Intravitreal ranibizumab associated with subfoveal choroidal thinning in idiopathic subfoveal choroidal neovascularization -...
Intravitreal ranibizumab therapy was associated with thinning of the subfoveal choroid in patients treated for unilateral idiopathic subfoveal choroidal neovascularization, a study found. The prospective study included 16 patients with unilateral idiopathic subfoveal choroidal neovascularization who underwent a single intravitreal injection of 0.5 mg ranibizumab and subsequent injections as needed. Investigators used enhanced depth imaging optical coherence tomography to measure subfoveal choroidal thickness (SFCT). Mean patient age was 31.9 years. Visual acuity was also evaluated. Full Story →. ...http://www.linkoph.com/2014/04/16/intravitreal-ranibizumab-associated-with-subfoveal-choroidal-thinning-in-idiopathic-subfoveal-choroidal-neovascularization/
Laser-induced Choroidal Neovascularization in the Yucatan Minipig - Characterization of a Novel Model of Neovascular Age...
Purpose : Historically, large animal models of neovascular age-related macular degeneration have been unpredictable, with only 70% of laser-induced choroidal neovascularization (CNV) lesions in non-human primates (NHP) considered clinically relevant. Furthermore, only up to 40% of these CNV lesions are considered ideal, exhibiting Grade IV leakage on fluorescein angiography. This inefficiency leads to excess animal use and high study cost. Previous swine CNV models displayed extensive retinal damage and only minimal choroidal involvement when neovascularization was present. We aimed to create a reproducible, predictable swine model of laser-induced CNV improving efficiency and lowering cost compared to available NHP CNV models. Methods : Yucatan minipigs were used to optimize laser induction of CNV. Bilaterally, six lesions were created using a 532nm green argon laser under direct visualization with a slit lamp and condensing lens. Follow-up ...http://iovs.arvojournals.org/article.aspx?articleid=2639951
Intravitreal pegaptanib sodium (Macugen®) for treatment of myopic choroidal neovascularization: a morphologic and functional...
BACKGROUND:: To report the morphologic and functional outcomes resulting from the use of intravitreal pegaptanib (IVP) sodium (Macugen) in patients with myopic choroidal neovascularization. METHODS:: An open-label, nonrandomized, prospective clinical trial was performed. Morphologic outcome, such as foveal thickness, was assessed by optical coherence tomography, whereas functional outcomes were assessed by best-corrected visual acuity and microperimetry. Treatment protocol consisted of 3 consecutive IVP (0.3 mg/0.05 mL; baseline, 6th week, and 12th week). Follow-up checks were scheduled at the following intervals: baseline, 18, 24, 36, and 48 weeks. RESULTS:: Twenty eyes from 20 patients were studied. All patients completed follow-up at 48 weeks. After IVP, a significant decrease in foveal thickness occurred (-20%), and at the end of follow-up, choroidal neovascularization closure was obtained in all eyes. An improvement of functional ...https://iris.unina2.it/handle/11591/183044
Expression of Pigment Epithelium-Derived Factor in Normal Adult Rat Eye and Experimental Choroidal Neovascularization | IOVS |...
purpose. Pigment epithelium-derived factor (PEDF) is a protein produced by the retinal pigment epithelial (RPE) cells. Recent studies have implicated PEDF in activities that are inhibitory to angiogenesis. In this study, the expression of PEDF was investigated in normal rat eyes and in eyes with experimentally induced choroidal neovascularization and compared with the expression of vascular endothelial growth factor (VEGF).. methods. Choroidal neovascularization was induced by laser photocoagulation in rat eyes. At intervals of up to 2 weeks after photocoagulation, the eyes were removed and prepared for in situ hybridization and immunohistochemical study. In situ hybridization was performed with digoxigenin-labeled PEDF riboprobes. Protein expression of PEDF and VEGF was studied immunohistochemically.. results. In normal adult rat eyes, PEDF mRNA was observed mainly in the corneal epithelial and endothelial cells, lens epithelial cells, ...http://iovs.arvojournals.org/article.aspx?articleid=2200160
Visual and anatomical outcomes of intravitreal bevacizumab for idiopathic choroidal neovascularization | IOVS | ARVO Journals
Purpose: To evaluate the visual and anatomical outcomes of intravitreal bevacizumab in patients with idiopathic choroidal neovascularization.. Methods: Twenty seven eyes of 27 patients with idiopathic choroidal neovascularization were treated with a single intravitreal injection of bevacizumab, followed by as-needed dosing based on spectral domain-optical coherence tomography findings including intraretinal edema, subretinal fluid, or pigment epithelial detachment. Changes in best-corrected visual acuity (BCVA), central foveal thickness, and subfoveal choroidal thickness were evaluated. The subfoveal choroidal thickness of the normal fellow eye were measured for comparative analysis. 17 eyes for normal control were collected for comparative analysis of subfoveal choroidal thickenss.. Results: The mean number of injections was 2.74 (±2.30) for 27 eyes during the mean follow-up of 11.48 ...http://iovs.arvojournals.org/article.aspx?articleid=2148679
