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*  Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis (Journal Article) |...
60 APPLIED LIFE SCIENCES; AMINOTRANSFERASES; APOPTOSIS; BILE; BILIARY TRACT; CHOLIC ACID; CONCENTRATION RATIO; GLYCINE; HUMAN ... Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition ... of the model bile acid glycochenodeoxycholic acid (GCDC). Treatment with GCDC resulted in necrosis with no increase in ... Individual bile acid levels were determined in serum and bile by UPLC/QTOFMS in patients with extrahepatic cholestasis with, or ...
https://www.osti.gov/scitech/biblio/22465712