The Crosstalk Between Transforming Growth Factor-β1 and Delta Like-1 Mediates Early Chondrogenesis During Embryonic...
... its effects on chondrogenesis. In this model, Dlk1/FA1 functions as a negative regulator of chondrogenesis whose expression is ... suggesting regulation of Dlk1/FA1 by TGF-β1 signaling in chondrogenesis. TGF-β1-induced Smad phosphorylation and chondrogenesis ... In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998; 238: 265-272.. *CrossRef , ... Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. J Biol Chem 2005; 280: ...http://onlinelibrary.wiley.com/doi/10.1002/stem.792/full
An ex vivo human cartilage repair model to evaluate the potency of a cartilage cell transplant | Journal of Translational...
Chondrogenesis of mesenchymal stem cells in an osteochondral environment is mediated by the subchondral bone. Tissue Eng Part A ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1065-8
The Acceleration of Articular Cartilage Degeneration in Osteoarthritis by Nonsteroidal Anti-inflammatory Drugs - Journal of...
Differential regulation of EP receptor during chondrogenesis and chondrocyte maturation. Biochem Biophys Res Commun. 2005;328: ...http://journalofprolotherapy.com/the-acceleration-of-articular-cartilage-degeneration-in-osteoarthritis-by-nonsteroidal-anti-inflammatory-drugs/
7. Regulation of growth plate chondrocytes and bone cells
... a developmental disorder characterised by deformations of the hands and feet and heterotopic chondrogenesis (Kaplan, Tabas & ...http://archive.unu.edu/unupress/food2/UID06E/UID06E0V.HTM
Chondrogenesis - Everything2.com
Chon`dro*gen'e*sis (?), n. [Gr. cartilage + genesis.] Physiology|Physiol. The development of cartilage. © Webst...https://everything2.com/title/Chondrogenesis
Chondrogenesis - Semantic Scholar
Chondrogenesis in a cell-polymer-bioreactor system.. *Lisa E. Freed, Anthony P Hollander, Ivan Martin, John R. Barry, Robert ... Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development.. *Ung-il Chung, Ernestina Schipani, ... Chondrogenesis. Known as: cartilage formation, cartilage organ development, cartilage biogenesis (More). The process whose ... Chondrogenesis was studied under controlled in vitro conditions using a cell-polymer-bioreactor system. Bovine calf articular… ...https://www.semanticscholar.org/topic/Chondrogenesis/23175
Chondrogenesis - Wikipedia
... during chondrogenesis. Noggin, a developmental protein, inhibits chondrogenesis by preventing condensation and differentiation ... Chondrogenesis is the process by which cartilage is developed. In embryogenesis, the skeletal system is derived from the ... L-Sox5 is also thought to be involved primarily in embryonic chondrogenesis, while Sox6 is thought to be involved in post-natal ... Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, ...https://en.wikipedia.org/wiki/Chondrogenesis
Metabolomic Analysis of Differential Changes in Metabolites during ATP Oscillations in Chondrogenesis
H. J. Kwon, "TGF-β but not BMP signaling induces prechondrogenic condensation through ATP oscillations during chondrogenesis," ... We recently found that ATP oscillations play a key role in prechondrogenic condensation during chondrogenesis [2-4]. It was ... In this study, insulin which stimulates chondrogenesis of ATDC5 cells  was used in induction of ATP oscillations during ... Metabolomic Analysis of Differential Changes in Metabolites during ATP Oscillations in Chondrogenesis. Hyuck Joon Kwon1 and ...https://www.hindawi.com/journals/bmri/2013/213972/
Autologous matrix-induced chondrogenesis - Wikipedia
Autologous matrix-induced chondrogenesis (AMIC) is a treatment for articular cartilage damage. There is tentative short to ... Autologous Matrix Induced Chondrogenesis (AMIC) surgery is a single step procedure. After arthroscopic evaluation of the ... Shaikh, N; Seah, MKT; Khan, WS (18 July 2017). "Systematic review on the use of autologous matrix-induced chondrogenesis for ...https://en.wikipedia.org/wiki/Autologous_matrix-induced_chondrogenesis
Accelerated chondrogenesis in nanofiber polymeric scaffolds embedded with BMP-2 genetically engineered chondrocytes
... ter and accelerated chondrogenesis than controls. This cell engineered construct has potential use in one-step cartilage repair ... This study evaluated chondrogenesis within a nanofiber polymeric scaffold seeded with isolated untreated chondrocytes, isolated ... This study evaluated chondrogenesis within a nanofiber polymeric scaffold seeded with isolated untreated chondrocytes, isolated ... Wilke, M.M., Nydam, D.V. and Nixon, A.J. (2007) Enhanced early chondrogenesis in articular defects following arthroscopic ...https://www.scirp.org/journal/PaperInformation.aspx?PaperID=2667
Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and...