Macrophage Depletion Inhibits Experimental Choroidal Neovascularization | IOVS | ARVO Journals
objective. To investigate the role of macrophages in the development of laser-induced choroidal neovascularization (CNV) by selective depletion with liposomal clodronate (Cl2MDP-LIP).. methods. Laser photocoagulation was used to induce CNV in wild-type C57BL/6J mice. Animals were treated with intravenous (IV) and/or subconjunctival (SC) Cl2MDP-LIP or PBS-LIP at the following time points: 2 days before, immediately after, 2 days before and immediately after, or 2 days after laser injury. CNV responses were compared on the basis of en masse volumetric measurements and fluorescein angiography after laser photocoagulation. Macrophages were identified by immunostaining for F4/80, and vascular endothelial growth factor (VEGF) expression was quantified by ELISA.. results. Macrophages invaded the site of laser injury within 1 day of photocoagulation and peaked at 3 days. IV Cl2MDP-LIP significantly decreased the volume of CNV and angiographic leakage when administered 2 days before ...http://iovs.arvojournals.org/article.aspx?articleid=2200256
Choroidal Neovascularization Market by Application, Type, Deployment, Organization Size, Verticals Forecast 2020 | Healthcare
The market presents significant growth opportunities for vendors. Companies are increasingly forming strategic alliances and engaging in M&A to increase their market share. As the development cost of ophthalmic drugs is high, small biotechnology firms are forming alliances with big pharmaceutical companies for product development.". Ask Sample PDF of Choroidal Neovascularization Market Report @ http://www.marketreportsworld.com/enquiry/request-sample/10278447 According to the Choroidal Neovascularization report, Better infrastructure in terms of healthcare facilities and sophisticated treatment options has led to a rise in the life expectancy rates, leading to a rise in the number of people over 60 years. The normal aging process results in reduced choroidal blood flow, which leads to ischemia. This, in turn, leads to increased expression of VEGF and development of excess blood vessels resulting in choroidal ...http://beforeitsnews.com/healthcare/2017/02/choroidal-neovascularization-market-by-application-type-deployment-organization-size-verticals-forecast-2020-2501044.html
Choroidal Neovascularization - Pipeline Review, H2 2017
... Summary Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Choroidal Neovascularization - Market research report and industry analysis - 11207704https://www.marketresearch.com/Global-Markets-Direct-v3480/Choroidal-Neovascularization-Pipeline-Review-H2-11207704/
Choroidal Filling Delay in Choroidal Neovascularization due to Pathologic Myopia | British Journal of Ophthalmology
Aims: To assess the choroidal thickness and choroidal circulatory changes in eyes with myopic choroidal neovascularization (mCNV).. Methods: Retrospective, consecutive, observational case series. Forty-two consecutive eyes (17 eyes with newly diagnosed mCNV and 25 eyes without CNV) were included. Choroidal circulation was evaluated by indocyanine green angiography (ICGA) and choroidal thickness was measured by spectral-domain optical coherence tomography (SD-OCT). The factors associated with mCNV were evaluated.. Results: Sixteen (94%) of 17 eyes with mCNV and 6 (24%) of 25 eyes without mCNV had well-defined hypofluorescence at the macular region on arterial phase ICGA, i.e., a choroidal filling delay. Older age (P,0.001), the presence of a choroidal filling delay (P,0.001), and reduced choroidal thickness (P =0.003) were significantly associated with mCNV ...http://bjo.bmj.com/content/early/2009/10/21/bjo.2009.163535
Characterization of Experimental Choroidal Neovascularization in Wildtype Mice Over Different Timepoints | IOVS | ARVO Journals
Purpose: : The main cause of severe vision loss in patients with age-related macular degeneration (AMD) is choroidal neovascularization (CNV). Basement membranes (BM) are key components of vascular walls, inner limiting membrane, Bruch's membrane, etc. In vitro has been shown that changes in BM proteins play an important role in angiogenesis. We investigated different BM proteins nidogen-1, nidogen-2, laminins (γ1 and γ3 chain), collagen type-IV and perlecan, their expression and the structure of CNV lesions over a course of time. Methods: : An experimental animal model of AMD was used to investigate the role of BM proteins. Laser photocoagulation was performed to induce rupture of Bruch's membrane and subsequent neovascular growth in C57Bl/6J (WT) animals. We determined 4 different time points to investigate the changes 24 hours, 1 week, 2 weeks and 4 weeks after laser procedure.The choroid was flatmounted and labeled with Isolectin IB-4.Distribution and expression of the ...http://iovs.arvojournals.org/article.aspx?articleid=2363482
Photodynamic Therapy Or Macular Translocation For Subfoveal Choroidal Neovascularization In Age-related Macular Degeneration |...
Abstract: : Purpose: To compare the visual outcome of a demonstated treatment of subfoveal classic neovascularization in age-related macular degeneration (AMD), photodynamic therapy (PDT), to a treatment under evaluation, limited macular translocation (LMT). Methods: A retrospective review was conducted on a consecutive series of 60 eyes of 60 patients with subfoveal neovascularization due to AMD: 28 were treated by PDT with verteporfin, 32 underwent LMT with scleral imbrication . The follow-up was at least 6 months. The main outcome criteria were final best-corrected visual acuity and a 2 lines or more change in visual acuity. Results: Both groups were similar for age, refraction, and the size of the neovascular membrane (mean, 950µm). The initial visual acuity was lower in the translocation group than in the PDT group (20/200 versus 20/100). The average displacement in the LMT group was 940µm (range, 250 to 1,900µm). The number of retreatment in the PDT group was in ...http://iovs.arvojournals.org/article.aspx?articleid=2420777
Photodynamic therapy in non-subfoveal choroidal neovascularization secondary to pathological myopia: 1-year outcome | British...
This prospective, open-label, non-comparative, interventional case series evaluates the results of photodynamic therapy (PDT) in juxtafoveal and extrafoveal choroidal neovascularization (CNV) secondary to pathologic myopia in 27 eyes of 27 patients.. The average visual acuity dropped from 58.5 letters to 49.19. The visual acuity remained stable in 13 patients (48.1%), whereas 14 patients (51.9%) lost more than 8 letters due to the extension of the lesion to subfoveal space. A strong association was found between advanced age and a worse visual prognosis (p = 0.001 ...http://bjo.bmj.com/content/91/12/1722
"Prevention of experimental choroidal neovascularization with intravitr" by Magdalena G. Krzystolik, Mehran A. Afshari et al.
OBJECTIVE: To evaluate the safety and efficacy of intravitreal injections of an antigen-binding fragment of a recombinant humanized monoclonal antibody directed toward vascular endothelial growth factor (rhuFab VEGF) in a monkey model of choroidal neovascularization (CNV). METHODS: In phase 1 of the study, each animal received intravitreal injections, 500 microg per eye, of rhuFab VEGF in one eye (prevention eye), while the contralateral eye received rhuFab VEGF vehicle (control eye) at 2-week intervals. On day 21, laser photocoagulation was performed to induce CNV. In phase 2, the vehicle-treated eye was crossed over and both eyes received 500 microg of rhuFab VEGF beginning 21 days following laser-induced injury at days 42 and 56. The eyes were monitored by ophthalmic examinations, color photographs, and fluorescein angiography. RESULTS: rhuFab VEGF did not cause any ocular hemorrhages. All eyes treated with rhuFab VEGF developed acute anterior chamber inflammation within ...http://escholarship.umassmed.edu/prevbeh_pp/311/
Bevacizumab Intravitreal Injection for Myopic Choroidal Neovascularization | IOVS | ARVO Journals
Purpose: : To evaluate the clinical results of bevacizumab intravitreal injection (BII) in choroidal neovascularization (CNV) secondary to pathologic myopia (PM-CNV). Methods: : 30 patients with subfoveal PM-CNV, were treated with of 1.25 mg BII. ETDRS best corrected visual acuity, macular thickness on OCT scans, and angiographic features were recorded and evaluated. The aspect of OCT scans passing across the PM-CNV was also analyzed. BII were repeated only in case of persistent angiographic leakage and if OCT scans showed retinal thickening or edema and serous retinal detachment. The follow-up period was at least 1 year. Results: : The mean age of the study patients was 43 years (28-51) and the mean refractive error -14.75 D. At 12 months post-treatment, mean VA increased from 20/100 (20/400 -20/40) to 20/60 (20/200-20/25). Only 2 patients lost 38 letters due to macular atrophy; the other 18 increased or stabilized their VA. Mean macular thickness decreased from 329 to 258 ...http://iovs.arvojournals.org/article.aspx?articleid=2364683
A Model of the Incidence and Consequences of Choroidal Neovascularization Secondary to Age-related Macular Degeneration | JAMA...
ObjectiveTo describe the comparative impact of current and preventive treatments on incidence of choroidal neovascularization (CNV) and severe vision loss in pahttps://jamanetwork.com/journals/jamaophthalmology/fullarticle/263178
Study Evaluating Intravitreal hI-con1™ in Patients With Choroidal Neovascularization Secondary to Age-related Macular...
The purpose of this study is to evaluate the safety, biological activity and pharmacodynamic effect of repeated intravitreal doses of hI-con1 0.3 mg administered as monotherapy and in combination with ranibizumab 0.5 mg compared to ranibizumab 0.5 mg monotherapy in treating patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD ...https://clinicaltrials.gov/ct2/show/NCT02358889?term=iconic+therapeutics&rank=1
Research on Choroidal Neovascularization and other conditions
Index and summaries of Choroidal Neovascularization research on nutrition, lifestyle, and other factors related to Glaucoma, Macular Degeneration, Diabetic Retinopathy, Cataracts, Computer Eye Syndrome, Dry Eyes, Retinitis Pigmentosa and other conditionshttp://www.naturaleyecare.com/studies_bydisease.asp?s_num=68&disease=Choroidal+Neovascularization
GMS | 22nd Annual Meeting of the German Retina Society | Effects of Ranibizumab in patients with subfoveal choroidal...
Purpose: To demonstrate not only prevention of vision loss but also improvement in best-corrected visual acuity after intermittent treatment with 0.5 mg intravitreal ranibizumab over 24 months.. Methods: 138 eyes of 138 patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration were treated with 0.5 mg intravitreal ranibizumab (Lucentis; Novartis, Basel, Switzerland). After single initial treatment, follow-up examinations were carried out monthly. Retreatment with single injection was performed in case of one of the following: sign of subretinal fluid or intraretinal edema, increase in central retinal thickness on optical coherence tomography, active choroidal neovascularization on fluorescein angiography, increase of metamorphopsia, and loss of more than 5 letters on ETDRS chart. Main outcome measures were: proportion of eyes gaining 15 or more letters, proportion of eyes losing or gaining less than15 ...http://www.egms.de/static/en/meetings/rg2009/09rg17.shtml
Suppression of experimental choroidal neovascularization by curcumin in mice | IOVS | ARVO Journals
C57BL/6N mice were pretreated with intraperitoneal injections of curcumin daily for 3 days prior to laser-induced CNV, and the drug treatments were continued until the end of the study. The CNV area was analyzed by fluorescein-labeled dextran angiography of retinal pigment epithelium (RPE)-choroid flat mounts on day 7 and 14, and CNV leakage was evaluated by fluorescein angiography (FA) on day 14 after laser photocoagulation. The infiltration of F4/80 positive macrophages and GR-1 positive granulocytes were evaluated by immunohistochemistry on RPE-choroid flat mounts on day 3. Their expression in RPE-choroid complex was quantified by real-time PCR (F4/80) and Western blotting (GR-1) on day 3. RPE-choroid levels of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, and intercellular adhesion molecule (ICAM)-1 were examined by ELISA on day 3. Double immunostaining of F4/80 and VEGF was performed on cryo-sections of CNV lesions on day 3. ...http://iovs.arvojournals.org/article.aspx?articleid=2145829
Associations of IL-10 with Choroidal Neovascularization in high myopia | IOVS | ARVO Journals
Purpose: To determine the relationship between the levels of intraocular inflammatory cytokines and choroidal neovascularization in high myopia.. Methods: Prospective cohort study. Choroidal neovascularization (CNV) in patients with high myopia (axial length ≥ 26.5 mm) was defined as myopic CNV (mCNV). Forty one patients with mCNV and 44 control subjects were studied. The levels of VEGF, MCP-1, IL-4, IL-10, and IL-23 in the aqueous humor samples from mCNV patients and control subjects were assessed for significant associations with mCNV. Logistic regression analysis was used to compute the odds ratios (ORs) and 95% confidence intervals (CIs).. Results: Axial length significantly correlated with levels of MCP-1 and IL-4 by Spearman correlation analysis (MCP-1: ρ=0.36, P=0.003, IL-4: ρ=0.33, P=0.009). In contrast, VEGF, IL-10, and IL-23 levels were independent of axial length. In mCNV patients, IL-10, IL-4, and MCP-1 were significantly higher ...http://iovs.arvojournals.org/article.aspx?articleid=2148957
