Chromosomal instability determines taxane response.. Swanton C1, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A ... lines in response to MTS agents and observed that these genes are overexpressed in tumors exhibiting chromosomal instability ( ... A) Quantification of gene repression following paclitaxel treatment of cell lines with increasing chromosomal numerical ... Colorectal cancer cell lines with increasing chromosomal numerical heterogeneity uncouple mitotic arrest from cell death. Cell ...
Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the presence of extra centrosomes. However, a ... A mechanism linking extra centrosomes to chromosomal instability.. Ganem NJ1, Godinho SA, Pellman D. ...
According to Pellman, chromosomal instability, it turns out, "is actually a side effect of the cells ability to cluster their ... Link Unraveled Between Chromosomal Instability, Centrosome Defects In Cancer Cells. by Sam Savage ... but the correction process creates other problems that result in chromosomal instability." ... "Such instability may be a double-edged sword. It may confer a survival benefit on cancer cells by enabling them to adapt to a ...
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.. Theunissen JW1, Kaplan MI, ... The mice also exhibited pronounced chromosomal instability. Despite this phenotypic spectrum, the animals were not prone to ... These data indicate that defective cell cycle checkpoints and chromosomal instability are insufficient to significantly enhance ... We propose that in Mre11(ATLD1/ATLD1) mice, genome instability and cell cycle checkpoint defects reduce viability in early ...
Chromosomal Instability Confers Intrinsic Multidrug Resistance. Alvin J.X. Lee, David Endesfelder, Andrew J. Rowan, Axel ... Chromosomal Instability Confers Intrinsic Multidrug Resistance. Alvin J.X. Lee, David Endesfelder, Andrew J. Rowan, Axel ... Chromosomal Instability Confers Intrinsic Multidrug Resistance. Alvin J.X. Lee, David Endesfelder, Andrew J. Rowan, Axel ... The more common form of genomic instability in CRC is chromosomal instability (CIN), resulting in ongoing numerical and ...
... chromosomal instability, and aneuploidy. Since genetic instability is a common feature in chronic myeloid leukemia (CML), we ... Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability.. Giehl M1, ... that centrosome defects are a common and early detectable feature in CML that may contribute to acquisition of chromosomal ...
Mad1 up-regulation causes chromosomal instability. Sean D. Ryan, Eric M. C. Britigan, Lauren M. Zasadil, Kristen Witte, Anjon ... Mad1 up-regulation causes chromosomal instability. Sean D. Ryan, Eric M. C. Britigan, Lauren M. Zasadil, Kristen Witte, Anjon ... 2002) Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell 3:351-365. ... 2008) Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol 180:665-672. ...
Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers.. Miyoshi Y1 ... which results in chromosomal instability (CIN) in cell culture. In the present study, we investigated the correlation of STK15/ ...
Chromosomal instability in mouse metastatic pancreatic cancer--its Kras and Tp53 after all. [Cancer Cell. 2005] ... Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ... The primary carcinomas and metastases demonstrate a high degree of genomic instability manifested by nonreciprocal ...
Genomic instability may play an essential role in leukemogenesis by promoting the accumulation of genetic lesions responsible ... Clearly, genetic instability and clonal evolution are driving forces for leukemic transformation. Understanding the mechanisms ... Chromosomal instability (CIN) is a characteristic feature of cancer. In this review, we concentrate on mechanisms leading to ... and advanced MDS and underlined the important role of dysfunctional telomeres in the development of genetic instability and ...
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... perhaps reflecting different functional classes of chromosomal instability. High levels of chromosomal instability are likely ... Our results provide direct evidence for chromosomal instability in breast cancer and show that this instability occurs at ... suggesting that these neoplasms have instability of chromosome numbers. To directly test for possible chromosomal instability ... Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer.. Yoon DS1, Wersto RP, Zhou ...
Telomere shortening and chromosomal instability in the duct epithelium might be associated with carcinogenesis of the pancreas ... Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and ... Gradual Telomere Shortening and Increasing Chromosomal Instability among PanIN Grades and Normal Ductal Epithelia with and ... Gradual Telomere Shortening and Increasing Chromosomal Instability among PanIN Grades and Normal Ductal Epithelia with and ...
The aneuploid index was calculated as the sum of all the consistent chromosomal gains or losses present in the karyotype. Thus ...
Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics ... Olga Tšuiko „Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics". ... Olga Tšuiko „Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics" ... On 26 November at 15 Olga Tšuiko will defend her doctoral thesis „Unravelling chromosomal instability in mammalian ...
RAD51 Mutants Cause Replication Defects and Chromosomal Instability. Tae Moon Kim, Jun Ho Ko, Lingchuan Hu, Sung-A Kim, ... RAD51 Mutants Cause Replication Defects and Chromosomal Instability. Tae Moon Kim, Jun Ho Ko, Lingchuan Hu, Sung-A Kim, ... RAD51 Mutants Cause Replication Defects and Chromosomal Instability. Tae Moon Kim, Jun Ho Ko, Lingchuan Hu, Sung-A Kim, ... RAD51 Mutants Cause Replication Defects and Chromosomal Instability Message Subject (Your Name) has forwarded a page to you ...
Gene mutation rates (EGFR, KRAS, STK11, TP53), chromosomal instability, regional copy number, and genomewide DNA methylation ... Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, ...
Chromosomal and microsatellite instability in colorectal cancer (Homo sapiens). From WikiPathways. Revision as of 11:47, 15 ... Pino MS, Chung DC; The chromosomal instability pathway in colon cancer.; Gastroenterology, 2010 PubMed Europe PMC Scholia* ... The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of ... Genomic instability. Inactivating mutation. CSNK1A1L. CSNK1A1. CTNNB1. P. P. P. Survival. EXOC2. TBK1. REL. Cell-survival. ...
Chromosomal and microsatellite instability in colorectal cancer (Homo sapiens). From WikiPathways. Revision as of 19:20, 12 ... Pino MS, Chung DC; The chromosomal instability pathway in colon cancer.; Gastroenterology, 2010 PubMed Europe PMC Scholia* ... Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations ...
Chromosomal and microsatellite instability in colorectal cancer (Homo sapiens). From WikiPathways. Revision as of 00:00, 21 ... The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of ... Pino MS, Chung DC; The chromosomal instability pathway in colon cancer.; Gastroenterology, 2010 PubMed Europe PMC*Mazzoni ... The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or ...
DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP. ...
This type of chromosomal instability is by far the most frequent form of genetic instability among solid tumor cells and ... Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Sigrid A. ... Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 2001;3:433-8. ... 6E, arrow, and F), which provided further evidence for chromosomal instability (38). ...
Testing for Herpesvirus Infection Is Essential in Children with Chromosomal-Instability Syndromes. Petra Lankisch, Heiko Adler ... While active EBV replication may obviously end up in significant clinical problems in patients with chromosomal instability ... Cases of herpesvirus infection in children with chromosomal instability syndromes, diagnosed since 2006 at the Department of ... Testing for Herpesvirus Infection Is Essential in Children with Chromosomal-Instability Syndromes ...
Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 2002;99:1978-83. ... Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut 2008;57:941-50. ... Chromosomal instability detected by fluorescence in situ hybridization in Japanese breast cancer patients. Clin Chim Acta 2001; ... Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res 2011;71:3447-52. ...
The chromosomal instability phenotype initiated by partial Bre1b knockdown (shBre1b1 cells grown without doxycycline) for 3 ... Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability ... Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability ... Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability ...