA virus ... Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer.. Authors * McGivern, David R1 ... Dysfunctional DNA damage and mitotic spindle checkpoints resulting from these interactions may promote chromosomal instability ... but chronic immune-mediated inflammation and associated oxidative chromosomal DNA damage probably play a role. Compelling data ...
https://www.mysciencework.com/publication/show/tumor-suppressors-chromosomal-instability-hepatitis-c-virus-associated-liver-cancer-390fa9c8
*  Centrosome-Mediated Chromosomal Instability and Steroid Hormones as Co factors in Human Papillomavirus-Associated Cervical...
Centrosome-Mediated Chromosomal Instability and Steroid Hormones as Co factors in Human Papillomavirus-Associated Cervical ... 2002) Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA 99:1978-83. ... Duensing A., Duensing S. (2008) Centrosome-Mediated Chromosomal Instability and Steroid Hormones as Co factors in Human ... chromosomal instability, and breast cancer in female ACI rats. Proc Natl Acad Sci USA 101:18123-8.PubMedCrossRefGoogle Scholar ...
https://rd.springer.com/chapter/10.1007/978-0-387-69080-3_10
*  "Kinase-independent role of cyclin D1 in chromosomal instability and ma" by Mathew C Casimiro, Gabriele Disante et al.
We conclude that the CDK-activating function of cyclin D1 is not necessary to induce either chromosomal instability or mammary ... and chromosomal instability (CIN) by gene expression profiling. Acute transgenic expression of either cyclin D1WT or cyclin ... We conclude that the CDK-activating function of cyclin D1 is not necessary to induce either chromosomal instability or mammary ... Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. ...
https://jdc.jefferson.edu/cbfp/76/
*  Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres |...
... is able to rescue chromosomal instability. For this, we scored chromosomal aberrations on primary splenocytes using Q‐FISH. ... Rescue of chromosomal instability in G4 Terc+/− siblings. Critically short telomeres in late generation Terc−/− mice in two ... The G4 Terc−/− progeny also showed a higher chromosomal instability than the G3 Terc−/− father (number 1 in Table 2), in ... For chromosomal instability determinations, between 25 and 31 metaphases were analyzed.. The chromosome Y was identified by ...
http://embor.embopress.org/content/2/9/800
*  In Vivo Study of Chromosomal Instability in Lymphocytes of Radiotherapy Patients | Radioprotection
In Vivo Study of Chromosomal Instability in Lymphocytes of Radiotherapy Patients. V. Vinnikov1, N. Maznyk1 and D. Lloyd2 ... research has been carried out to quantify chromosomal instability (ChI) occurring in their lymphocytes. Ten patients with ... Early and Retrospective Chromosomal Dosimetry in Chernobyl Clean-Up Workers Radioprotection 2008, Vol. 43, n° 5. ... The problem of delayed genomic instability occurring in human cells in vivo has recently come to prominence as an important ...
https://www.radioprotection.org/articles/radiopro/abs/2008/05/000020/000020.html