Growth factor localization in choroidal neovascular membranes of age-related macular degeneration. | IOVS | ARVO Journals
PURPOSE: Because several polypeptide growth factors are known to influence capillary endothelial cell mitogenesis, the authors investigated the presence of some of these molecules in choroidal neovascular membranes (CNVMs) removed surgically from human subjects with age-related macular degeneration (ARMD). METHODS: The authors performed immunoelectron microscopic studies on surgically removed submacular CNVMs from nine subjects with ARMD and from one subject with ARMD whose eye was studied after death. These were compared with retinal pigment epithelial (RPE) and choroidal tissue from eight normal subjects whose eyes were received after death and one received after massive trauma. RESULTS: RPE cells from the CNVMs were strongly immunoreactive for acidic and basic fibroblast growth factor (aFGF and bFGF) and for transforming growth factor beta (TGF beta). Some of the immunoreactivity was intracytoplasmic, but most was intralysosomal. In addition, some choriocapillary ...http://iovs.arvojournals.org/article.aspx?articleid=2179618
A Study of rhuFab V2 (Ranibizumab) in Subjects With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular...
Any concurrent intraocular condition in the study eye (e.g., cataract or diabetic retinopathy) that, in the opinion of the investigator, could either: (1) Require medical or surgical intervention during the 24-month study period to prevent or treat visual loss that might result from that condition, or (2) If allowed to progress untreated, could likely contribute to loss of at least 2 Snellen equivalent lines of BCVA over the 24-month study ...https://clinicaltrials.gov/ct2/show/NCT00090623
Role of IL-10 in choroidal neovascularization | IOVS | ARVO Journals
Abstract: : Purpose: The inflammatory response is thought to play a role in the laser-induced model of choroidal neovascularization (CNV). We examined the role of anti-inflammatory cytokine IL-10 in this model. Methods: Rupture of Bruch's membrane with krypton red laser was used to initiate CNV in C57Bl/6 mice and age-matched IL-10-/- mice. Four burns were placed around the optic nerve (50 microns, 0.05 seconds, 280 mW). One week after laser, the mice were perfused with FITC-labeled dextran, and choroidal flat mounts were prepared for analysis of CNV using confocal microscopy. Bone marrow chimeras were generated to determine if relevant IL-10 was produced by hematopoietic or non-hematopoietic cells. Results: IL-10 KO mice have a 50-60% reduction in the incidence and volume of CNV compared to wild type mice. CNV in IL-10-/- mice with wild type hematopoietic cells resembled wild type, while CNV in wild type mice with IL-10-/- hematopoietic cells resembled ...http://iovs.arvojournals.org/article.aspx?articleid=2407795
H1 Choroidal Neovascularization Market Pipeline Review 2017 Trend Analysis Report | Medgadget
Choroidal Neovascularization - Pipeline Review, H1 2017, provides an overview of the Choroidal Neovascularization (Ophthalmology) pipeline landscape. Chorohttps://www.medgadget.com/2017/05/h1-choroidal-neovascularization-market-pipeline-review-2017-trend-analysis-report.html
Functional study of Let-7 microRNA family in choroidal neovascularization | IOVS | ARVO Journals
Purpose: microRNAs (miRNAs or miRs) are important posttranscriptional regulators of gene expression, and are emerging as pivotal modulators of numerous disease processes. Manipulating the level of disease-associated miRNAs and their target genes has shown significant therapeutic implications for complex diseases. Let-7 family members are among the highly expressed miRNAs in the retinal tissues and angiogenic endothelial cells. However, their function in ocular angiogenesis is still unknown. Here we investigate the function of Let-7 family in physiological and pathological ocular angiogenesis.. Methods: Transgenic mouse model, laser injury induced AMD model and in vivo subretinal miRNA injection technologies were used to test the function of Let-7 family in angiogenesis and laser-induced choroidal neovascularization (CNV).. Results: Let-7 transgenic mice showed retinal vessel tortuosity. In response to laser injury in the choroid, Let-7 transgenic mice showed significantly ...http://iovs.arvojournals.org/article.aspx?articleid=2266555