Shakibaei M. (1998) Inhibition of chondrogenesis by integrin antibody in vitro. Exp Cell Res 240:95-106PubMedCrossRefGoogle ... Mesenchymal stem cells Chondrogenesis Adipogenesis Osteogenesis Ultrastructure The research was conducted in part for the ... Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU (1998) In vitro chondrogenesis of bone marrow-derived mesenchymal ... Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ...https://link.springer.com/article/10.1007%2Fs00418-007-0337-z
Bone-marrow-derived chondrogenesis in vitro | Journal of Cell Science
Bone marrow stromal cells from embryonic, neo-natal and adult chickens were grown in vitro over a 21-day period. Marrow stromal cells from embryonic and neonatal chicks produced clonally derived chondrocytic colonies. The cells within the colonies were surrounded by a refractile, Alcian-blue-positive matrix and their cartilagenous nature was shown biochemically and immunocytochemically by the synthesis of collagen types II and X. The ability of chick bone marrow cells to form chondrocytic colonies decreased during development and was lost by adulthood. In addition to chondrocytic colonies, fat cells and fibroblasts were also observed in the cultures. Our data demonstrate that chick bone marrow stroma contains cells that are capable of differentiating along different pathways within the same culture, providing further evidence for the presence in bone marrow of a stromal stem cell.. ...http://jcs.biologists.org/content/101/2/333
Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis | Development
Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis. Helen J. Dranse, Arthur V. ... Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis. Helen J. Dranse, Arthur V. ... Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis. Helen J. Dranse, Arthur V. ... Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis Message Subject (Your Name) has ...http://dev.biologists.org/content/138/17/e1705
Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones |...
Fgfr1 Neural crest cell Frontal bone Chondrogenesis Osteogenesis This is a preview of subscription content, log in to check ... In summary, our results indicate that loss of Fgfr1 in neural crest cells leads to heterotopic chondrogenesis and osteogenesis. ... Our results show that specific knockout of Fgfr1 in neural crest cells induced heterotopic chondrogenesis and osteogenesis at ... Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones. ...https://link.springer.com/article/10.1007%2Fs00795-018-0213-z
Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells
... ... Equally robust chondrogenesis was also observed in co-cultures, even when up to 75% of primary ACs were initially replaced with ... Meretoja, Ville V., Dahlin, Rebecca L., Kasper, F. Kurtis, et al.. "Enhanced chondrogenesis in co-cultures with articular ... order to evaluate if a majority of primary ACs can be replaced with MSCs without detrimental effects on in vitro chondrogenesis ...https://scholarship.rice.edu/handle/1911/78886
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. | Sigma-Aldrich
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.. [Takako ... Sox9 is a transcription factor of the SRY family required for several steps of chondrogenesis. It activates the expression of ... Consistent with a role of Tip60 in chondrogenesis, addition of Tip60 siRNA to limb-bud micromass cultures delayed chondrocyte ...https://www.sigmaaldrich.com/catalog/papers/18390577
Determinants of stem cell lineage differentiation toward chondrogenesis versus adipogenesis | Springer for Research &...
Stem cell Chondrogenesis Adipogenesis, Lineage differentiation This is a preview of subscription content, log in to check ... Li J, Zhao Z, Liu J, Huang N, Long D, Wang J, Li X, Liu Y (2010) MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone ... Im GI, Quan Z (2010) The effects of Wnt inhibitors on the chondrogenesis of human mesenchymal stem cells. Tissue Eng Part A 16( ... Shao HJ, Ho CC, Lee YT, Chen CS, Wang JH, Young TH (2012) Chondrogenesis of human bone marrow mesenchymal cells by transforming ...https://rd.springer.com/article/10.1007%2Fs00018-019-03017-4
LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes
Author Summary A fundamental problem studied by skeletal biologists is the development of regenerative therapies to replace cartilage tissues impacted by injury or disease, which for individuals affected by osteoarthritis represents nearly half of all of all adults over the age of sixty five. To date, no therapies exist to promote sustained cartilage regeneration, as we have not been able to recapitulate the programming events necessary to instruct cells to form articular cartilage without these cells continuing to differentiate into bone. Our analysis of the early programming events occurring during cartilage formation led to the identification of LncRNA-HIT a long noncoding RNA that is essential for the differentiation of the embryonic limb mesenchyme into cartilage. A genome wide analysis of LncRNA-HIT's distribution in the mesenchyme revealed strong association between LncRNA-HIT and numerous genes whose products facilitate cartilage formation. In the absence of LncRNA-HIT, the expression of thesehttps://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005680
Variations In Chondrogenesis Of Human Bone Marrow-Derived Mesenchymal Stem Cells in Fibrin/Alginate Blended Hydrogels
Fibrin and alginate hydrogels have been widely used to support chondrogenesis of bone marrow-derived mesenchymal stem cells (BM ... Variations in Chondrogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells in Fibrin/Alginate Blended Hydrogels, Acta ... Variations In Chondrogenesis Of Human Bone Marrow-Derived Mesenchymal Stem Cells in Fibrin/Alginate Blended Hydrogels ... Fibrin and alginate hydrogels have been widely used to support chondrogenesis of bone marrow-derived mesenchymal stem cells (BM ...https://www.morganlewis.com/pubs/variations-in-chondrogenesis-of-human-bone-marrow-derived-mesenchymal-stem-cells
Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe...
Chondrogenesis: The ASC culture was performed from cell "Micromass" starting with a high concentration of cells in a minimal ... Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe ... In Vitro Osteogenesis and Chondrogenesis Are Favored in Suprapatellar ASC. To further assess the stem cell characteristics from ... Alizarin red for osteogenesis and Alcian blue for chondrogenesis, versus infrapatellar. In addition, immunodetection of ...https://www.hindawi.com/journals/sci/2017/4758930/
IJMS | Free Full-Text | Molecular Study of a Hoxa2 Gain-of-Function in Chondrogenesis: A Model of Idiopathic Proportionate...
In a previous study using transgenic mice ectopically expressing Hoxa2 during chondrogenesis, we associated the animal ... Although chondrogenesis is similar in the overall endochondral skeleton (i.e., every skeletal element except some parts of the ... Yoon, B.S.; Lyons, K.M. Multiple functions of BMPs in chondrogenesis. J. Cell Biochem 2004, 93, 93-103. [Google Scholar] ... Hatakeyama, Y.; Tuan, R.S.; Shum, L. Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis. J. Cell Biochem ...http://mdpi.com/1422-0067/14/10/20386/htm
TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds
... ... and . "TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds." ... and would require a reduced concentration of TGF-β3 to achieve an equivalent level of chondrogenesis compared to monocultures ... ACs and MSCs require a reduced concentration and duration of TGF-β3 exposure to achieve an equivalent level of chondrogenesis ...https://scholarship.rice.edu/handle/1911/80894
Investigation of Integrin Expression in Human Mesenchymal Stem Cells during Chondrogenesis in Different Culture Systems -...
In all culture methods, alpha and beta integrin subunits were down-regulated in hMSCs undergoing chondrogenesis compared to the ... Integrin-mediated signalling is known to be important in chondrocytes and to drive chondrogenesis. In our study, we ... this work has led to an increased understanding of the expression of integrins in hMSCs and during chondrogenesis. This ... V which were upregulated in cells undergoing chondrogenesis . Moreover, similar transcript expression was identified ...https://infoscience.epfl.ch/record/173439
Autologous Matrix-Induced Chondrogenesis (AMIC) Market Value to Increase from US$ 96.11 Mn in 2016 to US$ 186.4 Mn Bn by 2024 |...
The global Autologous Matrix-Induced Chondrogenesis market value in 2016 is estimated to be US$ 96.11 Mn and this is expected ... Autologous Matrix-Induced Chondrogenesis (AMIC) Market: Global Industry Analysis and Forecast, 2016-2024'. In terms of revenue ... Persistence Market Research delivers key insights on the global Autologous Matrix-Induced Chondrogenesis (AMIC) Market in its ... Autologous Matrix-Induced Chondrogenesis (AMIC) Market Value to Increase from US$ 96.11 Mn in 2016 to US$ 186.4 Mn Bn by 2024. ...http://www.sbwire.com/press-releases/autologous-matrix-induced-chondrogenesis-amic-market-value-to-increase-from-us-9611-mn-in-2016-to-us-1864-mn-bn-by-2024-745374.htm
OP0127 In Vitro Chondrogenesis and in VIVO Repair of Osteochondral Defect with Human Induced Pluripotent Stem Cells | Annals of...
OP0127 In Vitro Chondrogenesis and in VIVO Repair of Osteochondral Defect with Human Induced Pluripotent Stem Cells ... OP0127 In Vitro Chondrogenesis and in VIVO Repair of Osteochondral Defect with Human Induced Pluripotent Stem Cells ... While successful in vitro induction of chondrogenesis with improved biochemical characteristics were obtained from hiPS cells, ...http://ard.bmj.com/content/72/Suppl_3/A94.2